[go: up one dir, main page]

DK1263504T3 - Anvendelse af forbindelser med 5-HT1A aktivitet, som er anvendelige til behandling af lidelser i den ydre retina - Google Patents

Anvendelse af forbindelser med 5-HT1A aktivitet, som er anvendelige til behandling af lidelser i den ydre retina

Info

Publication number
DK1263504T3
DK1263504T3 DK01918208T DK01918208T DK1263504T3 DK 1263504 T3 DK1263504 T3 DK 1263504T3 DK 01918208 T DK01918208 T DK 01918208T DK 01918208 T DK01918208 T DK 01918208T DK 1263504 T3 DK1263504 T3 DK 1263504T3
Authority
DK
Denmark
Prior art keywords
compounds
treatment
retinal disorders
activity useful
external retinal
Prior art date
Application number
DK01918208T
Other languages
Danish (da)
English (en)
Inventor
Mark R Hellberg
Robert J Collier Jr
Michael A Kapin
Thomas R Dean
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DK1263504T3 publication Critical patent/DK1263504T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Liquid Crystal Substances (AREA)
  • Indole Compounds (AREA)
DK01918208T 2000-03-17 2001-02-23 Anvendelse af forbindelser med 5-HT1A aktivitet, som er anvendelige til behandling af lidelser i den ydre retina DK1263504T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19027900P 2000-03-17 2000-03-17
PCT/US2001/005700 WO2001070222A2 (fr) 2000-03-17 2001-02-23 Composes a activite agoniste sur le recepteur 5-ht1a destines au traitement des affections de la retine externe

Publications (1)

Publication Number Publication Date
DK1263504T3 true DK1263504T3 (da) 2003-12-08

Family

ID=22700682

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01918208T DK1263504T3 (da) 2000-03-17 2001-02-23 Anvendelse af forbindelser med 5-HT1A aktivitet, som er anvendelige til behandling af lidelser i den ydre retina

Country Status (18)

Country Link
EP (3) EP1263434A1 (fr)
JP (5) JP2003527423A (fr)
KR (3) KR20030016239A (fr)
CN (2) CN1418100A (fr)
AR (1) AR028258A1 (fr)
AT (1) ATE247507T1 (fr)
AU (5) AU2001238552A1 (fr)
BR (3) BR0109193A (fr)
CA (3) CA2400637A1 (fr)
DE (1) DE60100625T2 (fr)
DK (1) DK1263504T3 (fr)
ES (1) ES2204848T3 (fr)
MX (3) MXPA02009071A (fr)
PL (1) PL203709B1 (fr)
PT (1) PT1263504E (fr)
TW (1) TWI268777B (fr)
WO (3) WO2001070223A1 (fr)
ZA (1) ZA200206350B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
CA2400637A1 (fr) * 2000-03-17 2001-09-27 Robert J. Collier, Jr. Composes a activite agoniste sur les recepteurs 5-ht2 et 5-ht1a destines au traitement du glaucome
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2003300915B2 (en) 2002-12-13 2008-08-28 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
CA2520813C (fr) * 2003-04-25 2009-10-27 Mitsubishi Pharma Corporation Formulations de derives d'alkylene dioxybenzene a liberation prolongee servant d'antagonistes du recepteur 5-ht1a
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
AR046890A1 (es) 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US8685924B2 (en) 2004-08-25 2014-04-01 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
WO2008117269A2 (fr) 2007-03-28 2008-10-02 Atir Holding S.A. Composés hétérocycliques comme agents sérotoninergiques et dopaminergiques et leurs utilisations
EP2018863B9 (fr) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
WO2008024846A2 (fr) * 2006-08-25 2008-02-28 Allergan, Inc. Compositions de brimonidine et de timolol
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
CN102724951A (zh) 2009-11-09 2012-10-10 阿勒根公司 用于刺激毛发生长的组合物和方法
WO2011071136A1 (fr) 2009-12-11 2011-06-16 アステラス製薬株式会社 Agent thérapeutique pour la fibromyalgie
HK1218850A1 (zh) 2013-02-15 2017-03-17 Allergan, Inc. 持续药物递送植入物
US12343337B2 (en) 2016-09-29 2025-07-01 The Regents Of The University Of California Compounds for increasing neural plasticity
WO2019131902A1 (fr) 2017-12-27 2019-07-04 武田薬品工業株式会社 Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale
WO2020176599A1 (fr) 2019-02-27 2020-09-03 The Regents Of The University Of California Azépino-indoles et autres hétérocycles pour traiter des troubles du cerveau
AU2020228289A1 (en) 2019-02-27 2021-09-09 The Regents Of The University Of California N-substituted indoles and other heterocycles for treating brain disorders
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途
JP2024546180A (ja) * 2021-12-23 2024-12-17 シルケア ディーイーヴィ 聴覚疾患の治療のための４－フェニル－テトラヒドロピリジン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262518A (ja) * 1989-04-03 1990-10-25 Kaken Pharmaceut Co Ltd 眼圧調整剤
JP2824863B2 (ja) * 1989-07-12 1998-11-18 エーザイ株式会社 α▲下１▼―ブロッカー点眼剤
TW270114B (fr) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
JP3958391B2 (ja) * 1995-10-25 2007-08-15 三菱化学株式会社 眼疾患用薬剤
US5998467A (en) * 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
WO1998018458A1 (fr) * 1996-10-31 1998-05-07 Alcon Laboratories, Inc. Compositions ophtalmologiques contenant un agoniste du recepteur de la serotonine du type 5-ht1a et leur utilisation dans le traitement du glaucome
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9819033D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
CA2400637A1 (fr) * 2000-03-17 2001-09-27 Robert J. Collier, Jr. Composes a activite agoniste sur les recepteurs 5-ht2 et 5-ht1a destines au traitement du glaucome

