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DK1578727T3 - Tetrahydroquinolin-derivater og deres anvendelse som FSH-receptor-modulatorer - Google Patents

Tetrahydroquinolin-derivater og deres anvendelse som FSH-receptor-modulatorer

Info

Publication number
DK1578727T3
DK1578727T3 DK03808299T DK03808299T DK1578727T3 DK 1578727 T3 DK1578727 T3 DK 1578727T3 DK 03808299 T DK03808299 T DK 03808299T DK 03808299 T DK03808299 T DK 03808299T DK 1578727 T3 DK1578727 T3 DK 1578727T3
Authority
DK
Denmark
Prior art keywords
receptor modulators
fsh receptor
tetrahydroquinoline derivatives
tetrahydroquinoline
derivatives
Prior art date
Application number
DK03808299T
Other languages
Danish (da)
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of DK1578727T3 publication Critical patent/DK1578727T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03808299T 2002-12-20 2003-12-16 Tetrahydroquinolin-derivater og deres anvendelse som FSH-receptor-modulatorer DK1578727T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43547902P 2002-12-20 2002-12-20
EP02102865 2002-12-20
PCT/EP2003/051024 WO2004056779A2 (fr) 2002-12-20 2003-12-16 Derives de tetrahydroquinoline

Publications (1)

Publication Number Publication Date
DK1578727T3 true DK1578727T3 (da) 2008-08-04

Family

ID=38799446

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03808299T DK1578727T3 (da) 2002-12-20 2003-12-16 Tetrahydroquinolin-derivater og deres anvendelse som FSH-receptor-modulatorer

Country Status (23)

Country Link
US (1) US7674909B2 (fr)
EP (1) EP1578727B1 (fr)
JP (1) JP4545000B2 (fr)
AR (1) AR042629A1 (fr)
AT (1) ATE392416T1 (fr)
AU (1) AU2003303221B2 (fr)
BR (1) BR0317514A (fr)
CA (1) CA2508923C (fr)
CL (1) CL43546B (fr)
DE (1) DE60320457T2 (fr)
DK (1) DK1578727T3 (fr)
ES (1) ES2304544T3 (fr)
MX (1) MXPA05006772A (fr)
NZ (1) NZ540577A (fr)
PE (1) PE20040799A1 (fr)
PL (1) PL376997A1 (fr)
PT (1) PT1578727E (fr)
RS (1) RS51196B (fr)
RU (1) RU2328487C2 (fr)
SI (1) SI1578727T1 (fr)
TW (1) TWI322012B (fr)
UA (1) UA80303C2 (fr)
WO (1) WO2004056779A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1406628E (pt) * 2001-07-02 2006-06-30 Akzo Nobel Nv Derivados de tera-hidroquinolina
TWI306855B (en) * 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
DE10260739B3 (de) 2002-12-23 2004-09-16 Outokumpu Oy Verfahren und Anlage zur Herstellung von Metalloxid aus Metallverbindungen
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
PL1879866T3 (pl) * 2005-05-04 2011-07-29 N V Organon Pochodne dihydropirydynowe
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
CA2607882A1 (fr) 2005-05-12 2006-11-23 Wyeth Pyrrolobenzodiazepines et derives de carboxamides heterocycliques constituant des antagonistes du recepteur de l'hormone folliculostimulante (fsh-r)
EP1879897A1 (fr) * 2005-05-12 2008-01-23 Wyeth a Corporation of the State of Delaware Pyrrolobenzodiazepines et derives heteroaryles, aryles et cycloalkylamino cetones utilises comme antagonistes du recepteur de l'hormone de stimulation folliculaire (fish-r)
EP1893615A1 (fr) 2005-06-09 2008-03-05 Wyeth a Corporation of the State of Delaware Pyrrolobenzodiazepine pyridine carboxamides et derives utilises comme antagonistes du recepteur de l'hormone de stimulation folliculaire
TW200918058A (en) * 2007-08-31 2009-05-01 Organon Nv TSH receptor antagonizing tetrahydroquinoline compounds
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
DK3071203T3 (da) 2013-11-18 2021-03-15 Forma Therapeutics Inc Tetrahydroquinolinsammensætninger som bet-bromdomæne-inhibitorer
WO2019055877A1 (fr) 2017-09-15 2019-03-21 Forma Therapeutics, Inc. Compositions de tétrahydroimidazo quinoléine utilisées en tant qu'inhibiteurs de cbp/p300
AU2019295790B2 (en) 2018-06-29 2023-07-13 Forma Therapeutics, Inc. Inhibiting creb binding protein (CBP)
WO2020190791A1 (fr) 2019-03-15 2020-09-24 Forma Therapeutics, Inc. Inhibition de la protéine de liaison à un élément sensible à l'amp cyclique (creb)
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686182A (en) * 1950-12-07 1954-08-10 Basf Ag O-hydroxy-dihydro-quinoline carboxylic acids
DE3879031T2 (de) 1987-08-08 1993-06-24 Akzo Nv Kontrazeptives implantat.
SK280617B6 (sk) * 1992-01-16 2000-05-16 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, spôsob ich prípravy, f
ATE269336T1 (de) * 1994-12-22 2004-07-15 Ligand Pharm Inc Steroidrezeptor-modulator verbindungen und methoden
CA2339018A1 (fr) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Analogues de l'hormone de stimulation des follicules pour traiter l'infertilite
US6200963B1 (en) * 1999-03-31 2001-03-13 American Home Products Corporation Aryl sulfonic acids as FSH antagonists
PT1406628E (pt) * 2001-07-02 2006-06-30 Akzo Nobel Nv Derivados de tera-hidroquinolina
TWI306855B (en) * 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
RS20050458A (sr) 2007-08-03
EP1578727B1 (fr) 2008-04-16
RU2005122924A (ru) 2006-01-27
CA2508923A1 (fr) 2004-07-08
EP1578727A2 (fr) 2005-09-28
PT1578727E (pt) 2008-05-23
SI1578727T1 (sl) 2008-08-31
PL376997A1 (pl) 2006-01-23
AU2003303221A1 (en) 2004-07-14
CA2508923C (fr) 2011-09-20
AR042629A1 (es) 2005-06-29
AU2003303221B2 (en) 2009-09-17
WO2004056779A3 (fr) 2004-08-12
ES2304544T3 (es) 2008-10-16
US20060167047A1 (en) 2006-07-27
RU2328487C2 (ru) 2008-07-10
UA80303C2 (en) 2007-09-10
JP2006512346A (ja) 2006-04-13
DE60320457D1 (de) 2008-05-29
TWI322012B (en) 2010-03-21
ATE392416T1 (de) 2008-05-15
DE60320457T2 (de) 2009-06-04
PE20040799A1 (es) 2004-12-02
BR0317514A (pt) 2005-11-16
MXPA05006772A (es) 2005-09-08
RS51196B (sr) 2010-12-31
CL43546B (es) 2005-04-08
US7674909B2 (en) 2010-03-09
WO2004056779A2 (fr) 2004-07-08
TW200418471A (en) 2004-10-01
NZ540577A (en) 2006-12-22
JP4545000B2 (ja) 2010-09-15

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