DK0904270T3 - Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midler - Google Patents
Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midlerInfo
- Publication number
- DK0904270T3 DK0904270T3 DK97904016T DK97904016T DK0904270T3 DK 0904270 T3 DK0904270 T3 DK 0904270T3 DK 97904016 T DK97904016 T DK 97904016T DK 97904016 T DK97904016 T DK 97904016T DK 0904270 T3 DK0904270 T3 DK 0904270T3
- Authority
- DK
- Denmark
- Prior art keywords
- branched
- straight
- dihydrobenzofuran
- cyclic alkyl
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/595,122 US5684031A (en) | 1996-02-01 | 1996-02-01 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| PCT/US1997/001311 WO1997028145A1 (fr) | 1996-02-01 | 1997-01-30 | Composes de dihydrobenzofurane utilises comme agents anti-inflammatoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0904270T3 true DK0904270T3 (da) | 2003-12-01 |
Family
ID=24381828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97904016T DK0904270T3 (da) | 1996-02-01 | 1997-01-30 | Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5684031A (fr) |
| EP (1) | EP0904270B1 (fr) |
| JP (1) | JP3095423B2 (fr) |
| KR (1) | KR100322400B1 (fr) |
| CN (1) | CN1109680C (fr) |
| AT (1) | ATE250594T1 (fr) |
| AU (1) | AU730263B2 (fr) |
| BR (1) | BR9707321A (fr) |
| CA (1) | CA2244402C (fr) |
| DE (1) | DE69725133T2 (fr) |
| DK (1) | DK0904270T3 (fr) |
| ES (1) | ES2208872T3 (fr) |
| MX (1) | MX9806249A (fr) |
| NO (1) | NO983527L (fr) |
| WO (1) | WO1997028145A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866579A (en) * | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| EP3827747A1 (fr) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Système pharma-informatique |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551456A (en) * | 1968-04-18 | 1970-12-29 | Universal Oil Prod Co | Acetyl derivatives of substituted chromans and coumarans |
| JPS6031829B2 (ja) * | 1975-06-26 | 1985-07-24 | ウェルファイド株式会社 | アミノアルコ−ル誘導体の製造法 |
| FR2370472A2 (fr) * | 1976-11-10 | 1978-06-09 | Continental Pharma | Amino-alcool heterocyclique, son sel et son procede de preparation |
| FR2332010A1 (fr) * | 1975-11-18 | 1977-06-17 | Continental Pharma | Amino-alcool heterocyclique, son sel et son procede de preparation |
| CH615031A5 (fr) * | 1976-04-30 | 1979-12-28 | Gretag Ag | |
| JPS6019305B2 (ja) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | ジヒドロベンゾフラン誘導体 |
| JPS603305B2 (ja) * | 1976-12-27 | 1985-01-26 | エーザイ株式会社 | ２，３―ジハイドロベンゾフラン誘導体 |
| US4398028A (en) * | 1977-01-14 | 1983-08-09 | Sandoz Ltd. | Bicyclic heterocyclic amino derivatives |
| US4130666A (en) * | 1977-05-16 | 1978-12-19 | Riker Laboratories, Inc. | Anti-inflammatory method |
| IT1093805B (it) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione |
| EP0026593A1 (fr) * | 1979-09-15 | 1981-04-08 | Pfizer Limited | Céto- et aminoacides, esters et amides bicycliques et compositions pharmaceutiques les contenant |
| US4470440A (en) * | 1982-09-30 | 1984-09-11 | Thor Harry A | Impact producing tool |
| GR81257B (fr) * | 1982-12-04 | 1984-12-11 | Lilly Industries Ltd | |
| EP0117675B1 (fr) * | 1983-02-19 | 1986-07-23 | Beecham Group Plc | Dérivés d'acide benzofuranne- et benzothiophène carboxylique |
| FI842738A7 (fi) * | 1983-07-14 | 1985-01-15 | Syntex Inc | Aroyylibentsofuraani- ja bentsotiofeenietikka- ja propionihapot. |
| US4613611A (en) * | 1983-10-14 | 1986-09-23 | American Cyanamid Company | Method of treating diabetes mellitus using arylglyoxals |
| AU4261285A (en) * | 1984-06-01 | 1985-12-05 | Tokyo Tanabe Company Limited | 1-propanone derivatives |
| US4708966A (en) * | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
| DE3777366D1 (de) * | 1986-12-27 | 1992-04-16 | Takeda Chemical Industries Ltd | 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung. |
