DK0700399T3 - Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidler - Google Patents
Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidlerInfo
- Publication number
- DK0700399T3 DK0700399T3 DK94916937T DK94916937T DK0700399T3 DK 0700399 T3 DK0700399 T3 DK 0700399T3 DK 94916937 T DK94916937 T DK 94916937T DK 94916937 T DK94916937 T DK 94916937T DK 0700399 T3 DK0700399 T3 DK 0700399T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- image
- alkylamino
- sec
- date
- Prior art date
Links
- 229930189077 Rifamycin Natural products 0.000 title abstract 3
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical group O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 title 1
- 229940081192 rifamycins Drugs 0.000 title 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229960003292 rifamycin Drugs 0.000 abstract 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- -1 4-oxo-3-pyridinyl carbonyloxy Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93108337 | 1993-05-24 | ||
| EP93110315 | 1993-06-29 | ||
| PCT/EP1994/001428 WO1994028002A1 (fr) | 1993-05-24 | 1994-05-05 | Derives-36 de rifamycines et leur utilisation comme agents anti-microbiens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0700399T3 true DK0700399T3 (da) | 2001-11-26 |
Family
ID=26133222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94916937T DK0700399T3 (da) | 1993-05-24 | 1994-05-05 | Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5786350A (fr) |
| JP (1) | JP3566962B2 (fr) |
| KR (1) | KR100325562B1 (fr) |
| AT (1) | ATE206427T1 (fr) |
| AU (1) | AU687817B2 (fr) |
| CA (1) | CA2160243C (fr) |
| DE (1) | DE69428535T2 (fr) |
| DK (1) | DK0700399T3 (fr) |
| ES (1) | ES2164704T3 (fr) |
| IL (1) | IL109691A (fr) |
| PT (1) | PT700399E (fr) |
| WO (1) | WO1994028002A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2185168C1 (ru) * | 2001-01-26 | 2002-07-20 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | Композиция для лечения туберкулеза |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| US7122525B2 (en) * | 2001-11-21 | 2006-10-17 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
| US7820652B2 (en) * | 2003-09-24 | 2010-10-26 | Activbiotics Pharma, Llc | Regimen for the administration of rifamycin-class antibiotics |
| US7238694B2 (en) * | 2004-01-13 | 2007-07-03 | Cumbre Pharmaceuticals, Inc. | Rifamycin imino derivatives effective against drug-resistant microbes |
| WO2005070940A2 (fr) * | 2004-01-13 | 2005-08-04 | Cumbre Pharmaceuticals Inc. | Derives de rifamycine efficaces contre des microbes pharmacoresistants |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| US7256187B2 (en) | 2004-03-10 | 2007-08-14 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime derivatives effective against drug-resistant microbes |
| US7250413B2 (en) * | 2004-04-26 | 2007-07-31 | Cumbre Pharmaceuticals Inc. | C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes |
| JP5236944B2 (ja) * | 2004-07-22 | 2013-07-17 | カムブァ、アイピー、ヴェンチュァズ、エル、ピー | 微生物感染を治療するためのリファマイシン誘導体 |
| EP3827747A1 (fr) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Système pharma-informatique |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| EP2895169A4 (fr) * | 2012-09-12 | 2016-02-24 | Salix Pharmaceuticals Inc | Méthodes d'administration de la rifaximine sans produire de résistance aux antibiotiques |
| US11325920B2 (en) | 2018-01-24 | 2022-05-10 | The Rockefeller University | Antibacterial compounds, compositions thereof, and methods using same |
| EP4003200A4 (fr) | 2019-07-23 | 2023-08-02 | The Rockefeller University | Composés antibactériens, compositions de ceux-ci et procédés les utilisant |
| CN119998299A (zh) | 2022-09-30 | 2025-05-13 | 生物验证系统股份公司 | 用于治疗疾病的利福布汀类似物 |
-
1994
- 1994-05-05 JP JP50015095A patent/JP3566962B2/ja not_active Expired - Lifetime
- 1994-05-05 US US08/792,035 patent/US5786350A/en not_active Expired - Lifetime
- 1994-05-05 AT AT94916937T patent/ATE206427T1/de active
- 1994-05-05 DK DK94916937T patent/DK0700399T3/da active
- 1994-05-05 ES ES94916937T patent/ES2164704T3/es not_active Expired - Lifetime
- 1994-05-05 PT PT94916937T patent/PT700399E/pt unknown
- 1994-05-05 DE DE69428535T patent/DE69428535T2/de not_active Expired - Lifetime
- 1994-05-05 CA CA002160243A patent/CA2160243C/fr not_active Expired - Lifetime
- 1994-05-05 WO PCT/EP1994/001428 patent/WO1994028002A1/fr not_active Ceased
- 1994-05-05 KR KR1019950705232A patent/KR100325562B1/ko not_active Expired - Lifetime
- 1994-05-05 AU AU68430/94A patent/AU687817B2/en not_active Expired
- 1994-05-19 IL IL10969194A patent/IL109691A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR960702466A (ko) | 1996-04-27 |
| CA2160243C (fr) | 2007-08-28 |
| JP3566962B2 (ja) | 2004-09-15 |
| PT700399E (pt) | 2002-02-28 |
| IL109691A (en) | 1998-10-30 |
| KR100325562B1 (ko) | 2002-07-22 |
| AU687817B2 (en) | 1998-03-05 |
| JPH08511249A (ja) | 1996-11-26 |
| ES2164704T3 (es) | 2002-03-01 |
| AU6843094A (en) | 1994-12-20 |
| WO1994028002A1 (fr) | 1994-12-08 |
| US5786350A (en) | 1998-07-28 |
| ATE206427T1 (de) | 2001-10-15 |
| IL109691A0 (en) | 1994-08-26 |
| DE69428535D1 (de) | 2001-11-08 |
| DE69428535T2 (de) | 2002-08-01 |
| CA2160243A1 (fr) | 1994-12-08 |
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