GR3024149T3 - Chemical compounds. - Google Patents

Chemical compounds.

Info

Publication number: GR3024149T3
Authority: GR; Greece
Prior art keywords: acid; nucleosides; fatty acid; ara; esters
Prior art date: 1991-10-07

Application number

GR970401799T

Other languages

English (en)

Inventor

Are Dalen

Finn Myhren

Bernt Boerretzen

Kjell Torgeir Stokke

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-07

Filing date

1997-07-16

Publication date

1997-10-31

1997-07-16 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1997-10-31 Publication of GR3024149T3 publication Critical patent/GR3024149T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
External Artificial Organs (AREA)
Mechanical Coupling Of Light Guides (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

GR970401799T 1991-10-07 1997-07-16 Chemical compounds. GR3024149T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9121257A GB2260319B (en)	1991-10-07	1991-10-07	Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
PCT/NO1992/000162 WO1993007163A1 (en)	1991-10-07	1992-09-30	Chemical compounds

Publications (1)

Publication Number	Publication Date
GR3024149T3 true GR3024149T3 (en)	1997-10-31

Family

ID=10702531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970401799T GR3024149T3 (en)	1991-10-07	1997-07-16	Chemical compounds.

Country Status (26)

Country	Link
US (1)	US6548486B1 (el)
EP (1)	EP0642525B1 (el)
JP (1)	JP2873313B2 (el)
KR (1)	KR100272732B1 (el)
AT (1)	ATE152454T1 (el)
CA (1)	CA2120725C (el)
CH (1)	CH0642525H1 (el)
CZ (1)	CZ288153B6 (el)
DE (1)	DE69219482T2 (el)
DK (1)	DK0642525T3 (el)
FI (2)	FI990270L (el)
GB (1)	GB2260319B (el)
GR (1)	GR3024149T3 (el)
HU (1)	HU219400B (el)
IL (1)	IL103351A (el)
MX (1)	MX9205715A (el)
NO (1)	NO300014B1 (el)
NZ (1)	NZ244535A (el)
PL (1)	PL170846B1 (el)
RU (1)	RU2126417C1 (el)
SG (1)	SG47759A1 (el)
SK (1)	SK281903B6 (el)
TW (1)	TW347333B (el)
UA (1)	UA41296C2 (el)
WO (1)	WO1993007163A1 (el)
ZA (1)	ZA927432B (el)

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GB9307043D0 (en) *	1993-04-05	1993-05-26	Norsk Hydro As	Chemical compounds
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
GB2321455A (en) *	1997-01-24	1998-07-29	Norsk Hydro As	Lipophilic derivatives of biologically active compounds
RU2178710C1 (ru) *	2001-02-08	2002-01-27	Кожемякин Леонид Андреевич	Индивидуальные вещества, полученные на основе химического взаимодействия дисульфидсодержащих пептидов с производными пуриновых или пиримидиновых оснований, фармацевтические композиции и препараты на их основе, способы их применения для лечения инфекционных заболеваний и профилактики осложнений
RU2328273C2 (ru) *	2001-12-19	2008-07-10	Рисерч Дивелопмент Фаундейшн	Липосомальная доставка соединений, основанных на витамине е
GB0201179D0 (en) *	2002-01-18	2002-03-06	Angeletti P Ist Richerche Bio	Therapeutic agents
TWI332507B (en) *	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
WO2008147454A1 (en) *	2006-11-16	2008-12-04	Case Western Reserve University	Selective inhibitors of translesion dna replication
US8114847B2 (en)	2005-03-16	2012-02-14	Case Western Reserve University	Selective inhibitors of translesion DNA replication
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
RU2435592C2 (ru) *	2005-12-14	2011-12-10	Ф.Хоффманн-Ля Рош Аг	Композиция пролекарства для борьбы с вирусом гепатита с
US8497292B2 (en) *	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
US20090111774A1 (en) *	2007-06-01	2009-04-30	Luitpold Pharmaceuticals, Inc.	Pmea lipid conjugates
MX2010000424A (es)	2007-07-09	2010-08-10	Easter Virginia Medical School	Derivados de nucleosidos sustituidos con propiedades antivirales y antimicrobianas.
US8399420B2 (en) *	2007-09-26	2013-03-19	Mount Sanai School of Medicine	Azacytidine analogues and uses thereof
WO2013033705A2 (en)	2011-09-01	2013-03-07	Case Western Reserve University	Non-natural nucleosides as theranostic agents
US9493500B2 (en)	2012-07-19	2016-11-15	Richard Daifuku	Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en)	2013-02-08	2017-11-21	Case Western Reserve University	Anti-cancer agents and methods of use
RU2561501C1 (ru) *	2014-08-05	2015-08-27	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ)	Антиретровирусные препараты на основе производных азидотимидина
RU2621145C2 (ru) *	2015-11-03	2017-05-31	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ")	Способ получения липосом
US20200407393A1 (en) *	2018-03-07	2020-12-31	Glaxosmithkline Intellectual Property (No. 2) Limited	Medical Use

