GR3035716T3 - Hiv protease inhibitors and intermediates - Google Patents
Hiv protease inhibitors and intermediatesInfo
- Publication number
- GR3035716T3 GR3035716T3 GR20010400567T GR20010400567T GR3035716T3 GR 3035716 T3 GR3035716 T3 GR 3035716T3 GR 20010400567 T GR20010400567 T GR 20010400567T GR 20010400567 T GR20010400567 T GR 20010400567T GR 3035716 T3 GR3035716 T3 GR 3035716T3
- Authority
- GR
- Greece
- Prior art keywords
- hiv protease
- protease inhibitors
- intermediates
- hiv
- inhibition
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19080994A | 1994-02-02 | 1994-02-02 | |
| PCT/US1994/011361 WO1995020965A1 (en) | 1994-02-02 | 1994-10-06 | Hiv protease inhibitors and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3035716T3 true GR3035716T3 (en) | 2001-07-31 |
Family
ID=22702879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010400567T GR3035716T3 (en) | 1994-02-02 | 2001-04-06 | Hiv protease inhibitors and intermediates |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5734057A (el) |
| EP (1) | EP0746320B1 (el) |
| JP (1) | JPH09508416A (el) |
| AT (1) | ATE198985T1 (el) |
| AU (1) | AU8074894A (el) |
| BR (1) | BR9408531A (el) |
| CA (1) | CA2182090A1 (el) |
| DE (1) | DE69426655T2 (el) |
| DK (1) | DK0746320T3 (el) |
| ES (1) | ES2153434T3 (el) |
| GR (1) | GR3035716T3 (el) |
| HU (1) | HUT74685A (el) |
| PT (1) | PT746320E (el) |
| WO (1) | WO1995020965A1 (el) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
| WO2007008646A2 (en) * | 2005-07-12 | 2007-01-18 | Massachusetts Institute Of Technology | Wireless non-radiative energy transfer |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| PE20190736A1 (es) | 2012-06-13 | 2019-05-23 | Incyte Holdings Corp | Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr) |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR102269032B1 (ko) | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| SI3788047T1 (sl) | 2018-05-04 | 2024-11-29 | Incyte Corporation | Trdne oblike inhibitorja fgfr in postopki priprave le-teh |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11607416B2 (en) | 2019-10-14 | 2023-03-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2395271A1 (fr) * | 1977-06-21 | 1979-01-19 | Parcor | Procede de preparation de thieno (2,3-c) et thieno (3,2-c) pyridines |
| US4749692A (en) * | 1977-06-22 | 1988-06-07 | Sanofi, S.A. | Therapeutic compositions having anti-thrombotic and anti-blood-platelet-aggregating activity |
| FR2397417A1 (fr) * | 1977-07-12 | 1979-02-09 | Parcor | Procede de preparation de derives de la thienopyridine |
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| US5026700A (en) * | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
| US5232928A (en) * | 1989-07-25 | 1993-08-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tetrahydroisoquinoline amides |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| DK0813867T3 (da) * | 1990-11-19 | 2005-10-03 | Monsanto Co | Retrovirale proteaseinhibitorer |
| CS35692A3 (en) * | 1991-02-08 | 1992-09-16 | Sankyo Co | Novel beta-amino-alpha-hydroxycarboxylic acids and pharmaceuticalcompositions comprising thereof |
| WO1993008184A1 (en) * | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
| WO1993013066A1 (en) * | 1991-12-20 | 1993-07-08 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
-
1994
- 1994-10-06 CA CA002182090A patent/CA2182090A1/en not_active Abandoned
- 1994-10-06 BR BR9408531A patent/BR9408531A/pt not_active Application Discontinuation
- 1994-10-06 DE DE69426655T patent/DE69426655T2/de not_active Expired - Fee Related
- 1994-10-06 AT AT94931802T patent/ATE198985T1/de not_active IP Right Cessation
- 1994-10-06 AU AU80748/94A patent/AU8074894A/en not_active Abandoned
- 1994-10-06 PT PT94931802T patent/PT746320E/pt unknown
- 1994-10-06 ES ES94931802T patent/ES2153434T3/es not_active Expired - Lifetime
- 1994-10-06 JP JP7520585A patent/JPH09508416A/ja active Pending
- 1994-10-06 WO PCT/US1994/011361 patent/WO1995020965A1/en not_active Ceased
- 1994-10-06 DK DK94931802T patent/DK0746320T3/da active
- 1994-10-06 HU HU9602106A patent/HUT74685A/hu unknown
- 1994-10-06 EP EP94931802A patent/EP0746320B1/en not_active Expired - Lifetime
-
1996
- 1996-08-05 US US08/695,150 patent/US5734057A/en not_active Expired - Fee Related
-
2001
- 2001-04-06 GR GR20010400567T patent/GR3035716T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69426655T2 (de) | 2001-06-13 |
| EP0746320A4 (en) | 1997-06-11 |
| ES2153434T3 (es) | 2001-03-01 |
| HU9602106D0 (en) | 1996-09-30 |
| DK0746320T3 (da) | 2001-02-19 |
| ATE198985T1 (de) | 2001-02-15 |
| CA2182090A1 (en) | 1995-08-10 |
| PT746320E (pt) | 2001-05-31 |
| BR9408531A (pt) | 1997-08-05 |
| AU8074894A (en) | 1995-08-21 |
| WO1995020965A1 (en) | 1995-08-10 |
| HUT74685A (en) | 1997-01-28 |
| JPH09508416A (ja) | 1997-08-26 |
| DE69426655D1 (de) | 2001-03-08 |
| US5734057A (en) | 1998-03-31 |
| EP0746320A1 (en) | 1996-12-11 |
| EP0746320B1 (en) | 2001-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |