[go: up one dir, main page]

DK3294865T3 - Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider - Google Patents

Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider Download PDF

Info

Publication number
DK3294865T3
DK3294865T3 DK16793332.4T DK16793332T DK3294865T3 DK 3294865 T3 DK3294865 T3 DK 3294865T3 DK 16793332 T DK16793332 T DK 16793332T DK 3294865 T3 DK3294865 T3 DK 3294865T3
Authority
DK
Denmark
Prior art keywords
epimerases
processes
production
benzylisoquinoline alkaloids
benzylisoquinoline
Prior art date
Application number
DK16793332.4T
Other languages
English (en)
Inventor
Christina D Smolke
Stephanie Galanie
Isis Trenchard
Catherine Thodey
Yanran Li
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57248432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3294865(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK3294865T3 publication Critical patent/DK3294865T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/99—Racemaces and epimerases (5.1) acting on other compounds (5.1.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01247—Codeinone reductase (NADPH) (1.1.1.247)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16793332.4T 2015-05-08 2016-05-09 Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider DK3294865T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562159122P 2015-05-08 2015-05-08
US201562174475P 2015-06-11 2015-06-11
PCT/US2016/031506 WO2016183023A1 (en) 2015-05-08 2016-05-09 Methods of producing epimerases and benzylisoquinoline alkaloids

Publications (1)

Publication Number Publication Date
DK3294865T3 true DK3294865T3 (da) 2023-05-08

Family

ID=57248432

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16793332.4T DK3294865T3 (da) 2015-05-08 2016-05-09 Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider

Country Status (13)