Family Cites Families (18)

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US3920630A (en) *	1970-09-24	1975-11-18	Upjohn Co	2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
GB1325797A (en) *	1970-09-24	1973-08-08	Upjohn Co	Medicines comprising cytidine derivatives
US4211773A (en) *	1978-10-02	1980-07-08	Sloan Kettering Institute For Cancer Research	5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de)	1981-01-09	1982-08-12	Dr. Thilo & Co GmbH, 8021 Sauerlach	5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en)	1981-05-21	1990-10-30		9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en)	1981-08-26	1986-07-11	Merck & Co Inc	9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en)	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
US5250535A (en)	1982-02-01	1993-10-05	Syntex Inc.	Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) *	1982-08-09	1985-12-03	Syntex (U.S.A.) Inc.	Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4684631A (en)	1984-10-09	1987-08-04	Toyama Chemical Co., Ltd.	Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
JPH0655755B2 (ja) *	1985-01-23	1994-07-27	富山化学工業株式会社	新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
US5223263A (en)	1988-07-07	1993-06-29	Vical, Inc.	Liponucleotide-containing liposomes
DE3665260D1 (en) *	1985-05-07	1989-10-05	Teijin Ltd	Antitumor agent
JPS6483092A (en) *	1987-09-24	1989-03-28	Arakawa Chotaro & Co	Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
WO1989003838A1 (en) *	1987-10-28	1989-05-05	Pro-Neuron, Inc.	Acyl deoxyribonucleoside derivatives and uses thereof
JPH0278696A (ja) *	1988-09-13	1990-03-19	Shoichiro Ozaki	５−フルオロウラシル誘導体
IE980216A1 (en)	1989-04-17	2000-02-23	Scotia Holdings Plc	Anti-virals
CA2079413C (en) *	1991-09-30	2003-09-09	Masakatsu Kaneko	Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use

1991
- 1991-10-07 GB GB9121257A patent/GB2260319B/en not_active Expired - Fee Related
1992
- 1992-09-28 ZA ZA927432A patent/ZA927432B/xx unknown
- 1992-09-29 NZ NZ244535A patent/NZ244535A/en not_active IP Right Cessation
- 1992-09-30 DK DK92922008.5T patent/DK0642525T3/da active
- 1992-09-30 SG SG1996004250A patent/SG47759A1/en unknown
- 1992-09-30 DE DE69219482T patent/DE69219482T2/de not_active Expired - Lifetime
- 1992-09-30 CA CA002120725A patent/CA2120725C/en not_active Expired - Lifetime
- 1992-09-30 FI FI990270A patent/FI990270L/fi unknown
- 1992-09-30 AT AT92922008T patent/ATE152454T1/de active
- 1992-09-30 UA UA94005489A patent/UA41296C2/uk unknown
- 1992-09-30 JP JP5506814A patent/JP2873313B2/ja not_active Expired - Lifetime
- 1992-09-30 PL PL92303098A patent/PL170846B1/pl unknown
- 1992-09-30 KR KR1019940701120A patent/KR100272732B1/ko not_active Expired - Lifetime
- 1992-09-30 SK SK397-94A patent/SK281903B6/sk not_active IP Right Cessation
- 1992-09-30 RU RU94021110/04A patent/RU2126417C1/ru active
- 1992-09-30 CZ CZ1994805A patent/CZ288153B6/cs not_active IP Right Cessation
- 1992-09-30 US US08/211,386 patent/US6548486B1/en not_active Expired - Lifetime
- 1992-09-30 HU HU9400988A patent/HU219400B/hu unknown
- 1992-09-30 WO PCT/NO1992/000162 patent/WO1993007163A1/en not_active Ceased
- 1992-09-30 CH CH92922008.5T patent/CH0642525H1/xx unknown
- 1992-09-30 EP EP92922008A patent/EP0642525B1/en not_active Expired - Lifetime
- 1992-10-03 TW TW081107870A patent/TW347333B/zh not_active IP Right Cessation
- 1992-10-05 IL IL10335192A patent/IL103351A/xx not_active IP Right Cessation
- 1992-10-06 MX MX9205715A patent/MX9205715A/es unknown
1994
- 1994-04-06 FI FI941574A patent/FI105035B/fi not_active IP Right Cessation
- 1994-04-07 NO NO941269A patent/NO300014B1/no not_active IP Right Cessation
1997
- 1997-07-16 GR GR970401799T patent/GR3024149T3/el unknown

