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DK0506826T3 - Antistofantagonister mod humant interleukin-4 - Google Patents

Antistofantagonister mod humant interleukin-4

Info

Publication number
DK0506826T3
DK0506826T3 DK91902038.8T DK91902038T DK0506826T3 DK 0506826 T3 DK0506826 T3 DK 0506826T3 DK 91902038 T DK91902038 T DK 91902038T DK 0506826 T3 DK0506826 T3 DK 0506826T3
Authority
DK
Denmark
Prior art keywords
binding
antibody antagonists
antagonists
receptors
against human
Prior art date
Application number
DK91902038.8T
Other languages
Danish (da)
English (en)
Inventor
Lata Ramanathan
Gail F Seelig
Paul P Trotta
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0506826T3 publication Critical patent/DK0506826T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK91902038.8T 1989-12-20 1990-12-18 Antistofantagonister mod humant interleukin-4 DK0506826T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45357089A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
DK0506826T3 true DK0506826T3 (da) 1996-05-13

Family

ID=23801108

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902038.8T DK0506826T3 (da) 1989-12-20 1990-12-18 Antistofantagonister mod humant interleukin-4

Country Status (26)

Country Link
US (1) US6358509B1 (fr)
EP (1) EP0506826B1 (fr)
JP (1) JPH0730116B2 (fr)
KR (1) KR960016862B1 (fr)
AT (1) ATE136906T1 (fr)
AU (1) AU639754B2 (fr)
CA (1) CA2071908C (fr)
CZ (1) CZ283050B6 (fr)
DE (1) DE69026627T2 (fr)
DK (1) DK0506826T3 (fr)
ES (1) ES2085983T3 (fr)
FI (1) FI104180B (fr)
GR (1) GR3020325T3 (fr)
HU (1) HU215245B (fr)
IE (1) IE74708B1 (fr)
IL (1) IL96714A0 (fr)
MX (1) MX9203401A (fr)
MY (1) MY106507A (fr)
NO (1) NO922457L (fr)
NZ (1) NZ236511A (fr)
OA (1) OA09704A (fr)
PT (1) PT96230B (fr)
SK (1) SK279933B6 (fr)
TW (1) TW221675B (fr)
WO (1) WO1991009059A1 (fr)
ZA (1) ZA9010190B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
KR100398819B1 (ko) 1993-09-02 2004-02-05 트러스티스 오브 다트마우스 칼리지 gp39길항제를포함하는약제조성물
AP583A (en) * 1993-09-07 1997-04-14 Smithkline Beecham Corp Recombination IL4 antibodies useful in treatment of IL4 mediated disorders.
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
CA2252790A1 (fr) * 1997-02-28 1998-09-03 Enzo Therapeutics, Inc. Nouveaux procedes de retro-regulation immunitaire selective (sidr)
WO2000036103A1 (fr) 1998-12-14 2000-06-22 Genetics Institute, Inc. Chaine de recepteurs de cytokine
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
EP1142961B1 (fr) * 2000-04-06 2008-08-06 FUJIFILM Corporation Complexe de colorant et support d'enregistrement optique d'information
MXPA02011682A (es) 2000-05-26 2003-05-14 Immunex Corp Uso de antagonistas de interleuquina-4 y composiciones de los mismos.
AU2001273413A1 (en) * 2000-07-12 2002-01-21 Immunex Corporation Method for treating cancer using an interleukin- 4 antagonist
US20030170258A1 (en) * 2001-05-09 2003-09-11 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (SIDR)
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
AU2003251633A1 (en) * 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
WO2004096849A2 (fr) * 2003-04-25 2004-11-11 University Of Manitoba Vaccins peptidiques a base de cytokines/chimiokines contre l'allergie
WO2005047331A2 (fr) 2003-11-07 2005-05-26 Immunex Corporation Anticorps liant un recepteur de l'interleucine 4
DK3718564T3 (da) 2003-12-23 2023-11-06 Genentech Inc Nye anti-IL-13-antistoffer og anvendelser
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
RU2382049C2 (ru) * 2004-08-03 2010-02-20 Новартис Аг ЧЕЛОВЕЧЕСКИЕ МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА К ЧЕЛОВЕЧЕСКОМУ ИНТЕРЛЕЙКИНУ-4 (hIL-4)
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
CN102216323B (zh) * 2008-11-17 2016-08-03 哥本哈根大学 用于调节慢性炎症反应和治疗自身免疫性疾病的源自il-4的肽
KR101860963B1 (ko) 2010-04-23 2018-05-24 제넨테크, 인크. 이종다량체 단백질의 생산
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
RU2013140685A (ru) 2011-02-04 2015-03-10 Дженентек, Инк. ВАРИАНТЫ Fc, СПОСОБЫ ИХ ПОЛУЧЕНИЯ
EP2981286A4 (fr) * 2013-04-05 2016-08-24 Hoffmann La Roche Anticorps anti-il-4 et anticorps bispécifiques et leurs utilisations
ES2915378T3 (es) 2013-09-13 2022-06-22 Hoffmann La Roche Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares
KR102571391B1 (ko) 2013-09-13 2023-08-29 제넨테크, 인크. 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물
CN106471117A (zh) 2014-05-06 2017-03-01 豪夫迈·罗氏有限公司 使用哺乳动物细胞产生异多聚体蛋白
WO2019148405A1 (fr) * 2018-02-01 2019-08-08 北京凯因科技股份有限公司 ANTICORPS D'IL-4Rα ET SON UTILISATION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83761B (pt) * 1985-11-19 1989-06-30 Schering Biotech Corp Metodo para a producao de interleuquina-4 de mamifero
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
US5013824A (en) * 1985-11-19 1991-05-07 Schering Corporation Human interleukin-4 peptides and conjugates thereof
ZA872781B (en) 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor
WO1989006975A1 (fr) * 1988-02-02 1989-08-10 Schering Biotech Corporation Procede de reduction des reactions dues a l'immunoglobuline e

