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DK1626979T3 - Genetisk modificeret gærart og fremgangsmåder til fermentering, hvor den genetisk modificerede gær anvendes - Google Patents

Genetisk modificeret gærart og fremgangsmåder til fermentering, hvor den genetisk modificerede gær anvendes

Info

Publication number
DK1626979T3
DK1626979T3 DK04751126.6T DK04751126T DK1626979T3 DK 1626979 T3 DK1626979 T3 DK 1626979T3 DK 04751126 T DK04751126 T DK 04751126T DK 1626979 T3 DK1626979 T3 DK 1626979T3
Authority
DK
Denmark
Prior art keywords
genetically modified
modified yeast
fermentation
methods
species
Prior art date
Application number
DK04751126.6T
Other languages
English (en)
Inventor
Vineet Rajgarhia
Chris Miller
Kari Koivuranta
Merja Penttilae
Pirkko Suominen
Aristos Aristidou
Stacey Olson
Laura Ruohonen
Marja Ilmen
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Application granted granted Critical
Publication of DK1626979T3 publication Critical patent/DK1626979T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/14—Multiple stages of fermentation; Multiple types of microorganisms or re-use of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01017—Xylulokinase (2.7.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02003—Phosphoglycerate kinase (2.7.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01037—Xylan 1,4-beta-xylosidase (3.2.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01001—Pyruvate decarboxylase (4.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03002—UDP-glucose 4-epimerase (5.1.3.2), i.e. UDP-galactose 4-epimerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01005—Xylose isomerase (5.3.1.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK04751126.6T 2003-05-02 2004-05-03 Genetisk modificeret gærart og fremgangsmåder til fermentering, hvor den genetisk modificerede gær anvendes DK1626979T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46772703P 2003-05-02 2003-05-02
PCT/US2004/013592 WO2004099381A2 (en) 2003-05-02 2004-05-03 Genetically modified yeast species and fermentation processes using genetically modified yeast

Publications (1)

Publication Number Publication Date
DK1626979T3 true DK1626979T3 (da) 2012-07-09

Family

ID=33435110

Family Applications (4)

Application Number Title Priority Date Filing Date
DK04751126.6T DK1626979T3 (da) 2003-05-02 2004-05-03 Genetisk modificeret gærart og fremgangsmåder til fermentering, hvor den genetisk modificerede gær anvendes
DK10183662.5T DK2345662T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærarter og fermenteringsprocesser anvendende genetisk modificeret gær
DK10183744.1T DK2338895T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærspecies og fermenteringsproces under anvendelse af genetisk modificeret gær
DK10183712.8T DK2301949T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærarter og fermenteringsfremgangsmåder under anvendelse af genetisk modificeret gær

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK10183662.5T DK2345662T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærarter og fermenteringsprocesser anvendende genetisk modificeret gær
DK10183744.1T DK2338895T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærspecies og fermenteringsproces under anvendelse af genetisk modificeret gær
DK10183712.8T DK2301949T3 (da) 2003-05-02 2004-05-03 Genetisk modificerede gærarter og fermenteringsfremgangsmåder under anvendelse af genetisk modificeret gær

Country Status (12)

