DK0674515T3 - Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8 - Google Patents

Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8

Info

Publication number: DK0674515T3
Authority: DK; Denmark
Prior art keywords: interleukin; pct; inhibiting; inhibition; drug
Prior art date: 1993-10-21

Application number

DK94929670T

Other languages

English (en)

Inventor

Takahide Matsuda

Shigeru Owada

Hiroshi Muta

Miki Aihara

Hisao Takizawa

Ken-Ichi Imagawa

Mikio Kikuchi

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-21

Filing date

1994-10-17

Publication date

1999-12-20

1994-10-17 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1999-12-20 Application granted granted Critical

1999-12-20 Publication of DK0674515T3 publication Critical patent/DK0674515T3/da

Links

102000004890 Interleukin-8 Human genes 0.000 title abstract 3
108090001007 Interleukin-8 Proteins 0.000 title abstract 3
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 title abstract 3
229940096397 interleukin-8 Drugs 0.000 title abstract 3
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 4
230000004913 activation Effects 0.000 abstract 2
210000003714 granulocyte Anatomy 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)

DK94929670T 1993-10-21 1994-10-17 Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8 DK0674515T3 (da)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP26341993		1993-10-21
JP26341893		1993-10-21
JP26341793		1993-10-21
JP8964194		1994-04-27
PCT/JP1994/001739 WO1995011026A1 (en)	1993-10-21	1994-10-17	Carbostyril derivative for inhibiting production of interleukin-8

Publications (1)

Publication Number	Publication Date
DK0674515T3 true DK0674515T3 (da)	1999-12-20

Family

ID=27467652

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94929670T DK0674515T3 (da)	1993-10-21	1994-10-17	Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8

Country Status (14)

Country	Link
US (1)	US5637597A (da)
EP (1)	EP0674515B1 (da)
JP (1)	JP2839847B2 (da)
KR (1)	KR100191191B1 (da)
CN (1)	CN1073418C (da)
AT (1)	ATE184793T1 (da)
AU (1)	AU683697B2 (da)
CA (1)	CA2150546C (da)
DE (1)	DE69420832T2 (da)
DK (1)	DK0674515T3 (da)
ES (1)	ES2138092T3 (da)
GR (1)	GR3032091T3 (da)
TW (1)	TW296983B (da)
WO (1)	WO1995011026A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR004214A1 (es) *	1995-10-12	1998-11-04	Otsuka Pharma Co Ltd	Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
DE10029404B4 (de) *	2000-06-15	2009-10-29	Jagotec Ag	Arzneiformulierung enthaltend Ciclosporin und deren Verwendung
FR2812548B1 (fr) *	2000-08-01	2002-09-20	Sanofi Synthelabo	Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
WO2004091724A1 (en) *	2002-10-08	2004-10-28	Wyeth	Anthranilic acid derivatives useful in treating infection with hepatitis c virus
ATE373502T1 (de)	2003-07-30	2007-10-15	Otsuka Pharma Co Ltd	Carbostyril-derivative zur beschleunigten speichelabsonderung
TWI340650B (en) *	2004-01-21	2011-04-21	Otsuka Pharma Co Ltd	Amine saly of carbostyril derivative
MY149159A (en)	2005-11-15	2013-07-31	Hoffmann La Roche	Method for treating joint damage
WO2009022674A1 (en) *	2007-08-10	2009-02-19	Otsuka Pharmaceutical Co., Ltd.	Medical composition containing rebamipide
KR101104634B1 (ko) *	2009-08-25	2012-01-12	한림제약(주)	레바미피드를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물
KR101182114B1 (ko) *	2010-03-05	2012-09-12	한림제약(주)	유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물
US9248196B2 (en)	2011-02-25	2016-02-02	Nuformix Limited	Rebamipide complexes and cocrystals
WO2012128394A1 (en)	2011-03-24	2012-09-27	Otsuka Pharmaceutical Co., Ltd.	A pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide
JP6294773B2 (ja) *	2014-06-27	2018-03-14	株式会社ナールスコーポレーション	口腔粘膜疾患の予防または治療用経口製剤
WO2022128054A1 (en)	2020-12-14	2022-06-23	Symrise Ag	Medicament for fighting inflammatory conditions of human skin (iv)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI80022C (fi) *	1982-07-05	1990-04-10	Otsuka Pharma Co Ltd	Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
GB8334494D0 (en) *	1983-12-24	1984-02-01	Tanabe Seiyaku Co	Carbostyril derivatives
JPS63119467A (ja) *	1987-10-21	1988-05-24	Otsuka Pharmaceut Co Ltd	カルボスチリル誘導体
JPH02178227A (ja) *	1988-12-28	1990-07-11	Otsuka Pharmaceut Co Ltd	腎炎治療剤
JP2812998B2 (ja) *	1989-08-14	1998-10-22	大塚製薬株式会社	胃炎治療剤
DK0543018T3 (da) *	1991-06-07	1996-02-05	Otsuka Pharma Co Ltd	Antidiabetikum
AU648690B2 (en) *	1991-07-03	1994-04-28	Otsuka Pharmaceutical Co., Ltd.	Apoptosis regulator
TW227558B (da) *	1992-05-14	1994-08-01	Otsuka Pharma Co Ltd
JP2872546B2 (ja) *	1992-11-26	1999-03-17	大塚製薬株式会社	腸粘膜障害保護剤
WO1994014444A1 (fr) *	1992-12-24	1994-07-07	Otsuka Pharmaceutical Co., Ltd.	Remede contre le psoriasis
WO1994020107A1 (fr) *	1993-03-02	1994-09-15	Otsuka Pharmaceutical Co., Ltd.	Inhibiteur de rejet pour transplantations et inhibiteur de production d'interleukine 1

