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DK1678185T3 - 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose - Google Patents

2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Info

Publication number
DK1678185T3
DK1678185T3 DK04793412T DK04793412T DK1678185T3 DK 1678185 T3 DK1678185 T3 DK 1678185T3 DK 04793412 T DK04793412 T DK 04793412T DK 04793412 T DK04793412 T DK 04793412T DK 1678185 T3 DK1678185 T3 DK 1678185T3
Authority
DK
Denmark
Prior art keywords
nitroimidazo
tuberculosis
dihydro
treatment
oxazole compounds
Prior art date
Application number
DK04793412T
Other languages
Danish (da)
English (en)
Inventor
Hidetsugu Tsubouchi
Hirofumi Sasaki
Motohiro Itotani
Yoshikazu Haraguchi
Shin Miyamura
Makoto Matsumoto
Hiroyuki Hashizume
Tatsuo Grand Kawauch Tomishige
Masanori Kawasaki
Kinue Ohguro
Takumi Sumida
Takeshi Hasegawa
Kazuho Tanaka
Isao Takemura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of DK1678185T3 publication Critical patent/DK1678185T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK04793412T 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose DK1678185T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003373206 2003-10-31
JP2004111720 2004-04-06
PCT/JP2004/016492 WO2005042542A1 (fr) 2003-10-31 2004-10-29 Composes 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole pour le traitement de la tuberculose

Publications (1)

Publication Number Publication Date
DK1678185T3 true DK1678185T3 (da) 2008-12-08

Family

ID=34554779

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04793412T DK1678185T3 (da) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Country Status (19)

Country Link
US (1) US8163753B2 (fr)
EP (1) EP1678185B1 (fr)
KR (1) KR100851802B1 (fr)
AR (1) AR046777A1 (fr)
AT (1) ATE410430T1 (fr)
AU (1) AU2004285811B2 (fr)
BR (1) BRPI0414909A (fr)
CA (1) CA2539335A1 (fr)
CY (1) CY1108481T1 (fr)
DE (1) DE602004017037D1 (fr)
DK (1) DK1678185T3 (fr)
ES (1) ES2314460T3 (fr)
MY (1) MY146646A (fr)
PL (1) PL1678185T3 (fr)
PT (1) PT1678185E (fr)
RU (1) RU2365593C2 (fr)
SI (1) SI1678185T1 (fr)
TW (1) TWI335331B (fr)
WO (1) WO2005042542A1 (fr)

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JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
TW201233389A (en) 2005-10-05 2012-08-16 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
AU2006331676A1 (en) * 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds
JP2009537571A (ja) * 2006-05-22 2009-10-29 メルク フロスト カナダ リミテツド ステアロイル−コエンザイムａデルタ−９デサチュラーゼのインヒビターとしての環状アミン誘導体
US7678791B2 (en) 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (fr) 2009-01-14 2010-07-22 Genoscience Pharma Composés de pipéridin-4-ylpipérazine pour le traitement d'une infection à vhc
RU2540860C2 (ru) * 2009-07-31 2015-02-10 Глоубал Элаенс Фор Тб Драг Дивелопмент Нитроимидазооксазиновые и нитроимидазооксазольные аналоги и их применение
JP5916739B2 (ja) 2011-04-15 2016-05-11 大塚製薬株式会社 ６，７−ジヒドロイミダゾ［２，１−ｂ］［１，３］オキサジン化合物
KR20130083592A (ko) * 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
ES2707362T3 (es) * 2013-10-04 2019-04-03 Council Scient Ind Res 6-nitro-2,3-dihidroimidazo [2,1-b] oxazoles y un procedimiento de preparación de los mismos
CN107027307B (zh) * 2014-06-20 2020-12-22 韩国巴斯德研究所 一种抗感染化合物
EP2974729A1 (fr) 2014-07-17 2016-01-20 Abivax Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires
TWI687409B (zh) * 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
MX383020B (es) * 2014-10-01 2025-03-13 Henkel Ag & Co Kgaa Aceleradores de curado para composiciones curables anaerobicas.
CN107108650B (zh) * 2014-10-21 2019-10-18 印度科学工业研究所 抗分枝杆菌剂取代的1,2,3-三唑-1-基-甲基-2,3-二氢-2-甲基-6-硝基咪唑并[2,1-b]噁唑及其制备方法
BR112017015744A2 (pt) * 2015-01-29 2018-03-13 Medshine Discovery Inc composto apresentando uma estrutura de fórmula (i), um sal farmaceuticamente aceitável do mesmo ou um isômero ótico do mesmo, composição farmacêutica e uso do composto de fórmula (i) para o tratamento e prevenção de mycobacterium tuberculosis ou outras infecções microbianas
WO2017146246A1 (fr) * 2016-02-26 2017-08-31 大塚製薬株式会社 Dérivé de pipéridine
WO2018112842A1 (fr) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Modulateurs allostériques d'éther hétéroarylpipéridine 6,6-fusionné du récepteur muscarinique de l'acétylcholine m4
US20210251902A1 (en) 2018-06-11 2021-08-19 Otsuka Pharmaceutical Co., Ltd. Delamanid-containing composition
EP3669873A1 (fr) 2018-12-20 2020-06-24 Abivax Dérivés de quinoline destinés à être utilisés dans le traitement de maladies inflammatoires
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途

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JP3174524B2 (ja) 1997-02-21 2001-06-11 日本碍子株式会社 台板の下面清掃機構付きプッシャー型連続炉
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DE20023990U1 (de) 1999-09-29 2008-09-18 IBIDEN CO., LTD., Ogaki-shi Keramische Filteranordnung
TWI347946B (en) 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
PL375103A1 (en) * 2002-10-15 2005-11-28 Otsuka Pharmaceutical Co, Ltd. 1-substituted 4-nitroimidazole compound and process for producing the same
TWI335331B (en) * 2003-10-31 2011-01-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound
UA95251C2 (ru) * 2005-07-28 2011-07-25 Оцука Фармасьютикал Ко., Лтд. ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА

Also Published As

Publication number Publication date
US8163753B2 (en) 2012-04-24
KR100851802B1 (ko) 2008-08-13
MY146646A (en) 2012-09-14
US20080119478A1 (en) 2008-05-22
AU2004285811B2 (en) 2008-06-12
ATE410430T1 (de) 2008-10-15
RU2006118794A (ru) 2007-12-10
PT1678185E (pt) 2009-01-13
HK1097258A1 (zh) 2007-06-22
RU2365593C2 (ru) 2009-08-27
KR20060085644A (ko) 2006-07-27
SI1678185T1 (sl) 2009-02-28
AR046777A1 (es) 2005-12-21
ES2314460T3 (es) 2009-03-16
AU2004285811A1 (en) 2005-05-12
DE602004017037D1 (de) 2008-11-20
BRPI0414909A (pt) 2006-11-07
TWI335331B (en) 2011-01-01
EP1678185B1 (fr) 2008-10-08
TW200528460A (en) 2005-09-01
CA2539335A1 (fr) 2005-05-12
PL1678185T3 (pl) 2009-04-30
EP1678185A1 (fr) 2006-07-12
CY1108481T1 (el) 2014-04-09
WO2005042542A1 (fr) 2005-05-12

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