DK0500734T3 - Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf - Google Patents

Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf

Info

Publication number: DK0500734T3
Authority: DK; Denmark
Prior art keywords: factor viii; human factor; domain; activity; polypeptide
Prior art date: 1989-11-17

Application number

DK90917369.2T

Other languages

Danish (da)

English (en)

Inventor

Rae Lyn Burke

Barbara Chapman

Mirella Ezban Rasmussen

Jan Moeller Mikkelsen

Original Assignee

Chiron Corp

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1990-11-15

Publication date

1998-03-30

1990-11-15 Application filed by Chiron Corp, Novo Nordisk As filed Critical Chiron Corp

1998-03-30 Application granted granted Critical

1998-03-30 Publication of DK0500734T3 publication Critical patent/DK0500734T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Immunology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

DK90917369.2T 1989-11-17 1990-11-15 Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf DK0500734T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US43863989A	1989-11-17	1989-11-17

Publications (1)

Publication Number	Publication Date
DK0500734T3 true DK0500734T3 (da)	1998-03-30

Family

ID=23741420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90917369.2T DK0500734T3 (da)	1989-11-17	1990-11-15	Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf

Country Status (22)

Country	Link
EP (2)	EP0670332A3 (fr)
JP (3)	JP2865861B2 (fr)
KR (2)	KR960701899A (fr)
AT (1)	ATE163194T1 (fr)
AU (1)	AU656311B2 (fr)
CA (2)	CA2135744A1 (fr)
DE (1)	DE69032043T2 (fr)
DK (1)	DK0500734T3 (fr)
ES (1)	ES2112255T3 (fr)
FI (2)	FI922204L (fr)
GR (1)	GR3026176T3 (fr)
HU (2)	HUT64591A (fr)
IE (1)	IE904140A1 (fr)
IL (2)	IL96368A0 (fr)
NO (2)	NO921946L (fr)
NZ (1)	NZ236094A (fr)
PL (1)	PL167083B1 (fr)
PT (1)	PT95923B (fr)
SK (1)	SK130194A3 (fr)
WO (1)	WO1991007490A1 (fr)
YU (2)	YU218690A (fr)
ZA (1)	ZA909167B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE465222C5 (sv) *	1989-12-15	1998-02-10	Pharmacia & Upjohn Ab	Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5326700A (en) *	1990-11-06	1994-07-05	Eli Lilly And Company	DNA sequences encoding t-PA derivatives with cleavable sites
SE468050C (sv) *	1991-03-15	1998-04-27	Pharmacia & Upjohn Ab	Rekombinant derivat av human faktor VIII
CA2078721A1 (fr) *	1991-09-24	1993-03-25	Hiroshi Yonemura	Methode de preparation d'un complexe proteique du facteur viii de coagulation humaine
DK53792D0 (da) *	1992-04-24	1992-04-24	Novo Nordisk As	Fremgangsmaade til fremstilling af proteiner
EP0768361A1 (fr) *	1995-10-16	1997-04-16	Shin-Etsu Chemical Co., Ltd.	Composition liquide cristalline et élément d'affichage à cristaux liquides la comprenant
US8183344B2 (en)	1996-04-24	2012-05-22	University Of Michigan	Inactivation resistant factor VIII
DE69735421T2 (de)	1996-04-24	2006-10-19	The Regents Of The University Of Michigan, Ann Arbor	Gegen inaktivierung resistenter faktor viii
GB2318732A (en)	1996-11-01	1998-05-06	Johnson & Johnson Medical	Wound healing compositions containing alpha-1-antitrypsin
US6200560B1 (en)	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en)	1998-10-20	2001-04-24	Avigen, Inc.	Adeno-associated vectors for expression of factor VIII by target cells
EP1460131A3 (fr) *	2000-03-22	2005-06-01	Octagene GmbH	Préparation de facteurs de la coagulation sanguine recombinants en lignées cellulaires humaines
EP2298926A1 (fr)	2003-09-30	2011-03-23	The Trustees of The University of Pennsylvania	Clades (sous-types) et séquences de Virus Adeno-Associé (AAV), vecteurs les contenant et leurs utilistation
EP1707634A1 (fr)	2005-03-29	2006-10-04	Octapharma AG	Procédé pour l'isolation de protéines recombinantes
EP2357010B1 (fr)	2005-04-07	2013-06-12	The Trustees of The University of Pennsylvania	Procédé d'amélioration de la fonction d'un vecteur AAV
EP1739179A1 (fr)	2005-06-30	2007-01-03	Octapharma AG	Transfection stable exempt de sérum et production des protéines recombinantes humaines dans des lignées cellulaires humaines
WO2011095604A1 (fr)	2010-02-04	2011-08-11	Octapharma Biopharmaceuticals Gmbh	Prolongation de la demi-vie de protéines
US9315825B2 (en)	2010-03-29	2016-04-19	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
SG10201502270TA (en)	2010-03-29	2015-05-28	Univ Pennsylvania	Pharmacologically induced transgene ablation system
JP6224459B2 (ja)	2011-02-17	2017-11-01	ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア	組織特異性を改変し、ａａｖ９媒介遺伝子導入を改善するための組成物および方法
WO2015012924A2 (fr)	2013-04-29	2015-01-29	The Trustees Of The University Of Pennsylvania	Cassettes d'expression préférentielle pour tissus modifiées par un codon, vecteurs les contenant, et utilisation
US10058624B2 (en)	2015-04-16	2018-08-28	Emory University	Recombinant promoters and vectors for protein expression in liver and use thereof
KR20230042754A (ko)	2020-08-07	2023-03-29	아미쿠스 세라퓨틱스, 인코포레이티드	소포 표적화 단백질 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652530A (en)	1967-08-28	1972-03-28	American Nat Red Cross	Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en)	1970-05-01	1971-12-28	Baxter Laboratories Inc	Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US4069216A (en)	1975-06-16	1978-01-17	Edward Shanbrom, Inc.	Simplified methods for preparation of very high purity Factor VIII concentrate
AU577259B2 (en) *	1982-08-13	1988-09-22	Zymogenetics Inc.	Glycolytic promters for regulated protein expression protease inhibitor
JPH07106156B2 (ja) *	1983-10-28	1995-11-15	ジェネティックス、インスティチュ−ト	ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
JPH0788399B2 (ja) *	1985-04-12	1995-09-27	ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド	新規プロコアギュラント蛋白質
FI98829C (fi) *	1986-01-27	1997-08-25	Chiron Corp	Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
AU588965B2 (en) *	1986-02-06	1989-09-28	Alcatel Australia Limited	Telephone hook-switch