Also Published As

Publication number Publication date
WO2001070222A2 (fr) 2001-09-27
PL358306A1 (en) 2004-08-09
KR20020082885A (ko) 2002-10-31
JP2003527422A (ja) 2003-09-16
MXPA02009073A (es) 2003-03-12
PL203709B1 (pl) 2009-11-30
EP1267878A2 (fr) 2003-01-02
ZA200206350B (en) 2003-08-08
EP1263504B1 (fr) 2003-08-20
AU4531001A (en) 2001-10-03
WO2001070230A2 (fr) 2001-09-27
HK1051504A1 (en) 2003-08-08
AU2001238552A1 (en) 2001-10-03
BR0109211A (pt) 2003-02-11
CA2400639C (fr) 2011-08-16
KR20030009390A (ko) 2003-01-29
AU2001239836A1 (en) 2001-10-03
PT1263504E (pt) 2003-12-31
DE60100625D1 (de) 2003-09-25
BR0109230A (pt) 2003-06-03
JP2011153158A (ja) 2011-08-11
KR100749191B1 (ko) 2007-08-13
KR20030016239A (ko) 2003-02-26
EP1263504A2 (fr) 2002-12-11
WO2001070222A3 (fr) 2002-07-25
ES2204848T3 (es) 2004-05-01
CN1418100A (zh) 2003-05-14
AU2001245310B2 (en) 2005-03-17
AU2005202600A1 (en) 2005-07-07
MXPA02009071A (es) 2003-05-23
JP4789231B2 (ja) 2011-10-12
ATE247507T1 (de) 2003-09-15
CA2400639A1 (fr) 2001-09-27
MXPA02009072A (es) 2003-03-12
BR0109193A (pt) 2003-05-27
TWI268777B (en) 2006-12-21
AU2005202600B2 (en) 2008-07-31
EP1263434A1 (fr) 2002-12-11
WO2001070223A1 (fr) 2001-09-27
CA2399985A1 (fr) 2001-09-27
CA2400637A1 (fr) 2001-09-27
JP2003527427A (ja) 2003-09-16
AR028258A1 (es) 2003-04-30
WO2001070230A3 (fr) 2002-04-25
JP2011037901A (ja) 2011-02-24
CN1198605C (zh) 2005-04-27
DE60100625T2 (de) 2004-02-26
CN1418121A (zh) 2003-05-14
JP2003527423A (ja) 2003-09-16

Similar Documents

Publication Publication Date Title
DK1263504T3 (da) Anvendelse af forbindelser med 5-HT1A aktivitet, som er anvendelige til behandling af lidelser i den ydre retina
DE60217294D1 (de) Hauteinschnittblutentnahmegerät
IL176393A0 (en) Patterned laser treatment of the retina
PT1202722E (pt) Usos para o tratamento ou prevencao de disturbios do sono usando doses muito baixas de ciclobenzaprina
WO2005069865A3 (fr) Derives de pyrrolopyrimidine et analogues et utilisation dans le traitement et la prevention de maladies
DK1228032T3 (da) Præparater, som indeholder hydroxyicosatetraensyrederivater, og fremgangsmåder til anvendelse ved behandling af öjentörhedslidelser
PT1446122E (pt) Utilizacao de flibanserina no tratamento de disturbios de desejo sexual
DK1339406T3 (da) Piperazinderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf til behandling af lidelser i centralnervesystemet
DK1228028T3 (da) Hydroxyicosatetraenoatsalte, præparater og fremgangsmåder til anvendelse til behandling af öjentörhedslidelser
DE60305037D1 (de) Piperazinylacylpiperidinderivate, deren herstellung und deren therapeutische anwendung
DK1614419T3 (da) Midler til forebyggelse/behandling af retinale nervesygdomme, indeholdende alkyletherderivater eller salte deraf
DE60008935D1 (de) Pyridinsulfonylharnstoffderivate mit herbizider wirkung
DK1463735T3 (da) Imidazo-2,1-B -1,3,4-thiadiazol-sulfonamider
DE60228764D1 (de) R-bambuterol, seine herstellung und therapeutische verwendungen
NO20055098D0 (no) Anvendelse av 10-hydroksy-10,11-dihydrokarbamazepinderivater for behandling av affektive forstyrrelser
DK1309322T3 (da) Anvendelse af 3-benzoylphenyleddikesyrederivater til behandling af retinale lidelser
NO20031414L (no) Ny oksabispidinforbindelse som er nyttig i behandlingen av hjertearrytmier
ZA200501288B (en) Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma.
DK1463563T3 (da) Superoxiddismutas-mimetika til behandling af öjenlidelser og -sygdomme
DK1257278T3 (da) Anvendelse af mirtazapin til behandling af sövnforstyrrelser
DK1532141T3 (da) 2-pyrrolidin-2-yl-[1,3,4]-oxadiazol-derivater og anvendelse deraf som antidepressiv
DK1244438T3 (da) Anvendelse af beta-adrenoceptorantagonister til fremstilling af et medikament til behandling af sygdomme i den ydre nethinde
DK1534296T3 (da) Anvendelse af cilobradin eller de farmaceutisk acceptable salte deraf til behandling eller forebyggelse af hjertesvigt
BRPI0511125A (pt) usos de ácido 5,6,7-triidroxieptanóico seus e análogos
NO20042846L (no) Derivater av 5-(pyridin-3-yl)-1-azabicyklo[3.2.1]oktan, fremstilling derav og anvendelse av de samme som terapeutiske midler