Country Link
US (2) US11859225B2 (da)
EP (2) EP4253525A3 (da)
JP (3) JP7266966B2 (da)
KR (1) KR20180016396A (da)
CN (1) CN107960102A (da)
AU (3) AU2016261490B2 (da)
CA (1) CA2983445A1 (da)
DK (1) DK3294865T3 (da)
ES (1) ES2945359T3 (da)
GB (1) GB2555044B (da)
HK (1) HK1246354A1 (da)
IL (1) IL255136B2 (da)
WO (1) WO2016183023A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11124814B2 (en) 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
BR112016012595B1 (pt) 2013-12-04 2024-02-27 Epimeron Inc Método de produção de (r)-reticulina em uma célula de levedura
CN107002103B (zh) * 2014-11-17 2022-01-28 小利兰.斯坦福大学托管委员会 产生类诺斯卡品的微生物以及其制备和使用方法
CN107960102A (zh) 2015-05-08 2018-04-24 小利兰·斯坦福大学托管委员会 产生差向异构酶和苄基异喹啉生物碱的方法
US11060071B2 (en) 2016-08-09 2021-07-13 River Stone Biotech, LLC Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
JP2020513790A (ja) * 2017-02-06 2020-05-21 ザイマージェン インコーポレイテッド 発酵によりチラミンを生成させるための遺伝子操作型生合成経路
WO2019028390A1 (en) * 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
WO2019051046A1 (en) * 2017-09-08 2019-03-14 Intrexon Corporation MICROORGANISMS AND METHODS FOR THE FERMENTATION OF BENZYLISOQUINOLINE ALKALOIDS
EP3720964A4 (en) * 2017-12-05 2021-09-15 Antheia, Inc. NEOPINONE ISOMERASE AND METHODS OF USE
JP7483617B2 (ja) * 2018-02-08 2024-05-15 アンテイア インコーポレイテッド モルフィナンアルカロイドおよび誘導体を生成する方法
IL278082B2 (en) 2018-04-19 2025-03-01 Abbvie Inc Methods of treating heavy menstrual bleeding
WO2019243624A1 (en) 2018-06-22 2019-12-26 Valorbec, Limited Partnership Production of benzylisoquinoline alkaloids in recombinant hosts
CN109468351B (zh) * 2018-11-27 2020-07-14 湖南美可达生物资源股份有限公司 高效酶催化合成血根碱与白屈菜红碱的方法
CA3132968A1 (en) 2019-03-08 2020-09-17 The Board Of Trustees Of The Leland Stanford Junior Unversity Tropane alkaloid (ta) producing non-plant host cells, and methods of making and using the same
CA3134602A1 (en) * 2019-03-26 2020-10-01 Antheia, Inc. Methods of improving production of morphinan alkaloids and derivatives
CN112516143B (zh) * 2020-11-30 2023-03-21 重庆医科大学 双苄四氢异喹啉衍生物在制备抗冠状病毒药物中的应用
WO2024100063A1 (en) 2022-11-08 2024-05-16 River Stone Biotech Aps Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression
CN116536285B (zh) * 2023-05-26 2024-09-17 浙江中医药大学 一种粉防己乌药碱氮甲基转移酶cnmt及应用
CN119432631A (zh) * 2023-08-04 2025-02-14 陈云 一种重组菌及其在生产苯骈菲啶生物碱中的应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2778832A (en) 1954-06-22 1957-01-22 Merck & Co Inc Reduction of codeinone to codeine
US3785927A (en) 1973-02-12 1974-01-15 Merck & Co Inc Process for converting(-)reticuline to(+)salutaridine
ATE63554T1 (de) 1986-11-25 1991-06-15 Council Scient Ind Res Verfahren zur herstellung von codein aus morphin.
CA1324969C (en) 1988-05-06 1993-12-07 Jeffrey R. Shuster High level expression of proteins in yeast
GB8910958D0 (en) 1989-05-12 1989-06-28 Bruce Neil C Assay
CS277517B6 (sk) 1990-12-12 1993-02-17 Slovakofarma S P Spósob čistenia kodeinu připraveného metylizáciou morfínu
US6204337B1 (en) 1996-11-19 2001-03-20 The Board Of Regents Of The University And Community College System Of Neveda Solid-phase synthesis of codeine from morphine
AUPO887297A0 (en) 1997-08-29 1997-09-25 Johnson & Johnson Research Pty. Limited Cytochrome p450 reductase from poppy plants
AUPP946399A0 (en) 1999-03-26 1999-04-22 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy
DE60224383T3 (de) 2001-02-15 2012-06-28 The University Of Chicago Verfahren zum nachweis in hefe für mittel die proteinfaltung beeinflussen
EP1270727A1 (en) 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-O-acetyltransferase and derivatives thereof
DE10232930A1 (de) 2002-07-19 2004-02-05 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von Aminosäuren und Aminosäure-Derivaten der Phosphoglycerat-Familie
US6579985B1 (en) 2002-10-21 2003-06-17 Mallinckrodt Inc. Preparation of codeine from morphine
EP1512748A1 (en) 2003-09-03 2005-03-09 Johnson & Johnson Research Pty Limited O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum
US20070298481A1 (en) 2003-09-17 2007-12-27 Fumihiko Sato Method for Producing a Useful Intermediate in Alkaloid Biosynthesis By Using Rnai Technology
TWI223707B (en) 2003-12-30 2004-11-11 Univ Nat Yunlin Sci & Tech Drug sensor for the alkaloid measurement, the preparation thereof, and measuring systems comprising the same
US6949645B1 (en) 2004-05-20 2005-09-27 Acura Pharmaceuticals, Inc. Process for the production of opiates
US7482140B2 (en) 2004-06-15 2009-01-27 Ajinomoto Co., Inc. L-tyrosine-producing bacterium and a method for producing L-tyrosine
EP1632565A1 (en) 2004-08-12 2006-03-08 Johnson & Johnson Research Pty Limited Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis
US7531345B2 (en) 2005-05-16 2009-05-12 Massachusetts Institute Of Technology Mutations for enhanced tyrosine production
US8318474B1 (en) 2005-05-23 2012-11-27 California Institute Of Technology Engineered yeast cells and uses thereof
US20070199090A1 (en) 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
EP1837396A1 (en) 2006-03-23 2007-09-26 Institut für Pflanzenbiochemie-IPB Salutaridine reductase and morphine biosynthesis
US8975063B2 (en) 2006-10-19 2015-03-10 California Institute Of Technology Compositions and methods for producing benzylisoquinoline alkaloids
US20080102499A1 (en) 2006-10-27 2008-05-01 Lori Jean Templeton Method of enhancing L-tyrosine production in recombinant bacteria
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
EP2169075B1 (en) 2007-06-12 2016-09-14 Kyoto University Method for production of alkaloid
