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DK1303591T3 - MASP-2, et komplementfikserende enzym, og anvendelser af det - Google Patents

MASP-2, et komplementfikserende enzym, og anvendelser af det

Info

Publication number
DK1303591T3
DK1303591T3 DK01957763T DK01957763T DK1303591T3 DK 1303591 T3 DK1303591 T3 DK 1303591T3 DK 01957763 T DK01957763 T DK 01957763T DK 01957763 T DK01957763 T DK 01957763T DK 1303591 T3 DK1303591 T3 DK 1303591T3
Authority
DK
Denmark
Prior art keywords
masp
relates
present
fragments
inhibitors
Prior art date
Application number
DK01957763T
Other languages
Danish (da)
English (en)
Inventor
Steffen Thiel
Jens Christian Jensenius
Original Assignee
Helion Biotech Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helion Biotech Aps filed Critical Helion Biotech Aps
Application granted granted Critical
Publication of DK1303591T3 publication Critical patent/DK1303591T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
DK01957763T 2000-07-13 2001-07-13 MASP-2, et komplementfikserende enzym, og anvendelser af det DK1303591T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001089 2000-07-13
DKPA200100870 2001-06-01
PCT/DK2001/000499 WO2002006460A2 (fr) 2000-07-13 2001-07-13 Masp-2, enzyme de fixation de complements et ses utilisations

Publications (1)

Publication Number Publication Date
DK1303591T3 true DK1303591T3 (da) 2009-11-02

Family

ID=26068853

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01957763T DK1303591T3 (da) 2000-07-13 2001-07-13 MASP-2, et komplementfikserende enzym, og anvendelser af det

Country Status (13)

Country Link
US (1) US7112414B2 (fr)
EP (1) EP1303591B1 (fr)
JP (1) JP5226169B2 (fr)
CN (1) CN1449440A (fr)
AT (1) ATE434661T1 (fr)
AU (1) AU2001279586A1 (fr)
CA (2) CA2415751C (fr)
DE (1) DE60139072D1 (fr)
DK (1) DK1303591T3 (fr)
NO (1) NO20030114L (fr)
NZ (1) NZ523900A (fr)
RU (1) RU2003104524A (fr)
WO (1) WO2002006460A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969601B2 (en) 1997-04-03 2005-11-29 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
SE0202880D0 (sv) * 2002-07-26 2002-09-30 Wieslab Ab Complement system deficiency assay
US7666627B2 (en) 2002-08-08 2010-02-23 Targetex Kft. Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
US20060188963A1 (en) * 2002-09-10 2006-08-24 Natlmmune A/S Collectin-complement activating protein chimeras
EP1570075A2 (fr) * 2002-12-03 2005-09-07 Aarhus Universitet Technique de determination de predisposition a une manifestation de maladies associees au systeme immunitaire
WO2004065626A2 (fr) * 2003-01-17 2004-08-05 Rigshospitalet Procede permettant de pronostiquer une sepsie
MXPA05008570A (es) * 2003-02-21 2005-11-04 Tanox Inc Metodos para la prevencion y tratamiento de danos tisulares asociados con una lesion por isquemia-reperfusion.
ES2629344T3 (es) 2003-05-12 2017-08-08 Helion Biotech Aps Anticuerpos contra la MASP-2
US8951522B2 (en) 2011-04-08 2015-02-10 University Of Leicester Methods for treating conditions associated with MASP-2 dependent complement activation
US20060018896A1 (en) * 2004-06-10 2006-01-26 University Of Leicester Methods for treating conditions associated with lectin-dependent complement activation
ES2601497T3 (es) * 2004-06-10 2017-02-15 Omeros Corporation Métodos para tratar afecciones asociadas con la activación del complemento dependiente de MASP-2
AU2013201561B2 (en) * 2004-06-10 2016-03-31 Omeros Corporation Methods for treating conditions associated with MASP-2-dependent complement activation
GB0412966D0 (en) * 2004-06-10 2004-07-14 Univ Leicester Genetically modified non-human mammals and cells
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
AU2011265532B2 (en) * 2004-06-10 2014-04-24 Omeros Corporation Methods for treating conditions associated with MASP-2-dependent complement activation
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2006068469A1 (fr) * 2004-12-23 2006-06-29 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Méthode de dosage fonctionnel des sérine protéases associées à la lectine liant la mannane (masp) et des complexes desdites protéases
WO2007095154A2 (fr) * 2006-02-10 2007-08-23 The Brigham And Women's Hospital, Inc. Dosages de la voie du complement de la lectine et compositions et procedes associes
CN101587125B (zh) * 2008-05-21 2013-07-24 林标扬 高表达癌症标记物和低表达组织器官标记物组合试剂盒
AU2010272483B2 (en) 2009-07-17 2016-07-21 Omeros Corporation MASP isoforms as inhibitors of complement activation
AU2013201443B2 (en) * 2009-10-16 2015-02-05 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation
CA2777845C (fr) * 2009-10-16 2017-08-01 Omeros Corporation Methodes pour traiter la coagulation intravasculaire disseminee par inhibition de l'activation du complement dependante de masp-2
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
CA3025762C (fr) 2011-05-04 2021-11-09 Omeros Corporation Compositions pour inhibition d'activation du complement dependant de masp-2
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
WO2015114343A1 (fr) * 2014-01-29 2015-08-06 Enzymatica Ab Nouveaux traitements
US11007254B2 (en) 2016-10-17 2021-05-18 Musc Foundation For Research Development Compositions and methods for treating central nervous system injury
CN112237630A (zh) * 2020-02-21 2021-01-19 中国人民解放军军事科学院军事医学研究院 针对masp-2、冠状病毒n蛋白或其结合的物质在制备冠状病毒所致疾病药物中的应用
WO2021163980A1 (fr) * 2020-02-21 2021-08-26 中国人民解放军军事科学院军事医学研究院 Substance ciblant les protéines masp-2 et n ou leur liaison pour la prévention et/ou le traitement d'une infection à coronavirus
CN112023045A (zh) * 2020-03-31 2020-12-04 中国人民解放军军事科学院军事医学研究院 抑制masp-2及其下游补体活化效应的物质在制备冠状病毒所致疾病药物中的应用
WO2023060167A1 (fr) * 2021-10-07 2023-04-13 Omeros Corporation Molécules d'activation de complément catalytique ciblées et procédés d'utilisation associés
EP4493597A1 (fr) * 2022-03-18 2025-01-22 Inmagene Pte. Ltd. Anticorps ciblant masp-2 et leurs utilisations

