[go: up one dir, main page]

DK1214075T3 - Polymorfer af N-methyl-N-(3-(3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl)phenyl)acetamid og beslægtede sammensætninger og fremgangsmåder - Google Patents

Polymorfer af N-methyl-N-(3-(3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl)phenyl)acetamid og beslægtede sammensætninger og fremgangsmåder

Info

Publication number
DK1214075T3
DK1214075T3 DK00957941T DK00957941T DK1214075T3 DK 1214075 T3 DK1214075 T3 DK 1214075T3 DK 00957941 T DK00957941 T DK 00957941T DK 00957941 T DK00957941 T DK 00957941T DK 1214075 T3 DK1214075 T3 DK 1214075T3
Authority
DK
Denmark
Prior art keywords
thienylcarbonyl
polymorphs
pyrazol
pyrimidin
acetamide
Prior art date
Application number
DK00957941T
Other languages
English (en)
Inventor
William J Thiele
Patrick B O'donnell
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of DK1214075T3 publication Critical patent/DK1214075T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00957941T 1999-09-02 2000-09-01 Polymorfer af N-methyl-N-(3-(3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl)phenyl)acetamid og beslægtede sammensætninger og fremgangsmåder DK1214075T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38952499A 1999-09-02 1999-09-02
US42162099A 1999-10-19 1999-10-19
PCT/US2000/024051 WO2001015700A1 (en) 1999-09-02 2000-09-01 POLYMORPHS OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-α]-PYRIMIDIN -7-YL }PHENYL )ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO
EP00957941A EP1214075B1 (en) 1999-09-02 2000-09-01 POLYMORPHS OF N-METHYL-N-(3- 3- 2-THIENYLCARBONYL]-PYRAZOL- 1,5-$g(a)]-PYRIMIDIN-7-YL PHENYL)ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO

Publications (1)

Publication Number Publication Date
DK1214075T3 true DK1214075T3 (da) 2004-10-25

Family

ID=27012737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00957941T DK1214075T3 (da) 1999-09-02 2000-09-01 Polymorfer af N-methyl-N-(3-(3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl)phenyl)acetamid og beslægtede sammensætninger og fremgangsmåder

Country Status (26)

Country Link
EP (2) EP1214075B1 (da)
JP (1) JP4592241B2 (da)
KR (1) KR20020035585A (da)
CN (2) CN1198824C (da)
AP (1) AP1631A (da)
AT (1) ATE269082T1 (da)
AU (2) AU769856B2 (da)
BR (1) BR0014459A (da)
CA (1) CA2382588C (da)
CZ (1) CZ2002783A3 (da)
DE (1) DE60011638T2 (da)
DK (1) DK1214075T3 (da)
EA (1) EA004706B1 (da)
ES (1) ES2222920T3 (da)
HK (1) HK1047407B (da)
HU (1) HUP0202698A3 (da)
IL (2) IL148242A0 (da)
MX (1) MXPA02002314A (da)
NO (1) NO322752B1 (da)
NZ (1) NZ517298A (da)
OA (1) OA12200A (da)
PL (1) PL353362A1 (da)
PT (1) PT1214075E (da)
SK (1) SK2782002A3 (da)
TR (1) TR200200534T2 (da)
WO (1) WO2001015700A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2493359C (en) 2002-08-26 2009-10-27 Neurocrine Biosciences, Inc. Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
EP1918290A1 (en) * 2006-10-11 2008-05-07 Ferrer Internacional, S.A. Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
US20120028045A1 (en) * 2009-03-24 2012-02-02 Glenmark Generics Ltd Processes for the Preparation of Indiplon and Intermediates Thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
SG30590G (en) * 1985-05-13 1995-09-18 American Cyanamid Co D7-(3-disubstituted amino) phenylaepyrazolod 1,5-aaepyrimidines
US5421422A (en) * 1993-11-19 1995-06-06 Boretec Inc Roller cutter mount for tunneling machine

