DK0696577T3 - Syntetiske excitatoriske aminosyrer - Google Patents

Syntetiske excitatoriske aminosyrer

Info

Publication number: DK0696577T3
Authority: DK; Denmark
Prior art keywords: amino acids; excitatory amino; synthetic excitatory; synthetic; acids
Prior art date: 1994-08-12

Application number

DK95305632T

Other languages

Danish (da)

English (en)

Inventor

James Allen Monn

David R Helton

Darryle D Schoepp

Joseph P Tizzano

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-12

Filing date

1995-08-11

Publication date

1999-06-23

1995-06-29 Priority claimed from US08/496,643 external-priority patent/US5750566A/en

1995-08-11 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-06-23 Application granted granted Critical

1999-06-23 Publication of DK0696577T3 publication Critical patent/DK0696577T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/38—Unsaturated compounds containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK95305632T 1994-08-12 1995-08-11 Syntetiske excitatoriske aminosyrer DK0696577T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US28995794A	1994-08-12	1994-08-12
US33734994A	1994-11-10	1994-11-10
US08/496,643 US5750566A (en)	1994-08-12	1995-06-29	Synthetic excitatory amino acids

Publications (1)

Publication Number	Publication Date
DK0696577T3 true DK0696577T3 (da)	1999-06-23

Family

ID=27403949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95305632T DK0696577T3 (da)	1994-08-12	1995-08-11	Syntetiske excitatoriske aminosyrer

Country Status (24)

Country	Link
US (2)	US5925782A (fr)
EP (1)	EP0696577B1 (fr)
JP (1)	JP2883297B2 (fr)
CN (1)	CN1066135C (fr)
AP (1)	AP758A (fr)
AT (1)	ATE172186T1 (fr)
AU (2)	AU3325195A (fr)
BG (1)	BG62728B1 (fr)
CA (1)	CA2156024C (fr)
CZ (1)	CZ291270B6 (fr)
DE (1)	DE69505318T2 (fr)
DK (1)	DK0696577T3 (fr)
ES (1)	ES2122456T3 (fr)
FI (1)	FI114861B (fr)
HU (1)	HU223845B1 (fr)
IL (2)	IL114910A (fr)
MY (1)	MY115977A (fr)
NO (1)	NO306342B1 (fr)
NZ (1)	NZ272772A (fr)
PL (1)	PL182285B1 (fr)
RO (1)	RO119147B1 (fr)
SK (1)	SK281288B6 (fr)
TW (1)	TW438741B (fr)
WO (1)	WO1996005175A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL118727A (en) *	1995-06-29	2003-01-12	Lilly Co Eli	(-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
TR199800877T2 (xx) *	1995-11-16	1998-09-21	Eli Lilly And Company	Uyar�c� amino asit t�revleri.
BR9611521A (pt)	1995-11-16	1999-06-29	Lilly Co Eli	Antagonistas de receptor de aminoácido excitador
GB9605429D0 (en) *	1995-11-16	1996-05-15	Lilly Co Eli	Excitatory amino acid receptor antagonists
US5688826A (en) *	1995-11-16	1997-11-18	Eli Lilly And Company	Excitatory amino acid derivatives
US5912248A (en) *	1995-11-16	1999-06-15	Eli Lilly And Company	Excitatory amino acid receptor antagonists
ZA969485B (en) *	1995-11-16	1998-05-12	Lilly Co Eli	Excitatory amino acid receptor antagonists.
US6017903A (en)	1996-09-27	2000-01-25	Guilford Pharmaceuticals Inc.	Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US5824662A (en) *	1996-09-27	1998-10-20	Guilford Pharmaceuticals Inc.	Treatment of global and focal ischemia using naaladase inhibitors
CN1230889A (zh)	1996-09-27	1999-10-06	吉尔福特药业有限公司	NAALADase组合物和治疗谷氨酸异常及在动物中产生神经元活性的方法
AU6248798A (en) *	1997-01-29	1998-08-18	Eli Lilly And Company	Treatment for premenstrual dysphoric disorder
ZA983930B (en) *	1997-05-14	1999-11-08	Lilly Co Eli	Excitatory amino acid receptor modulators.
US6825211B1 (en)	1997-07-18	2004-11-30	Georgetown University	Bicyclic metabotropic glutamate receptor ligands
PT891978E (pt) *	1997-07-18	2002-07-31	Hoffmann La Roche	Derivados de 5h-tiazolo (3,2-a) pirimidina
WO1999003822A1 (fr) *	1997-07-18	1999-01-28	Georgetown University	Ligands des recepteurs bicycliques metabotropiques du glutamate
JP3727791B2 (ja) *	1998-01-08	2005-12-14	ファイザー・プロダクツ・インク	二環式［３．１．０］ヘキサン及び関連化合物
AU734812B2 (en)	1998-01-28	2001-06-21	Taisho Pharmaceutical Co., Ltd.	Fluorine-containing amino acid derivatives
US5933378A (en) *	1998-02-26	1999-08-03	Micron Technology, Inc.	Integrated circuit having forced substrate test mode with improved substrate isolation
EP1396273A1 (fr) *	1998-03-17	2004-03-10	Pfizer Products Inc.	Bicyclo(2.2.1.)heptanes et composés associés
KR100372981B1 (ko) *	1998-03-17	2003-02-25	화이자 프로덕츠 인크.	비시클로[2.2.1]헵탄 및 관련 화합물
GB9815542D0 (en) *	1998-07-17	1998-09-16	Lilly Co Eli	Bicyclohexane derivatives
KR100469182B1 (ko)	1998-08-31	2005-02-02	다이쇼 세이야꾸 가부시끼가이샤	6-플루오로비시클로[3.1.0]헥산 유도체
CH694053A5 (de) *	1998-09-03	2004-06-30	Hoffmann La Roche	Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja)	1999-04-16	2008-12-10	住友化学株式会社	光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) *	1999-07-21	2011-09-28	大正製薬株式会社	含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) *	1999-11-03	2001-05-09	Lilly Co Eli	Heterocyclic amino acids
US7256217B2 (en) *	2001-01-11	2007-08-14	Eli Lilly And Company	Prodrugs of excitatory amino acids
EP1310480A1 (fr) *	2001-11-07	2003-05-14	Eli Lilly & Company	Prodrugs d'aminoacides excitants
WO2002055485A1 (fr)	2001-01-11	2002-07-18	Eli Lilly And Company	Promedicaments d'acides amines excitateurs
WO2003045898A1 (fr) *	2001-11-23	2003-06-05	Eli Lilly And Company	Promedicaments d'acides amines excitateurs
US7456221B2 (en)	2001-12-21	2008-11-25	Eli Lilly And Company	Prodrugs of excitatory amino acids
AU2002361611A1 (en) *	2001-12-21	2003-07-24	Eli Lilly And Company	Prodrugs of excitatory amino acids
US20040116489A1 (en) *	2002-02-12	2004-06-17	Massey Steven Marc	Synthetic excitatory amino acids
CA2580730C (fr) *	2003-09-25	2015-01-13	Cenomed, Inc.	Derives de tetrahydroindolone destines au traitement d'etats neurologiques
US20050107439A1 (en) *	2003-11-10	2005-05-19	Helton David R.	Composition and method for treating emesis
EP2219648A4 (fr) *	2007-11-09	2010-11-03	Cenomed Biosciences Llc	Traitement des troubles du stress post-traumatique avec des composés de tétrahydroindolone et d'arylpipérazine
US20090264443A1 (en) *	2008-04-18	2009-10-22	David Helton	Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (fr)	2009-03-27	2010-09-30	Eli Lilly And Company	Traitement optimisé de la schizophrénie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) *	1970-10-30	1972-11-28	American Home Prod	Bialicyclic amino acids
US3746495A (en) *	1971-06-01	1973-07-17	American Home Prod	Anti-ulcer therapy
JP2757960B2 (ja)	1988-10-17	1998-05-25	サントリー株式会社	（２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン
EP0564658B1 (fr)	1991-10-18	1996-04-24	Suntory Limited	2-(2,3-dicarboxycyclopropyl)glycine et son procede de production
GB9325368D0 (en) *	1993-12-10	1994-02-16	Univ Bristol	Organic compounds
US5750566A (en) *	1994-08-12	1998-05-12	Eli Lilly And Company	Synthetic excitatory amino acids
IL118727A (en)	1995-06-29	2003-01-12	Lilly Co Eli	(-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5688826A (en)	1995-11-16	1997-11-18	Eli Lilly And Company	Excitatory amino acid derivatives

