[go: up one dir, main page]

DK1947189T3 - Fremgangsmåde til vitaminfremstilling - Google Patents

Fremgangsmåde til vitaminfremstilling

Info

Publication number
DK1947189T3
DK1947189T3 DK08003596.7T DK08003596T DK1947189T3 DK 1947189 T3 DK1947189 T3 DK 1947189T3 DK 08003596 T DK08003596 T DK 08003596T DK 1947189 T3 DK1947189 T3 DK 1947189T3
Authority
DK
Denmark
Prior art keywords
vitamin preparation
geranylgeraniol
microorganism
farnesol
phosphate
Prior art date
Application number
DK08003596.7T
Other languages
English (en)
Inventor
James R Millis
Gabriel G Saucy
Julie Maurina-Brunker
Thomas W Mcmullin
Original Assignee
Dcv Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dcv Inc filed Critical Dcv Inc
Application granted granted Critical
Publication of DK1947189T3 publication Critical patent/DK1947189T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/723,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01QANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00Details of, or arrangements associated with, antennas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK08003596.7T 1998-07-06 1999-07-06 Fremgangsmåde til vitaminfremstilling DK1947189T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9198398P 1998-07-06 1998-07-06
US9195198P 1998-07-06 1998-07-06
US9196498P 1998-07-06 1998-07-06
EP99932295A EP1095002A4 (en) 1998-07-06 1999-07-06 PROCESS FOR PRODUCING VITAMINS

Publications (1)

Publication Number Publication Date
DK1947189T3 true DK1947189T3 (da) 2011-03-14

Family

ID=27377004

Family Applications (3)

Application Number Title Priority Date Filing Date
DK08003596.7T DK1947189T3 (da) 1998-07-06 1999-07-06 Fremgangsmåde til vitaminfremstilling
DK10180179T DK2305825T3 (da) 1998-07-06 1999-07-06 Fremgangsmåde til fremstilling af vitaminer
DK09004155.9T DK2100963T3 (da) 1998-07-06 1999-07-06 Fremgangsmåde til vitaminfremstilling.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10180179T DK2305825T3 (da) 1998-07-06 1999-07-06 Fremgangsmåde til fremstilling af vitaminer
DK09004155.9T DK2100963T3 (da) 1998-07-06 1999-07-06 Fremgangsmåde til vitaminfremstilling.

Country Status (11)

