DK0512693T3 - Fremstilling af diagnostiske midler - Google Patents
Fremstilling af diagnostiske midlerInfo
- Publication number
- DK0512693T3 DK0512693T3 DK92303236T DK92303236T DK0512693T3 DK 0512693 T3 DK0512693 T3 DK 0512693T3 DK 92303236 T DK92303236 T DK 92303236T DK 92303236 T DK92303236 T DK 92303236T DK 0512693 T3 DK0512693 T3 DK 0512693T3
- Authority
- DK
- Denmark
- Prior art keywords
- microcapsules
- wall
- manufacture
- forming material
- diagnostic agents
- Prior art date
Links
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003094 microcapsule Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
- Y10S516/928—Mixing combined with non-mixing operation or step, successively or simultaneously, e.g. heating, cooling, ph change, ageing, milling
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919107628A GB9107628D0 (en) | 1991-04-10 | 1991-04-10 | Preparation of diagnostic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0512693T3 true DK0512693T3 (da) | 2000-08-28 |
Family
ID=10693031
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95110723T DK0681843T3 (da) | 1991-04-10 | 1992-04-10 | Fremstilling af diagnostiske midler |
| DK92303236T DK0512693T3 (da) | 1991-04-10 | 1992-04-10 | Fremstilling af diagnostiske midler |
| DK99203198T DK0972526T3 (da) | 1991-04-10 | 1992-04-10 | Fremstilling af diagnostiske midler |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95110723T DK0681843T3 (da) | 1991-04-10 | 1992-04-10 | Fremstilling af diagnostiske midler |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99203198T DK0972526T3 (da) | 1991-04-10 | 1992-04-10 | Fremstilling af diagnostiske midler |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5518709A (da) |
| EP (6) | EP0972526B1 (da) |
| JP (2) | JP2865866B2 (da) |
| KR (1) | KR0129861B1 (da) |
| CN (1) | CN1066977A (da) |
| AT (3) | ATE194082T1 (da) |
| AU (2) | AU655016B2 (da) |
| CA (1) | CA2083260A1 (da) |
| DE (3) | DE69233489T2 (da) |
| DK (3) | DK0681843T3 (da) |
| ES (3) | ES2203626T3 (da) |
| FI (1) | FI925600A7 (da) |
| GB (2) | GB9107628D0 (da) |
| GR (1) | GR3034462T3 (da) |
| HU (1) | HUT62805A (da) |
| IE (1) | IE921140A1 (da) |
| IL (2) | IL101564A (da) |
| MX (1) | MX9201694A (da) |
| NZ (1) | NZ242328A (da) |
| PT (2) | PT681843E (da) |
| RU (1) | RU2109521C1 (da) |
| WO (1) | WO1992018164A1 (da) |
| ZA (1) | ZA922636B (da) |
Families Citing this family (196)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US6989141B2 (en) | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| IN172208B (da) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| KR100291620B1 (ko) * | 1992-09-29 | 2001-10-24 | 추후제출 | 부갑상선호르몬의활성단편의폐를통한전달방법 |
| GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
| US6428844B1 (en) * | 1993-02-03 | 2002-08-06 | Rohm And Haas Company | Reduction of microfoam in a spray-applied waterborne composition |
| HUT74827A (en) * | 1993-07-02 | 1997-02-28 | Molecular Biosystems Inc | Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents |
| EP1550464A1 (en) † | 1993-07-30 | 2005-07-06 | IMCOR Pharmaceutical Co. | Stabilized microbubble composition for ultrasound |
| PT682530E (pt) | 1993-12-15 | 2003-06-30 | Bracco Research Sa | Misturas de gases uteis como meios de contraste para ultrassons |
| ATE264096T1 (de) | 1994-03-07 | 2004-04-15 | Nektar Therapeutics | Verfahren und mittel zur verabreichung von insulin über die lunge |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| JPH10503480A (ja) * | 1994-05-03 | 1998-03-31 | モレキュラー バイオシステムズ, インコーポレイテッド | 心筋の灌流を超音波で定量するための組成物 |
| WO1995031479A1 (en) * | 1994-05-18 | 1995-11-23 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
| US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
| US5965109A (en) * | 1994-08-02 | 1999-10-12 | Molecular Biosystems, Inc. | Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier |
