NO20030114D0 - MASP-2, et komplementfikserende enzym og anvendelse derav - Google Patents
MASP-2, et komplementfikserende enzym og anvendelse deravInfo
- Publication number
- NO20030114D0 NO20030114D0 NO20030114A NO20030114A NO20030114D0 NO 20030114 D0 NO20030114 D0 NO 20030114D0 NO 20030114 A NO20030114 A NO 20030114A NO 20030114 A NO20030114 A NO 20030114A NO 20030114 D0 NO20030114 D0 NO 20030114D0
- Authority
- NO
- Norway
- Prior art keywords
- masp
- relates
- present
- fragments
- inhibitors
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 title 1
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 title 1
- 108700034225 EC 3.4.21.104 Proteins 0.000 abstract 8
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001089 | 2000-07-13 | ||
| DKPA200100870 | 2001-06-01 | ||
| PCT/DK2001/000499 WO2002006460A2 (en) | 2000-07-13 | 2001-07-13 | Masp-2, a complement-fixing enzyme, and uses for it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20030114D0 true NO20030114D0 (no) | 2003-01-09 |
| NO20030114L NO20030114L (no) | 2003-02-25 |
Family
ID=26068853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030114A NO20030114L (no) | 2000-07-13 | 2003-01-09 | MASP-2, et komplementfikserende enzym og anvendelse derav |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7112414B2 (no) |
| EP (1) | EP1303591B1 (no) |
| JP (1) | JP5226169B2 (no) |
| CN (1) | CN1449440A (no) |
| AT (1) | ATE434661T1 (no) |
| AU (1) | AU2001279586A1 (no) |
| CA (2) | CA2415751C (no) |
| DE (1) | DE60139072D1 (no) |
| DK (1) | DK1303591T3 (no) |
| NO (1) | NO20030114L (no) |
| NZ (1) | NZ523900A (no) |
| RU (1) | RU2003104524A (no) |
| WO (1) | WO2002006460A2 (no) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| SE0202880D0 (sv) * | 2002-07-26 | 2002-09-30 | Wieslab Ab | Complement system deficiency assay |
| US7666627B2 (en) * | 2002-08-08 | 2010-02-23 | Targetex Kft. | Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof |
| CN1694961A (zh) * | 2002-09-10 | 2005-11-09 | 内蒂穆恩公司 | 胶原凝集素－补体激活蛋白嵌合体 |
| US20060275764A1 (en) * | 2002-12-03 | 2006-12-07 | Aarhus Universitet | Method for determining predisposition to manifestation of immune system related diseases |
| WO2004065626A2 (en) * | 2003-01-17 | 2004-08-05 | Rigshospitalet | A method of sepsis prognosis |
| WO2004075837A2 (en) | 2003-02-21 | 2004-09-10 | Tanox, Inc. | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
| PT2374819T (pt) * | 2003-05-12 | 2017-07-04 | Helion Biotech Aps | Anticorpos para masp-2 |
| AU2013201565B2 (en) * | 2004-06-10 | 2016-03-31 | Omeros Corporation | Methods for treating conditions associated with MASP-2-dependent complement activation |
| PL2465534T3 (pl) * | 2004-06-10 | 2017-08-31 | Omeros Corporation | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2 |
| GB0412966D0 (en) * | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2011265532B2 (en) * | 2004-06-10 | 2014-04-24 | Omeros Corporation | Methods for treating conditions associated with MASP-2-dependent complement activation |
| WO2005123776A1 (en) * | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with lectin-dependent complement activation |
| ATE438100T1 (de) * | 2004-12-23 | 2009-08-15 | Tno | Verfahren zum funktionellen nachweis von masps und dessen komplexen |
| US8524453B2 (en) * | 2006-02-10 | 2013-09-03 | The Brigham And Woman's Hospital, Inc. | Lectin complement pathway assays and related compositions and methods |
| CN101587125B (zh) * | 2008-05-21 | 2013-07-24 | 林标扬 | 高表达癌症标记物和低表达组织器官标记物组合试剂盒 |
| CN107513103A (zh) | 2009-07-17 | 2017-12-26 | 丹麦国家医院 | 作为补体激活的抑制剂的masp同种型 |
| CN106390117A (zh) * | 2009-10-16 | 2017-02-15 | 奥默罗斯公司 | 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法 |
| AU2013201443B2 (en) * | 2009-10-16 | 2015-02-05 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation |
