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DK0746320T3 - HIV-proteaseinhibitorer og mellemprodukter - Google Patents

HIV-proteaseinhibitorer og mellemprodukter

Info

Publication number
DK0746320T3
DK0746320T3 DK94931802T DK94931802T DK0746320T3 DK 0746320 T3 DK0746320 T3 DK 0746320T3 DK 94931802 T DK94931802 T DK 94931802T DK 94931802 T DK94931802 T DK 94931802T DK 0746320 T3 DK0746320 T3 DK 0746320T3
Authority
DK
Denmark
Prior art keywords
hiv protease
protease inhibitors
intermediates
hiv
inhibition
Prior art date
Application number
DK94931802T
Other languages
Danish (da)
English (en)
Inventor
William Joseph Hornback
John Edwin Munroe
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0746320T3 publication Critical patent/DK0746320T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94931802T 1994-02-02 1994-10-06 HIV-proteaseinhibitorer og mellemprodukter DK0746320T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19080994A 1994-02-02 1994-02-02
PCT/US1994/011361 WO1995020965A1 (fr) 1994-02-02 1994-10-06 Inhibiteurs de la protease du vih et leurs intermediaires

Publications (1)

Publication Number Publication Date
DK0746320T3 true DK0746320T3 (da) 2001-02-19

Family

ID=22702879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94931802T DK0746320T3 (da) 1994-02-02 1994-10-06 HIV-proteaseinhibitorer og mellemprodukter

Country Status (14)

Country Link
US (1) US5734057A (fr)
EP (1) EP0746320B1 (fr)
JP (1) JPH09508416A (fr)
AT (1) ATE198985T1 (fr)
AU (1) AU8074894A (fr)
BR (1) BR9408531A (fr)
CA (1) CA2182090A1 (fr)
DE (1) DE69426655T2 (fr)
DK (1) DK0746320T3 (fr)
ES (1) ES2153434T3 (fr)
GR (1) GR3035716T3 (fr)
HU (1) HUT74685A (fr)
PT (1) PT746320E (fr)
WO (1) WO1995020965A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
CN101860089B (zh) * 2005-07-12 2013-02-06 麻省理工学院 无线非辐射能量传递
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
WO2014172644A2 (fr) 2013-04-19 2014-10-23 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
UA121669C2 (uk) 2015-02-20 2020-07-10 Інсайт Корпорейшн Біциклічні гетероцикли як інгібітори fgfr
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
SI3788047T1 (sl) 2018-05-04 2024-11-29 Incyte Corporation Trdne oblike inhibitorja fgfr in postopki priprave le-teh
WO2020185532A1 (fr) 2019-03-08 2020-09-17 Incyte Corporation Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4045151A1 (fr) 2019-10-14 2022-08-24 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4069695A1 (fr) 2019-12-04 2022-10-12 Incyte Corporation Dérivés d'un inhibiteur de fgfr
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
WO2021146424A1 (fr) 2020-01-15 2021-07-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
CA3220155A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques utiles en tant qu'inhibiteurs de fgfr
WO2022261160A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2395271A1 (fr) * 1977-06-21 1979-01-19 Parcor Procede de preparation de thieno (2,3-c) et thieno (3,2-c) pyridines
US4749692A (en) * 1977-06-22 1988-06-07 Sanofi, S.A. Therapeutic compositions having anti-thrombotic and anti-blood-platelet-aggregating activity
FR2397417A1 (fr) * 1977-07-12 1979-02-09 Parcor Procede de preparation de derives de la thienopyridine
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (fr) * 1988-06-13 1999-06-08 Balraj Krishan Handa Derive d'aminoacides
EP0361341A3 (fr) * 1988-09-28 1991-07-03 Miles Inc. Agents thérapeutiques contre le SIDA basés sur des inhibiteurs des protéases du HIV
US5026700A (en) * 1989-05-16 1991-06-25 Merrell Dow Pharmaceuticals Certain quinolines and thienopyridines as excitatory amino acid antagonists
US5232928A (en) * 1989-07-25 1993-08-03 Boehringer Ingelheim Pharmaceuticals, Inc. Tetrahydroisoquinoline amides
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
DE69133464T2 (de) * 1990-11-19 2006-05-18 Pharmacia Corp.(N.D.Ges.D.Staates Delaware) Retrovirusprotease Inhibitoren
AU647239B2 (en) * 1991-02-08 1994-03-17 Sankyo Company Limited New beta-amino- alpha-hydroxycarboxylic acids and their use
WO1993008184A1 (fr) * 1991-10-23 1993-04-29 Merck & Co., Inc. Inhibiteurs de la protease du vih______________________
WO1993013066A1 (fr) * 1991-12-20 1993-07-08 Syntex (U.S.A.) Inc. Amides cycliques d'acides 3-amino-2-hydroxy-carboxyliques utilises comme inhibiteurs de la protease du vih
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors

Also Published As

Publication number Publication date
EP0746320A4 (fr) 1997-06-11
US5734057A (en) 1998-03-31
HU9602106D0 (en) 1996-09-30
BR9408531A (pt) 1997-08-05
HUT74685A (en) 1997-01-28
DE69426655T2 (de) 2001-06-13
CA2182090A1 (fr) 1995-08-10
EP0746320B1 (fr) 2001-01-31
EP0746320A1 (fr) 1996-12-11
ES2153434T3 (es) 2001-03-01
AU8074894A (en) 1995-08-21
ATE198985T1 (de) 2001-02-15
GR3035716T3 (en) 2001-07-31
PT746320E (pt) 2001-05-31
DE69426655D1 (de) 2001-03-08
WO1995020965A1 (fr) 1995-08-10
JPH09508416A (ja) 1997-08-26

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