| EP0699445A3 (en) * | 1994-08-04 | 1996-04-17 | Gakko Houjin Toin Gakuen | Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| IL116328A (en) * | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US5955108A (en) * | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
| US5820850A (en) * | 1995-06-07 | 1998-10-13 | Molecular Biosystems, Inc. | Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents |
| WO1996040277A2 (en) * | 1995-06-07 | 1996-12-19 | Brown University Research Foundation | Spray dried polymeric microparticles containing imaging agents |
| AU1354497A (en) * | 1995-12-21 | 1997-07-14 | Drexel University | Hollow polymer microcapsules and method of producing |
| US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
| IL126073A (en) * | 1996-03-05 | 2002-02-10 | Acusphere Inc | Microencapsulated fluorinated gases for use as imaging agents |
| GB9607035D0 (en) * | 1996-04-03 | 1996-06-05 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles |
| GB9610341D0 (en) * | 1996-05-17 | 1996-07-24 | Andaris Ltd | Formulation for inhalation |
| AU702955B2 (en) * | 1996-05-17 | 1999-03-11 | Quadrant Healthcare (Uk) Limited | Microparticles and their use in wound therapy |
| GB9610830D0 (en) | 1996-05-23 | 1996-07-31 | Andaris Ltd | Use of hollow microcapsules |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| GB9615435D0 (en) | 1996-07-23 | 1996-09-04 | Andaris Ltd | Spray-dried product and its therapeutic use |
| US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| JP2002515887A (ja) * | 1996-10-19 | 2002-05-28 | クウォドラント、ヘルスケアー、(ユーケー)、リミテッド | 診断および治療における中空マイクロカプセルの使用 |
| EP1028752B1 (en) * | 1996-10-21 | 2004-12-15 | Quadrant Drug Delivery Limited | Platelet substitutes and conjugation methods suitable for their preparation |
| US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
| US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| GB9701274D0 (en) | 1997-01-22 | 1997-03-12 | Andaris Ltd | Ultrasound contrast imaging |
| US6383810B2 (en) | 1997-02-14 | 2002-05-07 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
| US20040022666A1 (en) * | 1998-06-30 | 2004-02-05 | Invitrogen Corporation | Methods for reducing adventitious agents and toxins and cell culture reagents produced thereby |
| US6627426B2 (en) * | 1997-02-14 | 2003-09-30 | Invitrogen Corporation | Methods for reducing adventitious agents and toxins and cell culture reagents produced thereby |
| US20060003447A1 (en) * | 2003-12-30 | 2006-01-05 | Richard Fike | Dry powder cells and cell culture reagents and methods of production thereof |
| GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
| WO1998048783A1 (en) | 1997-04-30 | 1998-11-05 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream |
| US6610764B1 (en) | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US6867248B1 (en) | 1997-05-12 | 2005-03-15 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| WO1998055105A1 (en) | 1997-06-05 | 1998-12-10 | Hemosphere, Inc. | Fibrinogen-coated microspheres |
| US6045777A (en) * | 1997-06-30 | 2000-04-04 | Acusphere, Inc. | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
| DK1801214T3 (da) * | 1997-07-07 | 2011-01-24 | Medical Res Council | In vitro sorteringsfremgangsmåde |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| GB9727102D0 (en) * | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
| AU751610B2 (en) | 1997-12-22 | 2002-08-22 | Tepha, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| DE19813174A1 (de) * | 1998-03-25 | 1999-05-27 | Schering Ag | Mikropartikel aus Polymeren und mindestens einer gerüstbildenden Komponente und ihre Herstellung und Verwendung in der Ultraschalldiagnostik und zur ultraschallinduzierten Wirkstofffreisetzung |