| FR2613365B1 (fr) * | 1987-04-01 | 1989-07-28 | Adir | Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2613364B1 (fr) * | 1987-04-01 | 1989-06-09 | Adir | Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
| US4982006A (en) * | 1987-12-18 | 1991-01-01 | Norwich Eaton Pharmaceuticals, Inc. | Process for the preparation of certain substituted aromatic compounds |
| IL88674A0 (en) * | 1987-12-18 | 1989-07-31 | Norwich Eaton Pharma | Preparation of certain substituted aromatic compounds |
| JPH07121933B2 (ja) * | 1988-03-28 | 1995-12-25 | キッセイ薬品工業株式会社 | ジヒドロベンゾフラノン誘導体 |
| JP2855341B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 新規２―置換クマラン誘導体 |
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| FR2645537B1 (fr) * | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
| US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
| JP2808460B2 (ja) * | 1989-11-16 | 1998-10-08 | 大正製薬株式会社 | イミダゾール誘導体 |
| US5244918A (en) * | 1989-11-17 | 1993-09-14 | Meiji Milk Products Co., Ltd. | Benzofuran derivative and pharmaceutical comprising the same as active ingredient |
| JPH03215485A (ja) * | 1990-01-11 | 1991-09-20 | Taisho Pharmaceut Co Ltd | ベンゾチエニルイミダゾール誘導体 |
| US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
| JPH05505610A (ja) * | 1990-03-27 | 1993-08-19 | スミスクライン・ビーチャム・コーポレイション | ５―リポキシゲナーゼ阻害剤 |
| TW197435B (fr) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| TW229142B (fr) * | 1992-04-15 | 1994-09-01 | Nissan Detrochem Corp | |
| JPH06263733A (ja) * | 1993-01-14 | 1994-09-20 | Sankyo Co Ltd | ベンゼン誘導体 |
| JPH10506615A (ja) * | 1994-07-27 | 1998-06-30 | ザ、プロクター、エンド、ギャンブル、カンパニー | 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物 |
| US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
-
1996
- 1996-02-01 US US08/595,122 patent/US5684031A/en not_active Expired - Fee Related
-
1997
- 1997-01-30 AT AT97904016T patent/ATE250594T1/de not_active IP Right Cessation
- 1997-01-30 EP EP97904016A patent/EP0904270B1/fr not_active Expired - Lifetime
- 1997-01-30 JP JP09527759A patent/JP3095423B2/ja not_active Expired - Fee Related
- 1997-01-30 ES ES97904016T patent/ES2208872T3/es not_active Expired - Lifetime
- 1997-01-30 CN CN97192020A patent/CN1109680C/zh not_active Expired - Fee Related
- 1997-01-30 DK DK97904016T patent/DK0904270T3/da active
- 1997-01-30 KR KR1019980705948A patent/KR100322400B1/ko not_active Expired - Fee Related
- 1997-01-30 BR BR9707321A patent/BR9707321A/pt not_active IP Right Cessation
- 1997-01-30 WO PCT/US1997/001311 patent/WO1997028145A1/fr not_active Ceased
- 1997-01-30 AU AU18430/97A patent/AU730263B2/en not_active Ceased
- 1997-01-30 DE DE69725133T patent/DE69725133T2/de not_active Expired - Fee Related
- 1997-01-30 CA CA002244402A patent/CA2244402C/fr not_active Expired - Fee Related
-
1998
- 1998-07-31 NO NO983527A patent/NO983527L/no not_active Application Discontinuation
- 1998-08-03 MX MX9806249A patent/MX9806249A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO983527D0 (no) | 1998-07-31 |
| CA2244402C (fr) | 2003-10-07 |
| WO1997028145A1 (fr) | 1997-08-07 |
| NO983527L (no) | 1998-09-28 |
| ES2208872T3 (es) | 2004-06-16 |
| CN1210532A (zh) | 1999-03-10 |
| KR100322400B1 (ko) | 2002-05-09 |
| US5684031A (en) | 1997-11-04 |
| CN1109680C (zh) | 2003-05-28 |
| JP3095423B2 (ja) | 2000-10-03 |
| DE69725133T2 (de) | 2004-07-15 |
| ATE250594T1 (de) | 2003-10-15 |
| AU1843097A (en) | 1997-08-22 |
| EP0904270B1 (fr) | 2003-09-24 |
| CA2244402A1 (fr) | 1997-08-07 |
| DE69725133D1 (de) | 2003-10-30 |
| EP0904270A1 (fr) | 1999-03-31 |
| BR9707321A (pt) | 1999-04-13 |
| AU730263B2 (en) | 2001-03-01 |
| JPH11506120A (ja) | 1999-06-02 |
| MX9806249A (es) | 1998-11-30 |
| KR19990082220A (ko) | 1999-11-25 |
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