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DK1560823T3 - 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander - Google Patents

4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander

Info

Publication number
DK1560823T3
DK1560823T3 DK03779845T DK03779845T DK1560823T3 DK 1560823 T3 DK1560823 T3 DK 1560823T3 DK 03779845 T DK03779845 T DK 03779845T DK 03779845 T DK03779845 T DK 03779845T DK 1560823 T3 DK1560823 T3 DK 1560823T3
Authority
DK
Denmark
Prior art keywords
receptor
orl
substituted
aminocyclohexane derivatives
opiate
Prior art date
Application number
DK03779845T
Other languages
Danish (da)
English (en)
Inventor
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK1560823T3 publication Critical patent/DK1560823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03779845T 2002-11-11 2003-11-05 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander DK1560823T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10252666A DE10252666A1 (de) 2002-11-11 2002-11-11 N-Piperidyl-cyclohexan-Derivate
PCT/EP2003/012306 WO2004043949A1 (de) 2002-11-11 2003-11-05 4-substituierte 1-aminocyclohexan-derivate zur verwendung als orl1-rezeptor- und mu-opiat-rezeptor-liganden

Publications (1)

Publication Number Publication Date
DK1560823T3 true DK1560823T3 (da) 2008-11-10

Family

ID=32308522

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03779845T DK1560823T3 (da) 2002-11-11 2003-11-05 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander

Country Status (13)

Country Link
US (1) US7759385B2 (es)
EP (1) EP1560823B1 (es)
AR (1) AR041941A1 (es)
AT (1) ATE400569T1 (es)
AU (1) AU2003287993A1 (es)
CY (1) CY1108378T1 (es)
DE (2) DE10252666A1 (es)
DK (1) DK1560823T3 (es)
ES (1) ES2309373T3 (es)
PE (1) PE20040833A1 (es)
PT (1) PT1560823E (es)
SI (1) SI1560823T1 (es)
WO (1) WO2004043949A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
GEP20094675B (en) * 2003-07-24 2009-05-10 Euro Celtique Sa Heteroaryl- tetra-hydropiperidyl compounds useful for treating or preventing pain
PL1648878T3 (pl) * 2003-07-24 2009-10-30 Euro Celtique Sa Związki piperydynowe i zawierające je kompozycje farmaceutyczne
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023635A1 (de) 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2178534A4 (en) 2007-07-17 2011-03-30 Merck Sharp & Dohme SOLUBLE EPOXYHYDROLASE HEMMER, COMPOSITIONS WITH SUCH COMPOUNDS AND TREATMENT METHODS THEREWITH
US8470849B2 (en) * 2007-11-05 2013-06-25 Merck Patent Gmbh 7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors
AR070398A1 (es) * 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
AR071067A1 (es) 2008-03-27 2010-05-26 Gruenenthal Chemie Ciclohexildiaminas sustituidas
PL2271613T3 (pl) 2008-03-27 2014-09-30 Gruenenthal Gmbh Hydroksymetylocykloheksyloaminy
CA2719736C (en) 2008-03-27 2016-02-09 Gruenenthal Gmbh Spiro(5.5)undecane derivatives
WO2009118163A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
EP2502907B1 (de) * 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
US9580409B2 (en) 2011-11-07 2017-02-28 Sunovion Pharmaceuticals, Inc. Modulators of opioid receptors and methods of use thereof
EP3319444B1 (en) 2015-07-09 2022-03-09 The Regents of the University of California Mu opioid receptor modulators
WO2017023894A1 (en) * 2015-08-03 2017-02-09 Raze Therapeutics, Inc. Mthfd2 inhibitors and uses thereof
US20210147343A1 (en) 2018-04-04 2021-05-20 Epiodyne, Inc. Opioid receptor modulators and products and methods related thereto
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
WO2020120606A1 (en) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions
KR20220131520A (ko) 2019-12-26 2022-09-28 길가메쉬 파마슈티컬스, 인코포레이티드 아릴시클로헥실아민 유도체 및 정신장애 치료에서의 이의 용도
RS66496B1 (sr) 2020-02-18 2025-03-31 Gilgamesh Pharmaceuticals Inc Specifični triptamini za upotrebu u lečenju poremećaja raspoloženja
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12157722B1 (en) 2023-08-03 2024-12-03 Gilgamesh Pharmaceuticals, Inc. Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine

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Publication number Priority date Publication date Assignee Title
US4113555A (en) * 1973-11-08 1978-09-12 Svenska Traforskningsinstitutet Hard board or medium density board, process for production thereof and means for practicizing the process
US4113866A (en) * 1977-04-01 1978-09-12 The Upjohn Company Analgetic compounds, compositions and process of treatment
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6172087B1 (en) * 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
JP2003524634A (ja) * 1999-12-06 2003-08-19 ユーロ−セルティーク，エス．エイ． ノシセプチン受容体親和性を有するベンズイミダゾール化合物
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
DK1325910T3 (da) * 2000-10-06 2008-11-10 Mitsubishi Tanabe Pharma Corp Aliphatiske nitrogenholdige femleddede ringforbindelser
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
AU2003287993A1 (en) 2004-06-03
PT1560823E (pt) 2008-09-25
ATE400569T1 (de) 2008-07-15
AR041941A1 (es) 2005-06-01
EP1560823B1 (de) 2008-07-09
US7759385B2 (en) 2010-07-20
DE50310122D1 (de) 2008-08-21
WO2004043949A1 (de) 2004-05-27
CY1108378T1 (el) 2014-02-12
EP1560823A1 (de) 2005-08-10
SI1560823T1 (sl) 2008-12-31
DE10252666A1 (de) 2004-08-05
US20050277674A1 (en) 2005-12-15
PE20040833A1 (es) 2004-11-17
ES2309373T3 (es) 2008-12-16

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