DK3012259T3 - Fem-leddede heterocykliske pyridinforbindelser og fremstillingsfremgangsmåde og anvendelse deraf - Google Patents
Fem-leddede heterocykliske pyridinforbindelser og fremstillingsfremgangsmåde og anvendelse deraf Download PDFInfo
- Publication number
- DK3012259T3 DK3012259T3 DK14813825.8T DK14813825T DK3012259T3 DK 3012259 T3 DK3012259 T3 DK 3012259T3 DK 14813825 T DK14813825 T DK 14813825T DK 3012259 T3 DK3012259 T3 DK 3012259T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- membered heterocyclic
- pyridine compounds
- heterocyclic pyridine
- compounds
- Prior art date
Links
- -1 Heterocyclic Pyridine Compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310245354.8A CN104230922B (zh) | 2013-06-19 | 2013-06-19 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| PCT/CN2014/000600 WO2014201857A1 (zh) | 2013-06-19 | 2014-06-18 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3012259T3 true DK3012259T3 (da) | 2020-06-22 |
Family
ID=52103891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14813825.8T DK3012259T3 (da) | 2013-06-19 | 2014-06-18 | Fem-leddede heterocykliske pyridinforbindelser og fremstillingsfremgangsmåde og anvendelse deraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9988381B2 (da) |
| EP (1) | EP3012259B1 (da) |
| JP (1) | JP6594862B2 (da) |
| KR (1) | KR102289681B1 (da) |
| CN (1) | CN104230922B (da) |
| AU (1) | AU2014284013B2 (da) |
| BR (1) | BR112015030953B1 (da) |
| CA (1) | CA2908824C (da) |
| DK (1) | DK3012259T3 (da) |
| ES (1) | ES2802101T3 (da) |
| PT (1) | PT3012259T (da) |
| RU (1) | RU2668074C2 (da) |
| SG (1) | SG11201509511QA (da) |
| WO (1) | WO2014201857A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
| CA3236956A1 (en) * | 2021-11-05 | 2023-05-11 | Haihe Biopharma Co., Ltd. | Solid dispersion, preparation method therefor, and solid formulation comprising same |
| JP2024540399A (ja) * | 2021-11-05 | 2024-10-31 | ハイファ バイオファーマ カンパニー リミテッド | Ｍｅｔ受容体チロシンキナーゼ阻害剤を含む薬物の組み合わせ及びその使用 |
| CN119654152A (zh) | 2022-07-08 | 2025-03-18 | 阿斯利康(瑞典)有限公司 | 与hgf-受体抑制剂组合用于治疗癌症的表皮生长因子受体酪氨酸激酶抑制剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19834044A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| MXPA05008441A (es) * | 2003-02-14 | 2005-10-19 | Wyeth Corp | Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6. |
| BRPI0407811A (pt) * | 2003-02-27 | 2006-02-14 | Uriach Y Compania S A J | composto derivados de pirazolopiridina, processo para a preparação dos mesmos, composição farmacêutica e respectivos uso |
| WO2007098418A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| US20110130406A1 (en) * | 2007-09-06 | 2011-06-02 | Array Biopharma Inc. | Pyrazolo-pyridines as tyrosine kinase inhibitors |
| AR074024A1 (es) | 2008-11-14 | 2010-12-15 | Merial Ltd | Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria |
| KR101023580B1 (ko) | 2010-07-15 | 2011-03-21 | 전병수 | 승강기 와이어로프 장력 자동 균등화 장치 |
| JP5647356B2 (ja) | 2010-10-29 | 2014-12-24 | ファイザー・インク | Ｎ１／Ｎ２−ラクタムアセチル−ＣｏＡカルボキシラーゼ阻害剤 |
| MX367341B (es) * | 2012-05-08 | 2019-08-14 | Merck Sharp & Dohme | Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades. |
| RU2680100C9 (ru) | 2013-03-15 | 2019-04-18 | Плексксикон Инк. | Гетероциклические соединения и их применения |
| US20140303121A1 (en) * | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| TN2016000270A1 (en) * | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
-
2013
- 2013-06-19 CN CN201310245354.8A patent/CN104230922B/zh active Active
-
2014
- 2014-06-18 CA CA2908824A patent/CA2908824C/en active Active
- 2014-06-18 SG SG11201509511QA patent/SG11201509511QA/en unknown
- 2014-06-18 KR KR1020157032390A patent/KR102289681B1/ko active Active
- 2014-06-18 JP JP2016520243A patent/JP6594862B2/ja active Active
- 2014-06-18 ES ES14813825T patent/ES2802101T3/es active Active
- 2014-06-18 EP EP14813825.8A patent/EP3012259B1/en active Active
- 2014-06-18 BR BR112015030953-4A patent/BR112015030953B1/pt active IP Right Grant
- 2014-06-18 US US14/895,832 patent/US9988381B2/en active Active
- 2014-06-18 WO PCT/CN2014/000600 patent/WO2014201857A1/zh not_active Ceased
- 2014-06-18 DK DK14813825.8T patent/DK3012259T3/da active
- 2014-06-18 PT PT148138258T patent/PT3012259T/pt unknown
- 2014-06-18 RU RU2016101983A patent/RU2668074C2/ru active
- 2014-06-18 AU AU2014284013A patent/AU2014284013B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015030953B1 (pt) | 2022-03-29 |
| KR102289681B1 (ko) | 2021-08-17 |
| KR20160032003A (ko) | 2016-03-23 |
| RU2016101983A (ru) | 2017-07-24 |
| EP3012259A1 (en) | 2016-04-27 |
| CA2908824A1 (en) | 2014-12-24 |
| RU2668074C2 (ru) | 2018-09-26 |
| ES2802101T3 (es) | 2021-01-15 |
| AU2014284013B2 (en) | 2018-04-05 |
| US9988381B2 (en) | 2018-06-05 |
| CN104230922B (zh) | 2016-12-28 |
| JP6594862B2 (ja) | 2019-10-23 |
| EP3012259A4 (en) | 2016-11-23 |
| SG11201509511QA (en) | 2016-01-28 |
| WO2014201857A1 (zh) | 2014-12-24 |
| AU2014284013A1 (en) | 2016-02-11 |
| CN104230922A (zh) | 2014-12-24 |
| US20160137640A1 (en) | 2016-05-19 |
| EP3012259B1 (en) | 2020-06-03 |
| CA2908824C (en) | 2021-05-25 |
| PT3012259T (pt) | 2020-07-03 |
| JP2016521757A (ja) | 2016-07-25 |
| BR112015030953A8 (pt) | 2018-01-23 |
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