DK1362864T3 - Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf - Google Patents
Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte herafInfo
- Publication number
- DK1362864T3 DK1362864T3 DK03291600T DK03291600T DK1362864T3 DK 1362864 T3 DK1362864 T3 DK 1362864T3 DK 03291600 T DK03291600 T DK 03291600T DK 03291600 T DK03291600 T DK 03291600T DK 1362864 T3 DK1362864 T3 DK 1362864T3
- Authority
- DK
- Denmark
- Prior art keywords
- perindopril
- synthesis
- pharmaceutically acceptable
- acceptable salts
- new method
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291600A EP1362864B1 (fr) | 2003-06-30 | 2003-06-30 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1362864T3 true DK1362864T3 (da) | 2007-09-17 |
Family
ID=29266055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03291600T DK1362864T3 (da) | 2003-06-30 | 2003-06-30 | Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7220776B2 (da) |
| EP (1) | EP1362864B1 (da) |
| JP (1) | JP4347342B2 (da) |
| CN (1) | CN100383159C (da) |
| AR (1) | AR044943A1 (da) |
| AT (1) | ATE360638T1 (da) |
| AU (1) | AU2004255899B2 (da) |
| CY (1) | CY1106471T1 (da) |
| DE (1) | DE60313391T2 (da) |
| DK (1) | DK1362864T3 (da) |
| EA (1) | EA009458B1 (da) |
| ES (1) | ES2286393T3 (da) |
| MY (1) | MY136938A (da) |
| NZ (1) | NZ544004A (da) |
| PL (1) | PL211491B1 (da) |
| PT (1) | PT1362864E (da) |
| SI (1) | SI1362864T1 (da) |
| WO (1) | WO2005005461A2 (da) |
| ZA (1) | ZA200510324B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066135A2 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| DE602005009918D1 (de) | 2005-01-06 | 2008-11-06 | Ipca Lab Ltd | Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
| MX2008000250A (es) | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y |
| RU2430913C2 (ru) | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
| EP1978961B1 (en) | 2006-01-06 | 2016-03-16 | Sunovion Pharmaceuticals Inc. | Tetralone-based monoamine reuptake inhibitors |
| CN101421228B (zh) | 2006-03-31 | 2014-05-21 | 塞普拉柯公司 | 手性酰胺和胺的制备 |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| JP2008019214A (ja) * | 2006-07-13 | 2008-01-31 | Shiono Chemical Co Ltd | ペリンドプリルまたはその誘導体の製造方法 |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| EP2617704B1 (en) | 2007-05-31 | 2017-06-28 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
| CN111116709B (zh) * | 2019-12-31 | 2022-06-24 | 北京鑫开元医药科技有限公司 | 一种培哚普利制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| ES2240919T3 (es) * | 2003-03-12 | 2005-10-16 | Les Laboratoires Servier | Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables. |
| ES2256689T3 (es) * | 2003-06-30 | 2006-07-16 | Les Laboratoires Servier | Nuevo procedimiento de sintesis del perindopril y de sus sales farmaceuticamente aceptables. |
-
2003
- 2003-06-30 ES ES03291600T patent/ES2286393T3/es not_active Expired - Lifetime
- 2003-06-30 EP EP03291600A patent/EP1362864B1/fr not_active Expired - Lifetime
- 2003-06-30 AT AT03291600T patent/ATE360638T1/de active
- 2003-06-30 SI SI200330844T patent/SI1362864T1/sl unknown
- 2003-06-30 DE DE60313391T patent/DE60313391T2/de not_active Expired - Lifetime
- 2003-06-30 PT PT03291600T patent/PT1362864E/pt unknown
- 2003-06-30 DK DK03291600T patent/DK1362864T3/da active
-
2004
- 2004-06-28 ZA ZA200510324A patent/ZA200510324B/xx unknown
- 2004-06-28 PL PL379630A patent/PL211491B1/pl unknown
- 2004-06-28 MY MYPI20042539A patent/MY136938A/en unknown
- 2004-06-28 CN CNB2004800163249A patent/CN100383159C/zh not_active Expired - Fee Related
- 2004-06-28 EA EA200501900A patent/EA009458B1/ru not_active IP Right Cessation
- 2004-06-28 NZ NZ544004A patent/NZ544004A/xx not_active IP Right Cessation
- 2004-06-28 JP JP2006515296A patent/JP4347342B2/ja not_active Expired - Fee Related
- 2004-06-28 AU AU2004255899A patent/AU2004255899B2/en not_active Ceased
- 2004-06-28 US US10/562,950 patent/US7220776B2/en not_active Expired - Fee Related
- 2004-06-28 WO PCT/FR2004/001638 patent/WO2005005461A2/fr not_active Ceased
- 2004-06-29 AR ARP040102276A patent/AR044943A1/es not_active Application Discontinuation
-
2007
- 2007-05-16 CY CY20071100663T patent/CY1106471T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1362864A1 (fr) | 2003-11-19 |
| AU2004255899B2 (en) | 2008-03-13 |
| EA200501900A1 (ru) | 2006-06-30 |
| MY136938A (en) | 2008-11-28 |
| WO2005005461A2 (fr) | 2005-01-20 |
| US7220776B2 (en) | 2007-05-22 |
| ES2286393T3 (es) | 2007-12-01 |
| AR044943A1 (es) | 2005-10-12 |
| HK1089187A1 (zh) | 2006-11-24 |
| JP4347342B2 (ja) | 2009-10-21 |
| CN100383159C (zh) | 2008-04-23 |
| CN1805972A (zh) | 2006-07-19 |
| US20060148884A1 (en) | 2006-07-06 |
| PT1362864E (pt) | 2007-07-23 |
| AU2004255899A1 (en) | 2005-01-20 |
| WO2005005461A3 (fr) | 2005-03-31 |
| ZA200510324B (en) | 2007-03-28 |
| EA009458B1 (ru) | 2007-12-28 |
| EP1362864B1 (fr) | 2007-04-25 |
| PL379630A1 (pl) | 2006-10-30 |
| PL211491B1 (pl) | 2012-05-31 |
| DE60313391T2 (de) | 2008-01-17 |
| ATE360638T1 (de) | 2007-05-15 |
| NZ544004A (en) | 2009-03-31 |
| SI1362864T1 (sl) | 2007-08-31 |
| DE60313391D1 (de) | 2007-06-06 |
| CY1106471T1 (el) | 2012-01-25 |
| JP2008500263A (ja) | 2008-01-10 |
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