| CA2791841C (en) | 2010-03-05 | 2023-01-03 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| KR20220044616A (ko) | 2011-04-08 | 2022-04-08 | 유니버시티 오브 레스터 | Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| EP2704743B1 (en) * | 2011-05-04 | 2020-03-11 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| JP6718375B2 (ja) * | 2014-01-29 | 2020-07-08 | エンツィマティカ アクティエ ボラーグ | 新規治療法 |
| US11007254B2 (en) | 2016-10-17 | 2021-05-18 | Musc Foundation For Research Development | Compositions and methods for treating central nervous system injury |
| CN112237630A (zh) * | 2020-02-21 | 2021-01-19 | 中国人民解放军军事科学院军事医学研究院 | 针对masp-2、冠状病毒n蛋白或其结合的物质在制备冠状病毒所致疾病药物中的应用 |
| WO2021163980A1 (zh) * | 2020-02-21 | 2021-08-26 | 中国人民解放军军事科学院军事医学研究院 | 靶向masp-2、n蛋白或其结合的物质预防和/或治疗冠状病毒感染 |
| CN112023045A (zh) * | 2020-03-31 | 2020-12-04 | 中国人民解放军军事科学院军事医学研究院 | 抑制masp-2及其下游补体活化效应的物质在制备冠状病毒所致疾病药物中的应用 |
| TWI869713B (zh) * | 2021-10-07 | 2025-01-11 | 美商歐米諾斯公司 | 靶向催化性補體活化分子及其使用方法 |
| EP4493597A1 (en) * | 2022-03-18 | 2025-01-22 | Inmagene Pte. Ltd. | Masp-2-targetting antibodies and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989001519A1 (en) * | 1987-08-20 | 1989-02-23 | Children's Hospital Corporation | Human mannose binding protein |
| US6008017A (en) * | 1997-01-02 | 1999-12-28 | Smithkline Beecham Corporation | Human cardiac/brain tolloid-like protein |
| US5955309A (en) * | 1997-06-18 | 1999-09-21 | Smithkline Beecham Corporation | Polynucleotide encoding G-protein coupled receptor (H7TBA62) |
| US6297024B1 (en) * | 1998-10-15 | 2001-10-02 | Cell Activation, Inc. | Methods for assessing complement activation |
| EP1140171A4 (en) * | 1998-12-15 | 2002-03-13 | Brigham & Womens Hospital | METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM |
| US6235494B1 (en) * | 1999-02-08 | 2001-05-22 | The Scripps Research Institute | Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates |
| CA2296792A1 (en) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| WO2001010902A2 (en) * | 1999-08-11 | 2001-02-15 | Curagen Corporation | Nucleoc acids and secreted polypeptides encoded thereby |
| WO2001012212A1 (en) * | 1999-08-13 | 2001-02-22 | The Brigham And Women's Hospital, Inc. | Inhibitors of the lectin complement pathway (lcp) and their use |
| AU785149B2 (en) * | 1999-12-02 | 2006-10-05 | Jens Christian Jensenius | MASP-3, a complement-fixing enzyme, and uses for it |
-
2001
- 2001-07-13 WO PCT/DK2001/000499 patent/WO2002006460A2/en not_active Ceased
- 2001-07-13 AT AT01957763T patent/ATE434661T1/de not_active IP Right Cessation
- 2001-07-13 AU AU2001279586A patent/AU2001279586A1/en not_active Abandoned
- 2001-07-13 CN CN01814642A patent/CN1449440A/zh active Pending
- 2001-07-13 US US10/332,713 patent/US7112414B2/en not_active Expired - Lifetime
- 2001-07-13 DE DE60139072T patent/DE60139072D1/de not_active Expired - Lifetime
- 2001-07-13 CA CA2415751A patent/CA2415751C/en not_active Expired - Lifetime
- 2001-07-13 RU RU2003104524/13A patent/RU2003104524A/ru not_active Application Discontinuation
- 2001-07-13 DK DK01957763T patent/DK1303591T3/da active
- 2001-07-13 NZ NZ523900A patent/NZ523900A/en not_active IP Right Cessation
- 2001-07-13 CA CA 2887012 patent/CA2887012A1/en not_active Abandoned
- 2001-07-13 JP JP2002512353A patent/JP5226169B2/ja not_active Expired - Lifetime
- 2001-07-13 EP EP01957763A patent/EP1303591B1/en not_active Expired - Lifetime
-
2003
- 2003-01-09 NO NO20030114A patent/NO20030114L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2887012A1 (en) | 2002-01-24 |
| NZ523900A (en) | 2004-02-27 |
| EP1303591A2 (en) | 2003-04-23 |
| JP5226169B2 (ja) | 2013-07-03 |
| WO2002006460A3 (en) | 2002-05-02 |
| CN1449440A (zh) | 2003-10-15 |
| US20040038297A1 (en) | 2004-02-26 |
| WO2002006460A2 (en) | 2002-01-24 |
| AU2001279586A1 (en) | 2002-01-30 |
| US7112414B2 (en) | 2006-09-26 |
| EP1303591B1 (en) | 2009-06-24 |
| NO20030114L (no) | 2003-02-25 |
| CA2415751A1 (en) | 2002-01-24 |
| DK1303591T3 (da) | 2009-11-02 |
| RU2003104524A (ru) | 2005-01-20 |
| ATE434661T1 (de) | 2009-07-15 |
| JP2004504027A (ja) | 2004-02-12 |
| CA2415751C (en) | 2015-06-16 |
| DE60139072D1 (de) | 2009-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |