DK0727983T3 - Fremgangsmåde til fremstilling af et clodronat-præparat - Google Patents

Fremgangsmåde til fremstilling af et clodronat-præparat

Info

Publication number: DK0727983T3
Authority: DK; Denmark
Prior art keywords: clodronate; pct; preparation; tetrahydrate; disodium
Prior art date: 1993-11-12

Application number

DK95900155T

Other languages

English (en)

Inventor

Esko Pohjala

Kari Lehmussaari

Heikki Nupponen

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1994-11-11

Publication date

2001-09-24

1994-11-11 Application filed by Leiras Oy filed Critical Leiras Oy

2001-09-24 Application granted granted Critical

2001-09-24 Publication of DK0727983T3 publication Critical patent/DK0727983T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Medicinal Preparation (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Ceramic Products (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Seasonings (AREA)
Glanulating (AREA)
Peptides Or Proteins (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Detergent Compositions (AREA)
Glass Compositions (AREA)

DK95900155T 1993-11-12 1994-11-11 Fremgangsmåde til fremstilling af et clodronat-præparat DK0727983T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI935019A FI94926C (fi)	1993-11-12	1993-11-12	Menetelmä klodronaattivalmisteen valmistamiseksi
PCT/FI1994/000509 WO1995013054A1 (en)	1993-11-12	1994-11-11	Process for preparing a clodronate preparation

Publications (1)

Publication Number	Publication Date
DK0727983T3 true DK0727983T3 (da)	2001-09-24

Family

ID=8538945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95900155T DK0727983T3 (da)	1993-11-12	1994-11-11	Fremgangsmåde til fremstilling af et clodronat-præparat

Country Status (25)

Country	Link
US (1)	US5776499A (da)
EP (1)	EP0727983B1 (da)
JP (1)	JPH09504800A (da)
KR (1)	KR100352155B1 (da)
CN (1)	CN1040945C (da)
AT (1)	ATE202700T1 (da)
AU (1)	AU679586B2 (da)
CA (1)	CA2175994A1 (da)
CZ (1)	CZ286132B6 (da)
DE (1)	DE69427648T2 (da)
DK (1)	DK0727983T3 (da)
ES (1)	ES2160688T3 (da)
FI (1)	FI94926C (da)
GR (1)	GR3036470T3 (da)
HU (1)	HU220633B1 (da)
IL (1)	IL111596A (da)
NO (1)	NO312938B1 (da)
NZ (1)	NZ275833A (da)
PL (1)	PL176658B1 (da)
PT (1)	PT727983E (da)
RU (1)	RU2141323C1 (da)
SK (1)	SK280552B6 (da)
TW (1)	TW436297B (da)
WO (1)	WO1995013054A1 (da)
ZA (1)	ZA948974B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI109088B (fi) *	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) *	1998-02-24	1999-08-26	Schering Ag	Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es)	1999-10-20	2002-07-17	Cipla Ltd	Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro)	2001-07-04	2008-07-30	Sindan S.R.L.	Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
GB0616794D0 (en) *	2006-08-24	2006-10-04	Arrow Int Ltd	Solid dosage form
WO2017111643A1 (ru) *	2015-12-22	2017-06-29	Акционерное Общество "Чепецкий Механический Завод" (Ао Чмз)	Способ изготовления прутков из сплавов на основе титана
EP3713581A1 (en)	2017-11-22	2020-09-30	Inbiomotion S.L.	Therapeutic treatment of breast cancer based on c-maf
TWI806467B (zh)	2022-03-03	2023-06-21	金兆豐數位科技股份有限公司	金融商品提昇報酬率多維度決策方法
IT202300007269A1 (it)	2023-04-14	2024-10-14	Univ Degli Studi Magna Graecia Di Catanzaro	Formulazione farmaceutica composta da Peptide-C associato a un bisfosfonato in forma unica e suo uso nel trattamento dell’osteosarcopenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2040733T3 (es) *	1986-12-20	1993-11-01	Boehringer Mannheim Gmbh	Medicamentos que contienen clodronato y procedimiento para su preparacion.
SE501389C2 (sv) *	1992-04-24	1995-01-30	Leiras Oy	Farmaceutiskt preparat och förfarande för dess framställning
ATE128363T1 (de) *	1993-05-15	1995-10-15	Boehringer Mannheim Gmbh	Tablette mit verbesserter bioverfügbarkeit enthaltend dichlormethylendiphosphonsäure als wirkstoff.

