DK1066328T3 - Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion - Google Patents

Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion

Info

Publication number: DK1066328T3
Authority: DK; Denmark
Prior art keywords: chimeric protein; protein containing; sequence; insulin; imc
Prior art date: 1998-03-31

Application number

DK98912192T

Other languages

English (en)

Inventor

Zhongru Gan

Original Assignee

Tonghua Gantech Biotechnology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-31

Filing date

1998-03-31

Publication date

2009-02-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4575041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1066328(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-03-31 Application filed by Tonghua Gantech Biotechnology filed Critical Tonghua Gantech Biotechnology

2009-02-09 Application granted granted Critical

2009-02-09 Publication of DK1066328T3 publication Critical patent/DK1066328T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
102000037865 fusion proteins Human genes 0.000 title abstract 5
108020001507 fusion proteins Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
230000001876 chaperonelike Effects 0.000 title 1
239000002243 precursor Substances 0.000 abstract 4
108010006519 Molecular Chaperones Proteins 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000012752 auxiliary agent Substances 0.000 abstract 1
230000003196 chaotropic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK98912192T 1998-03-31 1998-03-31 Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion DK1066328T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/CN1998/000052 WO1999050302A1 (en)	1998-03-31	1998-03-31	Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production

Publications (1)

Publication Number	Publication Date
DK1066328T3 true DK1066328T3 (da)	2009-02-09

Family

ID=4575041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98912192T DK1066328T3 (da)	1998-03-31	1998-03-31	Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion

Country Status (15)

Country	Link
US (1)	US6924120B1 (da)
EP (1)	EP1066328B1 (da)
JP (1)	JP4472870B2 (da)
KR (1)	KR100554490B1 (da)
CN (1)	CN1197876C (da)
AT (1)	ATE408631T1 (da)
AU (1)	AU765574B2 (da)
BR (1)	BR9815788B1 (da)
CA (1)	CA2324513C (da)
DE (1)	DE69840035D1 (da)
DK (1)	DK1066328T3 (da)
ES (1)	ES2317665T3 (da)
IL (1)	IL138658A0 (da)
MX (1)	MXPA00009564A (da)
WO (1)	WO1999050302A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1179013A1 (en) *	1999-05-14	2002-02-13	Medical Research Council	Protein scaffold and its use to multimerise monomeric polypeptides
WO2000069886A2 (en) *	1999-05-14	2000-11-23	Medical Research Council	Oligomeric chaperone proteins
GB9913437D0 (en) *	1999-06-09	1999-08-11	Medical Res Council	Fusion proteins
US20020164712A1 (en) *	2000-12-11	2002-11-07	Tonghua Gantech Biotechnology Ltd.	Chimeric protein containing an intramolecular chaperone-like sequence
EP2336164A1 (en)	2005-12-22	2011-06-22	Genentech, Inc.	Recombinant production of heparin binding proteins
JP5566104B2 (ja) *	2006-07-14	2014-08-06	ジェネンテック，インコーポレイテッド	組み換えタンパク質の再折り畳み
US7951559B2 (en) *	2007-07-25	2011-05-31	E.I. Du Pont De Nemours And Company	Recombinant peptide production using a cross-linkable solubility tag
RU2447149C1 (ru) *	2011-03-24	2012-04-10	Винсорт Менеджемент Инк	РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА
CN102628072B (zh) *	2012-03-20	2013-12-04	甘李药业股份有限公司	一种胰岛素的制备方法
CN103439512B (zh) *	2013-07-30	2014-05-07	通化东宝药业股份有限公司	一种检测特异性重组人胰岛素大肠杆菌残留宿主蛋白的方法
CN112142848A (zh) *	2019-06-26	2020-12-29	中国科学院大连化学物理研究所	一种重组人胰岛素及其纯化制备方法
CN114805610B (zh) *	2022-06-23	2022-10-04	北京惠之衡生物科技有限公司	一种高表达甘精胰岛素前体的重组基因工程菌及其构建方法
CN114805544B (zh) *	2022-06-23	2022-09-09	北京惠之衡生物科技有限公司	一种赖脯胰岛素前体、其重组基因工程菌及其构建方法

