[go: up one dir, main page]

DK0642525T3 - Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre - Google Patents

Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre

Info

Publication number
DK0642525T3
DK0642525T3 DK92922008.5T DK92922008T DK0642525T3 DK 0642525 T3 DK0642525 T3 DK 0642525T3 DK 92922008 T DK92922008 T DK 92922008T DK 0642525 T3 DK0642525 T3 DK 0642525T3
Authority
DK
Denmark
Prior art keywords
nucleosides
fatty acid
acylated
acid
monounsaturated omega
Prior art date
Application number
DK92922008.5T
Other languages
Danish (da)
English (en)
Inventor
Are Dalen
Finn Myhren
Rretzen Bernt B
Kjell Torgeir Stokke
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Application granted granted Critical
Publication of DK0642525T3 publication Critical patent/DK0642525T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • External Artificial Organs (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92922008.5T 1991-10-07 1992-09-30 Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre DK0642525T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9121257A GB2260319B (en) 1991-10-07 1991-10-07 Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity

Publications (1)

Publication Number Publication Date
DK0642525T3 true DK0642525T3 (da) 1997-11-03

Family

ID=10702531

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92922008.5T DK0642525T3 (da) 1991-10-07 1992-09-30 Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre

Country Status (26)

Country Link
US (1) US6548486B1 (fr)
EP (1) EP0642525B1 (fr)
JP (1) JP2873313B2 (fr)
KR (1) KR100272732B1 (fr)
AT (1) ATE152454T1 (fr)
CA (1) CA2120725C (fr)
CH (1) CH0642525H1 (fr)
CZ (1) CZ288153B6 (fr)
DE (1) DE69219482T2 (fr)
DK (1) DK0642525T3 (fr)
FI (2) FI990270L (fr)
GB (1) GB2260319B (fr)
GR (1) GR3024149T3 (fr)
HU (1) HU219400B (fr)
IL (1) IL103351A (fr)
MX (1) MX9205715A (fr)
NO (1) NO300014B1 (fr)
NZ (1) NZ244535A (fr)
PL (1) PL170846B1 (fr)
RU (1) RU2126417C1 (fr)
SG (1) SG47759A1 (fr)
SK (1) SK281903B6 (fr)
TW (1) TW347333B (fr)
UA (1) UA41296C2 (fr)
WO (1) WO1993007163A1 (fr)
ZA (1) ZA927432B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
RU2178710C1 (ru) * 2001-02-08 2002-01-27 Кожемякин Леонид Андреевич Индивидуальные вещества, полученные на основе химического взаимодействия дисульфидсодержащих пептидов с производными пуриновых или пиримидиновых оснований, фармацевтические композиции и препараты на их основе, способы их применения для лечения инфекционных заболеваний и профилактики осложнений
RU2328273C2 (ru) * 2001-12-19 2008-07-10 Рисерч Дивелопмент Фаундейшн Липосомальная доставка соединений, основанных на витамине е
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2008147454A1 (fr) * 2006-11-16 2008-12-04 Case Western Reserve University Inhibiteurs sélectifs de la réplication d'adn de translésion
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
RU2435592C2 (ru) * 2005-12-14 2011-12-10 Ф.Хоффманн-Ля Рош Аг Композиция пролекарства для борьбы с вирусом гепатита с
US8497292B2 (en) * 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
US20090111774A1 (en) * 2007-06-01 2009-04-30 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
MX2010000424A (es) 2007-07-09 2010-08-10 Easter Virginia Medical School Derivados de nucleosidos sustituidos con propiedades antivirales y antimicrobianas.
US8399420B2 (en) * 2007-09-26 2013-03-19 Mount Sanai School of Medicine Azacytidine analogues and uses thereof
WO2013033705A2 (fr) 2011-09-01 2013-03-07 Case Western Reserve University Nucléosides non endogènes en tant qu'agents théranostiques
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use
RU2561501C1 (ru) * 2014-08-05 2015-08-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Антиретровирусные препараты на основе производных азидотимидина
RU2621145C2 (ru) * 2015-11-03 2017-05-31 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") Способ получения липосом
US20200407393A1 (en) * 2018-03-07 2020-12-31 Glaxosmithkline Intellectual Property (No. 2) Limited Medical Use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
GB1325797A (en) * 1970-09-24 1973-08-08 Upjohn Co Medicines comprising cytidine derivatives
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de) 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4684631A (en) 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
JPH0655755B2 (ja) * 1985-01-23 1994-07-27 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE3665260D1 (en) * 1985-05-07 1989-10-05 Teijin Ltd Antitumor agent
JPS6483092A (en) * 1987-09-24 1989-03-28 Arakawa Chotaro & Co Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
WO1989003838A1 (fr) * 1987-10-28 1989-05-05 Pro-Neuron, Inc. Derives de desoxyribonucleosides d'acyle et leurs utilisations
JPH0278696A (ja) * 1988-09-13 1990-03-19 Shoichiro Ozaki ５−フルオロウラシル誘導体
IE980216A1 (en) 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
CA2079413C (fr) * 1991-09-30 2003-09-09 Masakatsu Kaneko Derives de nucleoside pyrimidique ayant une action anti-tumorale, leur preparation et leur utilisation

