DK1301467T3 - 9-substituerede minocyclinforbindelser - Google Patents

9-substituerede minocyclinforbindelser

Info

Publication number: DK1301467T3
Authority: DK; Denmark
Prior art keywords: compounds; tetracycline; minocycline; minocycline compounds; substituted minocycline
Prior art date: 2000-07-07

Application number

DK01965828T

Other languages

English (en)

Inventor

Paul Hawkins

Mark L Nelson

Roger Frechette

Peter Viski

Mohamed Ismail

Todd Bowser

Glen Rennie

Darrell Koza

Paul Sheahan

Karen Stapleton

Beena Bhatia

Atul Verma

Laura Mcintyre

Tad Warchol

Jimmy Dumornay

Gui Liu

Original Assignee

Tufts College

Paratek Pharm Innc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-07

Filing date

2001-06-29

Publication date

2006-12-27

2001-06-29 Application filed by Tufts College, Paratek Pharm Innc filed Critical Tufts College

2006-12-27 Application granted granted Critical

2006-12-27 Publication of DK1301467T3 publication Critical patent/DK1301467T3/da

Links

DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title 1
239000004098 Tetracycline Substances 0.000 abstract 4
229960002180 tetracycline Drugs 0.000 abstract 4
229930101283 tetracycline Natural products 0.000 abstract 4
235000019364 tetracycline Nutrition 0.000 abstract 4
FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 abstract 3
-1 tetracycline compound Chemical class 0.000 abstract 3
230000000903 blocking effect Effects 0.000 abstract 2
208000035143 Bacterial infection Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
230000014509 gene expression Effects 0.000 abstract 1
229960004023 minocycline Drugs 0.000 abstract 1
150000003522 tetracyclines Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/50—Y being a hydrogen or an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
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- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK01965828T 2000-07-07 2001-06-29 9-substituerede minocyclinforbindelser DK1301467T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21665900P	2000-07-07	2000-07-07
US27562101P	2001-03-13	2001-03-13

Publications (1)

Publication Number	Publication Date
DK1301467T3 true DK1301467T3 (da)	2006-12-27

Family

ID=26911221

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01965828T DK1301467T3 (da)	2000-07-07	2001-06-29	9-substituerede minocyclinforbindelser
DK06007501.7T DK1679305T3 (da)	2000-07-07	2001-06-29	9-substituerede minocyclinforbindelser

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK06007501.7T DK1679305T3 (da)	2000-07-07	2001-06-29	9-substituerede minocyclinforbindelser

Country Status (24)

