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ES2191412T3 - Derivados de aminoacidos que contienen fluor. - Google Patents

Derivados de aminoacidos que contienen fluor.

Info

Publication number
ES2191412T3
ES2191412T3 ES99901877T ES99901877T ES2191412T3 ES 2191412 T3 ES2191412 T3 ES 2191412T3 ES 99901877 T ES99901877 T ES 99901877T ES 99901877 T ES99901877 T ES 99901877T ES 2191412 T3 ES2191412 T3 ES 2191412T3
Authority
ES
Spain
Prior art keywords
derivatives
amino acids
acids containing
containing fluor
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99901877T
Other languages
English (en)
Inventor
Atsuro Taisho Pharmac Nakazato
Toshihito Taisho Pharm Kumagai
Kazunari Taisho Pharm Sakagami
Kazuyuki Taisho Pharm Tomisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2191412T3 publication Critical patent/ES2191412T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un derivado de aminoácido que contiene flor representado por la fórmula **(Fórmula)** [en la que X1 representa un átomo de hidrógeno o un átomo de flúor, y R1 y R2 son iguales o diferentes y cada uno representa un átomo de hidrógeno o un grupo alquilo de 1 a 10 átomos de carbono], una sal del mismo farmacéuticamente permisible o un hidrato del mismo.
ES99901877T 1998-01-28 1999-01-27 Derivados de aminoacidos que contienen fluor. Expired - Lifetime ES2191412T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1544498 1998-01-28

Publications (1)

Publication Number Publication Date
ES2191412T3 true ES2191412T3 (es) 2003-09-01

Family

ID=11888991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99901877T Expired - Lifetime ES2191412T3 (es) 1998-01-28 1999-01-27 Derivados de aminoacidos que contienen fluor.

Country Status (12)

Country Link
US (1) US6316498B1 (es)
EP (1) EP1052246B1 (es)
KR (1) KR100446892B1 (es)
CN (1) CN1182105C (es)
AT (1) ATE236118T1 (es)
AU (1) AU734812B2 (es)
CA (1) CA2318800C (es)
DE (1) DE69906492T2 (es)
DK (1) DK1052246T3 (es)
ES (1) ES2191412T3 (es)
PT (1) PT1052246E (es)
WO (1) WO1999038839A1 (es)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
CN1247527C (zh) 1998-08-31 2006-03-29 大正制药株式会社 6－氟双环[3.1.0]己烷衍生物
DK1142860T3 (da) 1998-12-18 2004-11-22 Taisho Pharmaceutical Co Ltd Mellemprodukter og fremgangsmåde til fremstilling af en fluorholdig aminosyreforbindelse ved anvendelse deraf
EP1365758A2 (en) * 2000-10-30 2003-12-03 Annovis, Inc. Method for modulation, stimulation, and inhibition of glutamate reuptake
US7038077B2 (en) 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
IL156364A0 (en) 2001-01-11 2004-01-04 Lilly Co Eli Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
CA2441127A1 (en) * 2001-03-14 2002-09-19 Taisho Pharmaceutical Co., Ltd. Process for producing bicyclocarboxylic acid derivative
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
DE60325968D1 (de) * 2002-06-11 2009-03-12 Lilly Co Eli Prodrugs von exzitatorischen aminosäuren
EP1908492A4 (en) * 2005-06-22 2008-12-10 Ajinomoto Kk METABOTROPIC GLUTAMATE RECEPTOR ACTIVATOR
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US8722894B2 (en) * 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
SI2203439T1 (sl) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
NZ584152A (en) 2007-09-14 2011-11-25 Ortho Mcneil Janssen Pharm 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
PT2649069E (pt) 2010-11-08 2015-11-20 Janssen Pharmaceuticals Inc Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2
US9296710B2 (en) 2011-06-17 2016-03-29 Eli Lilly And Company Bicyclo (3.1.0) hexane-2, 6-dicarboxylic acid derivatives as mGlu2 receptor agonist
BR112014029478B1 (pt) 2012-06-01 2023-01-17 Taisho Pharmaceutical Co., Ltd Compostos, fármacos de aminoácido contendo flúor e uso destes
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
AU2015208233B2 (en) 2014-01-21 2019-08-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
ES2860298T3 (es) 2014-01-21 2021-10-04 Janssen Pharmaceutica Nv Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
CN105017048A (zh) * 2015-07-01 2015-11-04 上海应用技术学院 一种含有四取代碳手性中心的α-氟烷基-α-氨基酸类化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL182285B1 (pl) 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
US5661184A (en) 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
ZA983930B (en) 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.

Also Published As

Publication number Publication date
CN1295557A (zh) 2001-05-16
DE69906492D1 (de) 2003-05-08
US6316498B1 (en) 2001-11-13
PT1052246E (pt) 2003-06-30
EP1052246B1 (en) 2003-04-02
ATE236118T1 (de) 2003-04-15
CA2318800C (en) 2005-12-20
HK1036792A1 (en) 2002-01-18
DE69906492T2 (de) 2003-12-18
DK1052246T3 (da) 2003-06-16
EP1052246A1 (en) 2000-11-15
WO1999038839A1 (en) 1999-08-05
KR100446892B1 (ko) 2004-09-04
KR20010034418A (ko) 2001-04-25
CA2318800A1 (en) 1999-08-25
EP1052246A4 (en) 2001-11-07
AU734812B2 (en) 2001-06-21
CN1182105C (zh) 2004-12-29
AU2183599A (en) 1999-08-16

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