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JP2868777B2 (ja) * 1987-08-20 1999-03-10 チルドレンズ・ホスピタル・コーポレイション ヒトマンノース結合タンパク質
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US6297024B1 (en) * 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
JP2002532079A (ja) * 1998-12-15 2002-10-02 ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド 補体活性化に関連するレクチン補体経路を調節するための方法および産物
US6235494B1 (en) * 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
CA2296792A1 (fr) 1999-02-26 2000-08-26 Genset S.A. Sequences marqueurs exprimees et proteines humaines codees
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
WO2001010902A2 (fr) 1999-08-11 2001-02-15 Curagen Corporation Polynucleotides et polypeptides codes par ces derniers
CA2380979A1 (fr) 1999-08-13 2001-02-22 Brigham And Women's Hospital, Inc. Inhibiteurs de la voie du complement a lectine (lpc) et utilisation de ceux-ci
WO2001040451A2 (fr) 1999-12-02 2001-06-07 Jens Christian Jensenius Masp-3: enzyme de fixation du complement, et son utilisation

Also Published As

Publication number Publication date
EP1303591A2 (fr) 2003-04-23
US20040038297A1 (en) 2004-02-26
JP2004504027A (ja) 2004-02-12
WO2002006460A3 (fr) 2002-05-02
AU2001279586A1 (en) 2002-01-30
JP5226169B2 (ja) 2013-07-03
ATE434661T1 (de) 2009-07-15
NO20030114L (no) 2003-02-25
US7112414B2 (en) 2006-09-26
CN1449440A (zh) 2003-10-15
CA2415751C (fr) 2015-06-16
NO20030114D0 (no) 2003-01-09
CA2415751A1 (fr) 2002-01-24
WO2002006460A2 (fr) 2002-01-24
EP1303591B1 (fr) 2009-06-24
NZ523900A (en) 2004-02-27
RU2003104524A (ru) 2005-01-20
DE60139072D1 (de) 2009-08-06
CA2887012A1 (fr) 2002-01-24

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