DK1439839T3 - En forbindelse, der omfatter combretastatin og anticancermidler - Google Patents
En forbindelse, der omfatter combretastatin og anticancermidlerInfo
- Publication number
- DK1439839T3 DK1439839T3 DK02732758T DK02732758T DK1439839T3 DK 1439839 T3 DK1439839 T3 DK 1439839T3 DK 02732758 T DK02732758 T DK 02732758T DK 02732758 T DK02732758 T DK 02732758T DK 1439839 T3 DK1439839 T3 DK 1439839T3
- Authority
- DK
- Denmark
- Prior art keywords
- combretastatin
- compound
- anticancer agents
- anticancer
- agents
- Prior art date
Links
- LGZKGOGODCLQHG-CYBMUJFWSA-N 5-[(2r)-2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC=C1C[C@@H](O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-CYBMUJFWSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- LGZKGOGODCLQHG-UHFFFAOYSA-N combretastatin Natural products C1=C(O)C(OC)=CC=C1CC(O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27562701P | 2001-03-15 | 2001-03-15 | |
| PCT/EP2002/006758 WO2004037258A1 (fr) | 2001-03-15 | 2002-03-15 | Combinaison comprenant de la combretastatine et des agents anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1439839T3 true DK1439839T3 (da) | 2009-10-05 |
Family
ID=23053164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02732758T DK1439839T3 (da) | 2001-03-15 | 2002-03-15 | En forbindelse, der omfatter combretastatin og anticancermidler |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US20020183266A1 (fr) |
| EP (1) | EP1439839B8 (fr) |
| JP (1) | JP4991107B2 (fr) |
| KR (1) | KR100849610B1 (fr) |
| CN (2) | CN1290504C (fr) |
| AR (1) | AR032989A1 (fr) |
| AT (1) | ATE433750T1 (fr) |
| AU (1) | AU2002304574B2 (fr) |
| BR (1) | BR0208017A (fr) |
| CA (2) | CA2673449C (fr) |
| CY (1) | CY1109364T1 (fr) |
| CZ (1) | CZ302451B6 (fr) |
| DE (1) | DE60232673D1 (fr) |
| DK (1) | DK1439839T3 (fr) |
| EA (1) | EA006316B1 (fr) |
| EC (1) | ECSP034766A (fr) |
| ES (1) | ES2327617T3 (fr) |
| HR (1) | HRPK20030734B3 (fr) |
| HU (1) | HU228510B1 (fr) |
| IL (2) | IL157891A0 (fr) |
| MA (1) | MA27000A1 (fr) |
| ME (2) | ME00056B (fr) |
| MX (1) | MXPA03007552A (fr) |
| NO (1) | NO332661B1 (fr) |
| NZ (1) | NZ527526A (fr) |
| PE (1) | PE20020909A1 (fr) |
| PL (1) | PL205728B1 (fr) |
| PT (1) | PT1439839E (fr) |
| RS (1) | RS50682B (fr) |
| SI (1) | SI1439839T1 (fr) |
| SK (1) | SK287908B6 (fr) |
| TN (1) | TNSN03060A1 (fr) |
| TW (1) | TWI306028B (fr) |
| UA (1) | UA75127C2 (fr) |
| UY (1) | UY27208A1 (fr) |
| WO (2) | WO2002074229A2 (fr) |
| ZA (1) | ZA200306789B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2326761C (fr) * | 1998-04-03 | 2008-02-19 | Ajinomoto Co., Inc. | Agents antitumoraux |
| US20050209310A1 (en) * | 2000-12-22 | 2005-09-22 | Chaplin David J | Methods for modulating tumor growth and metastasis |
| GB0410817D0 (en) * | 2004-05-14 | 2004-06-16 | Angiogene Pharm Ltd | Vascular damaging therapy |
| CN100431606C (zh) * | 2004-11-22 | 2008-11-12 | 山东蓝金生物工程有限公司 | 一种抗癌药物组合物 |
| CN1319978C (zh) * | 2005-04-06 | 2007-06-06 | 西南合成制药股份有限公司 | 康布瑞汀化合物的制备方法 |
| FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
| US20080104512A1 (en) * | 2006-10-31 | 2008-05-01 | Motorola, Inc. | Method and apparatus for providing realtime feedback in a voice dialog system |
| EP2219451B1 (fr) * | 2007-11-21 | 2014-11-12 | Oxigene, Inc. | Procédé pour traiter des néoplasmes hématopoïétiques |