Country	Link
US (5)	US6846939B2 (da)
EP (4)	EP3461808A1 (da)
JP (3)	JP4925549B2 (da)
KR (2)	KR100699390B1 (da)
CN (2)	CN1690047B (da)
AT (2)	ATE544745T1 (da)
AU (4)	AU2001286388B2 (da)
BR (1)	BRPI0112269B8 (da)
CA (1)	CA2415178C (da)
CY (1)	CY1107524T1 (da)
CZ (2)	CZ303702B6 (da)
DE (1)	DE60122341T2 (da)
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Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6756365B2 (en) *	1991-11-06	2004-06-29	Trustees Of Tufts College	Reducing tetracycline resistance in living cells
JP2002501026A (ja) *	1998-01-23	2002-01-15	トルスティーズオブトゥフツカレッジ	薬学的に活性の化合物及びその利用法
US8106225B2 (en) *	1999-09-14	2012-01-31	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
PT1240133E (pt) *	1999-09-14	2006-07-31	Tufts College	Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao
EP1263442A1 (en) *	2000-01-24	2002-12-11	Trustees Of Tufts College	TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
DE60129116T2 (de) *	2000-03-31	2008-03-13	Trustees Of Tufts College, Medford	7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
EP1286954B1 (en) *	2000-05-15	2004-04-14	Paratek Pharmaceuticals, Inc.	7-substituted fused ring tetracycline compounds
US20040224927A1 (en) *	2000-06-16	2004-11-11	Trustees Of Tufts College	7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) *	2000-06-16	2002-09-19	Nelson Mark L.	7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) *	2000-06-16	2002-01-02	Trustees Of Tufts College	7-phenyl-substituted tetracycline compounds
MXPA03000055A (es) *	2000-07-07	2003-07-14	Tufts College	Compuestos de monociclina sustituidos en posicion 9..
US7094806B2 (en) *	2000-07-07	2006-08-22	Trustees Of Tufts College	7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) *	2001-03-13	2002-09-19	Paratek Pharmaceuticals, Inc.	7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en)	2001-03-13	2009-06-30	Paratek Pharmaceuticals, Inc.	9-aminomethyl substituted minocycline compounds
EP1241160A1 (en)	2001-03-13	2002-09-18	Glaxo Group Limited	Tetracycline derivatives and their use as antibiotic agents
EP2298732A1 (en) *	2001-03-13	2011-03-23	Paratek Pharmaceuticals, Inc.	7,9-Substituted tetracycline compounds
EP1381372A2 (en)	2001-03-14	2004-01-21	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en)	2001-04-24	2012-01-03	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
EP2332546A1 (en)	2001-07-13	2011-06-15	Paratek Pharmaceuticals, Inc.	Tetracyclines for the treatment of stroke
US20060194773A1 (en) *	2001-07-13	2006-08-31	Paratek Pharmaceuticals, Inc.	Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) *	2001-08-02	2003-07-10	Paratek Pharmaceuticals, Inc.	Medicaments
EP2311797A1 (en) *	2002-01-08	2011-04-20	Paratek Pharmaceuticals, Inc.	4-dedimethylamino tetracycline compounds
EA201000491A1 (ru)	2002-03-08	2010-08-30	Паратек Фармасьютикалс, Инк.	Аминометилзамещенные тетрациклиновые соединения
