[go: up one dir, main page]

DK3004366T3 - Mikroorganismer til diterpenproduktion - Google Patents

Mikroorganismer til diterpenproduktion Download PDF

Info

Publication number
DK3004366T3
DK3004366T3 DK14727821.2T DK14727821T DK3004366T3 DK 3004366 T3 DK3004366 T3 DK 3004366T3 DK 14727821 T DK14727821 T DK 14727821T DK 3004366 T3 DK3004366 T3 DK 3004366T3
Authority
DK
Denmark
Prior art keywords
diterpen
organisms
micro
production
diterpen production
Prior art date
Application number
DK14727821.2T
Other languages
English (en)
Inventor
Viktor Marius Boer
Erwin Suir
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of DK3004366T3 publication Critical patent/DK3004366T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK14727821.2T 2013-05-31 2014-06-02 Mikroorganismer til diterpenproduktion DK3004366T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201313907795A 2013-05-31 2013-05-31
PCT/EP2014/061399 WO2014191581A2 (en) 2013-05-31 2014-06-02 Microorganisms for diterpene production

Publications (1)

Publication Number Publication Date
DK3004366T3 true DK3004366T3 (da) 2019-05-20

Family

ID=50884399

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14727821.2T DK3004366T3 (da) 2013-05-31 2014-06-02 Mikroorganismer til diterpenproduktion

Country Status (9)

Country Link
US (3) US10689681B2 (da)
EP (2) EP3004366B1 (da)
CN (1) CN105452476B (da)
AU (1) AU2014273055A1 (da)
BR (1) BR112015029580A2 (da)
CA (1) CA2913876A1 (da)
DK (1) DK3004366T3 (da)
MX (1) MX367033B (da)
WO (1) WO2014191581A2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG186127A1 (en) 2010-06-02 2013-01-30 Evolva Nutrition Inc Recombinant production of steviol glycosides
MY190346A (en) 2013-02-06 2022-04-15 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
MY184253A (en) 2013-02-11 2021-03-29 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
EP3004366B1 (en) * 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganisms for diterpene production
EP3885443B1 (en) * 2013-07-15 2025-01-15 DSM IP Assets B.V. Diterpene production
EP3024941B1 (en) * 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
KR20170041209A (ko) 2014-08-11 2017-04-14 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
EP4592304A3 (en) 2014-09-09 2025-11-05 Danstar Ferment Ag Production of steviol glycosides in recombinant hosts
MY193955A (en) * 2014-12-17 2022-11-02 Cargill Inc Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
BR112017016338A2 (pt) 2015-01-30 2018-03-27 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
US20180057850A1 (en) * 2015-03-23 2018-03-01 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
US11344051B2 (en) 2015-04-03 2022-05-31 Dsm Ip Assets B.V. Steviol glycosides
JP2018521636A (ja) 2015-05-29 2018-08-09 カーギル・インコーポレイテッド 多段階供給を用いる、ステビオール配糖体を生成するための発酵方法
EP4063513A1 (en) * 2015-05-29 2022-09-28 Cargill, Incorporated Heat treatment to produce glycosides
WO2016196321A1 (en) 2015-05-29 2016-12-08 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high ph and compositions obtained therefrom
CA2994288A1 (en) 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
US10837041B2 (en) 2015-08-07 2020-11-17 Evolva Sa Production of steviol glycosides in recombinant hosts
MY195726A (en) * 2015-08-13 2023-02-07 Dsm Ip Assets Bv Steviol Glycoside Transport
US20200308616A1 (en) * 2015-11-30 2020-10-01 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
CN109804073B (zh) 2016-08-12 2023-05-16 阿迈瑞斯公司 用于高效生成瑞鲍迪苷的udp依赖性糖基转移酶
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
JP7160811B2 (ja) * 2016-12-22 2022-10-25 フイルメニツヒ ソシエテ アノニム マノオールの製造
EP3638804A1 (en) * 2017-06-15 2020-04-22 Evolva SA Production of mogroside compounds in recombinant hosts
CN108314620B (zh) * 2018-04-03 2021-01-01 中国科学院昆明植物研究所 异序乌桕素i和j及其药物组合物和其应用
WO2020097588A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110878288B (zh) * 2019-12-09 2020-12-29 安徽农业大学 多肽、核酸及其在合成橙花叔醇糖苷上的应用
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014423A1 (en) 1989-05-18 1990-11-29 The Infergene Company Microorganism transformation
DE69031710T2 (de) 1989-07-07 1998-03-05 Unilever N.V., Rotterdam Verfahren zur herstellung eines proteins mittels eines durch mehrfachkopieintegrierung eines expressionsvektors transformierten pilzes
DK0635574T3 (da) 1993-07-23 2003-08-11 Dsm Ip Assets Bv Selektionsmarkørgenfri rekombinantstammer, en fremgangsmåde til fremstilling af disse og anvendelse af disse stammer
JP5303084B2 (ja) 1997-04-11 2013-10-02 コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ 工業的組み換え生物を溝築するための手段としての遺伝子変換
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
JP2003527069A (ja) 1998-05-19 2003-09-16 デーエスエム・ナムローゼ・フェンノートシャップ セファロスポリンのｉｎｖｉｖｏ製造の改善
KR20010089672A (ko) 1998-12-22 2001-10-08 윌리암 로엘프 드 보에르 개선된 생체내 세팔로스포린 생산
DE60210298T2 (de) 2001-07-23 2006-11-02 Dsm Ip Assets B.V. Verfahren zur herstellung von polynucleotidvarianten
AU2002333269A1 (en) 2001-07-23 2003-02-17 Dsm Ip Assets B.V. Process for preparing variant polynucleotides
ES2319757T5 (es) 2002-01-23 2018-05-22 Dsm Ip Assets B.V. Fermentación de azúcares de pentosa
SE0202090D0 (sv) 2002-05-08 2002-07-04 Forskarpatent I Syd Ab A modifierd yeast consuming L-arabinose
DK1626979T3 (da) 2003-05-02 2012-07-09 Cargill Inc Genetisk modificeret gærart og fremgangsmåder til fermentering, hvor den genetisk modificerede gær anvendes
CA2532999C (en) 2003-07-15 2014-04-08 Mintek Oxidative leach process
AU2004272629A1 (en) 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
WO2005040186A2 (en) 2003-10-14 2005-05-06 Dsm Ip Assets B.V. Method for preparing a modified host cell
DK1781772T3 (da) 2004-07-16 2017-01-09 Dsm Ip Assets Bv Metabolisk modificering af xylose-fermenterende eukaryote celler
EP1863901A1 (en) 2005-03-11 2007-12-12 Forskarpatent i Syd AB Arabinose- and xylose-fermenting saccharomyces cerevisiae strains
US7217537B2 (en) * 2005-09-15 2007-05-15 E. I. Du Pont De Nemours And Company Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase
DE102006029299A1 (de) 2006-06-23 2007-12-27 Johnson Controls Gmbh Fahrzeugsitz mit einem Sitzteil und mit einer Rückhaltevorrichtung zur Verhinderung des Durchrutschens eines Passagiers, Rückhaltevorrichtung und Herstellungsverfahren
WO2008053019A2 (en) 2006-11-02 2008-05-08 Dsm Ip Assets B.V. Method for reducing the expression of a gene in a filamentous fungal cell
SG186127A1 (en) * 2010-06-02 2013-01-30 Evolva Nutrition Inc Recombinant production of steviol glycosides
EP2645847B1 (en) * 2010-11-30 2018-01-17 Massachusetts Institute of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
EP3792350A1 (en) * 2011-08-08 2021-03-17 Evolva SA Recombinant production of steviol glycosides
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
DK2825650T3 (da) 2012-03-12 2019-05-13 Dsm Ip Assets Bv Rekombinationssystem
DK2831238T3 (da) 2012-03-27 2018-04-03 Dsm Ip Assets Bv Kloningsfremgangsmåde
CA2892021A1 (en) * 2012-11-20 2014-05-30 Pronutria, Inc. Engineered secreted proteins and methods
WO2014086890A1 (en) * 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
US9200291B2 (en) * 2012-12-19 2015-12-01 Helge Zieler Compositions and methods for creating altered and improved cells and organisms
MY190346A (en) * 2013-02-06 2022-04-15 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
MY184253A (en) * 2013-02-11 2021-03-29 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
EP3004366B1 (en) * 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganisms for diterpene production
US10604743B2 (en) * 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
MY195726A (en) * 2015-08-13 2023-02-07 Dsm Ip Assets Bv Steviol Glycoside Transport
CA2993744A1 (en) * 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport

Also Published As

Publication number Publication date
CN105452476A (zh) 2016-03-30
BR112015029580A2 (pt) 2017-09-19
WO2014191581A2 (en) 2014-12-04
EP3502264A3 (en) 2019-11-06
WO2014191581A3 (en) 2015-03-05
CN105452476B (zh) 2020-08-14
EP3004366B1 (en) 2019-02-27
MX367033B (es) 2019-08-02
EP3502264A2 (en) 2019-06-26
US20160177360A1 (en) 2016-06-23
CA2913876A1 (en) 2014-12-04
US11725223B2 (en) 2023-08-15
EP3004366A2 (en) 2016-04-13
US20240068002A1 (en) 2024-02-29
US10689681B2 (en) 2020-06-23
AU2014273055A1 (en) 2015-12-17
US20200283815A1 (en) 2020-09-10
MX2015016388A (es) 2016-06-16

Similar Documents

Publication Publication Date Title
DK3004366T3 (da) Mikroorganismer til diterpenproduktion
DK3342773T3 (da) Syk-hæmmere
DK3613453T3 (da) Fordamper
DK3015467T3 (da) Morpholino-oligonukleotidfremstillingsfremgangsmåde
DK3077047T3 (da) Aramcholsalte
DK3052081T3 (da) Pastil
DK3060460T3 (da) Saddel
DK2943561T3 (da) Fotobioreaktor
DK3027598T3 (da) Oxoquinazolinyl-butanamidderivater
DK2956698T3 (da) Bindestrimler
BR112015021083A2 (pt) método
DK2946640T3 (da) Langmuir-probe
EP2943489A4 (en) DEUTERATED MOMELOTINIB
EP2969096A4 (en) Bottle pressurization delivery system
DE102013106534B8 (de) Chromatographiepipettenspitze
BR112016002104A2 (pt) método de síntese de 3-oxopent-4-enoil-coa
BR112015029076A2 (pt) método
EP2985113A4 (en) PRODUCTION PLANT
EP2991647A4 (en) DEUTERED AMLEXANOX
EP2970310A4 (en) 5-BROMO-indirubins
EP2853297A4 (en) kendama
DK3071227T3 (da) Fiskevaccine
DK3047028T3 (da) Fermenteringsfremgangsmåde
DE112014001252A5 (de) Aufbissschiene
DK3086679T3 (da) Sportssko