| GB9811116D0 (en) * | 1998-05-23 | 1998-07-22 | Andaris Ltd | Method of altering heartbeat |
| US6451349B1 (en) | 1998-08-19 | 2002-09-17 | Quadrant Healthcare (Uk) Limited | Spray-drying process for the preparation of microparticles |
| GB9817470D0 (en) * | 1998-08-11 | 1998-10-07 | Andaris Ltd | Pharmaceutical formulation |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| GB9900298D0 (en) * | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| JP4554084B2 (ja) | 1999-03-04 | 2010-09-29 | テファ, インコーポレイテッド | 組織操作のための生体吸収性、生体適合性ポリマー |
| DK1163019T3 (da) | 1999-03-25 | 2008-03-03 | Metabolix Inc | Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere |
| EP1039291A1 (en) * | 1999-03-26 | 2000-09-27 | Sony International (Europe) GmbH | Optochemical sensor and method for its construction |
| US6224554B1 (en) * | 1999-03-31 | 2001-05-01 | Point Biomedical Corporation | Method to measure ambient fluid pressure |
| AU6635900A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
| EP1202670A4 (en) * | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE |
| US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| CA2382821A1 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| NL1012933C2 (nl) * | 1999-08-30 | 2001-03-01 | Inst Agrotechnologisch Onderzoek Ato Dlo | Immobilisatie van actieve stoffen. |
| NL1014175C2 (nl) | 2000-01-25 | 2001-07-26 | Oldelft B V | Ultrageluid probe. |
| US8178150B2 (en) | 2000-02-22 | 2012-05-15 | Suzanne Jaffe Stillman | Water containing soluble fiber |
| US7892586B2 (en) | 2001-02-22 | 2011-02-22 | Suzanne Jaffe Stillman | Water containing soluble fiber |
| US7115297B2 (en) * | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
| CA2382133C (en) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| WO2002009669A2 (en) * | 2000-08-01 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution and particles made thereby |
| GB0022458D0 (en) * | 2000-09-13 | 2000-11-01 | Medical Res Council | Directed evolution method |
| AU2002232406C1 (en) * | 2000-11-06 | 2009-03-05 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
| GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
| EP1345629A2 (en) | 2000-12-29 | 2003-09-24 | Advanced Inhalation Research, Inc. | Particles for inhalation having sustained release properties |
| US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| JP3746766B2 (ja) * | 2001-02-23 | 2006-02-15 | 独立行政法人科学技術振興機構 | エマルションの製造方法およびその装置 |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| TW200300696A (en) * | 2001-11-01 | 2003-06-16 | Inhale Therapeutic Syst | Spray drying methods and related compositions |
| GB0127564D0 (en) * | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| CA2465675C (en) * | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
| AU2002346472A1 (en) * | 2001-11-20 | 2003-06-10 | Advanced Inhalation Research, Inc. | Particulate compositions for improving solubility of poorly soluble agents |
| WO2003048313A2 (en) * | 2001-11-30 | 2003-06-12 | Invitrogen Corporation | Cell culture media |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| US20030215394A1 (en) * | 2002-05-17 | 2003-11-20 | Short Robert E. | Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream |
| US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
| DE10234165B4 (de) * | 2002-07-26 | 2008-01-03 | Advanced Micro Devices, Inc., Sunnyvale | Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material |
| US6962006B2 (en) | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| EP1578536B1 (en) | 2002-12-30 | 2017-02-08 | Novartis AG | Prefilming atomizer |
| US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| EP2860292B1 (en) | 2003-05-08 | 2020-07-22 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
