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DK2945670T3 - Lægemiddelinjektionsanordning af pentypen med dosiskodemekanisme og omskifter mellem dosisindstillings- og dosisdispenseringtilstande - Google Patents

Lægemiddelinjektionsanordning af pentypen med dosiskodemekanisme og omskifter mellem dosisindstillings- og dosisdispenseringtilstande Download PDF

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Publication number
DK2945670T3
DK2945670T3 DK14700374.3T DK14700374T DK2945670T3 DK 2945670 T3 DK2945670 T3 DK 2945670T3 DK 14700374 T DK14700374 T DK 14700374T DK 2945670 T3 DK2945670 T3 DK 2945670T3
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Prior art keywords
dose
helical
sensors
track
groove
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DK14700374.3T
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English (en)
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Samuel Steel
Paul Richard Draper
Anthony Paul Morris
Stephen Gilmore
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Sanofi Aventis Deutschland
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D5/00—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
    • G01D5/12—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means
    • G01D5/244—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing characteristics of pulses or pulse trains; generating pulses or pulse trains
    • G01D5/245—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing characteristics of pulses or pulse trains; generating pulses or pulse trains using a variable number of pulses in a train
    • G01D5/2454—Encoders incorporating incremental and absolute signals
    • G01D5/2455—Encoders incorporating incremental and absolute signals with incremental and absolute tracks on the same encoder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D2205/00—Indexing scheme relating to details of means for transferring or converting the output of a sensing member
    • G01D2205/20—Detecting rotary movement
    • G01D2205/22—Detecting rotary movement by converting the rotary movement into a linear movement

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (14)

