DK2498756T3 - Tabletformuleringer af neratinibmaleat - Google Patents
Tabletformuleringer af neratinibmaleat Download PDFInfo
- Publication number
- DK2498756T3 DK2498756T3 DK10779339T DK10779339T DK2498756T3 DK 2498756 T3 DK2498756 T3 DK 2498756T3 DK 10779339 T DK10779339 T DK 10779339T DK 10779339 T DK10779339 T DK 10779339T DK 2498756 T3 DK2498756 T3 DK 2498756T3
- Authority
- DK
- Denmark
- Prior art keywords
- neratinibmaleate
- tablet formulations
- formulations
- tablet
- Prior art date
Links
- VXZCUHNJXSIJIM-MEBGWEOYSA-N (z)-but-2-enedioic acid;(e)-n-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound OC(=O)\C=C/C(O)=O.C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 VXZCUHNJXSIJIM-MEBGWEOYSA-N 0.000 title 1
- 229950008835 neratinib Drugs 0.000 title 1
- 239000007916 tablet composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25940309P | 2009-11-09 | 2009-11-09 | |
| PCT/IB2010/054964 WO2011055303A1 (en) | 2009-11-09 | 2010-11-02 | Tablet formulations of neratinib maleate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2498756T3 true DK2498756T3 (da) | 2019-11-25 |
| DK2498756T4 DK2498756T4 (da) | 2023-03-20 |
Family
ID=43478191
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK22169771.7T DK4066821T3 (da) | 2009-11-09 | 2010-11-02 | Tabletformuleringer af neratinibmaleat |
| DK10779339.0T DK2498756T4 (da) | 2009-11-09 | 2010-11-02 | Tabletformuleringer af neratinibmaleat |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK22169771.7T DK4066821T3 (da) | 2009-11-09 | 2010-11-02 | Tabletformuleringer af neratinibmaleat |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8518446B2 (da) |
| EP (4) | EP4570242A3 (da) |
| JP (3) | JP5835883B2 (da) |
| CN (2) | CN103893140B (da) |
| AR (2) | AR078952A1 (da) |
| AU (1) | AU2010316683B2 (da) |
| CA (1) | CA2780428C (da) |
| CY (1) | CY1122330T1 (da) |
| DK (2) | DK4066821T3 (da) |
| ES (3) | ES2757882T5 (da) |
| FI (3) | FI2498756T4 (da) |
| FR (1) | FR25C1035I1 (da) |
| HR (2) | HRP20250604T1 (da) |
| HU (3) | HUE071632T2 (da) |
| LT (3) | LT2498756T (da) |
| NZ (1) | NZ599763A (da) |
| PL (2) | PL2498756T5 (da) |
| PT (2) | PT2498756T (da) |
| RS (2) | RS66797B1 (da) |
| SI (2) | SI2498756T2 (da) |
| SM (2) | SMT202500153T1 (da) |
| TW (1) | TWI466690B (da) |
| WO (1) | WO2011055303A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| CN113952459B (zh) | 2005-02-03 | 2025-02-11 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
| CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| CN102641270A (zh) | 2008-06-17 | 2012-08-22 | 惠氏有限责任公司 | 含有hki-272和长春瑞滨的抗肿瘤组合 |
| HUE032958T2 (hu) | 2008-08-04 | 2017-11-28 | Wyeth Llc | 4-Anilino-3-ciano-kinolinok és capecitabin antineoplasztikus kombinációi |
| LT3000467T (lt) | 2009-04-06 | 2023-04-11 | Wyeth Llc | Krūties vėžio gydymo schema naudojant neratinibą |
| DK4066821T3 (da) * | 2009-11-09 | 2025-04-14 | Wyeth Llc | Tabletformuleringer af neratinibmaleat |
| EP2498751B1 (en) * | 2009-11-09 | 2019-04-03 | Wyeth LLC | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| JP6242810B2 (ja) | 2011-12-28 | 2017-12-06 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドGlobal Blood Therapeutics,Inc. | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN105246477A (zh) | 2013-03-15 | 2016-01-13 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA037091B1 (ru) | 2013-03-15 | 2021-02-04 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| MX379228B (es) | 2013-03-15 | 2025-03-10 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulación de la hemoglobina. |
| US9818967B2 (en) * | 2013-06-28 | 2017-11-14 | Universal Display Corporation | Barrier covered microlens films |
