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NO20030114L - MASP-2, et komplementfikserende enzym og anvendelse derav - Google Patents

MASP-2, et komplementfikserende enzym og anvendelse derav

Info

Publication number
NO20030114L
NO20030114L NO20030114A NO20030114A NO20030114L NO 20030114 L NO20030114 L NO 20030114L NO 20030114 A NO20030114 A NO 20030114A NO 20030114 A NO20030114 A NO 20030114A NO 20030114 L NO20030114 L NO 20030114L
Authority
NO
Norway
Prior art keywords
masp
relates
present
fragments
inhibitors
Prior art date
Application number
NO20030114A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030114D0 (no
Inventor
Jens Christian Jensenius
Steffen Thiel
Original Assignee
Steffen Thiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steffen Thiel filed Critical Steffen Thiel
Publication of NO20030114D0 publication Critical patent/NO20030114D0/no
Publication of NO20030114L publication Critical patent/NO20030114L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
NO20030114A 2000-07-13 2003-01-09 MASP-2, et komplementfikserende enzym og anvendelse derav NO20030114L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001089 2000-07-13
DKPA200100870 2001-06-01
PCT/DK2001/000499 WO2002006460A2 (fr) 2000-07-13 2001-07-13 Masp-2, enzyme de fixation de complements et ses utilisations

Publications (2)

Publication Number Publication Date
NO20030114D0 NO20030114D0 (no) 2003-01-09
NO20030114L true NO20030114L (no) 2003-02-25

Family

ID=26068853

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030114A NO20030114L (no) 2000-07-13 2003-01-09 MASP-2, et komplementfikserende enzym og anvendelse derav

Country Status (13)

Country Link
US (1) US7112414B2 (fr)
EP (1) EP1303591B1 (fr)
JP (1) JP5226169B2 (fr)
CN (1) CN1449440A (fr)
AT (1) ATE434661T1 (fr)
AU (1) AU2001279586A1 (fr)
CA (2) CA2415751C (fr)
DE (1) DE60139072D1 (fr)
DK (1) DK1303591T3 (fr)
NO (1) NO20030114L (fr)
NZ (1) NZ523900A (fr)
RU (1) RU2003104524A (fr)
WO (1) WO2002006460A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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US7083786B2 (en) 1997-04-03 2006-08-01 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
SE0202880D0 (sv) * 2002-07-26 2002-09-30 Wieslab Ab Complement system deficiency assay
US7666627B2 (en) * 2002-08-08 2010-02-23 Targetex Kft. Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
US20060188963A1 (en) * 2002-09-10 2006-08-24 Natlmmune A/S Collectin-complement activating protein chimeras
US20060275764A1 (en) * 2002-12-03 2006-12-07 Aarhus Universitet Method for determining predisposition to manifestation of immune system related diseases
WO2004065626A2 (fr) * 2003-01-17 2004-08-05 Rigshospitalet Procede permettant de pronostiquer une sepsie
JP2006518749A (ja) * 2003-02-21 2006-08-17 タノックス インコーポレーテッド 虚血再灌流障害に伴う組織損傷を予防及び治療するための方法
HUE024996T2 (en) * 2003-05-12 2016-01-28 Helion Biotech Aps Anti-MASP-2 antibodies
AU2011265532B2 (en) * 2004-06-10 2014-04-24 Omeros Corporation Methods for treating conditions associated with MASP-2-dependent complement activation
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
GB0412966D0 (en) * 2004-06-10 2004-07-14 Univ Leicester Genetically modified non-human mammals and cells
EP3047858A1 (fr) * 2004-06-10 2016-07-27 Omeros Corporation Procédés pour le traitement d'états pathologiques liés à l'activation du complément masp-2 dépendant
AU2013201558B2 (en) * 2004-06-10 2016-03-31 Omeros Corporation Methods for treating conditions associated with MASP-2-dependent complement activation
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2005123776A1 (fr) * 2004-06-10 2005-12-29 Omeros Corporation Procédés servant à traiter des affections associées à l'activation du complément dépendant de la lectine
WO2006068469A1 (fr) * 2004-12-23 2006-06-29 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Méthode de dosage fonctionnel des sérine protéases associées à la lectine liant la mannane (masp) et des complexes desdites protéases
US8524453B2 (en) * 2006-02-10 2013-09-03 The Brigham And Woman's Hospital, Inc. Lectin complement pathway assays and related compositions and methods
CN101587125B (zh) * 2008-05-21 2013-07-24 林标扬 高表达癌症标记物和低表达组织器官标记物组合试剂盒
CA2767755C (fr) 2009-07-17 2021-10-12 Rigshospitalet Inhibiteurs de l'activation du complement
AU2013201443B2 (en) * 2009-10-16 2015-02-05 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation
JP5911804B2 (ja) * 2009-10-16 2016-04-27 オメロス コーポレーション Ｍａｓｐ−２依存性の補体活性化を阻害することによって播種性血管内凝固を処置するための方法
US9815876B2 (en) 2010-03-05 2017-11-14 Omeros Corporation Chimeric inhibitor molecules of complement activation
ES2683307T3 (es) 2011-04-08 2018-09-26 University Of Leicester Métodos para tratar afecciones asociadas con la activación de complemento dependiente de MASP-2
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
SMT202000294T1 (it) 2011-05-04 2020-07-08 Omeros Corp Composizioni per inibire l'attivazione del complemento dipendente da masp-2
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
EP3932420A1 (fr) * 2014-01-29 2022-01-05 Enzymatica AB Nouveaux traitements
US11007254B2 (en) 2016-10-17 2021-05-18 Musc Foundation For Research Development Compositions and methods for treating central nervous system injury
CN112237630A (zh) * 2020-02-21 2021-01-19 中国人民解放军军事科学院军事医学研究院 针对masp-2、冠状病毒n蛋白或其结合的物质在制备冠状病毒所致疾病药物中的应用
WO2021163980A1 (fr) * 2020-02-21 2021-08-26 中国人民解放军军事科学院军事医学研究院 Substance ciblant les protéines masp-2 et n ou leur liaison pour la prévention et/ou le traitement d'une infection à coronavirus
CN112023045A (zh) * 2020-03-31 2020-12-04 中国人民解放军军事科学院军事医学研究院 抑制masp-2及其下游补体活化效应的物质在制备冠状病毒所致疾病药物中的应用
KR20240069776A (ko) * 2021-10-07 2024-05-20 오메로스 코포레이션 표적화된 촉매성 보체 활성화 분자 및 그것의 사용 방법
JP2025525363A (ja) * 2022-03-18 2025-08-05 インマージーン プライベート リミテッド Ｍａｓｐ－２を標的とする抗体及びその使用

