DK2996743T3 - Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning - Google Patents
Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning Download PDFInfo
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- DK2996743T3 DK2996743T3 DK14723059.3T DK14723059T DK2996743T3 DK 2996743 T3 DK2996743 T3 DK 2996743T3 DK 14723059 T DK14723059 T DK 14723059T DK 2996743 T3 DK2996743 T3 DK 2996743T3
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- dose
- housing
- piston rod
- drug delivery
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2477—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means to reduce play of ampoule within ampoule holder, e.g. springs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (16)
1. Indretning (2) til anvendelse i en lægemiddeladministrationsanordning (1) , 5 der omfatter en patron (14), et hus (7) og en patronholder (15), hvor patronholderen (15) er aftageligt fastgjort til huset (7) , og omfatter en stempelstang (3) , der er konfigureret til at blive bevæget fra en startposition til en slutposition til ) dispensering af en dosis medikament, når patronholderen (15) er fastgjort til huset (7), og hvor stempelstangen (3) er konfigureret til at blive nulstillet til startpositionen, når patronholderen (15) afmonteres fra huset (7), og omfatter et fleksibelt element (30), hvor det fleksible 5 element (30) er konfigureret til aksialt at fiksere patronen i patronholderen (15), når patronholderen (15) er fastgjort til huset (7), og yderligere omfatter et styreelement (8), der er i gevindindgreb med stempelstangen (3), hvor det fleksible ) element (30) er konfigureret til at fiksere styreelementet (8) i forhold til huset (7) på lægemiddeladministrationsanordningen (1) der er kendetegnet ved, at det fleksible element er fastspændt mellem patronen (14) og styreelementet (8), når patronholderen 5 (15) er fastgjort til huset (7), og ved, at det fleksible element (30) er konfigureret til at hindre en aksial og rotationel bevægelse af styreelementet (8), når patronholderen (15) er fastgjort til huset (7), ved udøvelse af en kraft på styreelementet (8), således at ) styreelementet (8) påvirkes mod en proksimal ende af lægemiddeladministrationsanordningen (1), hvorved styreelementet fastholdes i indgreb med indgrebsmidlet i huset (7) .
2. Indretning (2) ifølge krav 1, hvor det fleksible element (30) er konfigureret som en flad fjeder.
3. Indretning (2) ifølge et hvilket som helst af ovennævnte krav, hvor det fleksible element (30) er fikseret til styreelementet (8) .
4. Indretning (2) ifølge et hvilket som helst af ovennævnte 5 krav, hvor styreelementet (8) er frigjort fra indgreb med huset (7), når lægemiddeladministrationsanordningen er i en adskilt tilstand, hvorved det gøres i stand til at bevæge sig aksialt i forhold til huset (7).
) 5. Indretning (2) ifølge et hvilket som helst af ovennævnte krav, hvor stempelstangen (3) er konfigureret til at rotere gennem styreelementet (8) under dispensering af en dosis.
6. Indretning (2) ifølge et hvilket som helst af ovennævnte 5 krav, der omfatter en låsedel (17), der er fikseret i forhold til huset (7) under indstilling af en dosis og er konfigureret til at rotere i forhold til huset (7) under dispensering af en dosis, hvor en rotation af låsedelen (17) forårsager, at stempelstangen (3) bevæges i en distal retning, når ) lægemiddeladministrationsanordningen (1) er i en samlet tilstand.
7. Indretning (2) ifølge krav 6, hvor låsedelen (17) er konfigureret til at bevæge sig aksalt under dispensering af en 5 dosis.
8. Indretning (2) ifølge et hvilket som helst af kravene 6 eller 7, der omfatter en fjederdel (12), hvor relaksation af fjederdelen er konfigureret til at forårsage en rotation af ) låsedelen (17) i det mindste under dispensering af en dosis.
9. Indretning (2) ifølge krav 8, hvor låsedelen (17) er konfigureret til at hindre utilsigtet relaksation af fjederdelen (12) under nulstilling af stempelstangen (3).
10. Indretning (2) ifølge et hvilket som helst af kravene 6 til 9, hvor låsedelen (17) er i stand til at rotere i én retning under nulstilling af stempelstangen (3), og hvor rotation af låsedelen (17) i modsat retning hindres.