Family Cites Families (18)

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US4342832A (en)	1979-07-05	1982-08-03	Genentech, Inc.	Method of constructing a replicable cloning vehicle having quasi-synthetic genes
NZ199391A (en)	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US5254463A (en)	1981-09-18	1993-10-19	Genentech, Inc.	Method for expression of bovine growth hormone
US4665160A (en) *	1982-03-22	1987-05-12	Genentech, Inc.	Novel human growth hormone like protein HGH-V encoded in the human genome
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
US5191063A (en)	1989-05-02	1993-03-02	University Of Medicine And Dentistry Of New Jersey	Production of biologically active polypeptides by treatment with an exogenous peptide sequence
US5358857A (en)	1989-08-29	1994-10-25	The General Hospital Corp.	Method of preparing fusion proteins
US5422110A (en) *	1991-10-16	1995-06-06	University Of Saskatchewan	Enhanced immunogenicity using leukotoxin chimeras
SG46612A1 (en)	1992-12-02	1998-02-20	Hoechst Ag	Process for obtaining proinsulin in processing correctly linked cystine bridges
EP0645454A3 (en) *	1993-06-22	1997-01-15	Vladimir Glebovich Lunin	Protein containing a chimeric somatostatin, coding DNA, immunogenic compositions, and method for improving the productivity of farmes animals.
US6001604A (en)	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
CZ290079B6 (cs)	1994-12-29	2002-05-15	Bio-Technology General Corp.	Způsob produkce inzulinu a meziprodukt pro tento způsob
CA2212006A1 (en) *	1995-02-03	1996-08-08	G.D. Searle & Co.	Novel c-mpl ligands
US5559128A (en)	1995-04-18	1996-09-24	Merck & Co., Inc.	3-substituted piperidines promote release of growth hormone
SE9504019D0 (sv) *	1995-11-13	1995-11-13	Pharmacia Ab	Method for production of proteins
AUPO394896A0 (en)	1996-11-29	1997-01-02	May, Peter Andrew John	Hose mounting bracket
US20020164712A1 (en) *	2000-12-11	2002-11-07	Tonghua Gantech Biotechnology Ltd.	Chimeric protein containing an intramolecular chaperone-like sequence
WO2002079251A2 (en) *	2001-04-02	2002-10-10	Novo Nordisk A/S	Method for making human insulin precursors

1998
- 1998-03-31 DK DK98912192T patent/DK1066328T3/da active
- 1998-03-31 US US09/423,100 patent/US6924120B1/en not_active Expired - Fee Related
- 1998-03-31 DE DE69840035T patent/DE69840035D1/de not_active Expired - Lifetime
- 1998-03-31 ES ES98912192T patent/ES2317665T3/es not_active Expired - Lifetime
- 1998-03-31 IL IL13865898A patent/IL138658A0/xx unknown
- 1998-03-31 WO PCT/CN1998/000052 patent/WO1999050302A1/en not_active Ceased
- 1998-03-31 BR BRPI9815788-4A patent/BR9815788B1/pt not_active IP Right Cessation
- 1998-03-31 KR KR1020007010951A patent/KR100554490B1/ko not_active Expired - Fee Related
- 1998-03-31 EP EP98912192A patent/EP1066328B1/en not_active Expired - Lifetime
- 1998-03-31 AT AT98912192T patent/ATE408631T1/de active
- 1998-03-31 CA CA2324513A patent/CA2324513C/en not_active Expired - Fee Related
- 1998-03-31 MX MXPA00009564A patent/MXPA00009564A/es unknown
- 1998-03-31 AU AU67164/98A patent/AU765574B2/en not_active Ceased
- 1998-03-31 CN CNB988139413A patent/CN1197876C/zh not_active Expired - Lifetime
- 1998-03-31 JP JP2000541204A patent/JP4472870B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69840035D1 (de)	2008-10-30
CA2324513A1 (en)	1999-10-07
EP1066328A1 (en)	2001-01-10
AU765574B2 (en)	2003-09-25
EP1066328B1 (en)	2008-09-17
MXPA00009564A (es)	2004-03-10
AU6716498A (en)	1999-10-18
CA2324513C (en)	2013-05-28
IL138658A0 (en)	2001-10-31
KR100554490B1 (ko)	2006-03-03
CN1291199A (zh)	2001-04-11
BR9815788B1 (pt)	2013-06-04
JP2004505601A (ja)	2004-02-26
US6924120B1 (en)	2005-08-02
ATE408631T1 (de)	2008-10-15
BR9815788A (pt)	2000-11-28
CN1197876C (zh)	2005-04-20
JP4472870B2 (ja)	2010-06-02
WO1999050302A1 (en)	1999-10-07
EP1066328A4 (en)	2002-06-05
KR20010042383A (ko)	2001-05-25
ES2317665T3 (es)	2009-04-16