Also Published As

Publication number Publication date
SK39794A3 (en) 1994-10-05
JP2873313B2 (ja) 1999-03-24
GR3024149T3 (en) 1997-10-31
CZ288153B6 (en) 2001-05-16
EP0642525B1 (fr) 1997-05-02
JPH06511249A (ja) 1994-12-15
IL103351A (en) 2000-02-17
UA41296C2 (uk) 2001-09-17
HU219400B (hu) 2001-04-28
FI990270A0 (fi) 1999-02-10
HK1007430A1 (en) 1999-04-09
CA2120725C (fr) 2000-04-11
NO941269L (no) 1994-04-07
GB2260319A (en) 1993-04-14
CH0642525H1 (en) 1999-06-30
FI990270A7 (fi) 1999-02-10
US6548486B1 (en) 2003-04-15
WO1993007163A1 (fr) 1993-04-15
FI941574L (fi) 1994-04-06
RU2126417C1 (ru) 1999-02-20
HUT68008A (en) 1995-05-29
SG47759A1 (en) 1998-04-17
ZA927432B (en) 1993-06-09
EP0642525A1 (fr) 1995-03-15
CA2120725A1 (fr) 1993-04-15
AU672369B2 (en) 1996-10-03
GB2260319B (en) 1995-12-06
DE69219482T2 (de) 1997-10-23
GB9121257D0 (en) 1991-11-20
NO300014B1 (no) 1997-03-17
DE69219482D1 (de) 1997-06-05
FI990270L (fi) 1999-02-10
SK281903B6 (sk) 2001-09-11
ATE152454T1 (de) 1997-05-15
FI105035B (fi) 2000-05-31
MX9205715A (es) 1993-05-01
TW347333B (en) 1998-12-11
CZ80594A3 (en) 1994-12-15
FI941574A0 (fi) 1994-04-06
NZ244535A (en) 1995-08-28
PL170846B1 (en) 1997-01-31
IL103351A0 (en) 1993-03-15
KR100272732B1 (ko) 2000-11-15
HU9400988D0 (en) 1994-07-28
AU2867392A (en) 1993-05-03
NO941269D0 (no) 1994-04-07

Similar Documents

Publication Publication Date Title
DK0642525T3 (da) Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre
DK193488A (da) Saccharosefedtsyreester
NZ224197A (en) Indigestible shortening compositions
ES2014018B3 (es) Esteres de acidos grasos de azucares y azucares-alcoholes.
ES2124883T3 (es) Compuestos antiviricos.
DK572788D0 (da) Polysvovlsyreestere af bis-aldonamider og derivater deraf samt fremgangsmaade til fremstilling af samme
TW341574B (en) METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.
DK0495553T3 (da) Propylenglycoldiestere af mediumkædede og langkædede, mættede fedtsyrer, der er anvendelige som kakaosmørerstatninger med nedsat kalorieindhold og hårde smørtyper
IE810552L (en) Purines
EP0321777A3 (en) Process for the transesterification of fat and oil
MX9200843A (es) Esteres del acido acrilico triazinil-substituidos y procedimiento para su obtencion.
ES557560A0 (es) Un procedimiento para la prepracion de derivados de acidos griseolicos.
FI924823A0 (fi) Nya fasta, daoligt smaeltbara, fettliknande foereningar samt livsmedelskompositioner innehaollande desamma
IT9004727V0 (it) Mensola multiuso
IT8746302A0 (it) Meccanismo adibito a gioco da tavolo basato su un insieme di pedine esagonali
DE3862882D1 (de) Ameisensaeure-2,6-dimethyloctylester und lockmittel fuer tribolium castaneum herbst.
IT1255591B (it) Cruscotto di veicolo a faccia anteriore unica
IT218086Z2 (it) Struttura universale di supporto di pezzi meccanici aventi superfici oblique da orientare sul piano orizzontale per la loro lavorazione