WO2003079983A2 (en) *	2002-03-21	2003-10-02	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2003079984A2 (en) *	2002-03-21	2003-10-02	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
EA012136B1 (ru)	2002-07-12	2009-08-28	Пэрэтек Фамэсьютикэлс, Инк.	Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
JP2006503898A (ja) *	2002-10-24	2006-02-02	パラテックファーマシューティカルズ，インク．	マラリア治療のための置換テトラサイクリン化合物
WO2004038000A2 (en) *	2002-10-24	2004-05-06	Paratek Pharmaceuticals, Inc.	Methods of using substituted tetracycline compounds to modulate rna
WO2004091513A2 (en) *	2003-04-10	2004-10-28	Paratek Pharmaceuticals, Inc.	9-aminomethyl substituted minocycline compounds
US20060287283A1 (en) *	2003-07-09	2006-12-21	Paratek Pharmaceuticals, Inc.	Prodrugs of 9-aminomethyl tetracycline compounds
EP1648859B1 (en) *	2003-07-09	2013-02-27	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
JP4738333B2 (ja) *	2003-07-09	2011-08-03	パラテックファーマシューティカルズインコーポレイテッド	９−アミノメチルテトラサイクリン化合物のプロドラッグ
US8691258B2 (en) *	2003-12-12	2014-04-08	Medtronic, Inc.	Anti-infective medical device
EP2332904A3 (en)	2004-01-15	2012-04-11	Paratek Pharmaceuticals, Inc.	Derivatives of tetracycline compounds
CN101027279B (zh)	2004-05-21	2013-03-27	哈佛大学校长及研究员协会	四环素及其类似物的合成
TWI261038B (en) *	2004-08-11	2006-09-01	Bo-Cheng Chen	Bicycle gear-shifting handgrip
EP2284152A3 (en) *	2004-10-25	2011-10-05	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
CA2585418A1 (en) *	2004-10-25	2006-05-04	Paratek Pharmaceuticals, Inc.	4-aminotetracyclines and methods of use thereof
EP1848685A1 (en)	2005-02-04	2007-10-31	Paratek Pharmaceuticals, Inc.	11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos de preparacion
AR057033A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) *	2005-05-27	2007-11-28	Wyeth Corp	Tigeciclina y metodos para preparar 9-aminominociclina
AU2006272698B2 (en) *	2005-07-21	2012-11-01	Paratek Pharmaceuticals, Inc.	10-substituted tetracyclines and methods of use thereof
JP2009521456A (ja) *	2005-12-22	2009-06-04	ワイス	チゲサイクリンでの胃腸管感染症の治療法
CN101340895A (zh) *	2005-12-22	2009-01-07	惠氏公司	包含替加环素的口服制剂
EP1991236A2 (en)	2006-01-24	2008-11-19	Paratek Pharmaceuticals, Inc.	Methods of increasing oral bioavailability of tetracyclines
AU2007235279B2 (en) *	2006-04-07	2012-12-06	President And Fellows Of Harvard College	Synthesis of tetracyclines and analogues thereof
CA2652347A1 (en)	2006-05-15	2007-11-22	Paratek Pharmaceuticals, Inc.	Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en)	2006-10-11	2013-05-14	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of Bacillus anthracis infections
US7763735B2 (en) *	2006-10-11	2010-07-27	President And Fellows Of Harvard College	Synthesis of enone intermediate
AU2007338681B2 (en) *	2006-12-21	2013-09-26	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of inflammatory skin disorders
ES2548261T3 (es) *	2006-12-21	2015-10-15	Paratek Pharmaceuticals, Inc.	Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