| CA2543296A1 (en) | 2003-10-31 | 2005-05-12 | Point Biomedical Corporation | Reconstitutable microsphere compositions useful as ultrasonic contrast agents |
| NO20035401D0 (no) * | 2003-12-04 | 2003-12-04 | Amersham Health As | Metode |
| WO2005061088A1 (en) * | 2003-12-22 | 2005-07-07 | Finlay Warren H | Powder formation by atmospheric spray-freeze drying |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| ATE473021T1 (de) | 2004-08-03 | 2010-07-15 | Tepha Inc | Nichtkräuselnde polyhydroxyalkanoatnähte |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| EP1901715B1 (en) | 2005-07-05 | 2012-05-02 | Lonza AG | Spray-drying process for producing a dry carnitine powder or granulate |
| GB0516091D0 (en) | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
| GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| EP2004144A1 (en) * | 2005-12-02 | 2008-12-24 | Stichting Katholieke Universiteit | Method for obtaining hollow particles |
| JP2009519970A (ja) * | 2005-12-15 | 2009-05-21 | アキュスフィア, インコーポレイテッド | 粒子ベースの経口投与用製薬剤形の製造方法 |
| CA2631493A1 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
| EP3913375A1 (en) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP2021113A2 (en) | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| ES2691033T3 (es) | 2007-02-11 | 2018-11-23 | Map Pharmaceuticals Inc. | Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US7706912B2 (en) * | 2007-11-30 | 2010-04-27 | Caterpillar Inc. | Orifice formation control system |
| CN101585892B (zh) * | 2008-05-22 | 2010-09-29 | 中国科学院化学研究所 | 一种制备聚合物微球的方法 |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
| US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
| EP2216054A1 (en) | 2009-02-06 | 2010-08-11 | ProFibrix BV | Biodegradable extravascular support |
| CA2991390A1 (en) * | 2009-02-09 | 2010-08-12 | Cellutech Ab | Cellulose shells |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| GB0909136D0 (en) | 2009-05-28 | 2009-07-01 | Profibrix Bv | Dry powder composition |
| GB0909131D0 (en) | 2009-05-28 | 2009-07-01 | Quadrant Drug Delivery Ltd | Dry powder fibrin sealant |
| AU2010252929B2 (en) * | 2009-05-28 | 2015-08-27 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
| WO2011042564A1 (en) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| KR20120125465A (ko) | 2010-01-08 | 2012-11-15 | 프로피브릭스 비.브이. | 건조 분말 피브린 실란트 |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| RU2010139501A (ru) | 2010-09-24 | 2012-03-27 | Виктор Петрович Алфёров (RU) | Средство для подавления вредителей сельскохозяйственных растений, животных и продуктов |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| GB201101740D0 (en) | 2011-02-01 | 2011-03-16 | Haemostatix Ltd | Therapeutic agents with improved fibrinogen binding |
| WO2012109600A2 (en) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| MX350838B (es) | 2011-02-11 | 2017-09-18 | Grain Proc Corporation * | Composicion de sal. |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| US8944288B2 (en) | 2011-02-22 | 2015-02-03 | Gojo Industries, Inc. | Collapsible container |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| RU2013155713A (ru) | 2011-07-06 | 2015-08-20 | Профибрикс Бв | Составы для лечения ран |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| ES2810003T3 (es) | 2011-11-18 | 2021-03-08 | Regeneron Pharma | Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico |
| GB201201751D0 (en) | 2012-02-01 | 2012-03-14 | Haemostatix Ltd | Haemostatic wound dressing |
| FR2991885A1 (fr) | 2012-06-14 | 2013-12-20 | Univ Lorraine | Procede pour l'obtention de structures d'encapsulation |
| JP6108382B2 (ja) * | 2012-09-04 | 2017-04-05 | 国立大学法人九州大学 | 新規イオン液体およびその用途 |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| EP3180040B1 (en) | 2014-08-15 | 2020-05-13 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