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EP0375736B1 (fr) * 1987-08-20 1998-05-13 Children's Medical Center Corporation Fragments d'acide nucleique codant des fragments du proteine humaine liant le mannose
US6008017A (en) * 1997-01-02 1999-12-28 Smithkline Beecham Corporation Human cardiac/brain tolloid-like protein
US5955309A (en) * 1997-06-18 1999-09-21 Smithkline Beecham Corporation Polynucleotide encoding G-protein coupled receptor (H7TBA62)
US6297024B1 (en) * 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
WO2000035483A1 (fr) * 1998-12-15 2000-06-22 The Brigham And Women's Hospital, Inc. Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine
US6235494B1 (en) * 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
CA2296792A1 (fr) * 1999-02-26 2000-08-26 Genset S.A. Sequences marqueurs exprimees et proteines humaines codees
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
WO2001010902A2 (fr) 1999-08-11 2001-02-15 Curagen Corporation Polynucleotides et polypeptides codes par ces derniers
EP1204419A1 (fr) * 1999-08-13 2002-05-15 The Brigham And Women's Hospital, Inc. Inhibiteurs de la voie du complement a lectine (lpc) et utilisation de ceux-ci
CN1433466A (zh) * 1999-12-02 2003-07-30 詹斯·C·詹斯尼厄斯 Masp－3,一种固定补体的酶,及其应用

Also Published As

Publication number Publication date
CA2415751A1 (fr) 2002-01-24
CA2415751C (fr) 2015-06-16
CN1449440A (zh) 2003-10-15
NO20030114D0 (no) 2003-01-09
US20040038297A1 (en) 2004-02-26
ATE434661T1 (de) 2009-07-15
EP1303591A2 (fr) 2003-04-23
CA2887012A1 (fr) 2002-01-24
EP1303591B1 (fr) 2009-06-24
JP5226169B2 (ja) 2013-07-03
RU2003104524A (ru) 2005-01-20
DK1303591T3 (da) 2009-11-02
NZ523900A (en) 2004-02-27
DE60139072D1 (de) 2009-08-06
AU2001279586A1 (en) 2002-01-30
WO2002006460A2 (fr) 2002-01-24
JP2004504027A (ja) 2004-02-12
WO2002006460A3 (fr) 2002-05-02
US7112414B2 (en) 2006-09-26

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