| US20090209496A1 (en) * | 2008-02-15 | 2009-08-20 | David Chaplin | Methods and compositions for enhancing the efficacy of rtk inhibitors |
| FR2939665B1 (fr) * | 2008-12-12 | 2011-10-07 | Sanofi Aventis | Combinaison antitumorale associant l'ave8062a et le docetaxel |
| FR2945210B1 (fr) | 2009-05-07 | 2011-07-01 | Sanofi Aventis | Combinaison antitumorale comprenant l'ave8062 et le sorafenib |
| CN103140224A (zh) | 2010-06-18 | 2013-06-05 | 赛诺菲 | 包含奥瑞布林、紫杉烷衍生物和铂衍生物的抗肿瘤组合 |
| EP2481404A1 (fr) | 2010-11-15 | 2012-08-01 | Sanofi | Combinaison antitumorale comprenant de l'ombrabuline, un dérivé de taxane et un dérivé de platine |
| EP2397135A1 (fr) | 2010-06-18 | 2011-12-21 | Sanofi | Combinaison antitumorale comprenant de l'ombrabuline, un dérivé de taxane et un dérivé de platine |
| EP2407161A1 (fr) | 2010-07-13 | 2012-01-18 | Sanofi | Combinaison antitumorale comprenant de l'ombrabuline et du bevacizumab |
| FR2968557A1 (fr) | 2010-12-09 | 2012-06-15 | Sanofi Aventis | Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab |
| FR2978663A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cetuximab, associee a la radiotherapie |
| FR2978662A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cisplatine, associee a la radiotherapie |
| EP3337495A4 (fr) | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | Utilisation de vda pour améliorer des thérapies d'immunomodulation contre des tumeurs |
| US9980953B2 (en) * | 2016-09-26 | 2018-05-29 | Chong Kun Dang Pharmaceutical Corp. | Combined composition for preventing or treating cancer comprising a benzophenone thiazole derivatives as a VDA and topoisomerase inhibitor |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| US4996237A (en) | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5731353A (en) | 1993-09-08 | 1998-03-24 | Ajinomoto Co., Inc. | Stilbene derivatives and pharmaceutical compositions containing them |
| US5561122A (en) | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| TW334418B (en) * | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| CA2326761C (fr) * | 1998-04-03 | 2008-02-19 | Ajinomoto Co., Inc. | Agents antitumoraux |
| US6242770B1 (en) * | 1998-08-31 | 2001-06-05 | Gary Bela Bronner | Diode connected to a magnetic tunnel junction and self aligned with a metallic conductor and method for forming the same |
| GB9903404D0 (en) * | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis |
| JP2002541200A (ja) * | 1999-04-14 | 2002-12-03 | デイナ−ファーバー キャンサー インスティチュート,インコーポレイテッド | 癌の処置のための方法および組成物 |
| US6465448B1 (en) * | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
| US6448030B1 (en) * | 2000-02-18 | 2002-09-10 | University Of Nevada-Las Vegas | Method for predicting the efficacy of anti-cancer drugs |
| IL155509A0 (en) * | 2000-10-27 | 2003-11-23 | Aventis Pharma Sa | A combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
| CA2432792C (fr) * | 2000-12-22 | 2012-04-03 | Bristol-Myers Squibb Company | Procedes relatifs a la modulation de la croissance tumorale et de la metastase |
| US6466448B1 (en) * | 2001-06-11 | 2002-10-15 | Network Appliance, Inc. | Riser board retaining and air ducting structure for printed circuit boards |
-
2002
- 2002-03-08 US US10/092,508 patent/US20020183266A1/en not_active Abandoned
- 2002-03-14 AR ARP020100914A patent/AR032989A1/es unknown
