ES2093579T3 - Monoclorhidrato de terazosina y procedimiento y productos intermediarios para la preparacion. - Google Patents
Monoclorhidrato de terazosina y procedimiento y productos intermediarios para la preparacion.Info
- Publication number
- ES2093579T3 ES2093579T3 ES95103186T ES95103186T ES2093579T3 ES 2093579 T3 ES2093579 T3 ES 2093579T3 ES 95103186 T ES95103186 T ES 95103186T ES 95103186 T ES95103186 T ES 95103186T ES 2093579 T3 ES2093579 T3 ES 2093579T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- monoclorhidrato
- terazosine
- procedure
- intermediary products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001693 terazosin Drugs 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FUKUFMFMCZIRNT-UHFFFAOYSA-N hydron;methanol;chloride Chemical compound Cl.OC FUKUFMFMCZIRNT-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SUMINISTRA UN POLIMORFO CRISTALINO DE MONOHIDROCLORURO DE TERAZOSIN DESIGNADA FORMA III Y METODOS PARA SU PREPARACION. TAMBIEN SE PRESENTA UN METANOLATO DE MONOHIDROCLORURO DE TERAZOSIN Y UN PROCESO PARA SU PRODUCCION ASI COMO PROCESOS PARA SU CONVERSION EN OTRAS FORMAS CRISTALINAS DE MONOHIDROCLORURO DE TERAZOSIN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/246,526 US5412095A (en) | 1993-04-29 | 1994-05-20 | Terazosin monohydrochloride and processes and intermediate for its production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2093579T1 ES2093579T1 (es) | 1997-01-01 |
| ES2093579T3 true ES2093579T3 (es) | 1999-11-01 |
Family
ID=22931058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95103186T Expired - Lifetime ES2093579T3 (es) | 1994-05-20 | 1995-03-06 | Monoclorhidrato de terazosina y procedimiento y productos intermediarios para la preparacion. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5412095A (es) |
| EP (1) | EP0683167B1 (es) |
| JP (1) | JP2755918B2 (es) |
| AT (1) | ATE182592T1 (es) |
| CA (1) | CA2143974C (es) |
| DE (2) | DE69510999T2 (es) |
| DK (1) | DK0683167T3 (es) |
| ES (1) | ES2093579T3 (es) |
| GR (2) | GR960300046T1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| IT1286789B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridato anidro |
| IT1286790B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridrato anidro |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| ATE353892T1 (de) * | 1996-12-20 | 2007-03-15 | Heumann Pharma Gmbh & Co | Neue polymorphe form von doxazosinmesylat (form iii) |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| US20030068829A1 (en) * | 2001-06-25 | 2003-04-10 | Symyx Technologies, Inc. | High throughput crystallographic screening of materials |
| TWI353979B (en) * | 2002-04-10 | 2011-12-11 | Nippon Zoki Pharmaceutical Co | Novel crystal form of 5-hydroxy-1-methylhydantoin |
| WO2008021891A2 (en) * | 2006-08-08 | 2008-02-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| ATE72244T1 (de) * | 1986-03-21 | 1992-02-15 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2furoyl-(2-piperazin)-1-yl>-4-amino-6,7- dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
| US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
| JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | 1−(4−アミノ−6,7−ジメトキシ−2−キナゾリニル)−4−(2−テトラヒドロフロイル)ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
-
1994
- 1994-05-20 US US08/246,526 patent/US5412095A/en not_active Expired - Fee Related
-
1995
- 1995-03-06 DE DE69510999T patent/DE69510999T2/de not_active Expired - Fee Related
- 1995-03-06 ES ES95103186T patent/ES2093579T3/es not_active Expired - Lifetime
- 1995-03-06 DK DK95103186T patent/DK0683167T3/da active
- 1995-03-06 CA CA002143974A patent/CA2143974C/en not_active Expired - Fee Related
- 1995-03-06 AT AT95103186T patent/ATE182592T1/de not_active IP Right Cessation
- 1995-03-06 EP EP95103186A patent/EP0683167B1/en not_active Expired - Lifetime
- 1995-03-06 DE DE0683167T patent/DE683167T1/de active Pending
- 1995-03-15 JP JP7055912A patent/JP2755918B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-31 GR GR960300046T patent/GR960300046T1/el unknown
-
1999
- 1999-09-16 GR GR990402341T patent/GR3031248T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2755918B2 (ja) | 1998-05-25 |
| DE69510999D1 (de) | 1999-09-02 |
| EP0683167A1 (en) | 1995-11-22 |
| DE69510999T2 (de) | 2000-02-17 |
| CA2143974C (en) | 1997-06-03 |
| GR960300046T1 (en) | 1996-08-31 |
| DE683167T1 (de) | 1996-11-07 |
| HK1012629A1 (en) | 1999-08-06 |
| ES2093579T1 (es) | 1997-01-01 |
| DK0683167T3 (da) | 2000-02-07 |
| CA2143974A1 (en) | 1995-11-21 |
| GR3031248T3 (en) | 1999-12-31 |
| JPH0848685A (ja) | 1996-02-20 |
| US5412095A (en) | 1995-05-02 |
| ATE182592T1 (de) | 1999-08-15 |
| EP0683167B1 (en) | 1999-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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