1994
- 1994-10-17 CA CA002150546A patent/CA2150546C/en not_active Expired - Lifetime
- 1994-10-17 EP EP94929670A patent/EP0674515B1/en not_active Expired - Lifetime
- 1994-10-17 DE DE69420832T patent/DE69420832T2/de not_active Expired - Lifetime
- 1994-10-17 JP JP6250473A patent/JP2839847B2/ja not_active Expired - Fee Related
- 1994-10-17 US US08/448,577 patent/US5637597A/en not_active Expired - Lifetime
- 1994-10-17 CN CN94190812.7A patent/CN1073418C/zh not_active Expired - Lifetime
- 1994-10-17 KR KR1019950702533A patent/KR100191191B1/ko not_active Expired - Fee Related
- 1994-10-17 ES ES94929670T patent/ES2138092T3/es not_active Expired - Lifetime
- 1994-10-17 AT AT94929670T patent/ATE184793T1/de active
- 1994-10-17 AU AU78641/94A patent/AU683697B2/en not_active Expired
- 1994-10-17 WO PCT/JP1994/001739 patent/WO1995011026A1/en not_active Ceased
- 1994-10-17 DK DK94929670T patent/DK0674515T3/da active
- 1994-10-20 TW TW083109726A patent/TW296983B/zh not_active IP Right Cessation
1999
- 1999-12-08 GR GR990403182T patent/GR3032091T3/el unknown

Also Published As

Publication number	Publication date
ATE184793T1 (de)	1999-10-15
KR950703957A (ko)	1995-11-17
CA2150546C (en)	2004-11-09
US5637597A (en)	1997-06-10
TW296983B (da)	1997-02-01
KR100191191B1 (ko)	1999-06-15
CN1073418C (zh)	2001-10-24
JP2839847B2 (ja)	1998-12-16
CA2150546A1 (en)	1995-04-27
CN1117268A (zh)	1996-02-21
DE69420832T2 (de)	2000-01-13
JPH0812578A (ja)	1996-01-16
EP0674515A1 (en)	1995-10-04
DE69420832D1 (de)	1999-10-28
AU683697B2 (en)	1997-11-20
ES2138092T3 (es)	2000-01-01
AU7864194A (en)	1995-05-08
WO1995011026A1 (en)	1995-04-27
EP0674515B1 (en)	1999-09-22
GR3032091T3 (en)	2000-03-31

Publication	Publication Date	Title
FI943948A0 (fi)	1994-08-26	Heterosykliset hiilihappojohdannaiset
DK0597088T3 (da)	2001-04-09	Nye imidazolderivater, deres fremstilling og terapeutiske anvendelser
DK0674515T3 (da)	1999-12-20	Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8
FR16C1001I1 (fr)	2016-07-01	"Dérivé de 2-oxo-1-pyrrolidine et ses applications pharmaceutique"
ATE202346T1 (de)	2001-07-15	Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption
ATE185797T1 (de)	1999-11-15	Stilben-derivate verwendbar als cyclooxygenase-2 hemmer
DK0613894T3 (da)	1999-11-01	N-Heteroaryl-N'-phenylurinstofderivater, fremstilling og anvendelse deraf
ATE316962T1 (de)	2006-02-15	Pyrimidin-derivate als selective inhibitoren von cox-2
ATE148108T1 (de)	1997-02-15	Beta,beta-dimethyl-4-piperidinethanamin-derivat als inhibitoren der cholesterin-biosynthese
CA2238875A1 (en)	1997-06-26	Tri-aryl ethane derivatives as pde iv inhibitors
NO962855L (no)	1996-07-05	Nye piperidin-derivater med PAF-antagonist-aktivitet
DE69500673D1 (de)	1997-10-16	Arzneimittel zur therapeutischen und prophylaktischen Behandlung von Krankheiten, die durch Hyperplasie der glatten Muskelzellen bedingt sind
NO306400B1 (no)	1999-11-01	N-substituerte azabicykloheptan-derivater, anvendelse derav og farmasöytisk preparat
DK0966283T3 (da)	2006-10-09	Farmaceutiske præparater til helbredelse og forebyggelse af sygdomme, som stammer fra beskadigelse af vaskulære endotelceller
YU31995A (sh)	1998-12-23	Benzotiofeni glikopiranozida, postupak za njihovo dobijanje i njihova farmaceutska formulacija
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
ATE186642T1 (de)	1999-12-15	Interleukin-1 inhibitor
ATE294780T1 (de)	2005-05-15	Arylpiperidin- und aryl-1,2,5,6- tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
NO961719D0 (no)	1996-04-29	3-aryl-4-alkyl og 4,5-dialkyl-4H-1,2,4-triazoler som er anvendbare som hukommelsesforsterkere
SE9401965D0 (sv)	1994-06-07	New compounds
EE03488B1 (et)	2001-08-15	Meetod anhüdroekgoniini estrite valmistamiseks
CA2239053A1 (en)	1997-06-26	Diphenyl pyridyl ethane derivatives as pde iv inhibitors
DE69528984D1 (de)	2003-01-09	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
ES2079997A1 (es)	1996-01-16	Compuestos de fenil fenol sustituidos antagonistas de leucotrieno, procedimiento para su obtencion y formulaciones farmaceuticas de los mismos.