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DK3250593T3 - Anti-transthyretin-antistoffer - Google Patents

Anti-transthyretin-antistoffer Download PDF

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Publication number
DK3250593T3
DK3250593T3 DK16702990.9T DK16702990T DK3250593T3 DK 3250593 T3 DK3250593 T3 DK 3250593T3 DK 16702990 T DK16702990 T DK 16702990T DK 3250593 T3 DK3250593 T3 DK 3250593T3
Authority
DK
Denmark
Prior art keywords
transthyretin antibodies
transthyretin
antibodies
Prior art date
Application number
DK16702990.9T
Other languages
English (en)
Inventor
Avijit Chakrabartty
Tarlochan S Nijjar
Jeffrey N Higaki
Original Assignee
Prothena Biosciences Ltd
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prothena Biosciences Ltd, Univ Health Network filed Critical Prothena Biosciences Ltd
Application granted granted Critical
Publication of DK3250593T3 publication Critical patent/DK3250593T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16702990.9T 2015-01-28 2016-01-28 Anti-transthyretin-antistoffer DK3250593T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109004P 2015-01-28 2015-01-28
US201562266555P 2015-12-11 2015-12-11
PCT/IB2016/050416 WO2016120811A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Publications (1)

Publication Number Publication Date
DK3250593T3 true DK3250593T3 (da) 2022-08-22

Family

ID=55300737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16702990.9T DK3250593T3 (da) 2015-01-28 2016-01-28 Anti-transthyretin-antistoffer

Country Status (25)

Country Link
US (1) US20160257737A1 (da)
EP (1) EP3250593B1 (da)
JP (1) JP7101927B2 (da)
KR (1) KR102649788B1 (da)
CN (1) CN107406500B (da)
AU (1) AU2016210889C1 (da)
CA (1) CA2974993A1 (da)
CO (1) CO2017008482A2 (da)
CU (1) CU20170098A7 (da)
DK (1) DK3250593T3 (da)
EA (1) EA036014B1 (da)
ES (1) ES2925716T3 (da)
HR (1) HRP20220918T1 (da)
HU (1) HUE059592T2 (da)
MX (1) MX389911B (da)
MY (1) MY193701A (da)
PE (1) PE20180218A1 (da)
PL (1) PL3250593T3 (da)
PT (1) PT3250593T (da)
RS (1) RS63513B1 (da)
SA (1) SA517381981B1 (da)
SG (2) SG10201906696RA (da)
SI (1) SI3250593T1 (da)
TW (2) TWI711631B (da)
WO (1) WO2016120811A1 (da)

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US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007924A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
MX2020003549A (es) 2017-10-04 2020-08-03 Amgen Inc Fusiones de transtiretina e inmunoglobulina.
MX2020003041A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
MX2020003043A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Métodos para detectar transtiretina.
JOP20200132A1 (ar) 2017-11-29 2022-10-30 Prothena Biosciences Ltd [Ie/Ie] صيغة مجففة بالتبريد من جسم مضاد أحادي النسيلة ضد ترانس ثيرتين
WO2020003172A1 (en) 2018-06-26 2020-01-02 Mor Research Applications Transthyretin antibodies and uses thereof
CN111018976B (zh) * 2018-10-10 2022-04-01 东莞市朋志生物科技有限公司 一种抗人心肌肌钙蛋白i的重组抗体
JP7486821B2 (ja) * 2018-11-09 2024-05-20 ニューリミューン エイジー 患者由来アミロイド異種移植非ヒト動物モデル
KR20220016897A (ko) * 2019-06-04 2022-02-10 지앙수 헨그루이 메디슨 컴퍼니 리미티드 흉선 기질 림포포이에틴에 결합할 수 있는 항체 및 이의 용도
SG11202112762TA (en) * 2019-07-08 2021-12-30 Amgen Inc Multispecific transthyretin immunoglobulin fusions
KR20230026489A (ko) 2020-06-24 2023-02-24 프로테나 바이오사이언시즈 리미티드 소르틸린을 인지하는 항체
CN118059229A (zh) * 2020-10-14 2024-05-24 维里迪安治疗公司 用于治疗甲状腺眼病的组合物和方法
EP4257604A4 (en) * 2020-12-03 2024-11-13 Jiangsu Hengrui Pharmaceuticals Co., Ltd. PHARMACEUTICAL COMPOSITION OF ANTI-TSLP ANTIBODY AND ITS USE
AU2021398976A1 (en) * 2020-12-16 2023-07-06 Merus N.V. Multispecific antibodies for the treatment of cancer
WO2023039449A1 (en) 2021-09-07 2023-03-16 Siemens Healthcare Diagnostics Inc. Biomarker compositions and methods of use thereof
CN116804186B (zh) * 2023-07-05 2023-12-22 中国兽医药品监察所 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用
WO2025125544A1 (en) 2023-12-15 2025-06-19 Novo Nordisk A/S Stable liquid formulations

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Also Published As

Publication number Publication date
MX389911B (es) 2025-03-04
MX2017009803A (es) 2018-08-15
RS63513B1 (sr) 2022-09-30
CN107406500B (zh) 2022-02-25
TWI711631B (zh) 2020-12-01
CN107406500A (zh) 2017-11-28
ES2925716T3 (es) 2022-10-19
SA517381981B1 (ar) 2022-05-17
BR112017016345A2 (pt) 2018-03-27
HRP20220918T1 (hr) 2022-10-28
EP3250593A1 (en) 2017-12-06
TWI769570B (zh) 2022-07-01
JP2018510617A (ja) 2018-04-19
AU2016210889A1 (en) 2017-08-10
AU2016210889B2 (en) 2021-10-21
SI3250593T1 (sl) 2022-09-30
TW201636371A (zh) 2016-10-16
US20160257737A1 (en) 2016-09-08
WO2016120811A1 (en) 2016-08-04
CU20170098A7 (es) 2018-03-13
PL3250593T3 (pl) 2022-09-19
HUE059592T2 (hu) 2022-11-28
SG10201906696RA (en) 2019-08-27
KR102649788B1 (ko) 2024-03-20
CA2974993A1 (en) 2016-08-04
PE20180218A1 (es) 2018-01-31
SG11201706126WA (en) 2017-08-30
MY193701A (en) 2022-10-25
PT3250593T (pt) 2022-08-31
EA036014B1 (ru) 2020-09-14
AU2016210889C1 (en) 2022-02-10
CO2017008482A2 (es) 2018-01-16
EA201791710A1 (ru) 2017-12-29
KR20170120608A (ko) 2017-10-31
EP3250593B1 (en) 2022-06-22
JP7101927B2 (ja) 2022-07-19
TW202110896A (zh) 2021-03-16

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