1990
- 1990-11-15 FI FI922204A patent/FI922204L/fi not_active Application Discontinuation
- 1990-11-15 ZA ZA909167A patent/ZA909167B/xx unknown
- 1990-11-15 EP EP95107535A patent/EP0670332A3/fr not_active Ceased
- 1990-11-15 CA CA002135744A patent/CA2135744A1/fr not_active Abandoned
- 1990-11-15 JP JP3500068A patent/JP2865861B2/ja not_active Expired - Lifetime
- 1990-11-15 WO PCT/DK1990/000291 patent/WO1991007490A1/fr not_active Ceased
- 1990-11-15 HU HU9201629A patent/HUT64591A/hu unknown
- 1990-11-15 DE DE69032043T patent/DE69032043T2/de not_active Expired - Lifetime
- 1990-11-15 DK DK90917369.2T patent/DK0500734T3/da active
- 1990-11-15 KR KR1019950704440A patent/KR960701899A/ko not_active Abandoned
- 1990-11-15 EP EP90917369A patent/EP0500734B1/fr not_active Expired - Lifetime
- 1990-11-15 FI FI944903A patent/FI944903L/fi unknown
- 1990-11-15 HU HU9500546A patent/HUT70457A/hu unknown
- 1990-11-15 AT AT90917369T patent/ATE163194T1/de not_active IP Right Cessation
- 1990-11-15 AU AU67525/90A patent/AU656311B2/en not_active Ceased
- 1990-11-15 KR KR1019920701170A patent/KR927003812A/ko not_active Abandoned
- 1990-11-15 ES ES90917369T patent/ES2112255T3/es not_active Expired - Lifetime
- 1990-11-15 NZ NZ236094A patent/NZ236094A/xx unknown
- 1990-11-15 CA CA002068728A patent/CA2068728A1/fr not_active Abandoned
- 1990-11-16 IE IE414090A patent/IE904140A1/en not_active Application Discontinuation
- 1990-11-16 IL IL96368A patent/IL96368A0/xx unknown
- 1990-11-16 YU YU218690A patent/YU218690A/sh unknown
- 1990-11-16 PL PL90287807A patent/PL167083B1/pl unknown
- 1990-11-16 PT PT95923A patent/PT95923B/pt not_active IP Right Cessation
1992
- 1992-05-15 NO NO92921946A patent/NO921946L/no unknown
1994
- 1994-10-14 IL IL11130494A patent/IL111304A0/xx unknown
- 1994-10-18 NO NO943949A patent/NO943949D0/no unknown
- 1994-10-26 SK SK1301-94A patent/SK130194A3/sk unknown
- 1994-12-28 YU YU78194A patent/YU78194A/sh unknown
1995
- 1995-06-13 JP JP7146581A patent/JP2771129B2/ja not_active Expired - Lifetime
1998
- 1998-02-18 GR GR980400352T patent/GR3026176T3/el unknown
- 1998-08-24 JP JP10237850A patent/JPH11130800A/ja active Pending

