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DK2167523T3 - Syntese og anvendelse af anti-reverse phosphorothioatanaloger af messenger-rna-cappen - Google Patents

Syntese og anvendelse af anti-reverse phosphorothioatanaloger af messenger-rna-cappen

Info

Publication number
DK2167523T3
DK2167523T3 DK08771474.7T DK08771474T DK2167523T3 DK 2167523 T3 DK2167523 T3 DK 2167523T3 DK 08771474 T DK08771474 T DK 08771474T DK 2167523 T3 DK2167523 T3 DK 2167523T3
Authority
DK
Denmark
Prior art keywords
cappen
phosphorothioat
analogs
synthesis
reverse
Prior art date
Application number
DK08771474.7T
Other languages
English (en)
Inventor
Jacek Jemielity
Ewa M Grudzien-Nogalska
Joanna Kowalska
Edward Darzynkiewicz
Robert E Rhoads
Original Assignee
Univ Louisiana State
Univ Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisiana State, Univ Warszawski filed Critical Univ Louisiana State
Application granted granted Critical
Publication of DK2167523T3 publication Critical patent/DK2167523T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK08771474.7T 2007-06-19 2008-06-19 Syntese og anvendelse af anti-reverse phosphorothioatanaloger af messenger-rna-cappen DK2167523T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94484207P 2007-06-19 2007-06-19
PCT/US2008/067494 WO2008157688A2 (en) 2007-06-19 2008-06-19 Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap

Publications (1)

Publication Number Publication Date
DK2167523T3 true DK2167523T3 (da) 2014-09-08

Family

ID=40156965

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08771474.7T DK2167523T3 (da) 2007-06-19 2008-06-19 Syntese og anvendelse af anti-reverse phosphorothioatanaloger af messenger-rna-cappen

Country Status (14)

Country Link
US (1) US8153773B2 (da)
EP (1) EP2167523B1 (da)
CN (3) CN101855231B (da)
AU (1) AU2008265683B2 (da)
CA (1) CA2692906C (da)
CY (1) CY1115525T1 (da)
DK (1) DK2167523T3 (da)
EA (1) EA017740B1 (da)
ES (1) ES2500515T3 (da)
HR (1) HRP20140771T1 (da)
PL (1) PL2167523T3 (da)
PT (1) PT2167523E (da)
SI (1) SI2167523T1 (da)
WO (1) WO2008157688A2 (da)

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CN101855231B (zh) 2014-06-11
CY1115525T1 (el) 2017-01-04
CN107501370B (zh) 2021-06-18
CN107501370A (zh) 2017-12-22
AU2008265683A1 (en) 2008-12-24
WO2008157688A3 (en) 2009-02-26
EP2167523B1 (en) 2014-07-23
CA2692906A1 (en) 2008-12-24
PT2167523E (pt) 2014-09-22
EA017740B1 (ru) 2013-02-28
CN101855231A (zh) 2010-10-06
CN104072561A (zh) 2014-10-01
US20100233757A1 (en) 2010-09-16
US8153773B2 (en) 2012-04-10
ES2500515T3 (es) 2014-09-30
EP2167523A2 (en) 2010-03-31
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EP2167523A4 (en) 2011-06-15
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CN104072561B (zh) 2017-12-22
AU2008265683B2 (en) 2013-08-29

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