| CN104337782A (zh) * | 2013-08-02 | 2015-02-11 | 山东新时代药业有限公司 | 一种甲磺酸伊马替尼片剂 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| EP3097108B8 (en) | 2014-01-23 | 2021-04-07 | Immunolight, LLC | Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders |
| CN114213390A (zh) | 2014-02-07 | 2022-03-22 | 全球血液疗法股份有限公司 | 一种化合物的结晶多晶型物 |
| ES2805008T3 (es) | 2014-02-17 | 2021-02-10 | Childrens Nat Medical Ct | Procedimiento y sistema para proporcionar recomendaciones para la ejecución óptima de procedimientos quirúrgicos |
| SG10201900648SA (en) | 2014-07-25 | 2019-02-27 | Novartis Ag | Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide |
| US10016471B2 (en) | 2015-06-29 | 2018-07-10 | Phloronol, Inc. | Solid pharmaceutical compositions of brown algae |
| FI3383392T3 (fi) | 2015-12-04 | 2025-09-11 | Global Blood Therapeutics Inc | Annosteluohjelmat 2-hydroksi-6-((2-(1-isopropyyli-1h-pyratsol-5-yyli)pyridin-3-yyli)metoksi)bentsaldehydille |
| CN106831710A (zh) * | 2015-12-07 | 2017-06-13 | 常州爱诺新睿医药技术有限公司 | 一种无定型来那替尼或其药学上可接受的盐与药用辅料的固体分散体及其制备方法 |
| CN106913529B (zh) * | 2015-12-24 | 2020-12-04 | 江苏恒瑞医药股份有限公司 | 一种来那替尼或其可药用盐药物组合物的制备方法 |
| CA2937365C (en) * | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| KR102498693B1 (ko) * | 2016-09-07 | 2023-02-10 | 셀진 코포레이션 | 정제 조성물 |
| TWI778983B (zh) * | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CA3060316A1 (en) * | 2017-04-28 | 2018-11-01 | Asana Biosciences, Llc | Formulations, methods, kits, and dosage forms for treating atopic dermatitis and for improved stability of an active pharmaceutical ingredient |
| CA3079916A1 (en) * | 2017-10-24 | 2019-05-02 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition containing quinoline derivative |
| WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| IL295007A (en) | 2020-01-31 | 2022-09-01 | Nanocopoeia Llc | Amorphous nilotinib microparticles and uses thereof |
| WO2021222739A1 (en) * | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
| US20220378788A1 (en) * | 2020-04-30 | 2022-12-01 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib and in vitro characterization thereof |
| JP2023531606A (ja) * | 2020-06-19 | 2023-07-25 | アセルタ・ファーマ・ベスローテン・フェンノートシャップ | アカラブルチニブマレイン酸塩剤形 |
| CN116211859A (zh) * | 2021-12-03 | 2023-06-06 | 江苏奥赛康药业有限公司 | 一种含有马来酸奈拉替尼的药用组合物及其制备方法 |
| IL315415A (en) * | 2022-03-07 | 2024-11-01 | Janssen Pharmaceuticals Inc | The compositions containing eticarpant |
| WO2023172958A1 (en) * | 2022-03-08 | 2023-09-14 | Onkosxcel Therapeutics, Llc | Stable formulations of talabostat |
| WO2024187321A1 (zh) | 2023-03-10 | 2024-09-19 | 甫康(上海)健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
| CN117427076B (zh) * | 2023-12-05 | 2025-09-19 | 中国科学技术大学 | 来那替尼在制备预防或治疗动脉粥样硬化药物中的应用 |
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| US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| US6384051B1 (en) | 2000-03-13 | 2002-05-07 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
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| AR046544A1 (es) * | 2003-10-15 | 2005-12-14 | Wyeth Corp | Administracion oral de acido [2- (8,9 - dioxo - 2,6 - diazabiciclo [5.2.0] non -1 (7) - en - 2 - il ) alquil] fosfonico yderivados |
| CN101039952A (zh) * | 2004-10-13 | 2007-09-19 | 惠氏公司 | 作为pi3k抑制剂的17-羟基渥曼青霉素类似物 |
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| ES2340610T3 (es) * | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| EP1948180B1 (en) * | 2005-11-11 | 2013-03-13 | Boehringer Ingelheim International GmbH | Combination treatment of cancer comprising egfr/her2 inhibitors |
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| TW200806282A (en) * | 2006-05-05 | 2008-02-01 | Wyeth Corp | Solid dosage formulations |