US7935687B2 (en) *	2007-04-12	2011-05-03	Paratek Pharmaceuticals, Inc.	Methods for treating spinal muscular atrophy using tetracycline compounds
WO2008134048A2 (en) *	2007-04-27	2008-11-06	Paratek Pharmaceuticals, Inc.	Methods for synthesizing and purifying aminoalkyl tetracycline compounds
CN101784517A (zh)	2007-07-06	2010-07-21	帕拉特克药品公司	合成取代的四环素化合物的方法
TWI361690B (en)	2007-11-29	2012-04-11	Actelion Pharmaceuticals Ltd	Phosphonic acid derivatives
WO2009111064A2 (en)	2008-03-05	2009-09-11	Paratek Pharmaceuticals, Inc.	Minocycline compounds and methods of use thereof
PT2271348T (pt) *	2008-03-28	2018-04-16	Paratek Pharm Innc	Formulação de comprimido oral de composto de tetraciclina
CA2721399A1 (en) *	2008-04-14	2009-10-22	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
TW202021946A (zh) *	2008-05-19	2020-06-16	美商派洛泰克藥物股份有限公司	四環素化合物之甲苯磺酸鹽及同素異形體
ES2655911T3 (es) *	2008-08-08	2018-02-22	Tetraphase Pharmaceuticals, Inc.	Compuestos de tetraciclina sustituidos con C7-fluoro
JP5443720B2 (ja) *	2008-09-05	2014-03-19	住友化学株式会社	組成物、光学フィルム及びその製造方法、光学部材ならびに表示装置
CN101759598B (zh) *	2008-09-12	2011-11-09	山东轩竹医药科技有限公司	具有氨基烷基脒的四环素化合物
CN101684080B (zh) *	2008-09-16	2011-12-14	山东轩竹医药科技有限公司	含有甲酰肼基的四环素化合物
CN101684083B (zh) *	2008-09-16	2011-10-05	山东轩竹医药科技有限公司	胍基烷酰胺基取代的四环素衍生物
CN101759599B (zh) *	2008-09-17	2012-05-30	山东轩竹医药科技有限公司	具有氨基肟基的四环素类化合物
WO2010033939A1 (en) *	2008-09-19	2010-03-25	Paratek Pharmaceuticals, Inc.	Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
WO2010126607A2 (en)	2009-04-30	2010-11-04	President And Fellows Of Harvard College	Synthesis of tetracyclines and intermediates thereto
ES2627772T3 (es)	2009-05-08	2017-07-31	Tetraphase Pharmaceuticals, Inc.	Compuestos de tetraciclina
JP5944825B2 (ja)	2009-08-28	2016-07-05	テトラフェースファーマシューティカルズ，インコーポレイテッド	テトラサイクリン化合物
WO2013013505A1 (zh)	2011-07-26	2013-01-31	山东亨利医药科技有限责任公司	9-氨基甲基取代的四环素类化合物
HK1210593A1 (en) *	2012-07-13	2016-04-29	Paratek Pharmaceuticals, Inc.	Tetracycline compounds for treating neurodegenerative disorders
BR112015004523B1 (pt)	2012-08-31	2020-08-04	Tetraphase Pharmaceuticals, Inc	Compostos de tetraciclina, composições farmacêuticas e seus usos
KR102237887B1 (ko)	2013-03-15	2021-04-07	멜린타 서브시디어리 코프.	항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
TW201615195A (zh) *	2014-10-24	2016-05-01	朗齊生物醫學股份有限公司	阿那格雷藥物應用於癌症治療
EP4268897A3 (en)	2015-03-24	2024-01-03	Paratek Pharmaceuticals, Inc.	Minocycline compounds for biodefense
SG11201808246SA (en) *	2016-03-24	2018-10-30	Paratek Pharm Innc	Methods for treating and preventing c. difficile infection
ES2978198T3 (es)	2016-10-19	2024-09-06	Tetraphase Pharmaceuticals Inc	Formas cristalinas de eravaciclina
CN110087655A (zh)	2016-11-01	2019-08-02	帕拉特克药品公司	9-氨基甲基米诺环素化合物及其在治疗社区获得性细菌性肺炎(cabp)中的用途
EP3846805A4 (en) *	2018-09-04	2022-08-24	Paratek Pharmaceuticals, Inc.	Methods of treating mycobacterial infections using tetracycline compounds