Publication	Publication Date	Title
DK1066328T3 (da)	2009-02-09	Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion
IL157446A0 (en)	2004-03-28	Increased recovery of active proteins
EP3805248A3 (en)	2021-07-14	Process for concentration of antibodies and therapeutic products thereof
DK1761553T3 (da)	2010-02-01	MHC molecule-binding tumor-associated peptides
CY1112833T1 (el)	2016-02-10	Καινοφανης προσδετης της κυτοκινης ζcυτοr17
DK0981630T3 (da)	2009-03-09	Polypeptider med prolyldipeptidylaminopeptidaseaktivitet og nukleinsyrer, der koder for samme
WO2003020932A1 (en)	2003-03-13	Novel secretory proteins and dna thereof
DK0528932T3 (da)	1996-07-01	Protein associeret med akut pancreatitis og midler til diagnose af akut pancreatitis
DE50307984D1 (de)	2007-09-27	Streptavidin-Bindungspeptid
DK1417222T3 (da)	2010-12-13	Isolerede polypeptider baseret på den neutraliserende epitop af p17-proteinet fra HIV egnet til vacciner samt neutraliserende anti-p17-antistoffer, der specifikt genkender nævnte neutraliserende epitop
BR0213779A (pt)	2004-10-13	Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina
FI930626A0 (fi)	1993-02-12	Proteinstruktur hos vaexttoxingelonin
DE60219645D1 (de)	2007-05-31	Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft
EA200101161A1 (ru)	2002-06-27	Способ получения рекомбинантного инсулина из новых гибридных белков
DK1387854T3 (da)	2012-07-09	SFRP og peptidmotiver som interagerer med SFRP og fremgangsmåder til anvendelse deraf
DK1127064T3 (da)	2006-05-22	Hidtil ukendte aminosyresekvenser, DNA, der koder for aminosyresekvenserme, antistoffer, der er rettet mod sådanne sekvenser, og forskellige anvendelser deraf
NO20012232L (no)	2001-05-04	Enzymatisk amidering av peptider
EA200400392A1 (ru)	2004-10-28	Связывающий каспазу-8 белок, его получение и применение
WO2002102847A1 (fr)	2002-12-27	Nouveau ligand et son adn
NO20052552D0 (no)	2005-05-26	Loselige Notch-baserte substrater for gamma-sekretase og fremgangsmater og blandinger for anvendelse av samme.
ATE466874T1 (de)	2010-05-15	Mit scytovirin der domäne 1 verwandte polypeptide
AU2002341238A1 (en)	2003-03-10	Diabetic model
WO2002038765A3 (en)	2004-02-26	Dna encoding bovine immunoglobulin a inducing protein and uses therefor
WO2002063009A8 (en)	2004-04-22	Lp mammalian proteins; related reagents
WO2003027150A1 (fr)	2003-04-03	Anticorps et son utilisation