DK0868424T3 - 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler - Google Patents
4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midlerInfo
- Publication number
- DK0868424T3 DK0868424T3 DK96944212T DK96944212T DK0868424T3 DK 0868424 T3 DK0868424 T3 DK 0868424T3 DK 96944212 T DK96944212 T DK 96944212T DK 96944212 T DK96944212 T DK 96944212T DK 0868424 T3 DK0868424 T3 DK 0868424T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrimidinyl
- pyrazinyl
- piperazinyl
- preparation
- antibacterial agents
- Prior art date
Links
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 title abstract 2
- GERHANPDTFFPHR-UHFFFAOYSA-N 3-phenyl-4-(4-pyrazin-2-ylpiperazin-1-yl)-1,3-oxazolidin-2-one Chemical class O=C1OCC(N2CCN(CC2)C=2N=CC=NC=2)N1C1=CC=CC=C1 GERHANPDTFFPHR-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US855495P | 1995-12-13 | 1995-12-13 | |
| PCT/US1996/019149 WO1997021708A1 (en) | 1995-12-13 | 1996-12-09 | 4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinone derivatives, their preparation and their use as anti-bacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0868424T3 true DK0868424T3 (da) | 2003-05-19 |
Family
ID=21732266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96944212T DK0868424T3 (da) | 1995-12-13 | 1996-12-09 | 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5719154A (da) |
| EP (1) | EP0868424B1 (da) |
| JP (1) | JP2000501731A (da) |
| KR (1) | KR19990072109A (da) |
| AT (1) | ATE232530T1 (da) |
| AU (1) | AU703784B2 (da) |
| CA (1) | CA2236677C (da) |
| DE (1) | DE69626218T2 (da) |
| DK (1) | DK0868424T3 (da) |
| ES (1) | ES2192235T3 (da) |
| PT (1) | PT868424E (da) |
| SI (1) | SI0868424T1 (da) |
| TW (1) | TW403749B (da) |
| WO (1) | WO1997021708A1 (da) |
| ZA (1) | ZA969622B (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9614238D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
| US6037354A (en) | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| EP1049682A1 (en) | 1998-01-23 | 2000-11-08 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| DK1054874T3 (da) * | 1998-02-13 | 2002-12-30 | Upjohn Co | Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler |
| SK18362000A3 (sk) | 1998-06-05 | 2001-06-11 | Astrazeneca Ab | Oxazolidinónové deriváty, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú |
| WO2000045177A1 (en) | 1999-01-27 | 2000-08-03 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
| KR100333493B1 (ko) * | 1999-05-27 | 2002-04-25 | 박호군 | 이소옥사졸릴 카르보닐 옥사졸리디논 유도체 및 이의 제조방법 |
| KR100333492B1 (ko) * | 1999-05-27 | 2002-04-25 | 박호군 | 이소옥사졸릴 메틸렌 옥사졸리디논 유도체 및 이의 제조방법 |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| KR100674096B1 (ko) * | 2000-06-05 | 2007-01-26 | 동아제약주식회사 | 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법 |
| GB0118407D0 (en) * | 2001-07-27 | 2001-09-19 | Cipla Ltd | Oxazolidinone derivatives as antibacterial agents |
| US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| AU2002319848A1 (en) * | 2002-07-29 | 2004-02-25 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| AU2002339721A1 (en) * | 2002-09-20 | 2004-04-08 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| US7547698B2 (en) * | 2004-09-20 | 2009-06-16 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD) |
| CN101090724A (zh) * | 2004-09-20 | 2007-12-19 | 泽农医药公司 | 用于抑制人硬脂酰CoA去饱和酶的吡啶衍生物 |
| MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
| AR051093A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa |
| AR051090A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| MX2007003332A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| JP5149009B2 (ja) * | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体 |
| EP1830837B1 (en) | 2004-09-20 | 2013-09-04 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| EP2029138A1 (en) * | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2119556C (en) * | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| US5556873A (en) * | 1993-02-24 | 1996-09-17 | Rhone-Poulenc Inc. | Pesticidal 1-aryl-5-(substituted alkyl (thio) amido)pyrazoles |
| CA2174107C (en) * | 1993-11-22 | 2005-04-12 | Steven J. Brickner | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
| US5609996A (en) * | 1996-02-29 | 1997-03-11 | Eastman Kodak Company | Photographic emulsion layer containing pyrazoloazole coupler exhibiting improved dye light fade |
| GB9614238D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
-
1996
- 1996-11-15 ZA ZA9609622A patent/ZA969622B/xx unknown
- 1996-11-27 TW TW085114663A patent/TW403749B/zh not_active IP Right Cessation
- 1996-12-09 DK DK96944212T patent/DK0868424T3/da active
- 1996-12-09 CA CA002236677A patent/CA2236677C/en not_active Expired - Fee Related
- 1996-12-09 PT PT96944212T patent/PT868424E/pt unknown
- 1996-12-09 JP JP09522076A patent/JP2000501731A/ja not_active Withdrawn
- 1996-12-09 AT AT96944212T patent/ATE232530T1/de not_active IP Right Cessation
- 1996-12-09 SI SI9630589T patent/SI0868424T1/xx unknown
- 1996-12-09 WO PCT/US1996/019149 patent/WO1997021708A1/en not_active Ceased
- 1996-12-09 KR KR1019980704424A patent/KR19990072109A/ko not_active Ceased
- 1996-12-09 ES ES96944212T patent/ES2192235T3/es not_active Expired - Lifetime
- 1996-12-09 AU AU14077/97A patent/AU703784B2/en not_active Ceased
- 1996-12-09 EP EP96944212A patent/EP0868424B1/en not_active Expired - Lifetime
- 1996-12-09 US US08/762,478 patent/US5719154A/en not_active Expired - Fee Related
- 1996-12-09 DE DE69626218T patent/DE69626218T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5719154A (en) | 1998-02-17 |
| AU703784B2 (en) | 1999-04-01 |
| ES2192235T3 (es) | 2003-10-01 |
| AU1407797A (en) | 1997-07-03 |
| ATE232530T1 (de) | 2003-02-15 |
| CA2236677A1 (en) | 1997-06-19 |
| EP0868424B1 (en) | 2003-02-12 |
| DE69626218T2 (de) | 2003-08-14 |
| CA2236677C (en) | 2005-05-03 |
| SI0868424T1 (en) | 2003-08-31 |
| EP0868424A1 (en) | 1998-10-07 |
| TW403749B (en) | 2000-09-01 |
| JP2000501731A (ja) | 2000-02-15 |
| PT868424E (pt) | 2003-06-30 |
| WO1997021708A1 (en) | 1997-06-19 |
| ZA969622B (en) | 1998-05-15 |
| DE69626218D1 (de) | 2003-03-20 |
| KR19990072109A (ko) | 1999-09-27 |
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