DK1947189T3 - Fremgangsmåde til vitaminfremstilling - Google Patents
Fremgangsmåde til vitaminfremstillingInfo
- Publication number
- DK1947189T3 DK1947189T3 DK08003596.7T DK08003596T DK1947189T3 DK 1947189 T3 DK1947189 T3 DK 1947189T3 DK 08003596 T DK08003596 T DK 08003596T DK 1947189 T3 DK1947189 T3 DK 1947189T3
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin preparation
- geranylgeraniol
- microorganism
- farnesol
- phosphate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01Q—ANTENNAS, i.e. RADIO AERIALS
- H01Q1/00—Details of, or arrangements associated with, antennas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9198398P | 1998-07-06 | 1998-07-06 | |
| US9195198P | 1998-07-06 | 1998-07-06 | |
| US9196498P | 1998-07-06 | 1998-07-06 | |
| EP99932295A EP1095002A4 (en) | 1998-07-06 | 1999-07-06 | PROCESS FOR PRODUCING VITAMINS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1947189T3 true DK1947189T3 (da) | 2011-03-14 |
Family
ID=27377004
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08003596.7T DK1947189T3 (da) | 1998-07-06 | 1999-07-06 | Fremgangsmåde til vitaminfremstilling |
| DK10180179T DK2305825T3 (da) | 1998-07-06 | 1999-07-06 | Fremgangsmåde til fremstilling af vitaminer |
| DK09004155.9T DK2100963T3 (da) | 1998-07-06 | 1999-07-06 | Fremgangsmåde til vitaminfremstilling. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10180179T DK2305825T3 (da) | 1998-07-06 | 1999-07-06 | Fremgangsmåde til fremstilling af vitaminer |
| DK09004155.9T DK2100963T3 (da) | 1998-07-06 | 1999-07-06 | Fremgangsmåde til vitaminfremstilling. |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP2100963B1 (da) |
| JP (1) | JP4579415B2 (da) |
| CN (1) | CN1330621A (da) |
| AT (2) | ATE537265T1 (da) |
| AU (1) | AU4863099A (da) |
| CA (2) | CA2831321C (da) |
| DE (1) | DE69943009D1 (da) |
| DK (3) | DK1947189T3 (da) |
| ES (2) | ES2534937T3 (da) |
| MX (2) | MX276941B (da) |
| WO (1) | WO2000001650A1 (da) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| MXPA01010486A (es) | 1999-04-15 | 2002-03-27 | Calgene Llc | Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol. |
| EP1260590B1 (en) * | 2000-03-02 | 2007-02-14 | TOUDAI TLO, Ltd. | Method of screening substance specifically inhibiting non-mevalonate pathway |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| US20030033626A1 (en) | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU9052201A (en) | 2000-08-07 | 2002-02-18 | Monsanto Technology Llc | Methyl-d-erythritol phosphate pathway genes |
| CA2433534A1 (en) | 2000-12-28 | 2002-07-11 | Toyota Jidosha Kabushiki Kaisha | Process for producing prenyl alcohol |
| JP2002253284A (ja) | 2000-12-28 | 2002-09-10 | Toyota Motor Corp | 微生物によるゲラニルゲラニオール及びその類縁化合物の製造方法 |
| JP3838033B2 (ja) * | 2000-12-28 | 2006-10-25 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
| JP4013535B2 (ja) * | 2000-12-28 | 2007-11-28 | トヨタ自動車株式会社 | 微生物によるプレニルアルコールの高生産方法 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| JP2003088368A (ja) * | 2001-09-18 | 2003-03-25 | Toyota Motor Corp | プレニルアルコールの製造方法 |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| CA2443865C (en) | 2001-05-09 | 2012-02-07 | Monsanto Technology Llc | Tyra genes and uses thereof |
| AU2002316966B2 (en) * | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
| US7244877B2 (en) | 2001-08-17 | 2007-07-17 | Monsanto Technology Llc | Methyltransferase from cotton and uses thereof |
| CN100400661C (zh) | 2001-10-25 | 2008-07-09 | 孟山都技术有限公司 | 芳族甲基转移酶及其应用 |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| BR0308740A (pt) | 2002-03-19 | 2007-01-09 | Monsanto Technology Llc | ácidos nucléicos e polipeptìdeos de homogentisado prenil transferase ("hpt"), e empregos destes |
| MXPA04012062A (es) | 2002-06-21 | 2005-03-07 | Dsm Ip Assets Bv | Proceso para producir carotenoides. |
| BR0313270A (pt) | 2002-08-05 | 2005-08-02 | Monsanto Technology Llc | Genes relacionados com a biosìntese de tocoferol e usos dos mesmos |