11. Indretning (2) ifølge et hvilket som helst af ovennævnte krav, der omfatter et drivelement (4), hvor rotation of 5 drivelementet (4) forårsager en rotationel og aksial bevægelse af stempelstangen (3) under dispensering af en dosis.
12. Indretning (2) ifølge krav 11, hvor låsedelen (17) er forbundet til stempelstangen ved hjælp af drivelementet (4). )
13. Indretning (2) ifølge krav 12, hvor drivelementet (4) er rotationsfikseret og aksialt bevægeligt i forhold til stempelstangen (3) .
14. Indretning (2) ifølge et hvilket som helst af ovennævnte krav, der omfatter en sidste-dosis-del (18), der er konfigureret til at hindre indstilling af en dosis, der er større end mængden af et lægemiddel, der er tilbage i lægemiddeladministrationsanordningen (1) . )
15. Indretning (2) ifølge et hvilket som helst af ovennævnte krav, hvor det fleksible element (30) er en integreret del af styreelementet (8) .
16. Lægemiddeladministrationsanordning (1), der omfatter en indretning (2) ifølge et hvilket som helst af kravene 1 til 15.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13167953 | 2013-05-16 | ||
| PCT/EP2014/059403 WO2014184080A1 (en) | 2013-05-16 | 2014-05-08 | Assembly for a drug delivery device and drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2996743T3 true DK2996743T3 (da) | 2019-04-01 |
Family
ID=48446141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14723059.3T DK2996743T3 (da) | 2013-05-16 | 2014-05-08 | Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10149946B2 (da) |
| EP (1) | EP2996743B1 (da) |
| JP (1) | JP6490057B2 (da) |
| CN (1) | CN105209091B (da) |
| DK (1) | DK2996743T3 (da) |
| TR (1) | TR201903611T4 (da) |
| WO (1) | WO2014184080A1 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK2996743T3 (da) * | 2013-05-16 | 2019-04-01 | Sanofi Aventis Deutschland | Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning |
| PL3261689T3 (pl) | 2015-02-27 | 2020-05-18 | Novo Nordisk A/S | Urządzenie do dostarczania leku z mechanizmem resetowania dawki |
| WO2016188985A1 (en) * | 2015-05-27 | 2016-12-01 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
| US20210283338A1 (en) * | 2016-08-31 | 2021-09-16 | Novo Nordisk A/S | Drug delivery device with over-torque protection mechanism |
| EP3573689B1 (en) | 2017-01-26 | 2022-04-06 | Sanofi-Aventis Deutschland GmbH | Flexible modules for injection devices |
| EP3727150B1 (en) | 2017-12-18 | 2024-07-24 | Sanofi | Nfc glucometer containing rechargeable battery for independed useage |
| JP6959452B2 (ja) * | 2018-01-09 | 2021-11-02 | エスエイチエル・メディカル・アーゲー | 支持構造 |
| CN112933346B (zh) * | 2021-02-03 | 2022-11-08 | 宁波易舒医疗科技有限公司 | 一种轴向推进机构、自动注射装置及该装置的工作方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US533575A (en) | 1895-02-05 | wilkens | ||
| US5226895A (en) | 1989-06-05 | 1993-07-13 | Eli Lilly And Company | Multiple dose injection pen |
| GB9007113D0 (en) | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
| ATE121953T1 (de) | 1991-07-24 | 1995-05-15 | Medico Dev Investment Co | Injektor. |
| DK175491D0 (da) | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Apparat |
| US5279586A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
| US5320609A (en) | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
| US5383865A (en) | 1993-03-15 | 1995-01-24 | Eli Lilly And Company | Medication dispensing device |
| ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
| US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
| JP3568959B2 (ja) | 1995-03-07 | 2004-09-22 | イーライ・リリー・アンド・カンパニー | 再利用可能な投薬装置 |
| US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
| US5674204A (en) | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
| DE19730999C1 (de) | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
| US5957896A (en) | 1997-08-11 | 1999-09-28 | Becton, Dickinson And Company | Medication delivery pen |