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US53711A (en) *		1866-04-03		Improvement in the construction of pulleys
USRE26271E (en)		1967-09-26		Reductive alkylation process
US2990331A (en)	1956-11-23	1961-06-27	Pfizer & Co C	Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en)	1957-10-29	1961-04-18	Pfizer & Co C	Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en)	1958-12-11	1962-11-06	Pfizer & Co C	Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3007965A (en)	1959-02-13	1961-11-07	American Cyanamid Co	New tetracyclines produced by streptomyces aureofaciens
FR1003M (fr) *	1960-03-09	1961-12-18	Erba Carlo Spa	Dérivés d'antibiotiques a base de tétracycline.
US3338963A (en) *	1960-10-28	1967-08-29	American Cyanamid Co	Tetracycline compounds
US3219671A (en)	1961-04-14	1965-11-23	American Cyanamid Co	Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines
GB955766A (en)	1961-06-14	1964-04-22	Ciba Ltd	New thioethers and process for their manufacture
US3165531A (en)	1962-03-08	1965-01-12	Pfizer & Co C	13-substituted-6-deoxytetracyclines and process utilizing the same
USRE26253E (en)	1963-05-17	1967-08-15		And z-alkylamino-g-deoxytetracycline
US3373193A (en)	1963-11-13	1968-03-12	Olin Mathieson	Dimeric halophospha (iii)-carboranes and their production
ES302929A1 (es)	1964-08-07	1964-12-01	Viladot Oliva Francisco	Procedimiento para la obtenciën de compuestos antibiëticos derivados de tetraciclina-penicilina
US3454697A (en)	1965-06-08	1969-07-08	American Cyanamid Co	Tetracycline antibiotic compositions for oral use
US3397230A (en)	1966-03-14	1968-08-13	American Cyanamid Co	Nitration of tetracyclines
US3341585A (en)	1966-05-06	1967-09-12	American Cyanamid Co	Substituted 7-and/or 9-amino-6-deoxytetracyclines
NL6607516A (da)	1966-05-31	1967-12-01
US3345410A (en)	1966-12-01	1967-10-03	American Cyanamid Co	Substituted 7- and/or 9-amino tetracyclines
US3483251A (en)	1967-03-03	1969-12-09	American Cyanamid Co	Reductive alkylation process
US3360561A (en)	1967-06-19	1967-12-26	American Cyanamid Co	Nitration of tetracyclines
US3518306A (en)	1968-02-19	1970-06-30	American Cyanamid Co	7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en)	1968-04-18	1971-05-18	American Cyanamid Co	Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
DE1767891C3 (de)	1968-06-28	1980-10-30	Pfizer	Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
CA999855A (en) *	1972-09-18	1976-11-16	Societa' Farmaceutici Italia S.P.A.	Process for the preparation of tetracyclines derivatives in the 7 position
US3957980A (en)	1972-10-26	1976-05-18	Pfizer Inc.	Doxycycline parenteral compositions
DE2527568A1 (de)	1974-06-25	1976-01-15	Farmaceutici Italia	Verfahren zur herstellung von alkyltetracyclinen und neue tetracyclinderivate
DE2442829A1 (de)	1974-09-06	1976-03-18	Merck Patent Gmbh	Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en)	1976-01-02	1977-04-19	Pfizer Inc.	Oxytetracycline compositions
US4126680A (en)	1977-04-27	1978-11-21	Pfizer Inc.	Tetracycline antibiotic compositions
US4806529A (en)	1982-11-18	1989-02-21	Trustees Of Tufts College, Tufts University	Tetracycline activity enhancement
US5064821A (en)	1982-11-18	1991-11-12	Trustees Of Tufts College	Method and compositions for overcoming tetracycline resistance within living cells
JP3009942B2 (ja) *	1991-06-27	2000-02-14	マツダ株式会社	車両の制御装置
ES2168254T3 (es) *	1991-10-04	2002-06-16	American Cyanamid Co	Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
US5281628A (en) *	1991-10-04	1994-01-25	American Cyanamid Company	9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5494903A (en)	1991-10-04	1996-02-27	American Cyanamid Company	7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en)	1992-08-13	1995-08-15	American Cyanamid Company	9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) *	1992-08-13	1995-05-30	American Cyanamid Company	7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en)	1992-08-13	1998-04-17	American Cyanamid Co	New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5284963A (en) *	1992-08-13	1994-02-08	American Cyanamid Company	Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5248797A (en)	1992-08-13	1993-09-28	American Cyanamid Company	Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en)	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
CA2103189C (en)	1992-11-17	2005-05-03	Lorne M. Golub	Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes
US5371076A (en)	1993-04-02	1994-12-06	American Cyanamid Company	9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en)	1994-02-17	1998-11-10	Pfizer Inc.	9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5675030A (en)	1994-11-16	1997-10-07	American Cyanamid Company	Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US6165999A (en)	1995-05-03	2000-12-26	Pfizer Inc	Tetracycline derivatives