| CA2965509C (en) | 2014-10-24 | 2023-03-14 | Avectas Limited | Delivery across cell plasma membranes |
| CN106668880B (zh) * | 2014-10-31 | 2019-11-22 | 苏州大学 | 超声/磁共振双模态造影剂的应用 |
| US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
| US9555155B2 (en) | 2014-12-11 | 2017-01-31 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
| IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
| US11827899B2 (en) | 2015-12-30 | 2023-11-28 | Avectas Limited | Vector-free delivery of gene editing proteins and compositions to cells and tissues |
| KR101908609B1 (ko) | 2017-03-27 | 2018-10-16 | 김재홍 | 노출 콘크리트 패널 및 그 제조방법 |
| RU203963U1 (ru) * | 2020-09-24 | 2021-04-29 | Федеральное государственное бюджетное учреждение науки Физический институт им. П.Н. Лебедева Российской академии наук (ФИАН) | Установка для получения полимерных микрокапсул сферической формы |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2797201A (en) † | 1953-05-11 | 1957-06-25 | Standard Oil Co | Process of producing hollow particles and resulting product |
| US2835586A (en) † | 1953-07-27 | 1958-05-20 | Instant Milk Company | Dried milk product and method of making same |
| US2805977A (en) * | 1955-01-04 | 1957-09-10 | Smith Kline French Lab | Sustained release pharmaceutical preparation |
| US3043782A (en) * | 1958-12-22 | 1962-07-10 | Upjohn Co | Process for preparing a more impermeable coating by liquid-liquid phase separation |
| US3501419A (en) * | 1962-06-07 | 1970-03-17 | Tee Pak Inc | Cellulose microspherical product |
| US3565559A (en) * | 1968-03-11 | 1971-02-23 | Sumitomo Chemical Co | Process for making microcapsules |
| AU439432B2 (en) * | 1968-11-28 | 1972-08-15 | Dulux Australia Ltd | Polymer and coating composition |
| US3781230A (en) * | 1968-12-23 | 1973-12-25 | Champion Int Corp | Microcapsular opacifier system |
| US4173488A (en) * | 1968-12-23 | 1979-11-06 | Champion International Corporation | Oil-in-water emulsions containing hydropholeic starch |
| US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
| US3863004A (en) * | 1972-03-20 | 1975-01-28 | Mallinckrodt Chemical Works | Denatured macroprotein with divalent tin for tagging with technetium-99m and method of preparation |
| US3960583A (en) * | 1974-05-02 | 1976-06-01 | Philadelphia Quartz Company | Method of preparing modified hollow, largely spherical particles by spray drying |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| JPS5134879A (en) * | 1974-09-19 | 1976-03-24 | Eisai Co Ltd | Bishochukuryushinoseizoho |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4089800A (en) * | 1975-04-04 | 1978-05-16 | Ppg Industries, Inc. | Method of preparing microcapsules |
| JPS5231981A (en) * | 1975-08-18 | 1977-03-10 | Takeda Chem Ind Ltd | Microcapsule preparation method |
| CA1077842A (en) * | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
| US4134554A (en) | 1976-10-26 | 1979-01-16 | Haybuster Manufacturing, Inc. | Grinder cylinder control for waste paper grinder |
| US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
| US4247406A (en) * | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| US4316391A (en) * | 1979-11-13 | 1982-02-23 | Ultra Med, Inc. | Flow rate measurement |
| JPS5933017B2 (ja) * | 1980-03-14 | 1984-08-13 | 株式会社成和化成 | マイクロカプセル用壁財 |
| US4315435A (en) | 1980-06-30 | 1982-02-16 | Second Foundation | Dual scan ultrasonic scanner |
| NL8004587A (nl) † | 1980-08-13 | 1982-03-16 | Stichting Nl I Zuivelonderzoek | Werkwijze en inrichting voor het continu oplossen van caseine bevattende melkeiwitten alsmede in water oplosbare melkeiwitten van een nieuw type. |
| US4442843A (en) * | 1980-11-17 | 1984-04-17 | Schering, Ag | Microbubble precursors and methods for their production and use |
