DK2417262T3 - Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaser - Google Patents
Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaserInfo
- Publication number
- DK2417262T3 DK2417262T3 DK10714403.2T DK10714403T DK2417262T3 DK 2417262 T3 DK2417262 T3 DK 2417262T3 DK 10714403 T DK10714403 T DK 10714403T DK 2417262 T3 DK2417262 T3 DK 2417262T3
- Authority
- DK
- Denmark
- Prior art keywords
- nanopartically
- medicated
- sequence
- supply
- specific nucleases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
- C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16738909P | 2009-04-07 | 2009-04-07 | |
| PCT/US2010/030155 WO2010118077A1 (en) | 2009-04-07 | 2010-04-07 | Nanoparticle mediated delivery of sequence specific nucleases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2417262T3 true DK2417262T3 (da) | 2015-06-22 |
Family
ID=42173819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10714403.2T DK2417262T3 (da) | 2009-04-07 | 2010-04-07 | Nanopartikelmedieret tilførsel af sekvensspecifikke nukleaser |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9187755B2 (da) |
| EP (1) | EP2417262B1 (da) |
| JP (3) | JP5755636B2 (da) |
| KR (1) | KR101701534B1 (da) |
| CN (1) | CN102369287B (da) |
| AR (1) | AR076225A1 (da) |
| AU (1) | AU2010234539B2 (da) |
| BR (1) | BRPI1015952B8 (da) |
| CA (1) | CA2757831C (da) |
| DK (1) | DK2417262T3 (da) |
| ES (1) | ES2539327T3 (da) |
| HR (1) | HRP20150564T1 (da) |
| HU (1) | HUE026053T2 (da) |
| IL (1) | IL214880A (da) |
| PT (1) | PT2417262E (da) |
| RU (3) | RU2612156C2 (da) |
| SI (1) | SI2417262T1 (da) |
| TW (1) | TWI576432B (da) |
| WO (1) | WO2010118077A1 (da) |
| ZA (1) | ZA201106262B (da) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9339539B2 (en) | 2008-11-07 | 2016-05-17 | Hidaca Limited | Transfection with magnetic nanoparticles |
| WO2012161764A1 (en) * | 2011-02-16 | 2012-11-29 | Fox Daniel N | Magnetic sorting of mammalian sperm having damaged membranes |
| US10030245B2 (en) | 2011-03-23 | 2018-07-24 | E I Du Pont De Nemours And Company | Methods for producing a complex transgenic trait locus |
| EP2697379B1 (en) * | 2011-03-23 | 2018-08-29 | Dow AgroSciences LLC | Quantum dot carrier peptide conjugates suitable for imaging and delivery applications in plants |
| CN102250944B (zh) * | 2011-06-02 | 2012-10-31 | 南京林业大学 | 一种CdSe/ZnS量子点与植物细胞的共孵育方法 |
| SG11201401658SA (en) * | 2011-10-21 | 2014-07-30 | Stemgenics Inc | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
| BR112014031891A2 (pt) | 2012-06-19 | 2017-08-01 | Univ Minnesota | direcionamento genético nas plantas utilizando vírus de dna |
| BR112015013784A2 (pt) | 2012-12-12 | 2017-07-11 | Massachusetts Inst Technology | aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| CN105531372A (zh) | 2013-06-14 | 2016-04-27 | 塞尔克蒂斯股份有限公司 | 植物中非转基因基因组编辑方法 |
| EP3011033B1 (en) | 2013-06-17 | 2020-02-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| DK3011031T3 (da) | 2013-06-17 | 2020-12-21 | Broad Inst Inc | Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi |
| EP3011030B1 (en) | 2013-06-17 | 2023-11-08 | The Broad Institute, Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| CA3109801C (en) | 2013-08-22 | 2024-01-09 | Andrew Cigan | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
| US10526616B2 (en) | 2013-09-23 | 2020-01-07 | Rensselaer Polytechnic Institute | Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations |
| KR20160089530A (ko) | 2013-12-12 | 2016-07-27 | 더 브로드 인스티튜트, 인코퍼레이티드 | Ｈｂｖ 및 바이러스 질병 및 질환을 위한 ｃｒｉｓｐｒｃａｓ 시스템 및 조성물의 전달，용도 및 치료적 적용 |
| WO2015089473A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| WO2015089351A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
| IL289736B2 (en) | 2013-12-12 | 2025-09-01 | Massachusetts Inst Technology | Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations |
| WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| JP6455912B2 (ja) * | 2014-03-24 | 2019-01-23 | 国立研究開発法人産業技術総合研究所 | 人工ヌクレアーゼの細胞への導入方法 |
| CN106687594A (zh) | 2014-07-11 | 2017-05-17 | 纳幕尔杜邦公司 | 用于产生对草甘膦除草剂具有抗性的植物的组合物和方法 |