US5789395A (en)	1996-08-30	1998-08-04	The Research Foundation Of State University Of New York	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
JP2002501026A (ja)	1998-01-23	2002-01-15	トルスティーズオブトゥフツカレッジ	薬学的に活性の化合物及びその利用法
ES2272097T3 (es) *	1998-11-18	2007-04-16	Collagenex Pharmaceuticals, Inc.	Nuevos derivados de 4-desdimetilaminotetraciclina.
US6506740B1 (en) *	1998-11-18	2003-01-14	Robert A. Ashley	4-dedimethylaminotetracycline derivatives
CA2352170A1 (en) *	1998-11-25	2000-06-02	Henkel Corporation	Resealable package containing an organic solvent or solution
US6849615B2 (en)	1999-09-14	2005-02-01	Paratek Pharmaceuticals, Inc.	13-substituted methacycline compounds
PT1240133E (pt)	1999-09-14	2006-07-31	Tufts College	Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao
US8106225B2 (en)	1999-09-14	2012-01-31	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en)	1999-09-14	2002-12-31	Paratek Pharmaceuticals, Inc.	13-substituted methacycline compounds
US7202035B2 (en)	1999-09-30	2007-04-10	University Of Guelph	Genetic markers for skatole metabolism
EP1263442A1 (en)	2000-01-24	2002-12-11	Trustees Of Tufts College	TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
DE60129116T2 (de)	2000-03-31	2008-03-13	Trustees Of Tufts College, Medford	7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
EP1286954B1 (en)	2000-05-15	2004-04-14	Paratek Pharmaceuticals, Inc.	7-substituted fused ring tetracycline compounds
AU2001268475A1 (en)	2000-06-16	2002-01-02	Trustees Of Tufts College	7-phenyl-substituted tetracycline compounds
US20020132798A1 (en)	2000-06-16	2002-09-19	Nelson Mark L.	7-phenyl-substituted tetracycline compounds
US20020128237A1 (en)	2000-06-16	2002-09-12	Nelson Mark L.	7-N-substituted phenyl tetracycline compounds
US20050143353A1 (en)	2000-07-07	2005-06-30	Paratek Pharmaceuticals, Inc.	13-Substituted methacycline compounds
US7094806B2 (en)	2000-07-07	2006-08-22	Trustees Of Tufts College	7, 8 and 9-substituted tetracycline compounds
MXPA03000055A (es)	2000-07-07	2003-07-14	Tufts College	Compuestos de monociclina sustituidos en posicion 9..
KR100997596B1 (ko)	2000-07-07	2010-11-30	파라테크 파마슈티컬스, 인크.	7-치환 테트라사이클린 화합물
DE60144375D1 (de) *	2000-07-07	2011-05-19	Trustees Of Tufts College Medford	7-, 8- und 9-substitutierte tetracyclinverbindungen
EP1241160A1 (en)	2001-03-13	2002-09-18	Glaxo Group Limited	Tetracycline derivatives and their use as antibiotic agents
WO2002072506A2 (en)	2001-03-13	2002-09-19	Paratek Pharmaceuticals, Inc.	7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en)	2001-03-13	2009-06-30	Paratek Pharmaceuticals, Inc.	9-aminomethyl substituted minocycline compounds
EP2298732A1 (en)	2001-03-13	2011-03-23	Paratek Pharmaceuticals, Inc.	7,9-Substituted tetracycline compounds
US6841546B2 (en)	2001-03-14	2005-01-11	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds as antifungal agents
EP1381372A2 (en)	2001-03-14	2004-01-21	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds as synergistic antifungal agents
US20040092490A1 (en)	2001-04-24	2004-05-13	Michael Draper	Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en)	2001-04-24	2012-01-03	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en)	2001-07-13	2006-08-31	Paratek Pharmaceuticals, Inc.	Tetracyline compounds having target therapeutic activities
EP2332546A1 (en)	2001-07-13	2011-06-15	Paratek Pharmaceuticals, Inc.	Tetracyclines for the treatment of stroke
WO2003055441A2 (en)	2001-08-02	2003-07-10	Paratek Pharmaceuticals, Inc.	Medicaments
EP2311797A1 (en)	2002-01-08	2011-04-20	Paratek Pharmaceuticals, Inc.	4-dedimethylamino tetracycline compounds
EA201000491A1 (ru)	2002-03-08	2010-08-30	Паратек Фармасьютикалс, Инк.	Аминометилзамещенные тетрациклиновые соединения
WO2003079984A2 (en)	2002-03-21	2003-10-02	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
EA012136B1 (ru)	2002-07-12	2009-08-28	Пэрэтек Фамэсьютикэлс, Инк.	Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
WO2004038000A2 (en)	2002-10-24	2004-05-06	Paratek Pharmaceuticals, Inc.	Methods of using substituted tetracycline compounds to modulate rna
EP1648859B1 (en)	2003-07-09	2013-02-27	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
JP4738333B2 (ja)	2003-07-09	2011-08-03	パラテックファーマシューティカルズインコーポレイテッド	９−アミノメチルテトラサイクリン化合物のプロドラッグ
EP2332904A3 (en)	2004-01-15	2012-04-11	Paratek Pharmaceuticals, Inc.	Derivatives of tetracycline compounds
CA2585418A1 (en)	2004-10-25	2006-05-04	Paratek Pharmaceuticals, Inc.	4-aminotetracyclines and methods of use thereof
EP2284152A3 (en)	2004-10-25	2011-10-05	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
AU2006272698B2 (en) *	2005-07-21	2012-11-01	Paratek Pharmaceuticals, Inc.	10-substituted tetracyclines and methods of use thereof