1995
- 1995-08-10 PL PL95309972A patent/PL182285B1/pl not_active IP Right Cessation
- 1995-08-11 IL IL11491095A patent/IL114910A/xx not_active IP Right Cessation
- 1995-08-11 ES ES95305632T patent/ES2122456T3/es not_active Expired - Lifetime
- 1995-08-11 AT AT95305632T patent/ATE172186T1/de not_active IP Right Cessation
- 1995-08-11 DE DE69505318T patent/DE69505318T2/de not_active Expired - Fee Related
- 1995-08-11 EP EP95305632A patent/EP0696577B1/fr not_active Expired - Lifetime
- 1995-08-11 MY MYPI95002351A patent/MY115977A/en unknown
- 1995-08-11 HU HU9502380A patent/HU223845B1/hu not_active IP Right Cessation
- 1995-08-11 DK DK95305632T patent/DK0696577T3/da active
- 1995-08-14 CN CN95115896A patent/CN1066135C/zh not_active Expired - Fee Related
- 1995-08-14 RO RO97-00275A patent/RO119147B1/ro unknown
- 1995-08-14 FI FI953837A patent/FI114861B/fi not_active IP Right Cessation
- 1995-08-14 CA CA002156024A patent/CA2156024C/fr not_active Expired - Fee Related
- 1995-08-14 NZ NZ272772A patent/NZ272772A/en unknown
- 1995-08-14 AP APAP/P/1997/000922A patent/AP758A/en active
- 1995-08-14 CZ CZ19952074A patent/CZ291270B6/cs not_active IP Right Cessation
- 1995-08-14 WO PCT/US1995/010319 patent/WO1996005175A1/fr not_active Ceased
- 1995-08-14 JP JP7207010A patent/JP2883297B2/ja not_active Expired - Fee Related
- 1995-08-14 AU AU33251/95A patent/AU3325195A/en not_active Abandoned
- 1995-08-14 NO NO953191A patent/NO306342B1/no unknown
- 1995-08-14 AU AU28530/95A patent/AU692276B2/en not_active Ceased
- 1995-08-14 SK SK133-97A patent/SK281288B6/sk unknown
- 1995-08-16 TW TW084108531A patent/TW438741B/zh not_active IP Right Cessation
1997
- 1997-02-11 BG BG101213A patent/BG62728B1/bg unknown
- 1997-05-05 US US08/851,154 patent/US5925782A/en not_active Expired - Fee Related
- 1997-09-23 US US08/935,737 patent/US5925680A/en not_active Expired - Fee Related
1999
- 1999-12-13 IL IL13349399A patent/IL133493A0/xx active IP Right Grant