| EP1543115B1 (en) * | 2002-09-27 | 2008-05-07 | DSM IP Assets B.V. | Squalene synthase (sqs) gene |
| ES2379368T3 (es) | 2004-05-21 | 2012-04-25 | The Regents Of The University Of California | Método para aumentar la producción de compuestos isoprenoides |
| US8828684B2 (en) | 2004-07-27 | 2014-09-09 | The Regents Of The University Of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| JP4824985B2 (ja) * | 2005-10-13 | 2011-11-30 | 株式会社Adeka | ファルネシル二リン酸の製造方法 |
| US8691555B2 (en) | 2006-09-28 | 2014-04-08 | Dsm Ip Assests B.V. | Production of carotenoids in oleaginous yeast and fungi |
| JP2010528627A (ja) | 2007-06-01 | 2010-08-26 | ソラザイム、インク | 微生物による油の生産 |
| CN101868532A (zh) | 2007-09-20 | 2010-10-20 | 阿迈瑞斯生物技术公司 | 类异戊二烯的制备 |
| JP5174430B2 (ja) * | 2007-11-06 | 2013-04-03 | 花王株式会社 | 2−フェニルエチルアルコールの製造方法 |
| BRPI0918936A2 (pt) | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
| ES2583639T3 (es) * | 2008-11-28 | 2016-09-21 | Terravia Holdings, Inc. | Producción de aceites específicos en microorganismos heterótrofos |
| SG10201504197SA (en) | 2010-05-28 | 2015-06-29 | Solazyme Inc | Food Compositions Comprising Tailored Oils |
| BR122021005297B1 (pt) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol |
| EP3521408B1 (en) | 2010-11-03 | 2021-12-22 | Corbion Biotech, Inc. | Genetically-engineered chlorella or prototheca microbe and oil produced therefrom |
| CN110066836A (zh) | 2011-02-02 | 2019-07-30 | 柯碧恩生物技术公司 | 产自重组产油微生物的定制油 |
| WO2012154626A1 (en) | 2011-05-06 | 2012-11-15 | Solazyme, Inc. | Genetically engineered microorganisms that metabolize xylose |
| AU2012253564A1 (en) * | 2011-05-09 | 2013-10-31 | Amyris, Inc. | Production of acetyl-coenzyme A derived compounds |
| JP6262653B2 (ja) | 2011-08-08 | 2018-01-17 | エヴォルヴァ エスアー.Evolva Sa. | ステビオール配糖体の組換え生産 |
| BR112014025719A8 (pt) | 2012-04-18 | 2017-10-03 | Solazyme Inc | Óleos customizados |
| KR20150115002A (ko) | 2013-02-06 | 2015-10-13 | 에볼바 에스아 | 레바우디오시드 d 및 레바우디오시드 m의 개선된 생산 방법 |
| CN105189771B (zh) | 2013-02-11 | 2019-11-05 | 埃沃尔瓦公司 | 在重组宿主中有效产生甜菊醇糖苷 |
| US9249252B2 (en) | 2013-04-26 | 2016-02-02 | Solazyme, Inc. | Low polyunsaturated fatty acid oils and uses thereof |
| MX369685B (es) | 2013-10-04 | 2019-11-19 | Terravia Holdings Inc | Aceites adaptables. |
| EP3620517A3 (en) | 2014-07-10 | 2020-07-29 | Corbion Biotech, Inc. | Ketoacyl acp synthase genes and uses thereof |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10612064B2 (en) | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP4148137A1 (en) | 2015-01-30 | 2023-03-15 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| BR112018002564A2 (pt) | 2015-08-07 | 2018-09-25 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| CN105153102A (zh) * | 2015-09-30 | 2015-12-16 | 宜春大海龟生命科学有限公司 | 以混合生育酚为原料制备α-生育酚的方法 |
| CN109195457A (zh) | 2016-04-13 | 2019-01-11 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN110100006A (zh) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
| CA3084263A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| CN109609579B (zh) * | 2018-12-31 | 2022-04-05 | 陕西师范大学 | 一种产β-胡萝卜素的基因工程菌及其构建方法 |
| CN109884216A (zh) * | 2019-04-10 | 2019-06-14 | 西南医科大学 | 一种高效液相色谱测定载药胶束中法尼醛含量的方法 |
| CN110950791B (zh) * | 2019-12-09 | 2021-12-14 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯制备方法 |
| CN110903190B (zh) * | 2019-12-09 | 2022-07-12 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯的制备方法 |
| EP4081505A1 (en) * | 2019-12-23 | 2022-11-02 | DSM IP Assets B.V. | Dehydrogenation process |
| CN113621631A (zh) * | 2021-08-11 | 2021-11-09 | 昆明理工大学 | 一种甲羟戊酸激酶基因rkmk及其应用 |
| CN113969288B (zh) * | 2021-10-29 | 2024-09-17 | 湖北冠众通科技有限公司 | 一种产法尼醇基因工程菌及其构建方法与应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE810299A (fr) * | 1974-01-29 | 1974-05-16 | Procede de fabrication de composes contenant un noyau chromane. | |
| US3862988A (en) | 1974-05-23 | 1975-01-28 | Eastman Kodak Co | 4,8 Dimethyl- 12-oxotridecanal |