2001
- 2001-06-29 MX MXPA03000055A patent/MXPA03000055A/es active IP Right Grant
- 2001-06-29 CA CA2415178A patent/CA2415178C/en not_active Expired - Lifetime
- 2001-06-29 EP EP18187132.8A patent/EP3461808A1/en not_active Withdrawn
- 2001-06-29 ES ES01965828T patent/ES2271070T3/es not_active Expired - Lifetime
- 2001-06-29 HR HR20030091A patent/HRP20030091B1/xx not_active IP Right Cessation
- 2001-06-29 SI SI200130646T patent/SI1301467T1/sl unknown
- 2001-06-29 DE DE60122341T patent/DE60122341T2/de not_active Expired - Lifetime
- 2001-06-29 CZ CZ20090877A patent/CZ303702B6/cs not_active IP Right Cessation
- 2001-06-29 DK DK01965828T patent/DK1301467T3/da active
- 2001-06-29 KR KR1020057025319A patent/KR100699390B1/ko not_active Expired - Fee Related
- 2001-06-29 KR KR1020037000160A patent/KR100674047B1/ko not_active Expired - Lifetime
- 2001-06-29 WO PCT/US2001/020721 patent/WO2002004406A2/en not_active Ceased
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- 2001-06-29 CN CN2005100530441A patent/CN1690047B/zh not_active Expired - Fee Related
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- 2001-06-29 CN CNB01815087XA patent/CN100473644C/zh not_active Expired - Lifetime
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- 2001-06-29 US US09/895,857 patent/US6846939B2/en not_active Expired - Lifetime
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- 2001-06-29 EA EA200401579A patent/EA013908B1/ru not_active IP Right Cessation
- 2001-06-29 PT PT01965828T patent/PT1301467E/pt unknown
- 2001-06-29 AU AU8638801A patent/AU8638801A/xx active Pending
- 2001-06-29 DK DK06007501.7T patent/DK1679305T3/da active
- 2001-06-29 CZ CZ2003344A patent/CZ2003344A3/cs unknown
- 2001-06-29 ES ES10182900T patent/ES2701599T3/es not_active Expired - Lifetime
- 2001-06-29 EA EA201000496A patent/EA201000496A1/ru unknown
- 2001-06-29 AT AT01965828T patent/ATE336481T1/de active
- 2001-07-06 TW TW090116602A patent/TWI299038B/zh not_active IP Right Cessation
- 2001-07-06 TW TW093140806A patent/TWI305528B/zh not_active IP Right Cessation
2003
- 2003-01-28 ZA ZA2003/00749A patent/ZA200300749B/en unknown
2004
- 2004-05-04 US US10/839,023 patent/US8048867B2/en not_active Expired - Fee Related
2005
- 2005-04-18 AU AU2005201623A patent/AU2005201623B8/en not_active Ceased
2006
- 2006-09-03 IL IL177854A patent/IL177854A/en active IP Right Grant
- 2006-10-13 CY CY20061101475T patent/CY1107524T1/el unknown
2008
- 2008-06-16 JP JP2008157219A patent/JP5037436B2/ja not_active Expired - Lifetime
2009
- 2009-01-09 US US12/351,405 patent/US8258120B2/en not_active Expired - Fee Related
- 2009-05-11 AU AU2009201857A patent/AU2009201857B9/en not_active Ceased
2012
- 2012-02-21 JP JP2012034839A patent/JP2012107045A/ja active Pending
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Also Published As