JP2009225669A (ja) 2008-03-19 2009-10-08 Ishikawa Pref Gov 植物ベンジルイソキノリンアルカロイドの生産方法
WO2009122436A2 (en) 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
US8541647B2 (en) 2008-05-29 2013-09-24 Tasmania Alkaloids Pty, Ltd. Papaver somniferum with high concentration of codeine
US20110288114A1 (en) 2008-06-20 2011-11-24 Kinemed, Inc. Compositions for the treatment of fibrotic diseases or conditions
WO2011058446A2 (en) 2009-11-12 2011-05-19 Uti Limited Partnership Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum
EP2585479B1 (en) 2010-06-22 2019-06-12 Sun Pharmaceutical Industries (Australia) Pty Limited Methyltransferase nucleic acids and polypeptides
EP3992203A1 (en) 2010-07-22 2022-05-04 Sun Pharmaceutical Industries (Australia) Pty Limited Plant cytochrome p450
JP5761723B2 (ja) 2010-09-22 2015-08-12 石川県公立大学法人 植物ベンジルイソキノリンアルカロイドの生産方法
US20140013465A1 (en) 2010-11-01 2014-01-09 Tpi Enterprises Ltd. Papaver bracteatum with modified alkaloid content
MX2013004944A (es) 2010-11-05 2013-06-28 Basf Plant Science Co Gmbh Metodo para aumentar el rendimiento y la produccion de quimicos finos en las plantas.
CN102657652A (zh) 2011-03-10 2012-09-12 李宏 通式ⅰ所述的双苄基异喹啉生物碱衍生物或类似物的新用途
WO2012135389A2 (en) 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
EP2565262A1 (en) 2011-08-31 2013-03-06 VTU Holding GmbH Protein expression
US8809028B2 (en) 2011-11-07 2014-08-19 University Of Georgia Research Foundation, Inc. Biosynthesis of caffeic acid and caffeic acid derivatives by recombinant microorganisms
MX2014007964A (es) 2011-12-27 2014-10-06 Commw Scient Ind Res Org Procesos para producir lipidos.
GB201204407D0 (en) 2012-03-13 2012-04-25 Glaxosmithkline Australia Pty Ltd Nucleic acid molecule
EP2970999A2 (en) 2013-03-15 2016-01-20 The Board Of Trustees Of The University Of the Leland Stanford Junior University Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
US10793885B2 (en) 2013-08-16 2020-10-06 Willow Biosciences Inc. Compositions and methods for making noscapine and synthesis intermediates thereof
US11124814B2 (en) 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
BR112016012595B1 (pt) * 2013-12-04 2024-02-27 Epimeron Inc Método de produção de (r)-reticulina em uma célula de levedura
US20160340704A1 (en) 2014-01-13 2016-11-24 Valorbec Société en Commandite Method of making a benzylisoquinoline alkaloid (bia) metabolite, enzymes therefore
CA2946771A1 (en) 2014-04-29 2015-11-05 Epimeron Inc. Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
US10006010B2 (en) * 2014-05-16 2018-06-26 The University Of York Cytochrome P450 fusion protein
CA2952638C (en) 2014-06-19 2024-04-09 Epimeron Inc. Compositions and methods for making (s)-norcoclaurine and (s)-norlaudanosoline, and synthesis intermediates thereof
US10227353B2 (en) 2014-08-22 2019-03-12 Epimeron Inc. Compositions and methods for making alkaloid morphinans
US10457918B2 (en) 2014-09-26 2019-10-29 The Regents Of The University Of California Tyrosine hydroxylase variants and methods of use thereof
CN107002103B (zh) 2014-11-17 2022-01-28 小利兰.斯坦福大学托管委员会 产生类诺斯卡品的微生物以及其制备和使用方法
US11085060B2 (en) 2015-01-02 2021-08-10 Georgia Tech Research Corporation Pterin-dependent biocatalysts and uses thereof
CA3104099A1 (en) 2015-03-10 2016-09-15 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine
WO2016149821A1 (en) 2015-03-23 2016-09-29 Valorbec Société en Commandite Methods of making morphinan alkaloids and enzymes therefore
WO2016179231A1 (en) 2015-05-04 2016-11-10 Board Of Trustees Of Michigan State University Compositions and methods for inhibiting bacterial growth
CA2983419A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CN107960102A (zh) 2015-05-08 2018-04-24 小利兰·斯坦福大学托管委员会 产生差向异构酶和苄基异喹啉生物碱的方法
GB201511156D0 (en) 2015-06-24 2015-08-05 Glaxosmithkline Australia Pty Ltd And University Of York Production of alkaloids
IL241462A0 (en) 2015-09-10 2015-11-30 Yeda Res & Dev Heterologous engineering of betalain pigments in plants
WO2017083632A1 (en) 2015-11-13 2017-05-18 President And Fellows Of Harvard College Host cells and systems for membrane protein expression
GB2546285A (en) 2016-01-13 2017-07-19 Sun Pharmaceutical Ind Australia Pty Ltd Modified plant
JP6368328B2 (ja) 2016-02-10 2018-08-01 株式会社豊田自動織機 レジスタおよび車両
CA3029263A1 (en) 2016-06-27 2018-01-04 Intrexon Corporation Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
CA3028817A1 (en) 2016-06-27 2018-01-04 Serturner Corp. Polynucleotides and polypeptides useful for making alkaloid compounds
US11060071B2 (en) 2016-08-09 2021-07-13 River Stone Biotech, LLC Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
CA2941315C (en) 2016-08-12 2018-03-06 Api Labs Inc. High thebaine poppy and methods of producing the same
US20190185869A1 (en) 2016-09-02 2019-06-20 Tasmanian Alkaloids Pty Ltd P. somniferum plants for the production of codeine
WO2018136654A1 (en) 2017-01-19 2018-07-26 Donald Danforth Plant Science Center Morphinan n-demethylase isolated from the methylobacterium thebainfresser and methods of use thereof
JP2020513790A (ja) 2017-02-06 2020-05-21 ザイマージェン インコーポレイテッド 発酵によりチラミンを生成させるための遺伝子操作型生合成経路
JP7268019B2 (ja) 2017-07-14 2023-05-02 クリシア リミテッド スペルミジン産生のための微生物細胞
JP7483617B2 (ja) 2018-02-08 2024-05-15 アンテイア インコーポレイテッド モルフィナンアルカロイドおよび誘導体を生成する方法
CA3132968A1 (en) 2019-03-08 2020-09-17 The Board Of Trustees Of The Leland Stanford Junior Unversity Tropane alkaloid (ta) producing non-plant host cells, and methods of making and using the same

