MY106507A - Antibody antagonists of human interleukin-4 - Google Patents
Antibody antagonists of human interleukin-4Info
- Publication number
- MY106507A MY106507A MYPI90002208A MYPI19902208A MY106507A MY 106507 A MY106507 A MY 106507A MY PI90002208 A MYPI90002208 A MY PI90002208A MY PI19902208 A MYPI19902208 A MY PI19902208A MY 106507 A MY106507 A MY 106507A
- Authority
- MY
- Malaysia
- Prior art keywords
- binding
- receptors
- antagonists
- antibody antagonists
- human interleukin
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 6
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 title 1
- 102000055229 human IL4 Human genes 0.000 title 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 8
- 230000027455 binding Effects 0.000 abstract 4
- 230000001413 cellular effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
TWO KINDS OF ANTIBODY ANTAGONISTS OF THE BINDING OF HUMAN IL-4 TO ACELLULAR RECEPTORS ARE PROVIDED BY THIS INVENTION. SOME OF THE ANTAGONISTS BIND TO SPECIFIC REGIONS OF IL-4 WHICH ARE BELIEVED TO BE INVOLVED IN INTERACTIONS BETWEEN IL-4 AND ITS RECEPTORS. BECAUSE OF THIS SPECIFIC BINDING BY THE ANTIBODIES TO THE IL-4, THE BINDING OF THE IL-4 TO THE RECEPTORS IS SUBSTANTIALLY INHIBITED. THE OTHER ANTIBODY ANTAGONISTS OF THE INVENTION ARE ANTI-IDIOTYPIC ANTIBODIES WHICH, WHILE LACKING IL-4 ACTIVITY, APPEAR TO MIMIC IL-4 AND TO COMPETE DIRECTLY WITH IF FOR BINDING TO THE CELLULAR RECEPTORS. POLYPEPTIDES USED TO MAKE THE ANTIBODY ANTAGONISTS ARE ALSO PROVIDED, TOGETHER WITH METHODS FOR USING THE ANTAGONISTS TO INHIBIT THE BINDING OF IL-4 TO ITS CELLULAR RECEPTORS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45357089A | 1989-12-20 | 1989-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY106507A true MY106507A (en) | 1995-06-30 |
Family
ID=23801108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI90002208A MY106507A (en) | 1989-12-20 | 1990-12-19 | Antibody antagonists of human interleukin-4 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6358509B1 (en) |
| EP (1) | EP0506826B1 (en) |
| JP (1) | JPH0730116B2 (en) |
| KR (1) | KR960016862B1 (en) |
| AT (1) | ATE136906T1 (en) |
| AU (1) | AU639754B2 (en) |
| CA (1) | CA2071908C (en) |
| CZ (1) | CZ283050B6 (en) |
| DE (1) | DE69026627T2 (en) |
| DK (1) | DK0506826T3 (en) |
| ES (1) | ES2085983T3 (en) |
| FI (1) | FI104180B (en) |
| GR (1) | GR3020325T3 (en) |
| HU (1) | HU215245B (en) |
| IE (1) | IE74708B1 (en) |
| IL (1) | IL96714A0 (en) |
| MX (1) | MX9203401A (en) |
| MY (1) | MY106507A (en) |
| NO (1) | NO922457L (en) |
| NZ (1) | NZ236511A (en) |
| OA (1) | OA09704A (en) |
| PT (1) | PT96230B (en) |
| SK (1) | SK279933B6 (en) |
| TW (1) | TW221675B (en) |
| WO (1) | WO1991009059A1 (en) |
| ZA (1) | ZA9010190B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714146A (en) * | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| KR100398819B1 (en) | 1993-09-02 | 2004-02-05 | 트러스티스 오브 다트마우스 칼리지 | Pharmaceutical composition containing gp39 antagonist |
| AP583A (en) * | 1993-09-07 | 1997-04-14 | Smithkline Beecham Corp | Recombination IL4 antibodies useful in treatment of IL4 mediated disorders. |
| US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| US5597710A (en) * | 1994-03-10 | 1997-01-28 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| CA2252790A1 (en) * | 1997-02-28 | 1998-09-03 | Enzo Therapeutics, Inc. | Novel processes implementing selective immune down regulation (sidr) |
| WO2000036103A1 (en) | 1998-12-14 | 2000-06-22 | Genetics Institute, Inc. | Cytokine receptor chain |
| US7553487B2 (en) | 1998-12-14 | 2009-06-30 | Genetics Institute, Llc | Method and compositions for treating asthma |
| EP1142961B1 (en) * | 2000-04-06 | 2008-08-06 | FUJIFILM Corporation | Dye complex and optical information recording medium |
| MXPA02011682A (en) | 2000-05-26 | 2003-05-14 | Immunex Corp | Use of interleukin-4 antagonists and compositions thereof. |
| AU2001273413A1 (en) * | 2000-07-12 | 2002-01-21 | Immunex Corporation | Method for treating cancer using an interleukin- 4 antagonist |
| US20030170258A1 (en) * | 2001-05-09 | 2003-09-11 | Enzo Therapeutics, Inc. | Novel processes implementing selective immune down regulation (SIDR) |
| FR2838444B1 (en) | 2002-04-10 | 2016-01-01 | Neovacs | NEW PEPTIDES AND THEIR THERAPEUTIC APPLICATION |
| US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
| AU2003251633A1 (en) * | 2002-07-01 | 2004-01-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Il-21 as a regulator of immunoglobin production |
| US20110223168A1 (en) * | 2002-12-27 | 2011-09-15 | Greg Winter | Ligand that has binding specificity for il-4 and/or il-13 |
| WO2004096849A2 (en) * | 2003-04-25 | 2004-11-11 | University Of Manitoba | Peptide-based cytokine/chemokine vaccines against allergy |
| WO2005047331A2 (en) | 2003-11-07 | 2005-05-26 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| DK3718564T3 (en) | 2003-12-23 | 2023-11-06 | Genentech Inc | Novel anti-IL-13 antibodies and applications |
| US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| AR049390A1 (en) | 2004-06-09 | 2006-07-26 | Wyeth Corp | ANTIBODIES AGAINST HUMAN INTERLEUQUINE-13 AND USES OF THE SAME |
| RU2382049C2 (en) * | 2004-08-03 | 2010-02-20 | Новартис Аг | HUMAN MONOCLONAL ANTIBODIES TO HUMAN INTERLEUKINE-4 (hIL-4) |
| AR050044A1 (en) * | 2004-08-03 | 2006-09-20 | Novartis Ag | IL-4 SPECIFIC ANTIBODY |
| CN102216323B (en) * | 2008-11-17 | 2016-08-03 | 哥本哈根大学 | For regulating chronic inflammatory reaction and the peptide being derived from IL-4 for the treatment of autoimmune disease |
| KR101860963B1 (en) | 2010-04-23 | 2018-05-24 | 제넨테크, 인크. | Production of heteromultimeric proteins |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| RU2013140685A (en) | 2011-02-04 | 2015-03-10 | Дженентек, Инк. | OPTIONS Fc, METHODS FOR PRODUCING THEM |
| EP2981286A4 (en) * | 2013-04-05 | 2016-08-24 | Hoffmann La Roche | ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF |
| ES2915378T3 (en) | 2013-09-13 | 2022-06-22 | Hoffmann La Roche | Methods for detecting and quantifying a host cell protein in cell lines |
| KR102571391B1 (en) | 2013-09-13 | 2023-08-29 | 제넨테크, 인크. | Methods and compositions comprising purified recombinant polypeptides |
| CN106471117A (en) | 2014-05-06 | 2017-03-01 | 豪夫迈·罗氏有限公司 | Production of heteromultimeric proteins using mammalian cells |
| WO2019148405A1 (en) * | 2018-02-01 | 2019-08-08 | 北京凯因科技股份有限公司 | IL-4Rα ANTIBODY AND USE THEREOF |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT83761B (en) * | 1985-11-19 | 1989-06-30 | Schering Biotech Corp | METHOD FOR THE PRODUCTION OF INTERLEUQUIN-4 OF MAMIFERO |
| US5041381A (en) * | 1986-07-03 | 1991-08-20 | Schering Corporation | Monoclonal antibodies against human interleukin-4 and hybridomas producing the same |
| US5013824A (en) * | 1985-11-19 | 1991-05-07 | Schering Corporation | Human interleukin-4 peptides and conjugates thereof |
| ZA872781B (en) | 1986-05-19 | 1987-10-05 | Immunology Ventures | B-cell stimulating factor |
| WO1989006975A1 (en) * | 1988-02-02 | 1989-08-10 | Schering Biotech Corporation | Method of reducing immunoglobulin e responses |
-
1990
- 1990-12-18 DE DE69026627T patent/DE69026627T2/en not_active Expired - Fee Related
- 1990-12-18 CA CA002071908A patent/CA2071908C/en not_active Expired - Fee Related
- 1990-12-18 NZ NZ236511A patent/NZ236511A/en unknown
- 1990-12-18 SK SK6352-90A patent/SK279933B6/en unknown
- 1990-12-18 MX MX9203401A patent/MX9203401A/en unknown
- 1990-12-18 KR KR1019920701458A patent/KR960016862B1/en not_active Expired - Fee Related
- 1990-12-18 AU AU71762/91A patent/AU639754B2/en not_active Ceased
- 1990-12-18 DK DK91902038.8T patent/DK0506826T3/en active
- 1990-12-18 WO PCT/US1990/007289 patent/WO1991009059A1/en not_active Ceased
- 1990-12-18 ES ES91902038T patent/ES2085983T3/en not_active Expired - Lifetime
- 1990-12-18 HU HU9202073A patent/HU215245B/en not_active IP Right Cessation
- 1990-12-18 PT PT96230A patent/PT96230B/en not_active IP Right Cessation
- 1990-12-18 ZA ZA9010190A patent/ZA9010190B/en unknown
- 1990-12-18 CZ CS906352A patent/CZ283050B6/en not_active IP Right Cessation
- 1990-12-18 IL IL96714A patent/IL96714A0/en unknown
- 1990-12-18 EP EP91902038A patent/EP0506826B1/en not_active Expired - Lifetime
- 1990-12-18 JP JP3502759A patent/JPH0730116B2/en not_active Expired - Fee Related
- 1990-12-18 AT AT91902038T patent/ATE136906T1/en not_active IP Right Cessation
- 1990-12-19 IE IE458990A patent/IE74708B1/en not_active IP Right Cessation
- 1990-12-19 TW TW079110658A patent/TW221675B/zh active
- 1990-12-19 MY MYPI90002208A patent/MY106507A/en unknown
-
1992
- 1992-06-18 FI FI922847A patent/FI104180B/en active
- 1992-06-19 NO NO92922457A patent/NO922457L/en not_active Application Discontinuation
- 1992-06-19 OA OA60233A patent/OA09704A/en unknown
-
1994
- 1994-07-07 US US08/271,539 patent/US6358509B1/en not_active Expired - Fee Related
-
1996
- 1996-06-24 GR GR960401694T patent/GR3020325T3/en unknown
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