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DK3277805T3 - CAS-9-retrovirale integrasesystemer til målrettet inkorporering af en dna-sekvens i en celles genom - Google Patents

CAS-9-retrovirale integrasesystemer til målrettet inkorporering af en dna-sekvens i en celles genom Download PDF

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Publication number
DK3277805T3
DK3277805T3 DK16715977.1T DK16715977T DK3277805T3 DK 3277805 T3 DK3277805 T3 DK 3277805T3 DK 16715977 T DK16715977 T DK 16715977T DK 3277805 T3 DK3277805 T3 DK 3277805T3
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cas
genome
cell
dna sequence
retroviral integrase
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DK16715977.1T
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English (en)
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Ferrukh Sheikh
Tetsuya Kawamura
Gloria Mo
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Sohm Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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DK16715977.1T 2015-03-31 2016-03-31 CAS-9-retrovirale integrasesystemer til målrettet inkorporering af en dna-sekvens i en celles genom DK3277805T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562140454P 2015-03-31 2015-03-31
US201562210451P 2015-08-27 2015-08-27
US201562240359P 2015-10-12 2015-10-12
PCT/US2016/025426 WO2016161207A1 (en) 2015-03-31 2016-03-31 Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism

Publications (1)

Publication Number Publication Date
DK3277805T3 true DK3277805T3 (da) 2025-06-10

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US (2) US20180080051A1 (da)
EP (2) EP3277805B1 (da)
JP (4) JP2018513681A (da)
KR (1) KR102769515B1 (da)
CN (1) CN108124453B (da)
DK (1) DK3277805T3 (da)
ES (1) ES3030433T3 (da)
WO (1) WO2016161207A1 (da)

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JP7599740B2 (ja) 2024-12-16
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