| WO2016040030A1 (en) | 2014-09-12 | 2016-03-17 | E. I. Du Pont De Nemours And Company | Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use |
| EP3985115A1 (en) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| EP3702456A1 (en) | 2014-12-24 | 2020-09-02 | The Broad Institute, Inc. | Crispr having or associated with destabilization domains |
| AU2016214301B2 (en) * | 2015-02-06 | 2022-05-19 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
| JPWO2016143223A1 (ja) * | 2015-03-09 | 2017-12-28 | 株式会社島津製作所 | 外部環境変化に対する耐性が向上した固定化プロテアーゼ |
| WO2016155482A1 (zh) * | 2015-03-16 | 2016-10-06 | 中国科学院遗传与发育生物学研究所 | 一种利用非遗传物质对植物基因组进行定点改造的方法 |
| US10450576B2 (en) | 2015-03-27 | 2019-10-22 | E I Du Pont De Nemours And Company | Soybean U6 small nuclear RNA gene promoters and their use in constitutive expression of small RNA genes in plants |
| WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| TWI813532B (zh) | 2015-06-18 | 2023-09-01 | 美商博得學院股份有限公司 | 降低脱靶效應的ｃｒｉｓｐｒ酶突變 |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| US20170000743A1 (en) * | 2015-07-02 | 2017-01-05 | Vindico NanoBio Technology Inc. | Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles |
| CN109069527B (zh) * | 2016-03-15 | 2022-05-03 | 北卡罗来纳州立大学 | 纳米颗粒、控释剂型和用于递送免疫治疗剂的方法 |
| ES2865481T3 (es) * | 2016-04-29 | 2021-10-15 | Poseida Therapeutics Inc | Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos |
| CA3039924A1 (en) * | 2016-10-11 | 2018-04-19 | Stemgenics, Inc. | Nanoparticles functionalized with gene editing tools and related methods |
| WO2018085693A1 (en) | 2016-11-04 | 2018-05-11 | Inari Agriculture, Inc. | Novel plant cells, plants, and seeds |
| CA3045131A1 (en) | 2016-12-14 | 2018-06-21 | Ligandal, Inc. | Methods and compositions for nucleic acid and protein payload delivery |
| EP3392339A1 (en) | 2017-04-18 | 2018-10-24 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Improved genome editing in plant cells |
| RU2663347C1 (ru) * | 2017-07-12 | 2018-08-03 | Общество с ограниченной ответственностью "Дока-Генные Технологии" | Способ доставки биологически активных макромолекул в клетки растений |
| US12084676B2 (en) | 2018-02-23 | 2024-09-10 | Pioneer Hi-Bred International, Inc. | Cas9 orthologs |
| AU2019255725A1 (en) * | 2018-04-18 | 2020-12-10 | Ligandal, Inc. | Methods and compositions for genome editing |
| US11518999B1 (en) | 2018-11-09 | 2022-12-06 | Inari Agriculture Technology, Inc. | Plant transformation |
| WO2020123887A2 (en) | 2018-12-14 | 2020-06-18 | Pioneer Hi-Bred International, Inc. | Novel crispr-cas systems for genome editing |
| CN111363013B (zh) * | 2018-12-25 | 2021-11-19 | 深圳先进技术研究院 | 多组分纳米颗粒簇的构建方法 |
| US11692197B2 (en) | 2019-05-06 | 2023-07-04 | Inari Agriculture Technology, Inc. | Delivery of biological molecules to plant cells |
| WO2020264016A1 (en) | 2019-06-25 | 2020-12-30 | Inari Agriculture, Inc. | Improved homology dependent repair genome editing |
| AU2021312243A1 (en) | 2020-07-20 | 2023-02-23 | Flagship Pioneering Innovations Vii, Llc | Viroid-derived polynucleotides for modification of plants |
| US20220040315A1 (en) * | 2020-08-09 | 2022-02-10 | Fulu Labs Corporation | Nuclease-dendrimer formulations for covid-19 and broad-spectrum antiviral therapy and prophylaxis |
| UY39997A (es) | 2021-11-01 | 2023-05-15 | Flagship Pioneering Innovations Vii Llc | Polinucleótidos para modificar organismos |
| IL314307A (en) | 2022-01-20 | 2024-09-01 | Flagship Pioneering Innovations Vii Llc | Polynucleotides for modifying organisms |
| EP4299739A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| EP4299733A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| WO2024005863A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| WO2024005864A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| WO2024229398A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial amalgavirus satellite rnas |
| AR132591A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de secoviridae artificiales |
| WO2024229395A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Partitiviral satellite rna amplification systems for plants |
| AR132587A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de martellivirales artificiales |