1993
- 1993-11-12 FI FI935019A patent/FI94926C/fi not_active IP Right Cessation
1994
- 1994-11-10 IL IL11159694A patent/IL111596A/en active IP Right Grant
- 1994-11-11 AU AU81087/94A patent/AU679586B2/en not_active Ceased
- 1994-11-11 CA CA002175994A patent/CA2175994A1/en not_active Abandoned
- 1994-11-11 US US08/646,359 patent/US5776499A/en not_active Expired - Lifetime
- 1994-11-11 ES ES95900155T patent/ES2160688T3/es not_active Expired - Lifetime
- 1994-11-11 CN CN94194083A patent/CN1040945C/zh not_active Expired - Fee Related
- 1994-11-11 AT AT95900155T patent/ATE202700T1/de not_active IP Right Cessation
- 1994-11-11 NZ NZ275833A patent/NZ275833A/en unknown
- 1994-11-11 SK SK606-96A patent/SK280552B6/sk unknown
- 1994-11-11 KR KR1019960702481A patent/KR100352155B1/ko not_active Expired - Fee Related
- 1994-11-11 DE DE69427648T patent/DE69427648T2/de not_active Expired - Fee Related
- 1994-11-11 PL PL94314299A patent/PL176658B1/pl unknown
- 1994-11-11 EP EP95900155A patent/EP0727983B1/en not_active Expired - Lifetime
- 1994-11-11 DK DK95900155T patent/DK0727983T3/da active
- 1994-11-11 RU RU96113106A patent/RU2141323C1/ru not_active IP Right Cessation
- 1994-11-11 WO PCT/FI1994/000509 patent/WO1995013054A1/en not_active Ceased
- 1994-11-11 JP JP7513620A patent/JPH09504800A/ja not_active Ceased
- 1994-11-11 CZ CZ19961327A patent/CZ286132B6/cs not_active IP Right Cessation
- 1994-11-11 HU HU9601257A patent/HU220633B1/hu not_active IP Right Cessation
- 1994-11-11 ZA ZA948974A patent/ZA948974B/xx unknown
- 1994-11-11 PT PT95900155T patent/PT727983E/pt unknown
- 1994-11-17 TW TW083110664A patent/TW436297B/zh not_active IP Right Cessation
1996
- 1996-05-10 NO NO19961906A patent/NO312938B1/no unknown
2001
- 2001-08-30 GR GR20010401329T patent/GR3036470T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2141323C1 (ru)	1999-11-20
HU9601257D0 (en)	1996-07-29
TW436297B (en)	2001-05-28
DE69427648T2 (de)	2002-04-18
KR100352155B1 (ko)	2002-12-31
AU8108794A (en)	1995-05-29
NZ275833A (en)	1997-10-24
WO1995013054A1 (en)	1995-05-18
CZ132796A3 (en)	1996-10-16
CA2175994A1 (en)	1995-05-18
SK280552B6 (sk)	2000-03-13
NO312938B1 (no)	2002-07-22
HUT75228A (en)	1997-04-28
NO961906D0 (no)	1996-05-10
IL111596A0 (en)	1995-01-24
ZA948974B (en)	1995-11-21
IL111596A (en)	1998-12-06
FI935019A0 (fi)	1993-11-12
US5776499A (en)	1998-07-07
FI94926B (fi)	1995-08-15
DE69427648D1 (de)	2001-08-09
PT727983E (pt)	2001-11-30
KR960705548A (ko)	1996-11-08
FI94926C (fi)	1995-11-27
CN1040945C (zh)	1998-12-02
GR3036470T3 (en)	2001-11-30
EP0727983B1 (en)	2001-07-04
ATE202700T1 (de)	2001-07-15
ES2160688T3 (es)	2001-11-16
CN1134664A (zh)	1996-10-30
FI935019L (fi)	1995-05-13
EP0727983A1 (en)	1996-08-28
AU679586B2 (en)	1997-07-03
SK60696A3 (en)	1997-02-05
HU220633B1 (hu)	2002-03-28
NO961906L (no)	1996-05-23
PL314299A1 (en)	1996-09-02
PL176658B1 (pl)	1999-07-30
CZ286132B6 (cs)	2000-01-12
JPH09504800A (ja)	1997-05-13

Publication	Publication Date	Title
DK0675710T3 (da)	2000-03-27	Fremgangsmåde til fremstilling af farmaceutiske former med styret frigivelse samt de herved opnåede former
CA2265766A1 (en)	1998-03-19	Rapidly disintegrating pellets
DK74187D0 (da)	1987-02-13	Praeparat til langsom frigivelse samt fremgangsmaade til fremstilling deraf
MY136231A (en)	2008-08-29	Slow release compositions
HUT52025A (en)	1990-06-28	Insecticide compositions containing cyclopropyl-substituted diaryl compounds as active component and process for producing the active components
DK0727983T3 (da)	2001-09-24	Fremgangsmåde til fremstilling af et clodronat-præparat
HUT47376A (en)	1989-03-28	Insecticide compositions containing /p-phenoxy-phenoxy/-methyl-heteroaromatic compounds as active components and process for producing the active components
MY113718A (en)	2002-05-31	Pharmaceutical formulation containing a hydrophobic active substance and an effervescent system, and process for the preparation of the formulation
ATE161423T1 (de)	1998-01-15	Verwendung von phosphinate zur behandlung der osteoporose
ATE59960T1 (de)	1991-02-15	Theophyllintabletten mit verzoegerter freigabe.
GR3015719T3 (en)	1995-07-31	Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure.
JPS5296729A (en)	1977-08-13	Mixed vaccin for cyanomycosis
DK0557389T3 (da)	1994-10-17	Fremgangsmåde til fremstilling af tabletter indeholdende cephalosporansyrederivater ved direkte komprimering
JPS5299207A (en)	1977-08-19	Remedy for cattle diarrhea
NO154683C (no)	1986-12-03	Fremgangsmaate for fremstilling av granuler inneholdende urea som hovedkomponent og gjoedningsblandinger av slike granuler.
ES2113408T3 (es)	1998-05-01	Procedimiento para preparar una composicion detergente granular.
JPS5389367A (en)	1978-08-05	Substrate crystal for semiconductor epitaxial growth
FR2703262B1 (fr)	1995-10-13	Mélanges gazeux.
DK260387D0 (da)	1987-05-22	Soenderdelingsapparat til tilvejebringelse af pastaagtige masser, isaer poelsemasse
HUT52762A (en)	1990-08-28	Herbicide compositions containing substituted sulfonyl-urea derivatives as active components and process for producing the active components
JPS53103441A (en)	1978-09-08	Preparation of optical active phenylglycines
RU94018502A (ru)	1995-11-10	Способ получения гербицидных гранулированных продуктов
JPS5375193A (en)	1978-07-04	Screening method for slag
JPS53122679A (en)	1978-10-26	Process for preparing forming tablets
UA6826A (uk)	1995-03-31	Кристалічний фосфат акваамінкобальту /п/ та спосіб його одержання