DK1714977T3 - Syntese af cyclosporinanaloger - Google Patents

Syntese af cyclosporinanaloger

Info

Publication number: DK1714977T3
Authority: DK; Denmark
Prior art keywords: isomers; isa; cyclosporine; derivatives; mixtures
Prior art date: 2001-10-19

Application number

DK06013976T

Other languages

English (en)

Inventor

Selvaraj Naicker

Randall W Yatscoff

Robert T Foster

Mark Abel

Seetharaman Jayaraman

Hans-Juergen Mair

Jean-Michel Adam

Bruno Lohri

Original Assignee

Isotechnika Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2002-10-17

Publication date

2009-07-06

2002-10-17 Application filed by Isotechnika Inc filed Critical Isotechnika Inc

2009-07-06 Application granted granted Critical

2009-07-06 Publication of DK1714977T3 publication Critical patent/DK1714977T3/da

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 5
108010036941 Cyclosporins Proteins 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
230000037361 pathway Effects 0.000 abstract 2
230000000707 stereoselective effect Effects 0.000 abstract 2
230000001988 toxicity Effects 0.000 abstract 2
231100000419 toxicity Toxicity 0.000 abstract 2
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
238000007239 Wittig reaction Methods 0.000 abstract 1
229910052796 boron Inorganic materials 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
125000002524 organometallic group Chemical group 0.000 abstract 1
229910052710 silicon Inorganic materials 0.000 abstract 1
239000010703 silicon Substances 0.000 abstract 1
229910052719 titanium Inorganic materials 0.000 abstract 1
239000010936 titanium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Nanotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Neurology (AREA)
Rheumatology (AREA)
General Engineering & Computer Science (AREA)
Dispersion Chemistry (AREA)
Biotechnology (AREA)
Medical Informatics (AREA)
Crystallography & Structural Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)

DK06013976T 2001-10-19 2002-10-17 Syntese af cyclosporinanaloger DK1714977T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US34620101P	2001-10-19	2001-10-19
US37059602P	2002-04-05	2002-04-05
PCT/CA2002/001559 WO2003033526A2 (en)	2001-10-19	2002-10-17	Synthesis of cyclosporin analogs

Publications (1)

Publication Number	Publication Date
DK1714977T3 true DK1714977T3 (da)	2009-07-06

Family

ID=26994746

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02767027T DK1436321T3 (da)	2001-10-19	2002-10-17	Syntese af cyclosporinanaloger
DK06013976T DK1714977T3 (da)	2001-10-19	2002-10-17	Syntese af cyclosporinanaloger

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02767027T DK1436321T3 (da)	2001-10-19	2002-10-17	Syntese af cyclosporinanaloger

Country Status (27)

Country	Link
US (13)	US7141648B2 (da)
EP (2)	EP1436321B9 (da)
JP (3)	JP4261355B2 (da)
KR (2)	KR101006206B1 (da)
CN (1)	CN100334106C (da)
AT (2)	ATE425178T1 (da)
AU (2)	AU2002331509B2 (da)
BR (1)	BRPI0213658A8 (da)
CA (1)	CA2461740C (da)
CO (1)	CO5580836A2 (da)
CY (1)	CY1105111T1 (da)
DE (2)	DE60231570D1 (da)
DK (2)	DK1436321T3 (da)
ES (2)	ES2326040T3 (da)
HR (2)	HRP20070058B1 (da)
IL (3)	IL160763A0 (da)
MA (1)	MA27293A1 (da)
MX (1)	MXPA04003625A (da)
NO (1)	NO332459B1 (da)
NZ (1)	NZ531944A (da)
PL (2)	PL210795B1 (da)
PT (2)	PT1436321E (da)
RU (1)	RU2321593C9 (da)
SI (1)	SI1436321T1 (da)
TN (1)	TNSN04068A1 (da)
WO (1)	WO2003033526A2 (da)
ZA (1)	ZA200402269B (da)