Also Published As

Publication number Publication date
ES2085983T3 (es) 1996-06-16
GR3020325T3 (en) 1996-09-30
CZ635290A3 (en) 1997-08-13
AU7176291A (en) 1991-07-18
ATE136906T1 (de) 1996-05-15
IE904589A1 (en) 1991-07-03
EP0506826A1 (fr) 1992-10-07
MY106507A (en) 1995-06-30
HU9202073D0 (en) 1992-09-28
HUT64568A (en) 1994-01-28
JPH0730116B2 (ja) 1995-04-05
NO922457D0 (no) 1992-06-19
FI104180B1 (fi) 1999-11-30
WO1991009059A1 (fr) 1991-06-27
PT96230A (pt) 1991-10-15
SK635290A3 (en) 1999-06-11
KR960016862B1 (ko) 1996-12-23
FI922847L (fi) 1992-06-18
MX9203401A (es) 1992-07-01
EP0506826B1 (fr) 1996-04-17
IL96714A0 (en) 1991-09-16
DE69026627T2 (de) 1996-08-22
PT96230B (pt) 1998-06-30
SK279933B6 (sk) 1999-06-11
HU215245B (hu) 1998-11-30
KR920703642A (ko) 1992-12-18
FI104180B (fi) 1999-11-30
NO922457L (no) 1992-06-19
CA2071908A1 (fr) 1991-06-21
IE74708B1 (en) 1997-07-30
DE69026627D1 (de) 1996-05-23
OA09704A (en) 1993-08-30
AU639754B2 (en) 1993-08-05
NZ236511A (en) 1993-02-25
CA2071908C (fr) 2002-04-30
TW221675B (fr) 1994-03-11
JPH04506359A (ja) 1992-11-05
ZA9010190B (en) 1991-08-28
CZ283050B6 (cs) 1997-12-17
FI922847A0 (fi) 1992-06-18
US6358509B1 (en) 2002-03-19

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