| AR133211A1 (es) | 2023-05-03 | 2025-09-10 | Flagship Pioneering Innovations Vii Llc | Arn satélite artificiales de tombusviridae |
| AR132589A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de solemoviridae artificiales |
| WO2024229385A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial ghabrivirales satellite rnas |
| AR132585A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Sistemas de amplificación de arn satélite endornavirales para plantas |
| AR132588A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de tymovirales artificiales |
| WO2025076141A1 (en) | 2023-10-03 | 2025-04-10 | Inari Agriculture Technology, Inc. | Viral delivery of grna to the scion |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050059031A1 (en) * | 2000-10-06 | 2005-03-17 | Quantum Dot Corporation | Method for enhancing transport of semiconductor nanocrystals across biological membranes |
| DE10254166A1 (de) * | 2002-11-20 | 2004-06-03 | Icon Genetics Ag | Verfahren zur Kontrolle eines zellulären Prozesses in Pflanzen |
| MXPA06000092A (es) | 2003-07-01 | 2006-04-07 | Biolex Inc | Transformacion de cloroplasto de la lenteja de agua. |
| CN1687427A (zh) * | 2005-03-30 | 2005-10-26 | 湖南大学 | 基于超声波介导的纳米颗粒作载体的基因转导方法 |
| MX2007010402A (es) * | 2005-04-20 | 2008-01-22 | Dendritic Nanotechnologies Inc | Polimeros dendriticos con amplificacion mejorada y funcionalidad interior. |
| US20070016985A1 (en) * | 2005-07-18 | 2007-01-18 | Pioneer Hi-Bred International, Inc. | Particle Preparation for Direct-Delivery Transformation |
| KR100821192B1 (ko) * | 2005-09-08 | 2008-04-11 | 주식회사바이테리얼즈 | 형광성을 가지는 자성 나노 입자 및 그 제조방법 |
| CA2621352A1 (en) | 2005-09-08 | 2007-03-15 | Biterials Co., Ltd. | Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof |
| WO2007050715A2 (en) * | 2005-10-26 | 2007-05-03 | Integrated Plant Genetics, Inc. | Compositions and methods for safe delivery of biologically-active plant transformation agents using non-fibrous silicon carbide powder |
| ES2776100T3 (es) * | 2006-03-31 | 2020-07-29 | Massachusetts Inst Technology | Sistema para el suministro dirigido de agentes terapéuticos |
| US9428756B2 (en) * | 2006-08-11 | 2016-08-30 | Dow Agrosciences Llc | Zinc finger nuclease-mediated homologous recombination |
| JP5507459B2 (ja) * | 2007-10-05 | 2014-05-28 | ダウ アグロサイエンシィズ エルエルシー | 植物細胞に分子性物質を移行させる方法 |
-
2010
- 2010-04-07 BR BRPI1015952A patent/BRPI1015952B8/pt active IP Right Grant
- 2010-04-07 HR HRP20150564TT patent/HRP20150564T1/hr unknown
- 2010-04-07 RU RU2015120061A patent/RU2612156C2/ru active
- 2010-04-07 JP JP2012504794A patent/JP5755636B2/ja active Active
- 2010-04-07 CA CA2757831A patent/CA2757831C/en active Active
- 2010-04-07 TW TW099110728A patent/TWI576432B/zh active
- 2010-04-07 WO PCT/US2010/030155 patent/WO2010118077A1/en not_active Ceased
- 2010-04-07 ES ES10714403.2T patent/ES2539327T3/es active Active
- 2010-04-07 RU RU2011144872/10A patent/RU2556376C2/ru active
- 2010-04-07 DK DK10714403.2T patent/DK2417262T3/da active
- 2010-04-07 KR KR1020117026339A patent/KR101701534B1/ko active Active
- 2010-04-07 SI SI201030952T patent/SI2417262T1/sl unknown
- 2010-04-07 US US12/755,447 patent/US9187755B2/en active Active
- 2010-04-07 AR ARP100101171A patent/AR076225A1/es active IP Right Grant
- 2010-04-07 PT PT107144032T patent/PT2417262E/pt unknown
- 2010-04-07 HU HUE10714403A patent/HUE026053T2/en unknown
- 2010-04-07 EP EP10714403.2A patent/EP2417262B1/en active Active
- 2010-04-07 CN CN201080015582.0A patent/CN102369287B/zh active Active
- 2010-04-07 AU AU2010234539A patent/AU2010234539B2/en active Active
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2011
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2015
- 2015-05-27 JP JP2015107100A patent/JP6275668B2/ja active Active
- 2015-09-22 US US14/861,864 patent/US9719108B2/en active Active
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2017
- 2017-02-14 RU RU2017104660A patent/RU2664865C2/ru active
- 2017-05-17 JP JP2017098360A patent/JP6513127B2/ja active Active
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