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DK1392292T3 - Pyranoindazoler og deres anvendelse til behandling af glaukom - Google Patents

Pyranoindazoler og deres anvendelse til behandling af glaukom

Info

Publication number
DK1392292T3
DK1392292T3 DK02734575T DK02734575T DK1392292T3 DK 1392292 T3 DK1392292 T3 DK 1392292T3 DK 02734575 T DK02734575 T DK 02734575T DK 02734575 T DK02734575 T DK 02734575T DK 1392292 T3 DK1392292 T3 DK 1392292T3
Authority
DK
Denmark
Prior art keywords
pyranoindazoles
glaucoma
treatment
Prior art date
Application number
DK02734575T
Other languages
Danish (da)
English (en)
Inventor
Hwang-Hsing Chen
Bryon S Severns
Jesse A May
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DK1392292T3 publication Critical patent/DK1392292T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK02734575T 2001-06-01 2002-05-30 Pyranoindazoler og deres anvendelse til behandling af glaukom DK1392292T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29542901P 2001-06-01 2001-06-01

Publications (1)

Publication Number Publication Date
DK1392292T3 true DK1392292T3 (da) 2006-05-29

Family

ID=23137684

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02734575T DK1392292T3 (da) 2001-06-01 2002-05-30 Pyranoindazoler og deres anvendelse til behandling af glaukom

Country Status (19)

Country Link
US (2) US6696476B2 (fr)
EP (1) EP1392292B1 (fr)
JP (1) JP2004535418A (fr)
KR (1) KR100626255B1 (fr)
CN (1) CN100384417C (fr)
AR (1) AR036044A1 (fr)
AT (1) ATE318821T1 (fr)
AU (1) AU2002305732B2 (fr)
BR (1) BR0210241A (fr)
CA (1) CA2447480A1 (fr)
DE (1) DE60209486T2 (fr)
DK (1) DK1392292T3 (fr)
ES (1) ES2258631T3 (fr)
MX (1) MXPA03010807A (fr)
PL (1) PL366636A1 (fr)
PT (1) PT1392292E (fr)
RU (1) RU2273641C2 (fr)
WO (1) WO2002098350A2 (fr)
ZA (1) ZA200309034B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
JP2004538240A (ja) * 2000-03-31 2004-12-24 パーデュー・リサーチ・ファウンデーション ホスホラミデートおよびそのための方法
WO2002098350A2 (fr) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles et leur utilisation dans le traitement du glaucome
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2002360819A1 (en) * 2001-12-28 2003-07-24 Bayer Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
KR20050033654A (ko) * 2002-08-30 2005-04-12 알콘, 인코퍼레이티드 치환된 5-크로만-5-일-에틸아민 화합물 및 녹내장의 치료용그의 용도
EP1581209A4 (fr) 2002-12-13 2009-03-11 Alcon Inc Nouveaux analogues de benzopyranne et leur utilisation pour le traitement du glaucome
CA2537430A1 (fr) * 2003-09-04 2005-03-24 Merck & Co., Inc. Compositions ophtalmiques pour traiter l'hypertension oculaire
WO2005053688A1 (fr) * 2003-11-26 2005-06-16 Alcon, Inc. Furo[2,3-g] indazoles substitues destines au traitement du glaucome
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (fr) * 2003-12-15 2005-06-30 Alcon, Inc. [1,4]oxazino[2,3-g]indazoles substitues pour traiter le glaucome
EP2248524A3 (fr) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Agents preventifs/remedes pour l'incontinence de stress et procede de selecetion de ceux-ci
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007132841A1 (fr) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
WO2007149728A2 (fr) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Dérivés d'aryl et d'hétéroaryl tétrahydrobenzazépine et leur utilisation pour traiter le glaucome
AU2007279766A1 (en) * 2006-07-31 2008-02-07 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparation containing amide compound
US20080033184A1 (en) * 2006-08-01 2008-02-07 Alcon Manufacturing, Ltd. Intermediates and methods for serotonergic agonist synthesis
US20080033183A1 (en) * 2006-08-01 2008-02-07 Alcon Manufacturing, Ltd. Process for preparing pyranoindazole serotonergic receptor agonists
US20080058533A1 (en) * 2006-08-31 2008-03-06 Alcon, Inc. Pyranoindazole cyclic carbonates and methods of use
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
WO2011071136A1 (fr) 2009-12-11 2011-06-16 アステラス製薬株式会社 Agent thérapeutique pour la fibromyalgie
US20180030251A1 (en) * 2015-03-05 2018-02-01 Bridgestone Corporation Rubber composition, method for producing diene-based polymer, and tire
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
WO2019131902A1 (fr) 2017-12-27 2019-07-04 武田薬品工業株式会社 Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale
EP3768666A1 (fr) 2018-03-20 2021-01-27 Plexxikon Inc. Composés et procédés de modulation d'ido et de tdo, et indications pour ceux-ci