| PT1003581E (pt) | 1998-01-30 | 2001-04-30 | Novo Nordisk As | Seringa de injeccao |
| US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
| US5961495A (en) | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
| US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| WO2001010484A1 (en) | 1999-08-05 | 2001-02-15 | Becton, Dickinson And Company | Medication delivery pen |
| GB0007071D0 (en) | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
| DK2275158T3 (da) | 2001-05-16 | 2013-02-11 | Lilly Co Eli | Indretning til injektion af lægemidler |
| GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| DE102004063648A1 (de) | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Injektions- oder Infusionsgerät mit Lebensdauer-Ermittlungseinrichtung |
| AU2006207744B2 (en) * | 2005-01-21 | 2011-08-11 | Novo Nordisk A/S | An automatic injection device with a top release mechanism |
| DE102005032705B4 (de) * | 2005-05-24 | 2009-01-08 | Tecpharma Licensing Ag | Kunststofffeder |
| DK1909870T4 (da) | 2005-07-27 | 2016-04-18 | Novo Nordisk As | Dosismekanisme til en injektionsindretning til begrænsning af en dosisindstilling svarende til den tilbageværende medikamentmængde |
| WO2008116766A1 (en) * | 2007-03-23 | 2008-10-02 | Novo Nordisk A/S | An injection device comprising a locking nut |
| DE102007026083A1 (de) * | 2007-05-25 | 2008-11-27 | Haselmeier S.A.R.L. | Injektionsgerät |
| DE102008011881A1 (de) * | 2008-02-29 | 2009-09-10 | Tecpharma Licensing Ag | Leerschießgeschwindigkeitsbegrenzungsbremse |
| US8647309B2 (en) | 2008-05-02 | 2014-02-11 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
| EP2468344B1 (en) | 2008-10-13 | 2013-08-28 | Sanofi-Aventis Deutschland GmbH | Drug delivery device and method of manufacturing a drug delivery device |
| EP2370135B1 (en) * | 2008-12-09 | 2020-02-05 | Becton, Dickinson and Company | Lever and gear force multiplier medication delivery system for high pressure injection system |
| EP2414010B1 (en) * | 2009-03-31 | 2019-02-20 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| AR078458A1 (es) * | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | Conjunto de accionamiento, vastago de piston, dispositivo para la entrega de drogas, y uso de un resorte |
| WO2012062718A1 (en) * | 2010-11-08 | 2012-05-18 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for a drug delivery device, drug delivery system and drug delivery device |
| EP4410330A3 (en) * | 2011-03-16 | 2024-10-30 | Becton, Dickinson and Company | Multiple use disposable injection pen |
| TWI539981B (zh) * | 2011-05-06 | 2016-07-01 | 賽諾菲阿凡提斯德意志有限公司 | 供藥物輸送裝置用之組件及藥物輸送裝置 |
| EP2887981B1 (en) * | 2012-04-17 | 2017-03-01 | Carebay Europe Ltd. | Medicament delivery device |
| DK2996743T3 (da) * | 2013-05-16 | 2019-04-01 | Sanofi Aventis Deutschland | Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning |
-
2014
- 2014-05-08 DK DK14723059.3T patent/DK2996743T3/da active
- 2014-05-08 TR TR2019/03611T patent/TR201903611T4/tr unknown
- 2014-05-08 WO PCT/EP2014/059403 patent/WO2014184080A1/en not_active Ceased
- 2014-05-08 US US14/786,800 patent/US10149946B2/en active Active
- 2014-05-08 JP JP2016513295A patent/JP6490057B2/ja active Active
- 2014-05-08 EP EP14723059.3A patent/EP2996743B1/en active Active
- 2014-05-08 CN CN201480027637.8A patent/CN105209091B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105209091B (zh) | 2019-12-10 |
| WO2014184080A1 (en) | 2014-11-20 |
| US10149946B2 (en) | 2018-12-11 |
| US20160074589A1 (en) | 2016-03-17 |
| EP2996743A1 (en) | 2016-03-23 |
| EP2996743B1 (en) | 2018-12-19 |
| JP2016521187A (ja) | 2016-07-21 |
| JP6490057B2 (ja) | 2019-03-27 |
| CN105209091A (zh) | 2015-12-30 |
| TR201903611T4 (tr) | 2019-04-22 |
| HK1215551A1 (en) | 2016-09-02 |
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