Also Published As

Publication number Publication date
EP1477169A1 (en) 2004-11-17
CZ2002783A3 (cs) 2004-01-14
CN1680376A (zh) 2005-10-12
CA2382588A1 (en) 2001-03-08
JP4592241B2 (ja) 2010-12-01
HUP0202698A2 (hu) 2002-12-28
CN1374866A (zh) 2002-10-16
KR20020035585A (ko) 2002-05-11
IL148242A (en) 2006-12-10
WO2001015700A1 (en) 2001-03-08
EA004706B1 (ru) 2004-06-24
WO2001015700A9 (en) 2002-09-12
ATE269082T1 (de) 2004-07-15
PL353362A1 (en) 2003-11-17
ES2222920T3 (es) 2005-02-16
SK2782002A3 (en) 2003-04-01
AU6949100A (en) 2001-03-26
TR200200534T2 (tr) 2002-06-21
PT1214075E (pt) 2004-11-30
NO322752B1 (no) 2006-12-04
CA2382588C (en) 2008-11-25
HK1047407A1 (en) 2003-02-21
OA12200A (en) 2006-05-09
BR0014459A (pt) 2002-07-16
CN1331865C (zh) 2007-08-15
HUP0202698A3 (en) 2004-12-28
DE60011638D1 (de) 2004-07-22
EP1214075B1 (en) 2004-06-16
CN1198824C (zh) 2005-04-27
DE60011638T2 (de) 2004-10-21
AP2002002428A0 (en) 2002-03-31
MXPA02002314A (es) 2002-08-12
NO20021041L (no) 2002-04-03
IL148242A0 (en) 2002-09-12
EP1214075A4 (en) 2003-05-02
AP1631A (en) 2006-07-12
HK1047407B (en) 2004-12-24
NO20021041D0 (no) 2002-03-01
AU2004201356A1 (en) 2004-04-29
EP1214075A1 (en) 2002-06-19
AU769856B2 (en) 2004-02-05
NZ517298A (en) 2004-01-30
EA200200320A1 (ru) 2002-08-29
JP2003508440A (ja) 2003-03-04

Similar Documents

Publication Publication Date Title
DK1532152T3 (da) Ny polymorf af N-methyl-N- (3- (3- [2-thienylcarbonyl]-pyrazol- [1,5-alfa]-pyrimidin-7-yl) phenyl) acetamid og beslægtede sammensætninger og metoder
DE60101069D1 (de) Siliziumkarbid und Verfahren zu seiner Herstellung
FR15C0062I2 (fr) Nouveaux derives d'oxazolidinone
DE60016631D1 (de) Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1-hydroxycyclohexl)phenyl
NO20021831D0 (no) Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra
NO20003530D0 (no) Vedvarende frigivelsessammensetning, metode for dens produksjon og anvendelse derav
DK1169314T3 (da) Krystallinsk base af citalopram
DK1549153T3 (da) Tyggegummi med forbedret frigivelse af tyggegummiingredienser
FR2813366B1 (fr) Amortisseur d'oscillations
DE69711321D1 (de) Schwingstabbeschleunigungsmesser und Methode zu seiner Herstellung
DE60124152D1 (de) Kosmetische zusammensetzungen enthaltend siloxancopolymer-netzwerke
ATE286021T1 (de) Substituierte phenylderivate, ihre herstellung und verwendung
ATE361279T1 (de) N-[phenyl(piperidin-2-yl)methyl]benzamidderivat , verfahren zu ihrer herstellung und ihre therapeutische anwendung
ATE232364T1 (de) Zuckergusszusammensetzung
DE60105218D1 (de) Siliciumkarbid und Verfahren zu seiner Herstellung
EP1553451A4 (en) PHOTOSENSITIVE MEDIUM, PURIFICATION METHOD THEREFOR, AND PHOTOSENSITIVE COMPOSITIONS
FR2822211B1 (fr) Amortisseur d'oscillations de rotation
DK1383733T3 (da) Fremgangsmåde til fremstilling af 1,3-substituerede indener og aryl-sammenföjede azapolycykliske forbindelser
PL1771069T3 (pl) Pochodne N-(2-(hydroksymetylo)fenylo)-1H-pirazolo-4-karboksamidu i związki pokrewne jako mikrobójcze substancje czynne do zastosowania w ochronie roślin i materiałów
IS7343A (is) N-(3-bútýn-1-ýl) N-hýdroxý-þvagefni
DK1214075T3 (da) Polymorfer af N-methyl-N-(3-(3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl)phenyl)acetamid og beslægtede sammensætninger og fremgangsmåder
FR2836533B1 (fr) Amortisseur d'oscillations
DE69913556D1 (de) Herstellung von aminen
CY1105224T1 (el) Αντιμικροβιακες συνθεσεις ιστονης η1,κιτια, και μεθοδοι χρησιμοποιησεως αυτων
IS2473B (is) Samsetning sem inniheldur N-(3-metoxý-5-metýlpýrasín-2-ýl)-2-(4-(1,3,4-oxadíasól-2-ýl)fenýl)pýridín-3-súlfónamíð (ZD4054), eða lyfjafræðilega viðurkennt salt þess, og EGFR TKI, eða lyfjafræðilega viðurkennt salt þess