DK3030519T3 - Tricykliske benzoxaborol-forbindelser og anvendelser deraf - Google Patents

Tricykliske benzoxaborol-forbindelser og anvendelser deraf Download PDF

Info

Publication number: DK3030519T3
Authority: DK; Denmark
Prior art keywords: benzoxaborol compounds; tricyclic benzoxaborol; tricyclic; compounds; benzoxaborol
Prior art date: 2013-08-09

Application number

DK14834292.6T

Other languages

English (en)

Inventor

M R K Alley (Dickon)

Vincent S Hernandez

Jacob J Plattner

Xianfeng Li

David Barros-Aguirre

Ilaria Giordano

Original Assignee

Glaxosmithkline Ip No 2 Ltd

Anacor Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-08-09

Filing date

2014-08-08

Publication date

2022-01-31

2014-08-08 Application filed by Glaxosmithkline Ip No 2 Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Ip No 2 Ltd

2022-01-31 Application granted granted Critical

2022-01-31 Publication of DK3030519T3 publication Critical patent/DK3030519T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK14834292.6T 2013-08-09 2014-08-08 Tricykliske benzoxaborol-forbindelser og anvendelser deraf DK3030519T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361864496P	2013-08-09	2013-08-09
US201361918976P	2013-12-20	2013-12-20
PCT/US2014/050370 WO2015021396A2 (en)	2013-08-09	2014-08-08	Tricyclic benzoxaborole compounds and uses thereof

Publications (1)

Publication Number	Publication Date
DK3030519T3 true DK3030519T3 (da)	2022-01-31

Family

ID=52462052

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK14834292.6T DK3030519T3 (da)	2013-08-09	2014-08-08	Tricykliske benzoxaborol-forbindelser og anvendelser deraf

Country Status (35)

Country	Link
US (5)	US20160251380A1 (da)
EP (2)	EP4029870A1 (da)
JP (2)	JP6499175B2 (da)
KR (1)	KR102093783B1 (da)
CN (2)	CN105492388B (da)
AP (1)	AP2016009046A0 (da)
AU (2)	AU2014305792C1 (da)
BR (1)	BR112016002651B1 (da)
CA (1)	CA2919888C (da)
CL (1)	CL2016000313A1 (da)
CR (1)	CR20160064A (da)
CY (1)	CY1125030T1 (da)
DK (1)	DK3030519T3 (da)
DO (1)	DOP2016000045A (da)
EA (1)	EA032844B1 (da)
ES (1)	ES2905413T3 (da)
HR (1)	HRP20220384T1 (da)
HU (1)	HUE057365T2 (da)
IL (1)	IL243874B (da)
LT (1)	LT3030519T (da)
MX (1)	MX375556B (da)
MY (1)	MY175823A (da)
NZ (1)	NZ716350A (da)
PE (1)	PE20160752A1 (da)
PH (1)	PH12016500234B1 (da)
PL (1)	PL3030519T3 (da)
PT (1)	PT3030519T (da)
RS (1)	RS62887B1 (da)
SA (1)	SA516370551B1 (da)
SG (2)	SG10201914073PA (da)
SI (1)	SI3030519T1 (da)
SM (1)	SMT202200113T1 (da)
UA (1)	UA116908C2 (da)
WO (1)	WO2015021396A2 (da)
ZA (1)	ZA201600792B (da)

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AR094961A1 (es) *	2013-03-15	2015-09-09	Lilly Co Eli	1-hidroxi-benzooxaboroles como agentes antiparasitarios
KR101636431B1 (ko)	2013-07-30	2016-07-05	동아에스티 주식회사	트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
SI3030519T1 (sl) *	2013-08-09	2022-04-29	Glaxosmithkline Intellectual Property (No.2) Limited	Triciklične benzoksaborolne spojine in njihove uporabe
TW201625649A (zh)	2014-07-01	2016-07-16	第一三共股份有限公司	作爲抗菌劑的三環化合物
MA41494B1 (fr)	2015-02-12	2020-10-28	Glaxosmithkline Ip No 2 Ltd	Composés benzoxaborole substitués en position 4 et utilisations associées
CN109503637B (zh)	2016-05-12	2021-03-16	安纳考尔医药公司	用于治疗寄生虫疾病的化合物
CN109387594B (zh) *	2017-08-08	2021-01-19	武汉武药科技有限公司	一种分离和分析贝达喹啉光学异构体的方法
CA3087139A1 (en) *	2018-01-09	2019-07-18	Halcyon Labs Private Limited	Process for the preparation of crisaborole and its intermediates
WO2021257466A1 (en) *	2020-06-15	2021-12-23	The Global Alliance For Tb Drug Development, Inc.	Combination antibacterial composition and method for antibacterial therapy
CN111606850B (zh) *	2020-07-07	2023-07-25	安徽贝克生物制药有限公司	贝达喹啉及其中间体的制备方法
US11793808B2 (en)	2021-02-22	2023-10-24	Mannkind Corp.	Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
CN119233977A (zh) *	2022-06-23	2024-12-31	上海盟科药业股份有限公司	硼化合物的前药及其在治疗细菌感染中的用途
WO2023246841A1 (en) *	2022-06-23	2023-12-28	Shanghai Micurx Pharmaceutical Co., Ltd.	Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
CN120835890A (zh)	2023-04-05	2025-10-24	葛兰素史密斯克莱知识产权（第2号）有限公司	3-(氨基甲基)-4-氯-7-(2-羟基乙氧基)苯并[c][1,2]氧杂硼杂环戊-1(3H)-醇的合成