Also Published As

Publication number Publication date
IL255136B1 (en) 2023-05-01
AU2016261490A1 (en) 2017-11-09
GB2555044A (en) 2018-04-18
NZ775919A (en) 2025-03-28
BR112017023816A2 (pt) 2018-07-31
GB201719939D0 (en) 2018-01-17
JP2018515093A (ja) 2018-06-14
AU2016261490B2 (en) 2019-10-31
IL255136B2 (en) 2023-09-01
JP7266966B2 (ja) 2023-05-01
AU2019246920B2 (en) 2022-05-12
GB2555044B (en) 2021-03-17
KR20180016396A (ko) 2018-02-14
US11859225B2 (en) 2024-01-02
JP2024038497A (ja) 2024-03-19
IL255136A0 (en) 2017-12-31
EP3294865A1 (en) 2018-03-21
AU2019246920A1 (en) 2019-11-14
US20240218408A1 (en) 2024-07-04
CN107960102A (zh) 2018-04-24
WO2016183023A1 (en) 2016-11-17
EP3294865A4 (en) 2019-06-26
US12497638B2 (en) 2025-12-16
AU2022215268A1 (en) 2022-09-01
EP3294865B1 (en) 2023-04-12
EP4253525A2 (en) 2023-10-04
ES2945359T3 (es) 2023-06-30
EP4253525A3 (en) 2023-10-18
AU2022215268B2 (en) 2025-04-10
US20180163241A1 (en) 2018-06-14
HK1246354A1 (zh) 2018-09-07
CA2983445A1 (en) 2016-11-17
JP2021129587A (ja) 2021-09-09

Similar Documents

Publication Publication Date Title
DK3294865T3 (da) Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider
DK3315610T3 (da) Fremgangsmåde til fremstilling af fucosylerede oligosaccharider
DK3491173T3 (da) Fremgangsmåde og anlæg til fremstilling af methanol
DK3192902T3 (da) Fremgangsmåde til fremstilling af graphenholdige viscosefibre
DK3524595T3 (da) Quinolinderivat af høj renhed og fremgangsmåde til fremstilling deraf
IL264143B (en) Processes for preparing olaparib
DK3325443T3 (da) Fremgangsmåde til fremstilling af pridopidin
DK3473621T3 (da) Fremgangsmåde til fremstilling af diphenylmethan-derivat
DK3210961T3 (da) Fremgangsmåde til fremstilling af methanol og indretning til fremstilling af methanol
DK3377201T3 (da) Fremgangsmåde til fremstilling af membraner
DK3166904T3 (da) Fremgangsmåde til fremstilling af betonelementer
DK3464305T3 (da) Fremgangsmåder til fremstilling af oligomerer
DK3218396T3 (da) Fremgangsmåde til fremstilling af højaffinitets antistoffer
DK3328810T3 (da) Tilblanding til fremstilling af infrastrukturelle og strukturelle produkter og tilhørende fremstillingsfremgangsmåde
GB201511156D0 (en) Production of alkaloids
DK3328574T3 (da) Fremgangsmåde til fremstilling af en monotektisk legering
IL254502A0 (en) Solid forms of menaquinols
DK3323485T3 (da) Krystalliseringssøjle og krystalliseringsfremgangsmåde
DK3286209T3 (da) Fremgangsmåde til fremstilling af gonadotrophin
DK3309149T3 (da) 6-Brom-3-hydroxy-2-pyrazincarboxamid-krystal og fremgangsmåde til fremstilling af dette
DK3362405T3 (da) Fremgangsmåde og produktionsenhed til fremstilling af methanol
DK3345501T3 (da) Paraply og metode til fremstilling af paraplyen
DK3307875T3 (da) Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler
GB201609170D0 (en) Method of manufacture
DK3442995T3 (da) Produktion af suberin