| US3917710A (en) | 1974-05-23 | 1975-11-04 | Eastman Kodak Co | Preparation of phytone via the addition of dimethylketene to 4,8-dimethyl-12-oxotridecanal |
| GB1479272A (en) * | 1974-12-23 | 1977-07-13 | Kuraray Co | Process for preparing a stereospecific farnesol |
| US4225734A (en) | 1978-08-08 | 1980-09-30 | The Regents Of The University Of California | Process for producing symmetrical olefins |
| US4743546A (en) | 1985-02-13 | 1988-05-10 | Biotechnica International, Inc. | Controlled gene excision |
| US4871721A (en) | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| US5589372A (en) | 1990-09-26 | 1996-12-31 | E. R. Squibb & Sons, Inc. | Squalene synthetase |
| US5460949A (en) * | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5475029A (en) | 1993-07-08 | 1995-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Farnesyl compounds as cholesterol lowering agents |
| JP3657298B2 (ja) | 1994-11-08 | 2005-06-08 | 株式会社クラレ | ゲラニルゲラニオ−ルの製造方法 |
| US5556990A (en) | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| JP3120684B2 (ja) | 1995-02-14 | 2000-12-25 | トヨタ自動車株式会社 | ゲラニルゲラニル二リン酸を合成する変異型ファルネシル二リン酸合成酵素及びそれをコードするdna |
| JP3151371B2 (ja) * | 1995-03-10 | 2001-04-03 | 麒麟麦酒株式会社 | カロチノイド生産量の増量に有用なdna鎖 |
| MX9606257A (es) | 1995-12-07 | 1998-04-30 | Univ Yale | Proteinas de sintasa de difosfato de geranilgeranilo, moleculas de acido nucleico, y usos de las mismas. |
| EP0870042B1 (en) * | 1995-12-22 | 2004-09-08 | DSM IP Assets B.V. | Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods |
| US5744341A (en) * | 1996-03-29 | 1998-04-28 | University Of Maryland College Park | Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes |
| EP0955363A3 (en) * | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
-
1999
- 1999-07-06 EP EP09004155A patent/EP2100963B1/en not_active Expired - Lifetime
- 1999-07-06 EP EP99932295A patent/EP1095002A4/en not_active Withdrawn
- 1999-07-06 AT AT09004155T patent/ATE537265T1/de active
- 1999-07-06 ES ES10180179.3T patent/ES2534937T3/es not_active Expired - Lifetime
- 1999-07-06 AT AT08003596T patent/ATE490332T1/de not_active IP Right Cessation
- 1999-07-06 CA CA2831321A patent/CA2831321C/en not_active Expired - Lifetime
- 1999-07-06 CA CA2331343A patent/CA2331343C/en not_active Expired - Lifetime
- 1999-07-06 MX MXPA04002408 patent/MX276941B/es unknown
- 1999-07-06 AU AU48630/99A patent/AU4863099A/en not_active Abandoned
- 1999-07-06 DK DK08003596.7T patent/DK1947189T3/da active
- 1999-07-06 DE DE69943009T patent/DE69943009D1/de not_active Expired - Lifetime
- 1999-07-06 DK DK10180179T patent/DK2305825T3/da active
- 1999-07-06 JP JP2000558056A patent/JP4579415B2/ja not_active Expired - Lifetime
- 1999-07-06 DK DK09004155.9T patent/DK2100963T3/da active
- 1999-07-06 WO PCT/US1999/015264 patent/WO2000001650A1/en not_active Ceased
- 1999-07-06 CN CN99810559A patent/CN1330621A/zh active Pending
- 1999-07-06 ES ES09004155T patent/ES2379212T3/es not_active Expired - Lifetime
- 1999-07-06 MX MXPA01000216 patent/MX219130B/es unknown
- 1999-07-06 EP EP08003596A patent/EP1947189B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000001650A1 (en) | 2000-01-13 |
| AU4863099A (en) | 2000-01-24 |
| EP1095002A4 (en) | 2005-08-03 |
| DK2100963T3 (da) | 2012-04-02 |
| EP1947189A2 (en) | 2008-07-23 |
| DE69943009D1 (de) | 2011-01-13 |
| CA2331343A1 (en) | 2000-01-13 |
| CA2831321C (en) | 2018-05-15 |
| ES2379212T3 (es) | 2012-04-23 |
| MX219130B (es) | 2004-02-10 |
| EP1947189A3 (en) | 2008-10-08 |
| ES2534937T3 (es) | 2015-04-30 |
| EP2100963B1 (en) | 2011-12-14 |
| ATE490332T1 (de) | 2010-12-15 |
| ATE537265T1 (de) | 2011-12-15 |
| DK2305825T3 (da) | 2015-03-02 |
| CN1330621A (zh) | 2002-01-09 |
| MX276941B (es) | 2010-06-28 |
| CA2831321A1 (en) | 2000-01-13 |
| EP1095002A1 (en) | 2001-05-02 |
| EP2100963A1 (en) | 2009-09-16 |
| MXPA01000216A (es) | 2002-10-17 |
| CA2331343C (en) | 2014-01-14 |
| EP1947189B1 (en) | 2010-12-01 |
| JP2002519049A (ja) | 2002-07-02 |
| JP4579415B2 (ja) | 2010-11-10 |
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