Country Link
US (5) US7943366B2 (da)
EP (4) EP2301949B1 (da)
JP (1) JP4711955B2 (da)
CN (2) CN1922198B (da)
AU (1) AU2004236724B2 (da)
BR (1) BRPI0409954B1 (da)
CA (1) CA2524387C (da)
DK (4) DK1626979T3 (da)
ES (4) ES2586618T3 (da)
PL (4) PL2301949T3 (da)
WO (1) WO2004099381A2 (da)
ZA (1) ZA200509697B (da)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
US7537826B2 (en) 1999-06-22 2009-05-26 Xyleco, Inc. Cellulosic and lignocellulosic materials and compositions and composites made therefrom
ES2319757T5 (es) 2002-01-23 2018-05-22 Dsm Ip Assets B.V. Fermentación de azúcares de pentosa
DK1781772T3 (da) * 2004-07-16 2017-01-09 Dsm Ip Assets Bv Metabolisk modificering af xylose-fermenterende eukaryote celler
US7708214B2 (en) 2005-08-24 2010-05-04 Xyleco, Inc. Fibrous materials and composites
US20150328347A1 (en) 2005-03-24 2015-11-19 Xyleco, Inc. Fibrous materials and composites
WO2007032792A2 (en) 2005-06-02 2007-03-22 Cargill, Inc. Genetically modified yeast of the species issatchenkia orientalis and closely related species and fermentation processes using same
WO2007038130A2 (en) 2005-09-22 2007-04-05 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
CA2631036A1 (en) 2005-11-23 2007-10-18 Natureworks Llc Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene
CN101442910A (zh) 2006-03-13 2009-05-27 卡吉尔公司 具有从磷酸二羟丙酮到甘油的途径被破坏的酵母细胞
WO2008048513A2 (en) * 2006-10-13 2008-04-24 Rowan University Ethanol resistant and furfural resistant strains of e. coli fbr5 for production of ethanol from cellulosic biomass
CN101463328B (zh) * 2007-12-19 2011-06-29 中国科学院微生物研究所 一株利用木糖发酵产乙醇的代谢工程酵母菌
US8455239B2 (en) * 2007-12-23 2013-06-04 Gevo, Inc. Yeast organism producing isobutanol at a high yield
JP2011514140A (ja) 2007-12-27 2011-05-06 ジーヴォ，インコーポレイテッド 低濃度水溶液からの高級アルコールの回収
US8440449B2 (en) * 2008-09-30 2013-05-14 The United States Of America, As Represented By The Secretary Of Agriculture Transformed Saccharomyces cerevisiae engineered for xylose utilization
CN102272303A (zh) * 2008-11-21 2011-12-07 马斯科马公司 用于使用纤维素进行同时糖化和发酵的表达纤维素酶的酵母
GB0822937D0 (en) 2008-12-16 2009-01-21 Terranol As Microorganism
EP2367928B1 (en) 2008-12-24 2018-03-14 DSM IP Assets B.V. Xylose isomerase genes and their use in fermentation of pentose sugars
US20100311137A1 (en) 2009-06-08 2010-12-09 Ut-Battelle, Llc Microorganisms Having Enhanced Tolerance To Inhibitors and Stress
EP2446043A4 (en) * 2009-06-22 2013-02-13 Gevo Inc YEAST ORGANISMS FOR THE MANUFACTURE OF ISOBUTANOL
EP2451960A2 (en) 2009-07-09 2012-05-16 Verdezyne, Inc. Engineered microorganisms with enhanced fermentation activity
US8772012B2 (en) 2009-12-22 2014-07-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Xylose isomerase and use thereof
JP5804378B2 (ja) * 2010-02-09 2015-11-04 国立大学法人山口大学 クルイベロマイセス・マルシアヌス由来の高発現プロモーター
CA2800343A1 (en) * 2010-04-21 2011-10-27 Dsm Ip Assets B.V. Process for the production of cells which are capable of converting arabinose
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
BR112012031362A2 (pt) 2010-06-03 2015-10-13 Mascoma Corp levedura expressando enzimas sacarolíticas para bioprocessamento consolidado usando amido e celulose
WO2012063344A1 (ja) * 2010-11-11 2012-05-18 トヨタ自動車株式会社 組換え酵母を用いたエタノールの製造方法
WO2012067510A1 (en) 2010-11-18 2012-05-24 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from glycerol
BR112013012130A2 (pt) 2010-11-22 2017-10-31 Cargill Inc composições e métodos para titulação aumentada de etanol a partir de biomassa
CA2825525A1 (en) 2011-01-25 2012-08-02 Jeanette M. HURYTA Compositions and methods for succinate production
CN102174549B (zh) 2011-02-22 2012-10-10 山东大学 一种编码木糖异构酶的核酸分子及其编码的木糖异构酶
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
ES2602808T3 (es) 2011-04-11 2017-02-22 Cargill, Incorporated Composiciones y métodos para la elevada producción de etanol a partir de biomasa
EP2546336A1 (en) 2011-07-11 2013-01-16 DSM IP Assets B.V. Yeast strains that consume uronic acids and produce fermentation products such as ethanol
CN102304541A (zh) * 2011-08-17 2012-01-04 中国药科大学 一种含组成型启动子pPGK和G418抗性基因的酿酒酵母表达载体及其构建方法
MY169074A (en) 2011-11-30 2019-02-13 Dsm Ip Assets Bv Yeast strains engineered to produce ethanol from acetic acid and glycerol
WO2013105651A1 (ja) 2012-01-13 2013-07-18 東レ株式会社 化学品の製造方法
CN104039970A (zh) 2012-01-13 2014-09-10 东丽株式会社 化学品的制造方法
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
CN102719481B (zh) * 2012-06-14 2014-11-05 中国科学院微生物研究所 一种将多个基因同时导入微生物基因组的方法
WO2014003439A1 (ko) * 2012-06-26 2014-01-03 한국생명공학연구원 에탄올 생산 경로가 봉쇄된 클루이베로마이세스 막시아누스 균주 및 이의 용도
BR112015001601A2 (pt) 2012-07-25 2017-11-07 Bioamber Sas células de levedura tendo curso de tca redutor de piruvato em succinato e superexpressão de uma enzima transidrogenase nad(p)+ exógena