- 2002-03-14 UY UY27208A patent/UY27208A1/es not_active Application Discontinuation
- 2002-03-15 KR KR1020037012033A patent/KR100849610B1/ko not_active Expired - Fee Related
- 2002-03-15 US US10/097,926 patent/US6933320B2/en not_active Expired - Fee Related
- 2002-03-15 HU HU0600233A patent/HU228510B1/hu not_active IP Right Cessation
- 2002-03-15 PE PE2002000204A patent/PE20020909A1/es not_active Application Discontinuation
- 2002-03-15 ES ES02732758T patent/ES2327617T3/es not_active Expired - Lifetime
- 2002-03-15 CA CA2673449A patent/CA2673449C/fr not_active Expired - Fee Related
- 2002-03-15 IL IL15789102A patent/IL157891A0/xx unknown
- 2002-03-15 HR HR20030734A patent/HRPK20030734B3/xx not_active IP Right Cessation
- 2002-03-15 DE DE60232673T patent/DE60232673D1/de not_active Expired - Lifetime
- 2002-03-15 CA CA002470484A patent/CA2470484C/fr not_active Expired - Fee Related
- 2002-03-15 JP JP2004545736A patent/JP4991107B2/ja not_active Expired - Fee Related
- 2002-03-15 UA UA2003109292A patent/UA75127C2/uk unknown
- 2002-03-15 BR BR0208017-6A patent/BR0208017A/pt not_active IP Right Cessation
- 2002-03-15 EP EP02732758A patent/EP1439839B8/fr not_active Expired - Lifetime
- 2002-03-15 CZ CZ20032476A patent/CZ302451B6/cs not_active IP Right Cessation
- 2002-03-15 ME MEP-2008-162A patent/ME00056B/me unknown
- 2002-03-15 PT PT02732758T patent/PT1439839E/pt unknown
- 2002-03-15 EA EA200301015A patent/EA006316B1/ru not_active IP Right Cessation
- 2002-03-15 NO NO20034022A patent/NO332661B1/no not_active IP Right Cessation
- 2002-03-15 SK SK1155-2003A patent/SK287908B6/sk not_active IP Right Cessation
- 2002-03-15 RS YUP-713/03A patent/RS50682B/sr unknown
- 2002-03-15 WO PCT/EP2002/003322 patent/WO2002074229A2/fr not_active Ceased
- 2002-03-15 TW TW091104922A patent/TWI306028B/zh not_active IP Right Cessation
- 2002-03-15 CN CNB028065832A patent/CN1290504C/zh not_active Expired - Fee Related
- 2002-03-15 MX MXPA03007552A patent/MXPA03007552A/es active IP Right Grant
- 2002-03-15 DK DK02732758T patent/DK1439839T3/da active
- 2002-03-15 PL PL374406A patent/PL205728B1/pl not_active IP Right Cessation
- 2002-03-15 NZ NZ527526A patent/NZ527526A/en not_active IP Right Cessation
- 2002-03-15 SI SI200230915T patent/SI1439839T1/sl unknown
- 2002-03-15 AU AU2002304574A patent/AU2002304574B2/en not_active Ceased
- 2002-03-15 CN CN2006101388753A patent/CN1935134B/zh not_active Expired - Fee Related
- 2002-03-15 WO PCT/EP2002/006758 patent/WO2004037258A1/fr not_active Ceased
- 2002-03-15 ME MEP-162/08A patent/MEP16208A/xx unknown
- 2002-03-15 AT AT02732758T patent/ATE433750T1/de active
-
2003
- 2003-07-08 TN TNPCT/EP2002/003322A patent/TNSN03060A1/en unknown
- 2003-08-29 ZA ZA2003/06789A patent/ZA200306789B/en unknown
- 2003-09-09 MA MA27301A patent/MA27000A1/fr unknown
- 2003-09-11 IL IL157891A patent/IL157891A/en not_active IP Right Cessation
- 2003-09-12 EC EC2003004766A patent/ECSP034766A/es unknown
-
2004
- 2004-11-23 US US10/995,998 patent/US20050075295A1/en not_active Abandoned
-
2007
- 2007-02-21 US US11/677,178 patent/US20070149476A1/en not_active Abandoned
-
2009
- 2009-09-16 CY CY20091100954T patent/CY1109364T1/el unknown
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| ITMI20011162A0 (it) | Alogenoarilsolfonammidi aventi caratteristiche antitumorali | |
| SE0102059D0 (sv) | New combination |