DK2968173T3 - Heterocykliske forbindelser og anvendelser deraf - Google Patents

Heterocykliske forbindelser og anvendelser deraf Download PDF

Info

Publication number: DK2968173T3
Authority: DK; Denmark
Prior art keywords: heterocyclic compounds; heterocyclic; compounds
Prior art date: 2013-03-14

Application number

DK14719472.4T

Other languages

English (en)

Inventor

Mingda Bi

Robert Kuehl

Original Assignee

Amgen Inc

Cytokinetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-14

Filing date

2014-03-14

Publication date

2020-12-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2968173(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-03-14 Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc

2020-12-21 Application granted granted Critical

2020-12-21 Publication of DK2968173T3 publication Critical patent/DK2968173T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

DK14719472.4T 2013-03-14 2014-03-14 Heterocykliske forbindelser og anvendelser deraf DK2968173T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361785763P	2013-03-14	2013-03-14
PCT/US2014/027104 WO2014152236A1 (en)	2013-03-14	2014-03-14	Heterocyclic compounds and their uses

Publications (1)

Publication Number	Publication Date
DK2968173T3 true DK2968173T3 (da)	2020-12-21

Family

ID=50549466

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK14719472.4T DK2968173T3 (da)	2013-03-14	2014-03-14	Heterocykliske forbindelser og anvendelser deraf
DK14720369.9T DK2970123T3 (da)	2013-03-14	2014-03-14	Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK14720369.9T DK2970123T3 (da)	2013-03-14	2014-03-14	Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf

Country Status (42)

Country	Link
US (15)	US9951015B2 (da)
EP (3)	EP2968173B1 (da)
JP (5)	JP6783138B2 (da)
KR (2)	KR102474467B1 (da)
CN (3)	CN105209437B (da)
AP (1)	AP2015008789A0 (da)
AR (2)	AR095542A1 (da)
AU (2)	AU2014240049C1 (da)
BR (2)	BR112015022857B1 (da)
CA (3)	CA2902646C (da)
CL (1)	CL2015002708A1 (da)
CR (1)	CR20150549A (da)
CY (2)	CY1122695T1 (da)
DK (2)	DK2968173T3 (da)
EA (1)	EA031185B1 (da)
ES (2)	ES2750676T3 (da)
HK (1)	HK1218080A1 (da)
HR (2)	HRP20201967T1 (da)
HU (2)	HUE046285T2 (da)
IL (2)	IL240788B (da)
JO (1)	JOP20140114B1 (da)
LT (2)	LT2968173T (da)
MA (2)	MA44637B1 (da)
ME (1)	ME03566B (da)
MX (3)	MX363347B (da)
MY (2)	MY204971A (da)
NZ (1)	NZ711225A (da)
PE (1)	PE20151786A1 (da)
PH (2)	PH12019500176B1 (da)
PL (2)	PL2968173T3 (da)
PT (2)	PT2970123T (da)
RS (2)	RS61215B1 (da)
RU (1)	RU2663663C2 (da)
SA (1)	SA515361088B1 (da)
SG (2)	SG11201507258PA (da)
SI (2)	SI2970123T1 (da)
SM (2)	SMT202000685T1 (da)
TN (1)	TN2015000380A1 (da)
TW (1)	TWI667026B (da)
UA (1)	UA117011C2 (da)
UY (1)	UY35449A (da)
WO (2)	WO2014152236A1 (da)

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TWI790189B (zh)	2015-01-02	2023-01-21	美商梅拉洛伊卡公司	細菌組成物
JP6858716B2 (ja)	2015-06-26	2021-04-14	アムジエン・インコーポレーテツド	心筋ミオシン活性化剤と洞房結節Ｉｆ電流阻害剤の併用療法
PT3645002T (pt)	2017-06-30	2025-01-24	Amgen Inc	Métodos de tratamento da insuficiência cardíaca com ativadores do sarcómero cardíaco
ES2882905T3 (es)	2017-06-30	2021-12-03	Amgen Inc	Síntesis de omecamtiv mecarbil
EA039850B1 (ru) *	2018-04-30	2022-03-21	Эмджен Инк.	Синтез омекамтива мекарбила
DK3594199T3 (da)	2018-07-09	2020-09-14	Fis Fabbrica Italiana Sintetici Spa	Krystallinsk 2-flour-3-nitrotoluen og proces til forberedelse deraf
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WO2020131574A1 (en)	2018-12-18	2020-06-25	Amgen Inc.	Method of reducing aromatic nitro compounds
EP3938042A1 (en) *	2019-03-12	2022-01-19	Amgen Inc.	Polymorphs of a cardiac troponin activator
US12187700B2 (en) *	2019-03-12	2025-01-07	Amgen Inc.	Polymorphs and cocrystals of a cardiac troponin activator
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EP4031541A1 (en)	2019-09-19	2022-07-27	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
WO2021070123A1 (en) *	2019-10-09	2021-04-15	Dr. Reddy’S Laboratories Limited	Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
AU2021221106A1 (en)	2020-02-10	2022-09-22	Amgen Inc.	Omecamtiv mecarbil tablet
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KR20230107282A (ko)	2020-11-12	2023-07-14	암젠 인크	오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
WO2022177927A1 (en) *	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
JP2024509797A (ja)	2021-03-10	2024-03-05	アムジェンインコーポレイテッド	オメカムチブメカルビルの合成
WO2024081611A1 (en)	2022-10-11	2024-04-18	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 (en)	2023-06-27	2024-05-21	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators

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PT3645002T (pt)	2017-06-30	2025-01-24	Amgen Inc	Métodos de tratamento da insuficiência cardíaca com ativadores do sarcómero cardíaco
ES2882905T3 (es) *	2017-06-30	2021-12-03	Amgen Inc	Síntesis de omecamtiv mecarbil
DK3594199T3 (da)	2018-07-09	2020-09-14	Fis Fabbrica Italiana Sintetici Spa	Krystallinsk 2-flour-3-nitrotoluen og proces til forberedelse deraf
WO2020014406A1 (en)	2018-07-12	2020-01-16	Assia Chemical Industries Ltd.	Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl
US11465969B2 (en)	2018-08-17	2022-10-11	Cytokinetics, Inc.	Salts and crystal forms of omecamtiv mecarbil
WO2020131574A1 (en)	2018-12-18	2020-06-25	Amgen Inc.	Method of reducing aromatic nitro compounds
US20220348543A1 (en)	2019-09-19	2022-11-03	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
EP4031541A1 (en)	2019-09-19	2022-07-27	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
WO2021070123A1 (en)	2019-10-09	2021-04-15	Dr. Reddy’S Laboratories Limited	Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
EP4041710A1 (en)	2019-10-09	2022-08-17	Dr. Reddy's Laboratories Limited	Alternate processes for the preparation of omecamtiv mecarbil
WO2021136477A1 (zh)	2020-01-03	2021-07-08	苏州科睿思制药有限公司	化合物i二盐酸盐的共晶及其制备方法和用途
AU2021221106A1 (en)	2020-02-10	2022-09-22	Amgen Inc.	Omecamtiv mecarbil tablet
KR20230107282A (ko)	2020-11-12	2023-07-14	암젠 인크	오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
WO2022177927A1 (en)	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
JP2024509797A (ja)	2021-03-10	2024-03-05	アムジェンインコーポレイテッド	オメカムチブメカルビルの合成
US11986474B1 (en)	2023-06-27	2024-05-21	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators

2014
- 2014-03-14 WO PCT/US2014/027104 patent/WO2014152236A1/en not_active Ceased
- 2014-03-14 RS RS20201513A patent/RS61215B1/sr unknown
- 2014-03-14 EP EP14719472.4A patent/EP2968173B1/en active Active
- 2014-03-14 LT LTEP14719472.4T patent/LT2968173T/lt unknown
- 2014-03-14 ME MEP-2019-283A patent/ME03566B/me unknown
- 2014-03-14 MX MX2015012414A patent/MX363347B/es unknown
- 2014-03-14 UA UAA201509685A patent/UA117011C2/uk unknown
- 2014-03-14 CA CA2902646A patent/CA2902646C/en active Active
- 2014-03-14 AP AP2015008789A patent/AP2015008789A0/xx unknown
- 2014-03-14 ES ES14720369T patent/ES2750676T3/es active Active
- 2014-03-14 AU AU2014240049A patent/AU2014240049C1/en active Active
- 2014-03-14 HU HUE14720369A patent/HUE046285T2/hu unknown
- 2014-03-14 CN CN201480018405.6A patent/CN105209437B/zh active Active
- 2014-03-14 SG SG11201507258PA patent/SG11201507258PA/en unknown
- 2014-03-14 AU AU2014239995A patent/AU2014239995B2/en active Active
- 2014-03-14 JP JP2016502348A patent/JP6783138B2/ja active Active
- 2014-03-14 CA CA3147180A patent/CA3147180C/en active Active
- 2014-03-14 CA CA2902436A patent/CA2902436A1/en active Pending
- 2014-03-14 CN CN201480014897.1A patent/CN105120844A/zh active Pending
- 2014-03-14 PE PE2015002000A patent/PE20151786A1/es unknown
- 2014-03-14 US US14/210,713 patent/US9951015B2/en active Active
- 2014-03-14 MA MA44637A patent/MA44637B1/fr unknown
- 2014-03-14 RS RS20191313A patent/RS59536B1/sr unknown
- 2014-03-14 EA EA201591728A patent/EA031185B1/ru unknown
- 2014-03-14 HK HK16106250.4A patent/HK1218080A1/zh unknown
- 2014-03-14 DK DK14719472.4T patent/DK2968173T3/da active
- 2014-03-14 HR HRP20201967TT patent/HRP20201967T1/hr unknown
- 2014-03-14 RU RU2015143643A patent/RU2663663C2/ru active
- 2014-03-14 SG SG10201706656RA patent/SG10201706656RA/en unknown
- 2014-03-14 PT PT147203699T patent/PT2970123T/pt unknown
- 2014-03-14 KR KR1020227007907A patent/KR102474467B1/ko active Active
- 2014-03-14 MX MX2015012429A patent/MX2015012429A/es unknown
- 2014-03-14 NZ NZ711225A patent/NZ711225A/en unknown
- 2014-03-14 ES ES14719472T patent/ES2837038T3/es active Active
- 2014-03-14 JP JP2016502336A patent/JP6498658B2/ja active Active
- 2014-03-14 SM SM20200685T patent/SMT202000685T1/it unknown
- 2014-03-14 SI SI201431358T patent/SI2970123T1/sl unknown
- 2014-03-14 DK DK14720369.9T patent/DK2970123T3/da active
- 2014-03-14 BR BR112015022857-7A patent/BR112015022857B1/pt active IP Right Grant
- 2014-03-14 MY MYPI2019004869A patent/MY204971A/en unknown
- 2014-03-14 PT PT147194724T patent/PT2968173T/pt unknown
- 2014-03-14 KR KR1020157025283A patent/KR102374159B1/ko active Active
- 2014-03-14 LT LT14720369T patent/LT2970123T/lt unknown
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MX2015012414A (es)	2016-04-25
IL240788B (en)	2020-09-30
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MY186048A (en)	2021-06-17
WO2014152236A1 (en)	2014-09-25
AR095542A1 (es)	2015-10-21
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RS61215B1 (sr)	2021-01-29

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