Publication number	Publication date
WO2002004406A3 (en)	2002-06-06
HRP20030091A2 (en)	2005-02-28
KR100699390B1 (ko)	2007-03-28
DE60122341T2 (de)	2007-08-09
ES2701599T3 (es)	2019-02-25
SI1301467T1 (sl)	2007-02-28
EA200300135A1 (ru)	2003-06-26
US6846939B2 (en)	2005-01-25
US8048867B2 (en)	2011-11-01
US9090541B2 (en)	2015-07-28
KR20060014446A (ko)	2006-02-15
EA013908B1 (ru)	2010-08-30
KR20030017610A (ko)	2003-03-03
TWI299038B (en)	2008-07-21
AU2009201857A8 (en)	2011-01-06
CA2415178A1 (en)	2002-01-17
EA201000496A1 (ru)	2010-10-29
ATE544745T1 (de)	2012-02-15
DK1679305T3 (da)	2012-05-29
EP1301467B1 (en)	2006-08-16
US20150265635A1 (en)	2015-09-24
HU229577B1 (en)	2014-02-28
BRPI0112269B8 (pt)	2021-05-25
US20040214801A1 (en)	2004-10-28
IL177854A (en)	2013-02-28
JP2004502752A (ja)	2004-01-29
IL177854A0 (en)	2006-12-31
CN1690047B (zh)	2010-10-06
CY1107524T1 (el)	2013-03-13
PT1301467E (pt)	2006-12-29
AU2005201623B2 (en)	2009-02-12
TWI305528B (en)	2009-01-21
US20030125348A1 (en)	2003-07-03
ATE336481T1 (de)	2006-09-15
CZ2003344A3 (cs)	2003-05-14
EA009175B1 (ru)	2007-12-28
EP1679305A1 (en)	2006-07-12
EA200401579A1 (ru)	2005-06-30
JP2009029785A (ja)	2009-02-12
WO2002004406A2 (en)	2002-01-17
JP4925549B2 (ja)	2012-04-25
CZ303702B6 (cs)	2013-03-20
AU2009201857B9 (en)	2012-05-10
US8258120B2 (en)	2012-09-04
KR100674047B1 (ko)	2007-01-25
BR0112269A (pt)	2003-07-01
EP3461808A1 (en)	2019-04-03
CN1690047A (zh)	2005-11-02
TW200519070A (en)	2005-06-16
DE60122341D1 (de)	2006-09-28
ZA200300749B (en)	2005-08-31
MXPA03000055A (es)	2003-07-14
US20120283201A1 (en)	2012-11-08
JP5037436B2 (ja)	2012-09-26
AU8638801A (en)	2002-01-21
JP2012107045A (ja)	2012-06-07
EP2308832B8 (en)	2019-04-24
EP1679305B1 (en)	2012-02-08
AU2005201623B8 (en)	2009-03-12
AU2009201857B2 (en)	2011-12-22
IL153639A0 (en)	2003-07-06
BRPI0112269B1 (pt)	2016-07-05
CA2415178C (en)	2010-05-25
EP1301467A2 (en)	2003-04-16
CN1471509A (zh)	2004-01-28
US20090325908A1 (en)	2009-12-31
EP2308832B1 (en)	2018-09-12
EP2308832A1 (en)	2011-04-13
CN100473644C (zh)	2009-04-01
AU2001286388B2 (en)	2005-07-14
AU2009201857A1 (en)	2009-06-04
ES2271070T3 (es)	2007-04-16
HUP0301169A2 (hu)	2003-08-28
HRP20030091B1 (en)	2011-10-31
AU2005201623A1 (en)	2005-05-05
HUP0301169A3 (en)	2009-08-28

Publication	Publication Date	Title
ATE336481T1 (de)	2006-09-15	9-substituierte minocyclinverbindungen
WO2002004407A3 (en)	2002-04-04	7-substituted tetracycline compounds
WO2003057169A3 (en)	2003-12-04	4-dedimethylamino tetracycline compounds
WO2003079984A3 (en)	2004-09-10	Substituted tetracycline compounds
CA2440383A1 (en)	2002-09-19	7,9-substituted tetracycline compounds
WO2004006850A3 (en)	2004-04-15	3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
WO2005009943A3 (en)	2005-06-16	Substituted tetracycline compounds
EP2949644A3 (en)	2016-04-20	Substituted tetracycline compounds
WO2006047671A3 (en)	2006-08-10	4-aminotetracyclines and methods of use thereof
WO2004091513A3 (en)	2005-04-07	9-aminomethyl substituted minocycline compounds
DE60141994D1 (de)	2010-06-10	13-substituierte Methacyclinverbindungen