DK1052246T3 - Fluorholdige aminosyrederivater - Google Patents
Fluorholdige aminosyrederivaterInfo
- Publication number
- DK1052246T3 DK1052246T3 DK99901877T DK99901877T DK1052246T3 DK 1052246 T3 DK1052246 T3 DK 1052246T3 DK 99901877 T DK99901877 T DK 99901877T DK 99901877 T DK99901877 T DK 99901877T DK 1052246 T3 DK1052246 T3 DK 1052246T3
- Authority
- DK
- Denmark
- Prior art keywords
- fluorine
- disturbance
- amino acid
- acid derivatives
- containing amino
- Prior art date
Links
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- 239000011737 fluorine Substances 0.000 title abstract 3
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000003823 glutamate receptor agonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000004899 motility Effects 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1544498 | 1998-01-28 | ||
| PCT/JP1999/000324 WO1999038839A1 (fr) | 1998-01-28 | 1999-01-27 | Derives d'acides amines renfermant du fluor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1052246T3 true DK1052246T3 (da) | 2003-06-16 |
Family
ID=11888991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99901877T DK1052246T3 (da) | 1998-01-28 | 1999-01-27 | Fluorholdige aminosyrederivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6316498B1 (fr) |
| EP (1) | EP1052246B1 (fr) |
| KR (1) | KR100446892B1 (fr) |
| CN (1) | CN1182105C (fr) |
| AT (1) | ATE236118T1 (fr) |
| AU (1) | AU734812B2 (fr) |
| CA (1) | CA2318800C (fr) |
| DE (1) | DE69906492T2 (fr) |
| DK (1) | DK1052246T3 (fr) |
| ES (1) | ES2191412T3 (fr) |
| PT (1) | PT1052246E (fr) |
| WO (1) | WO1999038839A1 (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1110943E (pt) | 1998-08-31 | 2004-08-31 | Taisho Pharmaceutical Co Ltd | Derivados 6-fluorobiciclo¬3.1.0|hexano |
| WO2000037410A1 (fr) | 1998-12-18 | 2000-06-29 | Taisho Pharmaceutical Co., Ltd. | Intermediaires et procedes de production de compose aminoacide contenant du fluor utilisant ces intermediaires |
| WO2002040002A2 (fr) * | 2000-10-30 | 2002-05-23 | Annovis, Inc. | Procede de modulation, de stimulation et d'inhibition de la reabsorption du glutamate |
| US7038077B2 (en) | 2001-01-11 | 2006-05-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| US7256217B2 (en) | 2001-01-11 | 2007-08-14 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1310480A1 (fr) * | 2001-11-07 | 2003-05-14 | Eli Lilly & Company | Prodrugs d'aminoacides excitants |
| KR20030083732A (ko) * | 2001-03-14 | 2003-10-30 | 다이쇼 세이야꾸 가부시끼가이샤 | 비시클로카르복실산 유도체의 제조 방법 |
| US7456221B2 (en) | 2001-12-21 | 2008-11-25 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| ATE421526T1 (de) | 2002-06-11 | 2009-02-15 | Lilly Co Eli | Prodrugs von exzitatorischen aminosäuren |
| JPWO2006137469A1 (ja) * | 2005-06-22 | 2009-01-22 | 味の素株式会社 | 代謝型グルタミン酸受容体活性化剤 |
| TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TWI475995B (zh) | 2007-09-14 | 2015-03-11 | Janssen Pharmaceuticals Inc | １’，３’－二取代－４－苯基－３，４，５，６－四氫－２ｈ，１’ｈ－〔１，４’〕聯吡啶基－２’－酮化物 |
| ATE516272T1 (de) | 2007-09-14 | 2011-07-15 | Ortho Mcneil Janssen Pharm | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one |
| JP5433579B2 (ja) * | 2007-09-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン |
| AU2008323287B2 (en) * | 2007-11-14 | 2011-07-14 | Addex Pharma S.A. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| EP2344470B1 (fr) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | Dérivés de 3-azabicyclo[3.1.0]hexyle comme modulateurs des récepteurs métabotropiques du glutamate |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| ES2440001T3 (es) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
| US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| WO2012062751A1 (fr) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | Dérivés de 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2 |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA2836485C (fr) | 2011-06-17 | 2016-12-13 | Eli Lilly And Company | Derives d'acide bicyclo(3.1.0)hexane-2,6-dicarboxylique en tant qu'agoniste du recepteur mglu2 |
| MY169069A (en) * | 2012-06-01 | 2019-02-12 | Taisho Pharmaceutical Co Ltd | Prodrug of fluorine-containing amino acid |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| PH12019500127B1 (en) | 2014-01-21 | 2022-05-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| EP3424535A1 (fr) | 2014-01-21 | 2019-01-09 | Janssen Pharmaceutica NV | Combinaisons comprenant des modulateurs allostériques positifs ou des agonistes orthostériques de récepteurs glutamatergiques métabotropes de sous-type 2 et leur utilisation |
| CN105017048A (zh) * | 2015-07-01 | 2015-11-04 | 上海应用技术学院 | 一种含有四取代碳手性中心的α-氟烷基-α-氨基酸类化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| US5750566A (en) | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
-
1999
- 1999-01-27 CA CA002318800A patent/CA2318800C/fr not_active Expired - Fee Related
- 1999-01-27 EP EP99901877A patent/EP1052246B1/fr not_active Expired - Lifetime
- 1999-01-27 ES ES99901877T patent/ES2191412T3/es not_active Expired - Lifetime
- 1999-01-27 CN CNB99804606XA patent/CN1182105C/zh not_active Expired - Fee Related
- 1999-01-27 PT PT99901877T patent/PT1052246E/pt unknown
- 1999-01-27 DE DE69906492T patent/DE69906492T2/de not_active Expired - Lifetime
- 1999-01-27 US US09/601,131 patent/US6316498B1/en not_active Expired - Lifetime
- 1999-01-27 AU AU21835/99A patent/AU734812B2/en not_active Ceased
- 1999-01-27 KR KR10-2000-7008189A patent/KR100446892B1/ko not_active Expired - Fee Related
- 1999-01-27 WO PCT/JP1999/000324 patent/WO1999038839A1/fr not_active Ceased
- 1999-01-27 AT AT99901877T patent/ATE236118T1/de active
- 1999-01-27 DK DK99901877T patent/DK1052246T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2183599A (en) | 1999-08-16 |
| CA2318800C (fr) | 2005-12-20 |
| EP1052246B1 (fr) | 2003-04-02 |
| US6316498B1 (en) | 2001-11-13 |
| DE69906492D1 (de) | 2003-05-08 |
| EP1052246A4 (fr) | 2001-11-07 |
| KR20010034418A (ko) | 2001-04-25 |
| WO1999038839A1 (fr) | 1999-08-05 |
| EP1052246A1 (fr) | 2000-11-15 |
| HK1036792A1 (en) | 2002-01-18 |
| CN1182105C (zh) | 2004-12-29 |
| ATE236118T1 (de) | 2003-04-15 |
| ES2191412T3 (es) | 2003-09-01 |
| DE69906492T2 (de) | 2003-12-18 |
| AU734812B2 (en) | 2001-06-21 |
| KR100446892B1 (ko) | 2004-09-04 |
| CA2318800A1 (fr) | 1999-08-25 |
| PT1052246E (pt) | 2003-06-30 |
| CN1295557A (zh) | 2001-05-16 |
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