IN2015DN01042A (da) 2012-08-28 2015-06-26 Dsm Ip Assets Bv
IN2015DN01041A (da) 2012-08-28 2015-06-26 Dsm Ip Assets Bv
US9745560B2 (en) 2012-08-29 2017-08-29 Lallemand Hungary Liquidity Management Llc Expression of enzymes in yeast for lignocellulose derived oligomer CBP
US8748152B1 (en) 2012-09-14 2014-06-10 The United States Of America, As Represented By The Secretary Of Agriculture Prevotella ruminicola xylose isomerase and co-expression with xylulokinase in yeast for xylose fermentation
US20140178954A1 (en) 2012-12-20 2014-06-26 E I Du Pont De Nemours And Company Expression of xylose isomerase activity in yeast
US9187743B2 (en) 2013-03-11 2015-11-17 E I Du Pont De Nemours And Company Bacterial xylose isomerases active in yeast cells
US8669076B1 (en) 2013-03-11 2014-03-11 E I Du Pont De Nemours And Company Cow rumen xylose isomerases active in yeast cells
JP6027559B2 (ja) 2013-03-28 2016-11-16 株式会社豊田中央研究所 キシロースイソメラーゼ活性を有するタンパク質及びその利用
TW201437367A (zh) 2013-03-29 2014-10-01 Far Eastern New Century Corp 可利用五碳糖及六碳糖生產乳酸之酵母菌
FI20135333L (fi) * 2013-04-05 2014-10-06 Teknologian Tutkimuskeskus Vtt Oy Hapon / happojen ja alkoholin tuotto sokereista käyttämällä hiivaa
EP3004366B1 (en) 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganisms for diterpene production
EP3885443B1 (en) 2013-07-15 2025-01-15 DSM IP Assets B.V. Diterpene production
BR112016002092B1 (pt) 2013-07-31 2020-12-15 Dsm Ip Assets B.V. Recuperação de glicosídeos de esteviol
CN104419716B (zh) * 2013-08-27 2017-12-29 天津大学 一种标准化、高精度、通用的功能模块构建方法
AR097480A1 (es) 2013-08-29 2016-03-16 Dsm Ip Assets Bv Células de levadura convertidoras de glicerol y ácido acético con una conversión de ácido acético mejorada
CN103421698B (zh) * 2013-09-05 2015-04-22 中国科学技术大学 木糖醇高温高产工程菌株的构建及应用
WO2015160257A1 (en) 2014-04-18 2015-10-22 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
BR102014027233A2 (pt) * 2014-10-30 2016-05-24 Biocelere Agroindustrial Ltda cassete de expressão, micro-organismo geneticamente modificado para expressão de xilose isomerase, processo para produção de biocombustíveis e/ou bioquímicos e biocombustível e/ou bioquímicos produzidos
TWI551688B (zh) * 2015-02-04 2016-10-01 遠東新世紀股份有限公司 發酵纖維素水解液來生成乙醇的方法
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
US20180057850A1 (en) 2015-03-23 2018-03-01 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
US11344051B2 (en) 2015-04-03 2022-05-31 Dsm Ip Assets B.V. Steviol glycosides
EP3286302A1 (en) 2015-04-21 2018-02-28 DSM IP Assets B.V. Geranylgeranyl pyrophosphate synthase
WO2017009294A1 (en) 2015-07-10 2017-01-19 Dsm Ip Assets B.V. Steviol glycoside composition
AU2016293487B2 (en) 2015-07-13 2021-07-01 MARA Renewables Corporation Enhancing microalgal metabolism of xylose
US10844363B2 (en) 2015-08-05 2020-11-24 Cargill, Incorporated Xylose isomerase-modified yeast strains and methods for bioproduct production
CA2993744A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
EP3359654B1 (en) 2015-10-05 2022-01-05 DSM IP Assets B.V. Kaurenoic acid hydroxylases
WO2017091610A1 (en) 2015-11-24 2017-06-01 Cargill, Incorporated Genetically modified yeasts and fermentation processes using genetically modified yeasts
WO2017101060A1 (en) * 2015-12-17 2017-06-22 Evonik Degussa (China) Co., Ltd. Gene cassette for homologous recombination knock-out in yeast cells
WO2017176875A1 (en) 2016-04-08 2017-10-12 E I Du Pont De Nemours And Company Arabinose isomerases for yeast
MY202890A (en) 2016-08-09 2024-05-28 Dsm Ip Assets Bv Crystallization of steviol glycosides
CA3033243A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
US11225647B2 (en) 2016-10-27 2022-01-18 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
JP2020500520A (ja) 2016-12-08 2020-01-16 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． カウレン酸ヒドロキシラーゼ
US10829789B2 (en) 2016-12-21 2020-11-10 Creatus Biosciences Inc. Methods and organism with increased xylose uptake
WO2018114995A1 (en) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Fermentation process for producing steviol glycosides
CN110892068B (zh) 2017-06-27 2024-03-08 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
US11718820B2 (en) 2017-08-17 2023-08-08 Cargill, Incorporated Genetically modified haploid Issatchenkia orientalis
WO2019185737A1 (en) 2018-03-27 2019-10-03 Basf Se Xylose metabolizing yeast
CN112424218A (zh) 2018-04-30 2021-02-26 帝斯曼知识产权资产管理有限公司 甜菊糖苷转运
US11788053B2 (en) 2020-06-15 2023-10-17 Melio Peptide Systems Inc. Microorganisms and methods for reducing bacterial contamination
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
CN115851806A (zh) * 2022-09-07 2023-03-28 四川大学华西第二医院 一种在马克斯克鲁维酵母菌株中表达外源基因的重组载体
CN116179587A (zh) * 2022-09-07 2023-05-30 四川大学华西第二医院 一种在马克斯克鲁维酵母菌株中表达外源基因的重组载体