| CA1170569A (en) | 1980-11-17 | 1984-07-10 | Julia S. Rasor | Microbubble precursors and methods for their production and use |
| JPS5787216A (en) | 1980-11-19 | 1982-05-31 | Nippon Gakki Seizo Kk | Amplifying circuit |
| US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| US4420442A (en) * | 1981-04-13 | 1983-12-13 | Pq Corporation | Manufacturing process for hollow microspheres |
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| ZA831343B (en) * | 1982-04-08 | 1983-11-30 | Pq Corp | Hollow microspheres with organosilicon-silicate surfaces |
| US4960351A (en) * | 1982-04-26 | 1990-10-02 | California Institute Of Technology | Shell forming system |
| US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| US4675381A (en) | 1983-07-01 | 1987-06-23 | Battelle Memorial Institute | Biodegradable polypeptide and its use for the gradual release of drugs |
| DE3324754A1 (de) | 1983-07-06 | 1985-01-17 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ultraschallkontrastmittel sowie dessen herstellung |
| EP0179023B1 (fr) | 1984-10-19 | 1991-01-23 | Battelle Memorial Institute | Polypeptide biodégradable et son utilisation pour le relargage progressif de médicaments |
| GB8510219D0 (en) | 1985-04-22 | 1985-05-30 | Bass Plc | Isolation of fermentation products |
| US4657767A (en) † | 1985-11-07 | 1987-04-14 | Dairyman's Cooperative Creamery Assoc. | Spray drying apparatus and method |
| CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
| CA1254945A (en) * | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
| BR8806573A (pt) | 1987-04-09 | 1989-10-31 | Delta Biotechnology Ltd | Vetor de levedo |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
| IE61591B1 (en) * | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| JP2907911B2 (ja) * | 1988-02-05 | 1999-06-21 | シエーリング アクチエンゲゼルシヤフト | 超音波造影剤、その製造方法及び該超音波造影剤からなる診断又は治療用製剤 |
| US4981625A (en) * | 1988-03-14 | 1991-01-01 | California Institute Of Technology | Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
| US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| EP0381543B1 (en) * | 1989-01-31 | 1993-05-26 | Coletica | Use of solutions of atelocollagen and polyholosides, for example glycosaminoglycans, for the manufacture of microcapsules, microcapsules produced in this way, processes for the manufacture of such microcapsules and cosmetic, pharmaceutical or food compositions in which they are present |
| US5543162A (en) * | 1989-02-10 | 1996-08-06 | Alko Group Ltd. | Polymeric capsules, method of making the same, and foodstuffs containing the same |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| GB8917788D0 (en) * | 1989-08-03 | 1989-09-20 | Smith & Nephew | Adhesive dressing |
| EP0499619B1 (en) | 1989-11-06 | 1996-02-07 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| US5271961A (en) * | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
| US4968562A (en) * | 1990-02-27 | 1990-11-06 | Minnesota Mining And Manufacturing Company | Hollow acid-free acrylate polymeric microspheres having multiple small voids |
| IN172208B (da) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| FR2660864A1 (fr) | 1990-04-13 | 1991-10-18 | Guerbet Sa | Composition de contraste, procede de preparation de cette composition et application a l'imagerie. |
| US5190982A (en) * | 1990-04-26 | 1993-03-02 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| JPH04145131A (ja) * | 1990-10-04 | 1992-05-19 | Japan Synthetic Rubber Co Ltd | 中空重合体粒子の製造方法 |
| EP0504340B1 (en) * | 1990-10-05 | 1995-06-21 | BRACCO International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
| DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
| GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
| US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5674468A (en) * | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
