DK0683167T3 - Terazosin monohydrochlorid og fremgangsmåder og mellemprodukter til dets fremstilling - Google Patents
Terazosin monohydrochlorid og fremgangsmåder og mellemprodukter til dets fremstillingInfo
- Publication number
- DK0683167T3 DK0683167T3 DK95103186T DK95103186T DK0683167T3 DK 0683167 T3 DK0683167 T3 DK 0683167T3 DK 95103186 T DK95103186 T DK 95103186T DK 95103186 T DK95103186 T DK 95103186T DK 0683167 T3 DK0683167 T3 DK 0683167T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- methods
- terazosin monohydrochloride
- intermediates
- terazosin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001693 terazosin Drugs 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/246,526 US5412095A (en) | 1993-04-29 | 1994-05-20 | Terazosin monohydrochloride and processes and intermediate for its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0683167T3 true DK0683167T3 (da) | 2000-02-07 |
Family
ID=22931058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95103186T DK0683167T3 (da) | 1994-05-20 | 1995-03-06 | Terazosin monohydrochlorid og fremgangsmåder og mellemprodukter til dets fremstilling |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5412095A (da) |
| EP (1) | EP0683167B1 (da) |
| JP (1) | JP2755918B2 (da) |
| AT (1) | ATE182592T1 (da) |
| CA (1) | CA2143974C (da) |
| DE (2) | DE683167T1 (da) |
| DK (1) | DK0683167T3 (da) |
| ES (1) | ES2093579T3 (da) |
| GR (2) | GR960300046T1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| IT1286789B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridato anidro |
| IT1286790B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridrato anidro |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| ES2282997T3 (es) * | 1996-12-20 | 2007-10-16 | Heumann Pcs Gmbh | Nueva forma polimorfa de mesilato e doxazosina (forma iii). |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| US20030068829A1 (en) * | 2001-06-25 | 2003-04-10 | Symyx Technologies, Inc. | High throughput crystallographic screening of materials |
| TWI353979B (en) * | 2002-04-10 | 2011-12-11 | Nippon Zoki Pharmaceutical Co | Novel crystal form of 5-hydroxy-1-methylhydantoin |
| US20080039473A1 (en) * | 2006-08-08 | 2008-02-14 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| ATE72244T1 (de) * | 1986-03-21 | 1992-02-15 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2furoyl-(2-piperazin)-1-yl>-4-amino-6,7- dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
| US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
| JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | 1−(4−アミノ−6,7−ジメトキシ−2−キナゾリニル)−4−(2−テトラヒドロフロイル)ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
-
1994
- 1994-05-20 US US08/246,526 patent/US5412095A/en not_active Expired - Fee Related
-
1995
- 1995-03-06 DE DE0683167T patent/DE683167T1/de active Pending
- 1995-03-06 DE DE69510999T patent/DE69510999T2/de not_active Expired - Fee Related
- 1995-03-06 ES ES95103186T patent/ES2093579T3/es not_active Expired - Lifetime
- 1995-03-06 AT AT95103186T patent/ATE182592T1/de not_active IP Right Cessation
- 1995-03-06 DK DK95103186T patent/DK0683167T3/da active
- 1995-03-06 EP EP95103186A patent/EP0683167B1/en not_active Expired - Lifetime
- 1995-03-06 CA CA002143974A patent/CA2143974C/en not_active Expired - Fee Related
- 1995-03-15 JP JP7055912A patent/JP2755918B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-31 GR GR960300046T patent/GR960300046T1/el unknown
-
1999
- 1999-09-16 GR GR990402341T patent/GR3031248T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1012629A1 (en) | 1999-08-06 |
| GR960300046T1 (en) | 1996-08-31 |
| US5412095A (en) | 1995-05-02 |
| ES2093579T1 (es) | 1997-01-01 |
| EP0683167A1 (en) | 1995-11-22 |
| CA2143974A1 (en) | 1995-11-21 |
| CA2143974C (en) | 1997-06-03 |
| DE683167T1 (de) | 1996-11-07 |
| DE69510999T2 (de) | 2000-02-17 |
| ES2093579T3 (es) | 1999-11-01 |
| JPH0848685A (ja) | 1996-02-20 |
| DE69510999D1 (de) | 1999-09-02 |
| GR3031248T3 (en) | 1999-12-31 |
| EP0683167B1 (en) | 1999-07-28 |
| ATE182592T1 (de) | 1999-08-15 |
| JP2755918B2 (ja) | 1998-05-25 |
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