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Publication number	Publication date
DE60231570D1 (de)	2009-04-23
US9765119B2 (en)	2017-09-19
MXPA04003625A (es)	2004-12-02
US20140142277A1 (en)	2014-05-22
ATE332917T1 (de)	2006-08-15
JP4261355B2 (ja)	2009-04-30
EP1436321B9 (en)	2008-11-12
HRP20040355A2 (en)	2005-04-30
DK1436321T3 (da)	2006-11-13
JP2010280710A (ja)	2010-12-16
US20030212249A1 (en)	2003-11-13
HRP20070058B1 (hr)	2014-05-23
HRP20070058A2 (en)	2008-09-30
DE60213115T2 (de)	2007-02-01
ES2326040T3 (es)	2009-09-29
PL210795B1 (pl)	2012-03-30
ES2266564T3 (es)	2007-03-01
BRPI0213658A8 (pt)	2016-12-06
US10472394B2 (en)	2019-11-12
RU2321593C2 (ru)	2008-04-10
CO5580836A2 (es)	2005-11-30
PL210841B1 (pl)	2012-03-30
CN100334106C (zh)	2007-08-29
US20140370082A1 (en)	2014-12-18
US20170362277A1 (en)	2017-12-21
MA27293A1 (fr)	2005-05-02
CN1571795A (zh)	2005-01-26
US20130078280A1 (en)	2013-03-28
DE60213115D1 (en)	2006-08-24
EP1436321B1 (en)	2006-07-12
EP1436321A2 (en)	2004-07-14
KR100982466B1 (ko)	2010-09-16
EP1714977B1 (en)	2009-03-11
TNSN04068A1 (en)	2006-06-01
PT1436321E (pt)	2006-10-31
PL370772A1 (en)	2005-05-30
US20100062976A1 (en)	2010-03-11
AU2002331509B2 (en)	2007-12-06
HK1062568A1 (en)	2004-11-12
NO20042031L (no)	2004-05-19
NZ531944A (en)	2006-03-31
US20070087963A1 (en)	2007-04-19
IL186140A (en)	2012-02-29
ATE425178T1 (de)	2009-03-15
US20080171850A1 (en)	2008-07-17
CA2461740C (en)	2013-02-12
US7141648B2 (en)	2006-11-28
US20030139326A1 (en)	2003-07-24
CY1105111T1 (el)	2010-03-03
BR0213658A (pt)	2004-10-26
US7332472B2 (en)	2008-02-19
EP1714977A2 (en)	2006-10-25
IL160763A0 (en)	2004-08-31
US6998385B2 (en)	2006-02-14
US20050192214A1 (en)	2005-09-01
US20160075741A1 (en)	2016-03-17
EP1714977A3 (en)	2007-01-10
JP2009046515A (ja)	2009-03-05
JP2005516893A (ja)	2005-06-09
KR101006206B1 (ko)	2011-01-07
KR20050037417A (ko)	2005-04-21
WO2003033526A3 (en)	2004-02-12
SI1436321T1 (sl)	2006-12-31
ZA200402269B (en)	2005-05-25
NO332459B1 (no)	2012-09-24
IL186140A0 (en)	2008-01-20
IL160763A (en)	2009-11-18
PL392749A1 (pl)	2011-01-03
WO2003033526A2 (en)	2003-04-24
PT1714977E (pt)	2009-06-23
KR20090130195A (ko)	2009-12-18
US20100311944A1 (en)	2010-12-09
RU2321593C9 (ru)	2008-06-20
CA2461740A1 (en)	2003-04-24
AU2010206069A1 (en)	2010-08-19
USRE48226E1 (en)	2020-09-29
RU2004110940A (ru)	2005-06-27
JP4887469B2 (ja)	2012-02-29
JP5396571B2 (ja)	2014-01-22
HRP20040355B1 (hr)	2012-10-31

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