Country Link
EP (3) EP2100963B1 (da)
JP (1) JP4579415B2 (da)
CN (1) CN1330621A (da)
AT (2) ATE537265T1 (da)
AU (1) AU4863099A (da)
CA (2) CA2831321C (da)
DE (1) DE69943009D1 (da)
DK (3) DK1947189T3 (da)
ES (2) ES2534937T3 (da)
MX (2) MX276941B (da)
WO (1) WO2000001650A1 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
MXPA01010486A (es) 1999-04-15 2002-03-27 Calgene Llc Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol.
EP1260590B1 (en) * 2000-03-02 2007-02-14 TOUDAI TLO, Ltd. Method of screening substance specifically inhibiting non-mevalonate pathway
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU9052201A (en) 2000-08-07 2002-02-18 Monsanto Technology Llc Methyl-d-erythritol phosphate pathway genes
CA2433534A1 (en) 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Process for producing prenyl alcohol
JP2002253284A (ja) 2000-12-28 2002-09-10 Toyota Motor Corp 微生物によるゲラニルゲラニオール及びその類縁化合物の製造方法
JP3838033B2 (ja) * 2000-12-28 2006-10-25 トヨタ自動車株式会社 プレニルアルコールの製造方法
JP4013535B2 (ja) * 2000-12-28 2007-11-28 トヨタ自動車株式会社 微生物によるプレニルアルコールの高生産方法
US7501268B2 (en) 2000-12-28 2009-03-10 Toyota Jidosha Kabushiki Kaisha Methods of producing prenyl alcohols
JP2003088368A (ja) * 2001-09-18 2003-03-25 Toyota Motor Corp プレニルアルコールの製造方法
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
CA2443865C (en) 2001-05-09 2012-02-07 Monsanto Technology Llc Tyra genes and uses thereof
AU2002316966B2 (en) * 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
US7244877B2 (en) 2001-08-17 2007-07-17 Monsanto Technology Llc Methyltransferase from cotton and uses thereof
CN100400661C (zh) 2001-10-25 2008-07-09 孟山都技术有限公司 芳族甲基转移酶及其应用
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
BR0308740A (pt) 2002-03-19 2007-01-09 Monsanto Technology Llc ácidos nucléicos e polipeptìdeos de homogentisado prenil transferase ("hpt"), e empregos destes
MXPA04012062A (es) 2002-06-21 2005-03-07 Dsm Ip Assets Bv Proceso para producir carotenoides.
BR0313270A (pt) 2002-08-05 2005-08-02 Monsanto Technology Llc Genes relacionados com a biosìntese de tocoferol e usos dos mesmos
EP1543115B1 (en) * 2002-09-27 2008-05-07 DSM IP Assets B.V. Squalene synthase (sqs) gene
ES2379368T3 (es) 2004-05-21 2012-04-25 The Regents Of The University Of California Método para aumentar la producción de compuestos isoprenoides
US8828684B2 (en) 2004-07-27 2014-09-09 The Regents Of The University Of California Genetically modified host cells and use of same for producing isoprenoid compounds
CN103589650A (zh) 2005-03-18 2014-02-19 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
JP4824985B2 (ja) * 2005-10-13 2011-11-30 株式会社Adeka ファルネシル二リン酸の製造方法
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
JP2010528627A (ja) 2007-06-01 2010-08-26 ソラザイム、インク 微生物による油の生産
CN101868532A (zh) 2007-09-20 2010-10-20 阿迈瑞斯生物技术公司 类异戊二烯的制备
JP5174430B2 (ja) * 2007-11-06 2013-04-03 花王株式会社 2−フェニルエチルアルコールの製造方法
BRPI0918936A2 (pt) 2008-09-15 2019-09-24 Danisco Us Inc conversão de derivados de prenila em isopreno
ES2583639T3 (es) * 2008-11-28 2016-09-21 Terravia Holdings, Inc. Producción de aceites específicos en microorganismos heterótrofos
SG10201504197SA (en) 2010-05-28 2015-06-29 Solazyme Inc Food Compositions Comprising Tailored Oils
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
EP3521408B1 (en) 2010-11-03 2021-12-22 Corbion Biotech, Inc. Genetically-engineered chlorella or prototheca microbe and oil produced therefrom
CN110066836A (zh) 2011-02-02 2019-07-30 柯碧恩生物技术公司 产自重组产油微生物的定制油
WO2012154626A1 (en) 2011-05-06 2012-11-15 Solazyme, Inc. Genetically engineered microorganisms that metabolize xylose
AU2012253564A1 (en) * 2011-05-09 2013-10-31 Amyris, Inc. Production of acetyl-coenzyme A derived compounds
JP6262653B2 (ja) 2011-08-08 2018-01-17 エヴォルヴァ エスアー.Evolva Sa. ステビオール配糖体の組換え生産
BR112014025719A8 (pt) 2012-04-18 2017-10-03 Solazyme Inc Óleos customizados
KR20150115002A (ko) 2013-02-06 2015-10-13 에볼바 에스아 레바우디오시드 d 및 레바우디오시드 m의 개선된 생산 방법
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
US9249252B2 (en) 2013-04-26 2016-02-02 Solazyme, Inc. Low polyunsaturated fatty acid oils and uses thereof
MX369685B (es) 2013-10-04 2019-11-19 Terravia Holdings Inc Aceites adaptables.
EP3620517A3 (en) 2014-07-10 2020-07-29 Corbion Biotech, Inc. Ketoacyl acp synthase genes and uses thereof
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
CN105153102A (zh) * 2015-09-30 2015-12-16 宜春大海龟生命科学有限公司 以混合生育酚为原料制备α-生育酚的方法
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
CN111868047A (zh) 2017-12-21 2020-10-30 齐默尔根公司 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物
CN109609579B (zh) * 2018-12-31 2022-04-05 陕西师范大学 一种产β-胡萝卜素的基因工程菌及其构建方法
CN109884216A (zh) * 2019-04-10 2019-06-14 西南医科大学 一种高效液相色谱测定载药胶束中法尼醛含量的方法
CN110950791B (zh) * 2019-12-09 2021-12-14 万华化学集团股份有限公司 一种维生素a及维生素a酯制备方法
CN110903190B (zh) * 2019-12-09 2022-07-12 万华化学集团股份有限公司 一种维生素a及维生素a酯的制备方法
EP4081505A1 (en) * 2019-12-23 2022-11-02 DSM IP Assets B.V. Dehydrogenation process
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用
CN113969288B (zh) * 2021-10-29 2024-09-17 湖北冠众通科技有限公司 一种产法尼醇基因工程菌及其构建方法与应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE810299A (fr) * 1974-01-29 1974-05-16 Procede de fabrication de composes contenant un noyau chromane.
US3862988A (en) 1974-05-23 1975-01-28 Eastman Kodak Co 4,8 Dimethyl- 12-oxotridecanal
US3917710A (en) 1974-05-23 1975-11-04 Eastman Kodak Co Preparation of phytone via the addition of dimethylketene to 4,8-dimethyl-12-oxotridecanal
GB1479272A (en) * 1974-12-23 1977-07-13 Kuraray Co Process for preparing a stereospecific farnesol
US4225734A (en) 1978-08-08 1980-09-30 The Regents Of The University Of California Process for producing symmetrical olefins
US4743546A (en) 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
US4871721A (en) 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
US5589372A (en) 1990-09-26 1996-12-31 E. R. Squibb & Sons, Inc. Squalene synthetase
US5460949A (en) * 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5475029A (en) 1993-07-08 1995-12-12 The Board Of Trustees Of The Leland Stanford Junior University Farnesyl compounds as cholesterol lowering agents
JP3657298B2 (ja) 1994-11-08 2005-06-08 株式会社クラレ ゲラニルゲラニオ−ルの製造方法
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
JP3120684B2 (ja) 1995-02-14 2000-12-25 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸を合成する変異型ファルネシル二リン酸合成酵素及びそれをコードするdna
JP3151371B2 (ja) * 1995-03-10 2001-04-03 麒麟麦酒株式会社 カロチノイド生産量の増量に有用なdna鎖
MX9606257A (es) 1995-12-07 1998-04-30 Univ Yale Proteinas de sintasa de difosfato de geranilgeranilo, moleculas de acido nucleico, y usos de las mismas.
EP0870042B1 (en) * 1995-12-22 2004-09-08 DSM IP Assets B.V. Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods
US5744341A (en) * 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
EP0955363A3 (en) * 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids

