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WO2001092251A3 - Aryloxy ester and acid compounds - Google Patents

Aryloxy ester and acid compounds Download PDF

Info

Publication number
WO2001092251A3
WO2001092251A3 PCT/EP2001/006015 EP0106015W WO0192251A3 WO 2001092251 A3 WO2001092251 A3 WO 2001092251A3 EP 0106015 W EP0106015 W EP 0106015W WO 0192251 A3 WO0192251 A3 WO 0192251A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid compounds
aryloxy ester
aryloxy
ester
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/006015
Other languages
French (fr)
Other versions
WO2001092251A2 (en
Inventor
Joseph M Kapinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to CA002410633A priority Critical patent/CA2410633A1/en
Priority to JP2002500865A priority patent/JP2003535086A/en
Priority to AU2001267483A priority patent/AU2001267483A1/en
Priority to MXPA02010875A priority patent/MXPA02010875A/en
Priority to EP01945195A priority patent/EP1322633A2/en
Priority to IL15297001A priority patent/IL152970A0/en
Publication of WO2001092251A2 publication Critical patent/WO2001092251A2/en
Anticipated expiration legal-status Critical
Publication of WO2001092251A3 publication Critical patent/WO2001092251A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

This invention is directed to aryloxy ester and acid compounds of the formula (1): Ar-O-(CH2)n-COOR which can be utilized as intermediates in the synthesis of Factor Xa inhibitors to increase their potency and oral activity, and to a method for their production.
PCT/EP2001/006015 2000-05-31 2001-05-25 Aryloxy ester and acid compounds Ceased WO2001092251A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002410633A CA2410633A1 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
JP2002500865A JP2003535086A (en) 2000-05-31 2001-05-25 Aryloxy esters and acid compounds
AU2001267483A AU2001267483A1 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
MXPA02010875A MXPA02010875A (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds.
EP01945195A EP1322633A2 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
IL15297001A IL152970A0 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20818900P 2000-05-31 2000-05-31
US60/208,189 2000-05-31

Publications (2)

Publication Number Publication Date
WO2001092251A2 WO2001092251A2 (en) 2001-12-06
WO2001092251A3 true WO2001092251A3 (en) 2003-04-17

Family

ID=22773578

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006015 Ceased WO2001092251A2 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds

Country Status (7)

Country Link
EP (1) EP1322633A2 (en)
JP (1) JP2003535086A (en)
AU (1) AU2001267483A1 (en)
CA (1) CA2410633A1 (en)
IL (1) IL152970A0 (en)
MX (1) MXPA02010875A (en)
WO (1) WO2001092251A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065178A1 (en) 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A.J. SAGGIOMO ET AL.: "Alcoholation of the Trifluoromethyl Group. I. Ortho Esters Derived from 1- and 3-Trifluoromethylphenolthiazines (1).", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 6, 1969, PROVO US, pages 631 - 634, XP002188913 *
GUTHRIE, J. PETER: "Thermodynamics of ester and orthoester formation from trifluoroacetic acid", CAN. J. CHEM. (1976), 54(2), 202-9, XP001063910 *
J.F. KING ET AL.: "Alkyl 2,2,2-Trifluoroethanesulfonates (Tresylates): Elimination-Additions vs Bimolecular Nucelophilic Substitution in Reactions with Nucleophiles in Aqueous Media", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, EASTON US, pages 7250 - 7255, XP002188911 *
M.P. CAVA ET AL.: "Pyridine Derivatives. II. Some Halogen Substituted 2-Pyridoxyacetic Acids", JOURNAL OF ORGANIC CHEMISTRY, vol. 23, 1958, EASTON US, pages 1614 - 1616, XP002188915 *
P. TARRANT ET AL.: "Some Reactions of Fluoroethanes with Sodium Ethoxide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 75, 1953, DC US, pages 932 - 934, XP002188912 *
PEDERSEN, E. B. ET AL: "Thiophene chemistry. XXI. Alkylation of ambident ions from potential hydroxythiophenes", TETRAHEDRON (1972), 28(9), 2479-88, XP002188914 *

Also Published As

Publication number Publication date
JP2003535086A (en) 2003-11-25
WO2001092251A2 (en) 2001-12-06
CA2410633A1 (en) 2001-12-06
IL152970A0 (en) 2003-06-24
EP1322633A2 (en) 2003-07-02
AU2001267483A1 (en) 2001-12-11
MXPA02010875A (en) 2003-04-22

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