Also Published As

Publication number	Publication date
SK39794A3 (en)	1994-10-05
JP2873313B2 (ja)	1999-03-24
CZ288153B6 (en)	2001-05-16
EP0642525B1 (en)	1997-05-02
JPH06511249A (ja)	1994-12-15
IL103351A (en)	2000-02-17
UA41296C2 (uk)	2001-09-17
HU219400B (hu)	2001-04-28
FI990270A0 (fi)	1999-02-10
HK1007430A1 (en)	1999-04-09
CA2120725C (en)	2000-04-11
NO941269L (no)	1994-04-07
GB2260319A (en)	1993-04-14
CH0642525H1 (en)	1999-06-30
FI990270A7 (fi)	1999-02-10
US6548486B1 (en)	2003-04-15
WO1993007163A1 (en)	1993-04-15
FI941574L (fi)	1994-04-06
RU2126417C1 (ru)	1999-02-20
HUT68008A (en)	1995-05-29
SG47759A1 (en)	1998-04-17
ZA927432B (en)	1993-06-09
EP0642525A1 (en)	1995-03-15
CA2120725A1 (en)	1993-04-15
AU672369B2 (en)	1996-10-03
GB2260319B (en)	1995-12-06
DE69219482T2 (de)	1997-10-23
GB9121257D0 (en)	1991-11-20
NO300014B1 (no)	1997-03-17
DE69219482D1 (de)	1997-06-05
FI990270L (fi)	1999-02-10
DK0642525T3 (da)	1997-11-03
SK281903B6 (sk)	2001-09-11
ATE152454T1 (de)	1997-05-15
FI105035B (fi)	2000-05-31
MX9205715A (es)	1993-05-01
TW347333B (en)	1998-12-11
CZ80594A3 (en)	1994-12-15
FI941574A0 (fi)	1994-04-06
NZ244535A (en)	1995-08-28
PL170846B1 (en)	1997-01-31
IL103351A0 (en)	1993-03-15
KR100272732B1 (ko)	2000-11-15
HU9400988D0 (en)	1994-07-28
AU2867392A (en)	1993-05-03
NO941269D0 (no)	1994-04-07

Publication	Publication Date	Title
HU9400988D0 (en)	1994-07-28	Chemical compounds
DK193488A (da)	1988-10-11	Saccharosefedtsyreester
EP0236935A3 (en)	1989-02-22	Carboxylic purine nucleosides, their production and use
TW341574B (en)	1998-10-01	METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.
DE3884517D1 (de)	1993-11-04	Biologisch aktive carbonsaeureester.
CA2155329A1 (en)	1994-08-18	Acylfulvene analogues as antitumor agents
EP0321777A3 (en)	1990-05-09	Process for the transesterification of fat and oil
EP0940316A3 (en)	1999-09-15	Drawer tower
IE810552L (en)	1981-09-14	Purines
WO1991004754A3 (en)	1991-12-12	Illudin analogs as anti-tumor agents
CA2079889A1 (en)	1991-10-27	Solid, nondigestible, fat-like compounds and food compositions
AU4333889A (en)	1990-05-14	Nucleoside derivatives
CA2092705A1 (en)	1993-01-18	Compound having antitumor activity, nsc-lsc1, and process for producing the same
AU4562089A (en)	1990-06-07	Sialic acid derivative with active ester groups
GR3004905T3 (el)	1993-04-28
USD297140S (en)	1988-08-09	Simulated computer system
DE3862882D1 (de)	1991-06-27	Ameisensaeure-2,6-dimethyloctylester und lockmittel fuer tribolium castaneum herbst.
MY100163A (en)	1991-10-04	Benzohydroxamic acid derivates.