Also Published As

Publication number Publication date
WO2000001650A1 (en) 2000-01-13
AU4863099A (en) 2000-01-24
EP1095002A4 (en) 2005-08-03
DK2100963T3 (da) 2012-04-02
EP1947189A2 (en) 2008-07-23
DE69943009D1 (de) 2011-01-13
CA2331343A1 (en) 2000-01-13
CA2831321C (en) 2018-05-15
ES2379212T3 (es) 2012-04-23
MX219130B (es) 2004-02-10
EP1947189A3 (en) 2008-10-08
ES2534937T3 (es) 2015-04-30
EP2100963B1 (en) 2011-12-14
ATE490332T1 (de) 2010-12-15
ATE537265T1 (de) 2011-12-15
DK2305825T3 (da) 2015-03-02
CN1330621A (zh) 2002-01-09
MX276941B (es) 2010-06-28
CA2831321A1 (en) 2000-01-13
EP1095002A1 (en) 2001-05-02
EP2100963A1 (en) 2009-09-16
MXPA01000216A (es) 2002-10-17
CA2331343C (en) 2014-01-14
EP1947189B1 (en) 2010-12-01
JP2002519049A (ja) 2002-07-02
JP4579415B2 (ja) 2010-11-10

Similar Documents

Publication Publication Date Title
DK2100963T3 (da) Fremgangsmåde til vitaminfremstilling.
EP1130043A3 (en) Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
ES2104608T3 (es) Procedimiento para la produccion de una composicion que contiene zeaxantina utilizando un microorganismo de la especie flavobacterium multivorum.
NZ504429A (en) Fermentative lactic acid preparative method to produce at least 40g/litre free lactic acid
EP0913466A3 (en) Method for producing L-leucine
PT960944E (pt) Producao melhorada de taxol e de taxanos por culturas de celulas da especie taxus
UA32566C2 (uk) Спосіб одержання штаму мікроорганізму, спосіб продукування триптофану
MY127948A (en) L-glutamic acid producing bacterium and process for producing l-glutamic acid
AU3143097A (en) Enhanced production of taxanes by cell cultures of Taxus species
MY123972A (en) Method for producing l-glutamic acid by fermentation
ES2168971A1 (es) Procedimiento de produccion de beta-caroteno.
DE69622114D1 (de) Fermentative Herstellung von Vitamin B6
AU2001283132A1 (en) Enhancement of industrial production by increasing substrate transport
WO2002022841A3 (en) Process for production of_polyhydroxyalkanoate
GR3036276T3 (en) L-ascorbic acid production in microorganisms
DE69722852D1 (de) Fermentative Herstellung von Biotin
JPS572691A (en) Preparation of l-proline by fermentation method
RU2225881C2 (ru) Способ получения l-глутаминовой кислоты
AU3157893A (en) Process for preparing neuraminidase
KR910009933A (ko) 미생물에 의한 l-글루타민의 제조방법
KR880001823A (ko) 미생물에 의한 5'-구아닐산의 제조방법.
JPS56127096A (en) Preparation of l-methionine by fermentation
KR970043063A (ko) L-글루타민의 제조방법
KR910008140A (ko) 미생물에 의한 -l-글루타민의 제조방법
KR950014313A (ko) 발효에 의한 아드리아마이신의 제조방법