1. Lægemiddeldispenseringsanordning (100), der omfatter: et hus (102); mindst fire sensorer (212a til 212g); og en cylindrisk del (406), der er understøttet i huset, hvor den ydre overflade af den cylindriske del er forsynet med et spiralformet spor (300), hvilket spiralformede spor omfatter sporsegmenter af en første type (302) og sporsegmenter af en anden type (304), hvor den første og anden type sporsegment er i stand til at inducere henholdsvis første og anden responser i sensorerne; hvor: det spiralformede spor har en breddedimension (W); det spiralformede spor over dets bredde indbefatter mindst ét sporsegment af den første type og mindst ét sporsegment af den anden type i en flerhed af positioner langs længden af det spiralformede spor; anordningen er konfigureret, således at det spiralformede spor i en første fase af en lægemiddeldispenseringsfunktion bevæges aksialt, uden rotation, i forhold til sensorerne mellem en første position og en anden position, og sporet i en anden fase af lægemiddeldispenseringsfunktionen udfører en spiralbevægelse i forhold til sensorerne fra den anden position; og responser, der induceres i sensorerne ved hjælp af sporsegmenterne af det spiralformede spor, er forskellige i den første position sammenlignet med responser, der induceres i sensorerne ved hjælp af det spiralformede spor i den anden position.
2. Anordning ifølge krav 1, hvor sensorerne er indrettet til at få et respons induceret ved hjælp af en første og anden flerhed af sporsegmenterne, når det spiralformede spor er i henholdsvis den første og anden position i forhold til sensorerne.
3. Anordning ifølge krav 2, hvor mindst ét sporsegment i den første flerhed af sporsegmenter er af en anden type sammenlignet med sporsegmenterne i den anden flerhed af sporsegmenter.
4. Anordning ifølge et hvilket som helst af ovennævnte krav, hvor anordningen er konfigureret, således at det spiralformede spor kan bevæges i forhold til sensorerne langs første og anden spiralformede baner, der er aksialt forskudt i forhold til hinanden.
5. Anordning ifølge krav 4, hvor anordningen er konfigureret, således at responser, der under brug induceres i sensorerne ved hjælp af sporsegmenterne, når det spiralformede spor bevæges langs den første spiralformede bane, er forskellige fra de responser, der induceres i sensorerne ved hjælp af sporsegmenterne, når det spiralformede spor bevæges langs den anden spiralformede bane.
6. Anordning ifølge krav 4 eller 5, hvor anordningen er konfigureret, således at det spiralformede spor i den første fase af lægemiddeldispenseringsfunktionen bevæges aksialt, uden rotation, i forhold til flerheden af sensorer mellem en første position, der er placeret på den første spiralformede bane, og en anden position, der er placeret på den anden spiralformede bane, og det spiralformede spor i den anden fase af lægemiddeldispenseringsfunktionen bevæges langs den anden spiralformede bane.
7. Anordning ifølge et hvilket som helst af kravene 1 til 6, hvor anordningen har otte sensorer.
8. Anordning ifølge et hvilket som helst af ovennævnte krav, hvor det spiralformede spor omfatter et første sporsegment af den første type i en første placering på bredden af det spiralformede spor i hele længden af det spiralformede spor og et andet sporsegment af den anden type i en anden placering på bredden af det spiralformede spor i hele længden af det spiralformede spor.
9. Anordning ifølge krav 8, hvor det første sporsegment er i stand til at inducere et første respons i en sensor, når det spiralformede spor er i den første position i forhold til sensorerne, og det andet sporsegment er i stand til at inducere et andet respons i sensoren, når det spiralformede spor er i den anden position i forhold til sensorerne.
10. Anordning ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter en detektor til detektering af, når en dosis indstilles, og når en indstillet dosis er blevet helt dispenseret, hvilken detektor er i stand til at forårsage, at der tilføres kraft til sensorerne, når en dosis indstilles, og til at forårsage, at der ikke tilføres kraft til sensorerne, når en indstillet dosis er blevet helt dispenseret.
11. Anordning ifølge krav 10, hvor detektoren omfatter en første og anden del af en todels-mekanisme, hvor den første del er placeret på den cylindriske del, idet detektoren er konfigureret, således at den første og anden del deraf kun går i indgreb med hinanden, når en dosis er blevet indstillet eller en indstillet dosis er blevet helt dispenseret.
12. Anordning ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter en processor, der er konfigureret til at modtage og tolke elektriske signaler fra hver af sensorerne til bestemmelse af positionen af den cylindriske del i forhold til huset.
13. Anordning ifølge krav 12, hvor processoren er konfigureret til at bestemme en valgt lægemiddeldosis ved søgning i en søgetabel, der tilvejebringer en omregning mellem en position af den cylindriske del i forhold til huset og en valgt lægemiddeldosis.
14. Anordning ifølge krav 12 eller 13, hvor processoren er konfigureret til at bestemme en funktionstilstand for lægemiddeldispenseringsanordningen ved søgning i en søgetabel, der tilvejebringer en omregning mellem en position af den cylindriske del i forhold til huset og en funktionstilstand for lægemiddeldispenseringsanordningen.
DK14700374.3T 2013-01-15 2014-01-13 Lægemiddelinjektionsanordning af pentypen med dosiskodemekanisme og omskifter mellem dosisindstillings- og dosisdispenseringtilstande DK2945670T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13151373 2013-01-15
PCT/EP2014/050469 WO2014111342A1 (en) 2013-01-15 2014-01-13 Pen type drug injection device with dose encoder mechanism and dose setting/dose delivery mode switch

Publications (1)

Publication Number Publication Date
DK2945670T3 true DK2945670T3 (da) 2018-02-26

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Country Link
US (1) US10434260B2 (da)
EP (1) EP2945670B1 (da)
JP (1) JP6316313B2 (da)
CN (1) CN104918649B (da)
DK (1) DK2945670T3 (da)
TR (1) TR201802982T4 (da)
WO (1) WO2014111342A1 (da)

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CN104918649A (zh) 2015-09-16
JP2016506765A (ja) 2016-03-07
WO2014111342A1 (en) 2014-07-24
HK1211509A1 (en) 2016-05-27
US20150352290A1 (en) 2015-12-10
EP2945670B1 (en) 2017-12-06
US10434260B2 (en) 2019-10-08
EP2945670A1 (en) 2015-11-25
CN104918649B (zh) 2018-03-23
JP6316313B2 (ja) 2018-04-25

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