| US5626871A (en) * | 1992-06-12 | 1997-05-06 | Teijin Limited | Preparation for intratracheobronchial administration |
| ATE222754T1 (de) * | 1992-06-12 | 2002-09-15 | Teijin Ltd | Ultrafeines pulver zur inhalation und dessen herstellung |
| JP3313114B2 (ja) | 1992-06-16 | 2002-08-12 | 不二製油株式会社 | 乳化剤及び乳化組成物並びに粉末化組成物 |
| GB9221329D0 (en) | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| US5955108A (en) | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
| US6017310A (en) | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| JP2002515887A (ja) | 1996-10-19 | 2002-05-28 | クウォドラント、ヘルスケアー、(ユーケー)、リミテッド | 診断および治療における中空マイクロカプセルの使用 |
-
1991
- 1991-04-10 GB GB919107628A patent/GB9107628D0/en active Pending
-
1992
- 1992-04-09 IE IE114092A patent/IE921140A1/en unknown
- 1992-04-10 EP EP99203198A patent/EP0972526B1/en not_active Revoked
- 1992-04-10 DE DE69233489T patent/DE69233489T2/de not_active Expired - Fee Related
- 1992-04-10 CA CA002083260A patent/CA2083260A1/en not_active Abandoned
- 1992-04-10 JP JP4508032A patent/JP2865866B2/ja not_active Expired - Fee Related
- 1992-04-10 NZ NZ242328A patent/NZ242328A/en not_active IP Right Cessation
- 1992-04-10 PT PT95110723T patent/PT681843E/pt unknown
- 1992-04-10 ES ES95110723T patent/ES2203626T3/es not_active Expired - Lifetime
- 1992-04-10 DE DE69233148T patent/DE69233148T2/de not_active Expired - Fee Related
- 1992-04-10 HU HU9203891A patent/HUT62805A/hu unknown
- 1992-04-10 EP EP92303236A patent/EP0512693B1/en not_active Expired - Lifetime
- 1992-04-10 DK DK95110723T patent/DK0681843T3/da active
- 1992-04-10 MX MX9201694A patent/MX9201694A/es unknown
- 1992-04-10 FI FI925600A patent/FI925600A7/fi unknown
- 1992-04-10 ZA ZA922636A patent/ZA922636B/xx unknown
- 1992-04-10 AT AT92303236T patent/ATE194082T1/de not_active IP Right Cessation
- 1992-04-10 ES ES99203198T patent/ES2242355T3/es not_active Expired - Lifetime
- 1992-04-10 DK DK92303236T patent/DK0512693T3/da active
- 1992-04-10 CN CN92103376A patent/CN1066977A/zh active Pending
- 1992-04-10 EP EP05075544A patent/EP1547619A3/en not_active Withdrawn
- 1992-04-10 ES ES92303236T patent/ES2150908T3/es not_active Expired - Lifetime
- 1992-04-10 EP EP95110723A patent/EP0681843B2/en not_active Expired - Lifetime
- 1992-04-10 AU AU15891/92A patent/AU655016B2/en not_active Ceased
- 1992-04-10 IL IL10156492A patent/IL101564A/en not_active IP Right Cessation
- 1992-04-10 EP EP92908598A patent/EP0533886A1/en active Pending
- 1992-04-10 KR KR1019920703116A patent/KR0129861B1/ko not_active Expired - Fee Related
- 1992-04-10 WO PCT/GB1992/000643 patent/WO1992018164A1/en not_active Ceased
- 1992-04-10 AT AT99203198T patent/ATE290405T1/de not_active IP Right Cessation
- 1992-04-10 US US07/956,875 patent/US5518709A/en not_active Expired - Lifetime
- 1992-04-10 EP EP07075443A patent/EP1829557A3/en not_active Withdrawn
- 1992-04-10 DE DE69231195T patent/DE69231195T2/de not_active Expired - Fee Related
- 1992-04-10 DK DK99203198T patent/DK0972526T3/da active
- 1992-04-10 AT AT95110723T patent/ATE246519T1/de not_active IP Right Cessation
- 1992-04-10 PT PT92303236T patent/PT512693E/pt unknown
- 1992-10-29 RU RU92016571A patent/RU2109521C1/ru active
- 1992-12-09 GB GB9225716A patent/GB2260745B/en not_active Expired - Fee Related
-
1994
- 1994-10-07 AU AU74483/94A patent/AU691196B2/en not_active Ceased
-
1995
- 1995-08-22 US US08/517,590 patent/US6022525A/en not_active Expired - Fee Related
-
1998
- 1998-01-23 IL IL12303898A patent/IL123038A0/xx unknown
- 1998-08-19 JP JP10233181A patent/JPH11128232A/ja active Pending
-
1999
- 1999-09-28 US US09/407,370 patent/US6569405B1/en not_active Expired - Fee Related
-
2000
- 2000-09-21 GR GR20000402151T patent/GR3034462T3/el not_active IP Right Cessation
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