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
US4771001A (en) 1986-03-27 1988-09-13 Neurex Corp. Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification
US5866382A (en) 1990-04-06 1999-02-02 Xyrofin Oy Xylose utilization by recombinant yeasts
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
US5132456A (en) 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
FI913197A0 (fi) * 1991-07-01 1991-07-01 Xyrofin Oy Nya jaeststammar med reducerad foermaoga att metabolisera xylitol, foerfarande foer bildande av dessa och deras anvaendning vid framstaellning av xylitol.
US5420304A (en) 1992-03-19 1995-05-30 Biopak Technology, Ltd. Method to produce cyclic esters
AT398982B (de) 1993-02-18 1995-02-27 Vogelbusch Gmbh Verfahren zur abtrennung und reinigung von milchsäure
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
FR2712147B1 (fr) 1993-11-08 1996-02-02 Agronomique Inst Nat Rech Produit alimentaire, obtention et application à la fabrication de jus de fruits ou de vin.
US5789210A (en) 1993-11-08 1998-08-04 Purdue Research Foundation Recombinant yeasts for effective fermentation of glucose and xylose
IL109003A (en) 1994-03-16 1999-09-22 Yissum Res Dev Co Process and extractant composition for extracting water-soluble carboxylic and mineral acids
IN191596B (da) 1996-05-06 2003-12-06 Purdue Research Foundation
US6717014B1 (en) * 1996-06-28 2004-04-06 Fmc Corporation Processes for preparing haloamines and tertiary aminoalkylorganometallic compounds
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
DE69928656D1 (de) 1998-04-20 2006-01-05 Forskarpatent I Syd Ab Lund Gentechnisch hergestellte hefestämme und deren mutanten zur fermentierung von lignocellulosehydrolysate
SE9901298D0 (sv) * 1999-04-09 1999-04-09 Forskarpatent I Syd Ab Xylose isomerase with improved kinetic properties
US6485947B1 (en) 1999-05-21 2002-11-26 Cargill Dow Polymers, Llc Production of lactate using crabtree negative organisms in varying culture conditions
US6762339B1 (en) 1999-05-21 2004-07-13 3M Innovative Properties Company Hydrophilic polypropylene fibers having antimicrobial activity
WO2002006504A1 (en) * 2000-07-13 2002-01-24 Danisco Sweeteners Oy. Method for the production of xylitol
CN1249239C (zh) 2000-11-22 2006-04-05 加吉尔·道聚合物公司 合成有机产物的方法和材料
EP1474507B1 (en) 2001-11-23 2008-12-31 Cargill, Inc. Methods and materials for the production of organic products in cells of candida species
ES2319757T5 (es) 2002-01-23 2018-05-22 Dsm Ip Assets B.V. Fermentación de azúcares de pentosa
AU2003251381B2 (en) 2002-05-30 2008-04-03 Natureworks Llc Fermentation process using specific oxygen uptake rates as a process control
SE0302421D0 (sv) * 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Construction of new xylose utilizing Saccharomyces cerevisiae strain
WO2007032792A2 (en) * 2005-06-02 2007-03-22 Cargill, Inc. Genetically modified yeast of the species issatchenkia orientalis and closely related species and fermentation processes using same
CA2631036A1 (en) * 2005-11-23 2007-10-18 Natureworks Llc Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene
JP5219074B2 (ja) * 2008-01-24 2013-06-26 独立行政法人産業技術総合研究所 キシロース発酵能が優れた六炭糖・五炭糖同時発酵酵母およびそれを用いたエタノールの高効率生産方法
EP2464736A4 (en) * 2009-08-12 2013-07-31 Gevo Inc PATIENT LOCALIZATION OF CYTOSOLIC ISOBUTANOL FOR THE MANUFACTURE OF ISOBUTANOL

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