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DE60313357T2 (de)	2002-12-02	2008-01-03	Solvias Ag	Verfahren zur katalytischen hydrierung von kohlenstoff-heteroatom-doppelbindungen
SI3424932T1 (sl) *	2005-02-16	2021-08-31	Anacor Pharmaceuticals, Inc.	Boronoftalidi za terapevtsko uporabo
US7919422B2 (en)	2005-03-08	2011-04-05	Agency For Science, Technology And Research	Chiral bisoxazoline catalysts
CN101505603A (zh) *	2005-12-30	2009-08-12	安纳考尔医药公司	含硼的小分子
CA2635680A1 (en) *	2005-12-30	2007-07-12	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
KR100848491B1 (ko)	2007-01-16	2008-07-28	영진약품공업주식회사	베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) *	2007-06-20	2019-10-20	Anacor Pharmaceuticals Inc	جزيئات صغيرة تحتوي على البورون
CA2744231A1 (en)	2008-12-17	2010-07-15	Anacor Pharmaceuticals, Inc.	Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
WO2011127143A1 (en) *	2010-04-07	2011-10-13	Glaxosmithkline Llc	Process for preparing benzoxaboroles
PL3251678T3 (pl) *	2010-09-07	2022-01-10	Anacor Pharmaceuticals, Inc.	Pochodne benzoksaborolu do leczenia zakażeń bakteryjnych
WO2013093615A1 (en) *	2011-12-22	2013-06-27	Micurx Pharmaceuticals, Inc.	Tricyclic boron compounds for antimicrobial therapy
KR101636431B1 (ko)	2013-07-30	2016-07-05	동아에스티 주식회사	트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
SI3030519T1 (sl) *	2013-08-09	2022-04-29	Glaxosmithkline Intellectual Property (No.2) Limited	Triciklične benzoksaborolne spojine in njihove uporabe
MA41494B1 (fr) *	2015-02-12	2020-10-28	Glaxosmithkline Ip No 2 Ltd	Composés benzoxaborole substitués en position 4 et utilisations associées

2014
- 2014-08-08 SI SI201431939T patent/SI3030519T1/sl unknown
- 2014-08-08 AU AU2014305792A patent/AU2014305792C1/en active Active
- 2014-08-08 ES ES14834292T patent/ES2905413T3/es active Active
- 2014-08-08 US US14/387,384 patent/US20160251380A1/en not_active Abandoned
- 2014-08-08 DK DK14834292.6T patent/DK3030519T3/da active
- 2014-08-08 LT LTEPPCT/US2014/050370T patent/LT3030519T/lt unknown
- 2014-08-08 SG SG10201914073PA patent/SG10201914073PA/en unknown
- 2014-08-08 JP JP2016533471A patent/JP6499175B2/ja active Active
- 2014-08-08 CN CN201480049562.3A patent/CN105492388B/zh active Active
- 2014-08-08 CA CA2919888A patent/CA2919888C/en active Active
- 2014-08-08 HR HRP20220384TT patent/HRP20220384T1/hr unknown
- 2014-08-08 BR BR112016002651-9A patent/BR112016002651B1/pt active IP Right Grant
- 2014-08-08 UA UAA201600796A patent/UA116908C2/uk unknown
- 2014-08-08 MX MX2016001732A patent/MX375556B/es active IP Right Grant
- 2014-08-08 PL PL14834292T patent/PL3030519T3/pl unknown
- 2014-08-08 RS RS20220108A patent/RS62887B1/sr unknown
- 2014-08-08 KR KR1020167006314A patent/KR102093783B1/ko active Active
- 2014-08-08 MY MYPI2016700458A patent/MY175823A/en unknown
- 2014-08-08 AP AP2016009046A patent/AP2016009046A0/en unknown
- 2014-08-08 PT PT148342926T patent/PT3030519T/pt unknown
- 2014-08-08 PE PE2016000234A patent/PE20160752A1/es unknown
- 2014-08-08 EP EP21214787.0A patent/EP4029870A1/en not_active Withdrawn
- 2014-08-08 EA EA201690135A patent/EA032844B1/ru unknown
- 2014-08-08 CN CN201811396796.1A patent/CN110003253B/zh active Active
- 2014-08-08 SM SM20220113T patent/SMT202200113T1/it unknown
- 2014-08-08 EP EP14834292.6A patent/EP3030519B1/en active Active
- 2014-08-08 NZ NZ716350A patent/NZ716350A/en unknown
- 2014-08-08 HU HUE14834292A patent/HUE057365T2/hu unknown
- 2014-08-08 SG SG11201600787PA patent/SG11201600787PA/en unknown
- 2014-08-08 WO PCT/US2014/050370 patent/WO2015021396A2/en not_active Ceased
2016
- 2016-01-28 IL IL243874A patent/IL243874B/en active IP Right Grant
- 2016-02-03 PH PH12016500234A patent/PH12016500234B1/en unknown
- 2016-02-04 ZA ZA2016/00792A patent/ZA201600792B/en unknown
- 2016-02-07 SA SA516370551A patent/SA516370551B1/ar unknown
- 2016-02-08 CL CL2016000313A patent/CL2016000313A1/es unknown
- 2016-02-09 CR CR20160064A patent/CR20160064A/es unknown
- 2016-02-09 DO DO2016000045A patent/DOP2016000045A/es unknown
2017
- 2017-08-03 AU AU2017210567A patent/AU2017210567B2/en active Active
- 2017-10-24 US US15/792,251 patent/US10308668B2/en active Active
2019
- 2019-03-14 JP JP2019046582A patent/JP6764970B2/ja active Active
- 2019-04-16 US US16/385,547 patent/US10526352B2/en active Active
- 2019-11-26 US US16/695,253 patent/US10858376B2/en active Active
2020
- 2020-11-04 US US17/089,058 patent/US20210053999A1/en not_active Abandoned
2022
- 2022-03-01 CY CY20221100169T patent/CY1125030T1/el unknown