| MX2009007254A (es) * | 2007-01-12 | 2009-08-12 | Wyeth Corp | Composiciones de tableta en tableta. |
| ES2639854T3 (es) * | 2007-02-01 | 2017-10-30 | Takeda Pharmaceutical Company Limited | Preparación de comprimidos sin causar problemas de fabricación de comprimidos |
| JP2009089982A (ja) * | 2007-10-11 | 2009-04-30 | Ohara Yakuhin Kogyo Kk | 打錠用造粒物の造粒方法 |
| WO2009100176A2 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
| EP2448563A2 (en) * | 2009-07-02 | 2012-05-09 | Wyeth LLC | 3-cyanoquinoline tablet formulations and uses thereof |
| DK4066821T3 (da) * | 2009-11-09 | 2025-04-14 | Wyeth Llc | Tabletformuleringer af neratinibmaleat |
-
2010
- 2010-11-02 DK DK22169771.7T patent/DK4066821T3/da active
- 2010-11-02 LT LT10779339T patent/LT2498756T/lt unknown
- 2010-11-02 PL PL10779339.0T patent/PL2498756T5/pl unknown
- 2010-11-02 HU HUE22169771A patent/HUE071632T2/hu unknown
- 2010-11-02 AU AU2010316683A patent/AU2010316683B2/en active Active
- 2010-11-02 ES ES10779339T patent/ES2757882T5/es active Active
- 2010-11-02 NZ NZ599763A patent/NZ599763A/en unknown
- 2010-11-02 WO PCT/IB2010/054964 patent/WO2011055303A1/en not_active Ceased
- 2010-11-02 HU HUE10779339A patent/HUE046606T2/hu unknown
- 2010-11-02 SI SI201031952T patent/SI2498756T2/sl unknown
- 2010-11-02 ES ES22169771T patent/ES3029208T3/es active Active
- 2010-11-02 HR HRP20250604TT patent/HRP20250604T1/hr unknown
- 2010-11-02 DK DK10779339.0T patent/DK2498756T4/da active
- 2010-11-02 EP EP25160646.3A patent/EP4570242A3/en active Pending
- 2010-11-02 PT PT107793390T patent/PT2498756T/pt unknown
- 2010-11-02 FI FIEP10779339.0T patent/FI2498756T4/fi active
- 2010-11-02 LT LTEP22169771.7T patent/LT4066821T/lt unknown
- 2010-11-02 CN CN201410082103.7A patent/CN103893140B/zh active Active
- 2010-11-02 HR HRP20192026TT patent/HRP20192026T4/hr unknown
- 2010-11-02 EP EP19154710.8A patent/EP3566697B1/en active Active
- 2010-11-02 PT PT221697717T patent/PT4066821T/pt unknown
- 2010-11-02 RS RS20250477A patent/RS66797B1/sr unknown
- 2010-11-02 EP EP22169771.7A patent/EP4066821B1/en active Active
- 2010-11-02 SI SI201032155T patent/SI4066821T1/sl unknown
- 2010-11-02 SM SM20250153T patent/SMT202500153T1/it unknown
- 2010-11-02 RS RS20191417A patent/RS59599B2/sr unknown
- 2010-11-02 CN CN201080060546.6A patent/CN102724970B/zh active Active
- 2010-11-02 EP EP10779339.0A patent/EP2498756B2/en active Active
- 2010-11-02 PL PL22169771.7T patent/PL4066821T3/pl unknown
- 2010-11-02 FI FIEP22169771.7T patent/FI4066821T3/fi active
- 2010-11-02 SM SM20190632T patent/SMT201900632T1/it unknown
- 2010-11-02 CA CA2780428A patent/CA2780428C/en active Active
- 2010-11-02 ES ES19154710T patent/ES2998766T3/es active Active
- 2010-11-05 US US12/940,808 patent/US8518446B2/en active Active
- 2010-11-08 JP JP2010249385A patent/JP5835883B2/ja active Active
- 2010-11-08 TW TW99138396A patent/TWI466690B/zh active
- 2010-11-09 AR ARP100104156A patent/AR078952A1/es not_active Application Discontinuation
-
2013
- 2013-08-21 US US13/972,764 patent/US8790708B2/en active Active
-
2015
- 2015-02-06 JP JP2015021870A patent/JP2015091882A/ja not_active Withdrawn
-
2017
- 2017-02-06 JP JP2017019429A patent/JP2017075192A/ja not_active Withdrawn
-
2018
- 2018-11-14 AR ARP180103329A patent/AR114143A2/es not_active Application Discontinuation
-
2019
- 2019-11-14 CY CY20191101200T patent/CY1122330T1/el unknown
-
2025
- 2025-08-21 HU HUS2500035C patent/HUS2500035I1/hu unknown
- 2025-08-25 LT LTPA2025531C patent/LTPA2025531I1/lt unknown
- 2025-08-29 FI FIC20250029C patent/FIC20250029I1/fi unknown
- 2025-09-04 FR FR25C1035C patent/FR25C1035I1/fr active Active
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