DK2145627T3 - Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. - Google Patents
Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse.Info
- Publication number
- DK2145627T3 DK2145627T3 DK09173495.4T DK09173495T DK2145627T3 DK 2145627 T3 DK2145627 T3 DK 2145627T3 DK 09173495 T DK09173495 T DK 09173495T DK 2145627 T3 DK2145627 T3 DK 2145627T3
- Authority
- DK
- Denmark
- Prior art keywords
- choline
- disorder
- uridine
- treatment
- combination
- Prior art date
Links
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title abstract 6
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title abstract 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001231 choline Drugs 0.000 title abstract 3
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title abstract 3
- 229940045145 uridine Drugs 0.000 title abstract 3
- 208000027534 Emotional disease Diseases 0.000 title 1
- 208000019022 Mood disease Diseases 0.000 title 1
- 239000004381 Choline salt Substances 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 235000019417 choline salt Nutrition 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9500298P | 1998-07-31 | 1998-07-31 | |
| EP07116909A EP1870103B1 (en) | 1998-07-31 | 1999-07-30 | Use of uridine in combination with choline for the treatment of memory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2145627T3 true DK2145627T3 (da) | 2014-07-21 |
Family
ID=22248474
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07116909T DK1870103T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse |
| DK99937631T DK1140104T3 (da) | 1998-07-31 | 1999-07-30 | Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo |
| DK09173495.4T DK2145627T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. |
| DK10075660.0T DK2322187T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser |
| DK10075661.8T DK2329829T3 (da) | 1998-07-31 | 1999-07-30 | Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07116909T DK1870103T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse |
| DK99937631T DK1140104T3 (da) | 1998-07-31 | 1999-07-30 | Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10075660.0T DK2322187T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser |
| DK10075661.8T DK2329829T3 (da) | 1998-07-31 | 1999-07-30 | Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6989376B2 (da) |
| EP (5) | EP2329829B1 (da) |
| JP (1) | JP2003517437A (da) |
| AT (2) | ATE446097T1 (da) |
| CA (1) | CA2339008C (da) |
| CY (1) | CY1110570T1 (da) |
| DE (2) | DE69941586D1 (da) |
| DK (5) | DK1870103T3 (da) |
| ES (5) | ES2477568T3 (da) |
| PT (5) | PT2322187E (da) |
| WO (1) | WO2000006174A1 (da) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| US20060069061A1 (en) * | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
| US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| AU2001247474A1 (en) * | 2000-03-16 | 2001-09-24 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
| US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
| NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| MXPA05000451A (es) * | 2002-07-11 | 2005-03-23 | Yamasa Corp | Composicion medicinal para neuropatia inducida por farmaco. |
| US7053064B2 (en) * | 2002-11-08 | 2006-05-30 | The Mclean Hospital Corporation | Compounds for the treatment of tobacco dependence and withdrawal |
| CN100563660C (zh) * | 2002-12-20 | 2009-12-02 | 麦克莱恩医院 | 用于正常化睡眠/觉醒周期的化合物 |
| US20050113449A1 (en) * | 2003-10-08 | 2005-05-26 | Renshaw Perry F. | Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications |
| CA2542023A1 (en) * | 2003-10-08 | 2005-09-22 | The Mclean Hospital Corporation | Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids |
| WO2005112635A2 (en) * | 2004-05-13 | 2005-12-01 | Massachusetts Institute Of Technology | Uridine effects on dopamine release |
| EP1765364A4 (en) * | 2004-06-10 | 2010-09-22 | Mclean Hospital Corp | PYRIMIDINES, SUCH AS Z: B: CYTIDINE, IN THE TREATMENT OF PATIENTS WITH BIPOLAR DISORDER |
| WO2005122767A1 (en) * | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| EP1784199A4 (en) * | 2004-08-11 | 2010-06-23 | Mclean Hospital Corp | COMPOUNDS FOR TREATING MARIHUANA DEPENDENCE, DEDUCTION AND CONSUMPTION |
| AU2011253660B2 (en) * | 2004-09-15 | 2013-12-19 | Massachusetts Institute Of Technology | Compositions containing uridine, and methods utilizing same |
| CN102600199A (zh) * | 2004-09-15 | 2012-07-25 | 麻省理工学院 | 含有尿苷的组合物及使用其的方法 |
| AU2012203650B2 (en) * | 2005-05-23 | 2014-09-18 | Massachusetts Institute Of Technology | Compositions containing PUFA and methods of use thereof |
| CA2645647C (en) * | 2005-05-23 | 2016-07-12 | Massachusetts Institute Of Technology | Compositions containing pufa and/or uridine and methods of use thereof |
| AU2006293026B2 (en) * | 2005-09-22 | 2012-08-16 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| WO2007059762A1 (de) * | 2005-11-25 | 2007-05-31 | Gisela Susilo | Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid |
| PL1800675T4 (pl) * | 2005-12-23 | 2012-02-29 | Nutricia Nv | Kompozycja zawierająca wielonienasycone kwasy tłuszczowe, białka, mangan, i/lub molibden oraz nukleozydy/nukleotydy do leczenia otępienia |
| JP5140584B2 (ja) * | 2006-06-27 | 2013-02-06 | ヤマサ醤油株式会社 | 抗心理社会的ストレス剤 |
| US7972633B2 (en) * | 2007-02-07 | 2011-07-05 | Applied Cognitive Sciences, LLC | Nutritional supplements for healthy memory and mental function |
| EP2217075A4 (en) * | 2007-11-02 | 2012-01-25 | Massachusetts Inst Technology | URIDINE FOOD ADDITIONAL AGREEMENT PROCESS AND USE THEREOF |
| CA2727546A1 (en) * | 2008-06-12 | 2009-12-17 | Repligen Corporation | Methods of treatment of bipolar disorder |
| US20100041621A1 (en) * | 2008-08-15 | 2010-02-18 | Perry Renshaw | Methods and compositions for improving cognitive performance |
| JP6162125B2 (ja) | 2011-09-30 | 2017-07-12 | タフツ・ユニバーシティ | 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法 |
| WO2013066152A1 (en) | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Method for improving executive function |
| WO2014027882A1 (en) | 2012-08-13 | 2014-02-20 | N.V. Nutricia | Product and method for supporting uridine homeostasis |
| AU2013323188B2 (en) | 2012-09-28 | 2018-04-19 | Tufts University | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
| AR095442A1 (es) | 2013-03-13 | 2015-10-14 | Univ Tufts | Derivados de nucleósido de uridina, composiciones y métodos de uso |
| PT2968385T (pt) | 2013-03-13 | 2018-10-09 | Univ Tufts | Derivados nucleósidos de uridina, composições e métodos de uso |
| WO2015115885A1 (en) * | 2014-01-31 | 2015-08-06 | N.V. Nutricia | Method for reducing white matter lesions, white matter hyperintensities (wmh), leukoaraiosis or periventricular white matter disease in elderly |
| WO2016053085A1 (en) * | 2014-09-30 | 2016-04-07 | N.V. Nutricia | Composition comprising a uridine source and butyrate producing fibres for preventing gastrointestinal disorders |
| WO2016072842A1 (en) * | 2014-11-05 | 2016-05-12 | N.V. Nutricia | Method for preventing, reducing the risk of, or treating behavioral frontotemporal dementia |
| WO2017069613A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients |
| US20190151273A1 (en) | 2016-04-04 | 2019-05-23 | N.V. Nutricia | Method for reducing or preventing global developmental delay in children |