Also Published As

Publication number	Publication date
ES2905413T3 (es)	2022-04-08
AU2014305792A1 (en)	2016-03-10
EP3030519A4 (en)	2017-03-08
HRP20220384T1 (hr)	2022-07-22
CN110003253B (zh)	2022-03-18
MX2016001732A (es)	2016-05-18
US10308668B2 (en)	2019-06-04
AP2016009046A0 (en)	2016-02-29
LT3030519T (lt)	2022-04-11
MY175823A (en)	2020-07-10
NZ716350A (en)	2022-12-23
WO2015021396A9 (en)	2016-02-11
US10526352B2 (en)	2020-01-07
PT3030519T (pt)	2022-01-27
AU2014305792B2 (en)	2017-05-04
ZA201600792B (en)	2022-05-25
BR112016002651B1 (pt)	2022-11-29
MX375556B (es)	2025-03-06
US10858376B2 (en)	2020-12-08
EP3030519A2 (en)	2016-06-15
PH12016500234B1 (en)	2019-01-30
JP2016527321A (ja)	2016-09-08
US20190241586A1 (en)	2019-08-08
SI3030519T1 (sl)	2022-04-29
WO2015021396A3 (en)	2015-10-29
CN110003253A (zh)	2019-07-12
JP6764970B2 (ja)	2020-10-07
AU2017210567B2 (en)	2019-08-01
KR102093783B1 (ko)	2020-03-26
CN105492388A (zh)	2016-04-13
SG10201914073PA (en)	2020-03-30
SA516370551B1 (ar)	2017-10-31
UA116908C2 (uk)	2018-05-25
CY1125030T1 (el)	2023-03-24
US20180044355A1 (en)	2018-02-15
US20200095266A1 (en)	2020-03-26
HK1219939A1 (zh)	2017-04-21
CN105492388B (zh)	2018-12-21
SMT202200113T1 (it)	2022-05-12
HUE057365T2 (hu)	2022-05-28
CL2016000313A1 (es)	2016-09-23
EP4029870A1 (en)	2022-07-20
BR112016002651A2 (pt)	2017-08-01
EA032844B1 (ru)	2019-07-31
IL243874A0 (en)	2016-04-21
PH12016500234A1 (en)	2016-05-16
RS62887B1 (sr)	2022-03-31
CA2919888A1 (en)	2015-02-12
CR20160064A (es)	2016-06-01
SG11201600787PA (en)	2016-03-30
KR20160038901A (ko)	2016-04-07
AU2017210567A1 (en)	2017-08-24
EP3030519B1 (en)	2022-01-05
US20210053999A1 (en)	2021-02-25
PE20160752A1 (es)	2016-08-17
PL3030519T3 (pl)	2022-05-23
AU2014305792C1 (en)	2018-07-05
CA2919888C (en)	2022-10-18
IL243874B (en)	2018-11-29
DOP2016000045A (es)	2016-04-29
WO2015021396A2 (en)	2015-02-12
US20160251380A1 (en)	2016-09-01
JP2019123727A (ja)	2019-07-25
JP6499175B2 (ja)	2019-04-10
EA201690135A1 (ru)	2016-07-29

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