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DK1063228T5 - Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Info

Publication number
DK1063228T5
DK1063228T5 DK99907879T DK99907879T DK1063228T5 DK 1063228 T5 DK1063228 T5 DK 1063228T5 DK 99907879 T DK99907879 T DK 99907879T DK 99907879 T DK99907879 T DK 99907879T DK 1063228 T5 DK1063228 T5 DK 1063228T5
Authority
DK
Denmark
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Application number
DK99907879T
Other languages
Danish (da)
English (en)
Other versions
DK1063228T3 (da
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of DK1063228T3 publication Critical patent/DK1063228T3/da
Publication of DK1063228T5 publication Critical patent/DK1063228T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silicon Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK99907879T 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf DK1063228T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (fr) 1998-03-09 1999-03-08 Derives de cycloalcene, leur procede de fabrication et d'utilisation

Publications (2)

Publication Number Publication Date
DK1063228T3 DK1063228T3 (da) 2005-04-25
DK1063228T5 true DK1063228T5 (da) 2009-06-15

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99907879T DK1063228T5 (da) 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Country Status (19)

Country Link
US (1) US6495604B1 (fr)
EP (2) EP1524263A1 (fr)
JP (2) JP3665712B2 (fr)
KR (4) KR20050071719A (fr)
CN (1) CN100432049C (fr)
AT (1) ATE287393T1 (fr)
AU (1) AU747521B2 (fr)
BR (1) BR9908610A (fr)
CA (1) CA2320467C (fr)
DE (1) DE69923300T2 (fr)
DK (1) DK1063228T5 (fr)
ES (1) ES2232114T3 (fr)
HU (1) HU230061B1 (fr)
ID (1) ID25649A (fr)
NO (1) NO326426B1 (fr)
NZ (1) NZ505874A (fr)
PT (1) PT1063228E (fr)
RU (1) RU2214398C2 (fr)
WO (1) WO1999046242A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2214398C2 (ru) 1998-03-09 2003-10-20 Такеда Кемикал Индастриз, Лтд. Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
CN1210257C (zh) 1999-08-06 2005-07-13 武田药品工业株式会社 取代的芳香环化合物及其制备方法和用途
AU1553001A (en) * 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
KR100784752B1 (ko) * 2000-02-04 2007-12-13 다케다 야쿠힌 고교 가부시키가이샤 안정한 에멀젼 조성물
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
WO2002013816A1 (fr) * 2000-08-10 2002-02-21 Takeda Chemical Industries, Ltd. Composition pharmaceutique
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
KR100821546B1 (ko) 2000-10-18 2008-04-11 다케다 야쿠힌 고교 가부시키가이샤 광학 활성 술폰아미드의 제조 방법 및 그의 합성용 중간체
CA2431206C (fr) * 2000-12-08 2009-09-01 Takeda Chemical Industries, Ltd. Medicaments combines contenant un compose cycloalcene antisepticemique
DE60233647D1 (de) 2001-03-21 2009-10-22 Eisai R&D Man Co Ltd Reduziertes vitamin b2 enthaltende arzneimittel
US7960416B2 (en) * 2001-08-03 2011-06-14 Takeda Pharmaceutical Company Limited Stable emulsion composition
US20060058288A1 (en) * 2002-04-08 2006-03-16 Masayuki Ii Severe sepsis preventive therapeutic agent
US7511042B2 (en) 2003-12-03 2009-03-31 Boehringer Ingelheim Pharmaceuticals, Inc. Triazole compounds
TWI462745B (zh) * 2005-04-28 2014-12-01 Takeda Pharmaceutical 安定的乳化組成物
AU2006289921B2 (en) * 2005-09-14 2010-11-18 Daiichi Sankyo Company, Limited Substituted cycloalkene derivative
WO2007114296A1 (fr) 2006-03-30 2007-10-11 Hiroshima University Procede de criblage
US20090062355A1 (en) 2006-04-20 2009-03-05 Takeda Pharmaceutical Company Limited Pharmaceutical Product
JPWO2007132825A1 (ja) * 2006-05-15 2009-09-24 武田薬品工業株式会社 医薬
US20090209585A1 (en) * 2006-07-07 2009-08-20 Takashi Ichikawa Cycloalkene derivatives, process for production of the derivatives, and use of the same
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
NZ601635A (en) 2010-01-27 2013-06-28 Takeda Pharmaceutical Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent
ES2620243T3 (es) 2010-09-24 2017-06-28 Daiichi Sankyo Company, Limited Procedimiento de preparación de cristales de un derivado de cicloalqueno sustituido
WO2014008273A2 (fr) * 2012-07-03 2014-01-09 Jay Pravda Méthodes de traitement, de diagnostic et/ou de suivi de la progression d'états associés à un stress oxydatif
US9364438B2 (en) 2012-09-26 2016-06-14 Takeda Pharmaceutical Company Limited Process for producing solid particles
US9611244B2 (en) 2015-05-08 2017-04-04 Takeda Pharmaceutical Company Limited Cyclic compounds
EP3511320A4 (fr) 2016-09-09 2020-04-15 Takeda Pharmaceutical Company Limited Composé cyclique
US20200247761A1 (en) * 2017-02-24 2020-08-06 Taiwanj Pharmaceuticals Co., Ltd Sulfonamide or amide compounds, compositions and methods for the prophylaxis and/or treatment of autoimmune, inflammation or infection related disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0154343B1 (ko) 1990-11-06 1998-11-16 아만 히데아키 동결 건조 제제 및 이의 제조방법
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
HUT74735A (en) 1994-02-25 1997-02-28 Takeda Chemical Industries Ltd Injectable emulsion composition containing antifungal triazole derivatives and process for producing it
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
EP0776886A4 (fr) * 1994-08-18 1999-05-12 Chugai Pharmaceutical Co Ltd Derives aminoacides exer ant une activite inhibitrice de la synthetase du monoxyde d'azote
RU2214398C2 (ru) 1998-03-09 2003-10-20 Такеда Кемикал Индастриз, Лтд. Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения
KR100784752B1 (ko) 2000-02-04 2007-12-13 다케다 야쿠힌 고교 가부시키가이샤 안정한 에멀젼 조성물

Also Published As

Publication number Publication date
CA2320467A1 (fr) 1999-09-16
AU747521B2 (en) 2002-05-16
KR100492098B1 (ko) 2005-06-01
JP3665712B2 (ja) 2005-06-29
EP1524263A1 (fr) 2005-04-20
JP2000178246A (ja) 2000-06-27
HUP0101192A3 (en) 2003-09-29
KR100577044B1 (ko) 2006-05-08
DE69923300D1 (de) 2005-02-24
AU747521C (en) 1999-09-27
KR20060017921A (ko) 2006-02-27
ATE287393T1 (de) 2005-02-15
EP1063228A1 (fr) 2000-12-27
AU2746499A (en) 1999-09-27
CA2320467C (fr) 2010-05-04
CN1291184A (zh) 2001-04-11
EP1063228A4 (fr) 2001-08-08
KR20050026075A (ko) 2005-03-14
US6495604B1 (en) 2002-12-17
HUP0101192A2 (hu) 2001-08-28
JP2005232168A (ja) 2005-09-02
PT1063228E (pt) 2005-05-31
NZ505874A (en) 2003-09-26
CN100432049C (zh) 2008-11-12
PL342826A1 (en) 2001-07-02
HU230061B1 (hu) 2015-06-29
ID25649A (id) 2000-10-19
NO20004485L (no) 2000-09-08
ES2232114T3 (es) 2005-05-16
HK1031723A1 (en) 2001-06-22
RU2214398C2 (ru) 2003-10-20
KR20050071719A (ko) 2005-07-07
DK1063228T3 (da) 2005-04-25
NO326426B1 (no) 2008-12-01
JP4342453B2 (ja) 2009-10-14
BR9908610A (pt) 2000-12-05
EP1063228B1 (fr) 2005-01-19
WO1999046242A1 (fr) 1999-09-16
NO20004485D0 (no) 2000-09-08
KR100779889B1 (ko) 2007-11-28
KR20010034555A (ko) 2001-04-25
DE69923300T2 (de) 2006-01-05

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