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
ES2062102T5 (es) * 1988-09-06 2004-12-01 Pharmacia Ab Derivados de prostaglandinas para el tratamiento de glaucoma o hipertension ocular.
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
WO1992020338A1 (fr) 1991-05-10 1992-11-26 Merrell Dow Pharmaceuticals Inc. Procede de traitement d'un glaucome
JPH06508354A (ja) * 1991-06-21 1994-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
GB9224169D0 (en) * 1992-11-18 1993-01-06 Lilly Industries Ltd Pharmaceutical compounds
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (fr) * 1993-10-22 1996-02-11 Hoffmann La Roche
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5874477A (en) * 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
WO1997033579A1 (fr) 1996-03-13 1997-09-18 Glaxo Group Limited Medicaments comprenant des agonistes du recepteur de type 5ht1 presentant une meilleure absorption
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
WO1998018458A1 (fr) * 1996-10-31 1998-05-07 Alcon Laboratories, Inc. Compositions ophtalmologiques contenant un agoniste du recepteur de la serotonine du type 5-ht1a et leur utilisation dans le traitement du glaucome
WO1998030548A1 (fr) 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE
GB9700899D0 (en) 1997-01-17 1997-03-05 Smithkline Beecham Plc Novel treatment
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
DK1112106T3 (da) 1998-09-18 2005-12-12 Alcon Mfg Ltd Serotonerge 5HT2-agonister til behandling af glaukom
SK8192001A3 (en) 1998-12-17 2001-12-03 American Home Prod 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivatives being 5ht2c agonists
GB9902047D0 (en) 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
BR0012084A (pt) * 1999-06-15 2002-04-02 Bristol Myers Squibb Pharma Co Compostos, composição farmacêutica e usos dos compostos
US6713471B1 (en) * 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
JP2003535821A (ja) 2000-03-17 2003-12-02 アルコン，インコーポレイティド 緑内障を治療するための５−ヒドロキシインダゾール誘導体
AU5256301A (en) * 2000-04-28 2001-11-12 Yamanouchi Pharmaceutical Co., Ltd. Froindazole derivative
WO2002098350A2 (fr) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles et leur utilisation dans le traitement du glaucome

Also Published As

Publication number Publication date
PL366636A1 (en) 2005-02-07
WO2002098350A2 (fr) 2002-12-12
US20040106609A1 (en) 2004-06-03
PT1392292E (pt) 2006-05-31
ES2258631T3 (es) 2006-09-01
US6881749B2 (en) 2005-04-19
WO2002098350A3 (fr) 2003-02-27
MXPA03010807A (es) 2004-11-22
ZA200309034B (en) 2004-07-16
DE60209486T2 (de) 2006-08-03
BR0210241A (pt) 2004-08-10
HK1061212A1 (en) 2004-09-10
CA2447480A1 (fr) 2002-12-12
AR036044A1 (es) 2004-08-04
KR20040010669A (ko) 2004-01-31
EP1392292A4 (fr) 2004-08-11
US6696476B2 (en) 2004-02-24
JP2004535418A (ja) 2004-11-25
CN100384417C (zh) 2008-04-30
CN1592619A (zh) 2005-03-09
EP1392292A2 (fr) 2004-03-03
US20030171418A1 (en) 2003-09-11
RU2003137825A (ru) 2005-04-20
KR100626255B1 (ko) 2006-09-21
RU2273641C2 (ru) 2006-04-10
AU2002305732B2 (en) 2007-02-01
EP1392292B1 (fr) 2006-03-01
ATE318821T1 (de) 2006-03-15
DE60209486D1 (de) 2006-04-27

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