Also Published As

Publication number	Publication date
EP0696577B1 (fr)	1998-10-14
NO306342B1 (no)	1999-10-25
HU223845B1 (hu)	2005-02-28
IL114910A0 (en)	1995-12-08
NZ272772A (en)	1997-10-24
HK1013983A1 (en)	1999-09-17
BG101213A (en)	1998-03-31
NO953191D0 (no)	1995-08-14
PL182285B1 (pl)	2001-12-31
CA2156024A1 (fr)	1996-02-13
AU3325195A (en)	1996-03-07
MY115977A (en)	2003-10-31
EP0696577A1 (fr)	1996-02-14
DE69505318D1 (de)	1998-11-19
CZ207495A3 (en)	1996-05-15
WO1996005175A1 (fr)	1996-02-22
AP758A (en)	1999-09-10
CN1066135C (zh)	2001-05-23
HU9502380D0 (en)	1996-05-28
ES2122456T3 (es)	1998-12-16
FI114861B (fi)	2005-01-14
SK13397A3 (en)	1997-07-09
JP2883297B2 (ja)	1999-04-19
US5925782A (en)	1999-07-20
PL309972A1 (en)	1996-02-19
CA2156024C (fr)	2004-10-05
SK281288B6 (sk)	2001-02-12
IL133493A0 (en)	2001-04-30
RO119147B1 (ro)	2004-04-30
CZ291270B6 (cs)	2003-01-15
IL114910A (en)	2000-06-29
CN1123272A (zh)	1996-05-29
JPH08188561A (ja)	1996-07-23
AU692276B2 (en)	1998-06-04
ATE172186T1 (de)	1998-10-15
BG62728B1 (bg)	2000-06-30
AU2853095A (en)	1996-02-22
HUT75524A (en)	1997-05-28
FI953837A0 (fi)	1995-08-14
NO953191L (no)	1996-02-13
US5925680A (en)	1999-07-20
DE69505318T2 (de)	1999-03-25
AP9700922A0 (en)	1997-01-31
FI953837L (fi)	1996-02-13
TW438741B (en)	2001-06-07

Publication	Publication Date	Title
DK0696577T3 (da)	1999-06-23	Syntetiske excitatoriske aminosyrer
FI965005A7 (fi)	1997-02-13	Synteettiset johtajapeptidisekvensit
FI961350L (fi)	1996-03-25	Hapteenimerkityt peptidit
FI965225A7 (fi)	1997-02-26	Uusia peptidejä
ATE238984T1 (de)	2003-05-15	Sulfonylaminocarbonsäuren
NO993901L (no)	1999-10-12	Bisykliske aminosyrer
FI964318L (fi)	1996-12-23	Uusia kinoloni-5-(N-heterosubstituoitu amino)-antimikrobisia aineita
DE69635886D1 (de)	2006-05-04	Exzitatorisch wirkende Aminosäurederivate
BR9610239A (pt)	1999-06-15	Proteínas de fusão-alérgeno-xcd32
FI970168A0 (fi)	1997-01-15	Peptidejä
BR9609671A (pt)	1999-07-06	Amino uracilas substituídas
FI964363L (fi)	1996-12-23	Peptidejä
DK1043332T3 (da)	2007-03-12	Dipeptider indeholdende cyclopentan-beta-aminosyrer
SK2694U (sk)	2000-11-07	Aminokyselinové nukleové kyseliny
TR199701666A3 (tr)	1999-10-21	Sismanliga karsi proteinler
BR9606756A (pt)	1998-01-06	Peptídeo
FI963568L (fi)	1996-11-07	Peptidijohdannaisia
NO981052D0 (no)	1998-03-10	Peptidderivater
NO981051D0 (no)	1998-03-10	Peptidderivater
ZA956773B (en)	1997-02-14	Synthetic excitatory amino acids.
SI0696577T1 (en)	1999-04-30	Synthetic excitatory amino acids
BR1100812A (pt)	2000-08-08	Peptìdeo
SE9504467D0 (sv)	1995-12-12	Peptide
FI954924A0 (fi)	1995-10-16	Syntetiska smoerjmedelsbasoljor