| KR20200116096A (ko) * | 2018-02-01 | 2020-10-08 | 웰스태트 테러퓨틱스 코포레이션 | 우리딘의 전신 전달을 위한 조성물 및 장치 |
| US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| CN114990176A (zh) * | 2022-05-26 | 2022-09-02 | 宁夏华吉生物有限公司 | 一种生产尿嘧啶核苷的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2508474A1 (de) * | 1975-02-27 | 1976-09-02 | Boehringer Mannheim Gmbh | Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen |
| DE2629845A1 (de) * | 1976-07-02 | 1978-01-05 | Geb Graze Erika Graze | Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion |
| US4221784A (en) * | 1979-04-05 | 1980-09-09 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lecithin |
| IT1178044B (it) * | 1984-10-09 | 1987-09-03 | Polifarma Spa | Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina |
| US4609647A (en) * | 1985-05-28 | 1986-09-02 | Massachusetts Institute Of Technology | Cytidyl diphosphocholine-drug composition and process |
| ES2007350A6 (es) * | 1987-05-29 | 1989-06-16 | Ganadera Union Ind Agro | Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion. |
| DE3883374T2 (de) * | 1987-10-28 | 1993-12-09 | Pro Neuron Inc | Acylatiertes uridin und cytidin und deren verwendungen. |
| US5470838A (en) | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| IT1219667B (it) * | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
| RU2003332C1 (ru) * | 1989-06-09 | 1993-11-30 | Борис Витальевич Страдомский | Средство дл лечени депрессий |
| JPH0722495B2 (ja) * | 1990-01-30 | 1995-03-15 | 美穂 田中 | クロレラ含有油脂食品 |
| US5141943A (en) | 1990-04-12 | 1992-08-25 | Brown University Research Foundation | 5-benzyl barbiturate derivatives |
| US5567689A (en) * | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
| US5700590A (en) * | 1994-01-10 | 1997-12-23 | Abbott Laboratories | Nutritional formula with ribo-nucleotides |
| JPH07215879A (ja) * | 1994-02-02 | 1995-08-15 | Otsuka Pharmaceut Factory Inc | 抗ストレス組成物 |
| DE9412374U1 (de) * | 1994-08-01 | 1994-09-22 | Rauch-Petz, Gisela G., Dr., 80803 München | Nahrungsergänzungsmittel |
| JPH0930976A (ja) * | 1995-07-17 | 1997-02-04 | Otsuka Pharmaceut Factory Inc | 記憶低下改善剤 |
| US5843024A (en) * | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
| US5962459A (en) * | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
| IT1290781B1 (it) * | 1996-05-28 | 1998-12-10 | Polifarma Spa | Agente attivo terapeutico per il trattamento di malattie degenerative neuronali. |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| KR100879559B1 (ko) * | 1999-02-23 | 2009-01-22 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 미토콘드리아 장애의 치료 또는 예방용 제약조성물 |
| JP2001233776A (ja) * | 2000-02-25 | 2001-08-28 | Yamasa Shoyu Co Ltd | 学習・記憶能低下改善剤およびその用途 |
| US20030114415A1 (en) * | 2001-12-14 | 2003-06-19 | Wurtman Richard J. | Compositions and methods for treating and preventing memory impairment using citicoline |
-
1999
- 1999-07-30 ES ES10075660.0T patent/ES2477568T3/es not_active Expired - Lifetime
- 1999-07-30 DE DE69941586T patent/DE69941586D1/de not_active Expired - Lifetime
- 1999-07-30 PT PT100756600T patent/PT2322187E/pt unknown
- 1999-07-30 ES ES99937631T patent/ES2294850T3/es not_active Expired - Lifetime
- 1999-07-30 EP EP10075661.8A patent/EP2329829B1/en not_active Expired - Lifetime
- 1999-07-30 JP JP2000562028A patent/JP2003517437A/ja active Pending
- 1999-07-30 AT AT07116909T patent/ATE446097T1/de active
- 1999-07-30 EP EP09173495.4A patent/EP2145627B1/en not_active Expired - Lifetime
- 1999-07-30 DK DK07116909T patent/DK1870103T3/da active
- 1999-07-30 US US09/363,748 patent/US6989376B2/en not_active Expired - Lifetime
- 1999-07-30 DK DK99937631T patent/DK1140104T3/da active
- 1999-07-30 CA CA002339008A patent/CA2339008C/en not_active Expired - Lifetime
- 1999-07-30 DK DK09173495.4T patent/DK2145627T3/da active
- 1999-07-30 ES ES09173495.4T patent/ES2476940T3/es not_active Expired - Lifetime
- 1999-07-30 ES ES07116909T patent/ES2332669T3/es not_active Expired - Lifetime
- 1999-07-30 EP EP10075660.0A patent/EP2322187B1/en not_active Expired - Lifetime
- 1999-07-30 DE DE69937198T patent/DE69937198T2/de not_active Expired - Lifetime
- 1999-07-30 PT PT99937631T patent/PT1140104E/pt unknown
- 1999-07-30 EP EP99937631A patent/EP1140104B1/en not_active Expired - Lifetime
- 1999-07-30 PT PT100756618T patent/PT2329829E/pt unknown
- 1999-07-30 DK DK10075660.0T patent/DK2322187T3/da active
- 1999-07-30 ES ES10075661.8T patent/ES2478044T3/es not_active Expired - Lifetime
- 1999-07-30 WO PCT/US1999/017235 patent/WO2000006174A1/en not_active Ceased
- 1999-07-30 EP EP07116909A patent/EP1870103B1/en not_active Expired - Lifetime
- 1999-07-30 DK DK10075661.8T patent/DK2329829T3/da active
- 1999-07-30 AT AT99937631T patent/ATE374029T1/de active
- 1999-07-30 PT PT07116909T patent/PT1870103E/pt unknown
- 1999-07-30 PT PT91734954T patent/PT2145627E/pt unknown
-
2009
- 2009-12-01 CY CY20091101264T patent/CY1110570T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2145627T3 (da) | Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. | |
| DK1066036T3 (da) | Midler med serotoninrelateret aktivitet til behandling af sövnapnö | |
| DE59107331D1 (de) | Flupirtin in Kombination mit Antiparkinsonika zur Bekämpfung von Muskelverspannungen | |
| DK0450991T3 (da) | Anvendelse af phospholipider til behandling af luftvejsobstruktionssygdomme | |
| TR200101722T2 (tr) | Serivastatin ve fibratların birleşimi. | |
| MX9207008A (es) | Medicamentos para el tratamiento de condiciones inflamatorias o para la analgesia. | |
| ES2015512A4 (es) | Proceso para la preparacion de polialcoholes de polieter con reducida saturacion. | |
| DE69811158D1 (de) | Verfahren zur Herstellung von 2,2-Bis(3-amino-4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropan | |
| DE69200684D1 (de) | Vorrichtung zur thermischen Behandlung von laufenden Garnen. | |
| DK1007055T3 (da) | Anvendelse af amifostin | |
| BR9915460A (pt) | Método de tratamento de febre hemorrágica virótica | |
| TR199900505T2 (da) | ||
| BR9914899A (pt) | Uso de (r)-tofisopam opticamente puro para o tratamento e a prevenção de distúrbios de ansiedade e composição do mesmo | |
| BR9711575A (pt) | Emprego de 1-hidrÄxi-2-piridonas para o tratamento da dermatite seborr-ica | |
| NO983311L (no) | FremgangsmÕte for Õ forhindre sulfidst÷veksplosjoner i forbindelse med etterblÕsing | |
| DE69734461D1 (de) | Verwendung von mycobacterium vaccae zur therapie des chronischen müdigkeitssyndrom | |
| ATE287718T1 (de) | Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems | |
| DK671087D0 (da) | Anvendelse af 5-aryl-3h-1,2,4-triazol-3-oner som antikonvulsiva | |
| MX9205459A (es) | Compuesto de organosilicio para el tratamiento de fibras de poliester, metodo para el tratamiento de las fibras de poliester y las fibras asi producidas. | |
| TR199801798T2 (xx) | Otizm tedavisi. | |
| NO900009L (no) | Fremgangsmaate for fremstilling av aspiringranuler med regulert frigivningseffekt. | |
| DK0880971T3 (da) | Markofagstimulerende protein til behandling af sygdomme i centralnervesystemet | |
| ES1027603Y (es) | Estructura desmontable para el montaje de cajones. | |
| ES1029541Y (es) | Prenda para personas con trastornos mentales. | |
| ES1020134Y (es) | Mesa audiovisual para el juego de bingo. |