Also Published As

Publication number	Publication date
YU78194A (sh)	1997-05-28
IL96368A0 (en)	1991-08-16
FI944903A0 (fi)	1994-10-19
DE69032043D1 (de)	1998-03-19
AU6752590A (en)	1991-06-13
HUT64591A (en)	1994-01-28
JP2865861B2 (ja)	1999-03-08
IE904140A1 (en)	1991-05-22
CA2068728A1 (fr)	1991-05-18
NO943949D0 (no)	1994-10-18
FI922204A7 (fi)	1992-05-14
YU218690A (sh)	1993-05-28
ES2112255T3 (es)	1998-04-01
KR960701899A (ko)	1996-03-28
NO921946L (no)	1992-07-13
GR3026176T3 (en)	1998-05-29
PT95923A (pt)	1991-09-13
HUT70457A (en)	1995-10-30
NO943949L (no)	1992-07-13
JPH11130800A (ja)	1999-05-18
ATE163194T1 (de)	1998-02-15
ZA909167B (en)	1993-10-15
EP0670332A3 (fr)	1995-10-25
JP2771129B2 (ja)	1998-07-02
FI922204A0 (fi)	1992-05-14
FI922204L (fi)	1992-05-14
DE69032043T2 (de)	1998-06-04
SK130194A3 (en)	1997-06-04
AU656311B2 (en)	1995-02-02
CA2135744A1 (fr)	1991-05-18
HU9201629D0 (en)	1992-08-28
KR927003812A (ko)	1992-12-18
EP0500734B1 (fr)	1998-02-11
NZ236094A (en)	1993-04-28
JPH0856656A (ja)	1996-03-05
EP0670332A2 (fr)	1995-09-06
HU9500546D0 (en)	1995-04-28
FI944903A7 (fi)	1994-10-19
PT95923B (pt)	1998-04-30
NO921946D0 (no)	1992-05-15
PL167083B1 (pl)	1995-07-31
IL111304A0 (en)	1994-12-29
EP0500734A1 (fr)	1992-09-02
JPH05502025A (ja)	1993-04-15
FI944903L (fi)	1994-10-19
PL287807A1 (en)	1991-09-23
WO1991007490A1 (fr)	1991-05-30

Publication	Publication Date	Title
DK0500734T3 (da)	1998-03-30	Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf
DE60033138D1 (de)	2007-03-15	Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
ES2137931T3 (es)	2000-01-01	Proteinas gdf-1 y uog-1.
DE3650538D1 (de)	1996-08-08	Interleukin-4 protein mit bcgf- und tcgf-aktivität gegenüber menschlichen zellen (menschliches interleukin-4)
ES8306325A1 (es)	1983-06-01	"proceso para la produccion microbiana de interferon fibroblasto humano".
ATE414775T1 (de)	2008-12-15	Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren
DE69930955D1 (de)	2006-05-24	Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren
DK244289A (da)	1989-11-21	Fibronectinbindende protein, dets anvendelse og fremstilling samt midler til brug ved fremstillingen
DE69333346D1 (de)	2004-01-22	Neuartiges p- selectin ligandenprotein
ATE79403T1 (de)	1992-08-15	Herstellung von thrombin-inhibitoren.
DE69837475D1 (de)	2007-05-16	Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
FI90667C (fi)	1994-03-10	Menetelmä valmistaa uutta ihmisen tyypin I interferoniproteiinia
ATE295890T1 (de)	2005-06-15	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
HUP9801330A2 (hu)	1998-08-28	Új PKA-kötő fehérjék és alkalmazásuk
DK0414151T3 (da)	1995-05-22	Humane nervevæskstfaktorproteiner og fremstilling deraf
ATE317896T1 (de)	2006-03-15	Polypeptide mit glucanotransferase aktivität und dafür kodierende nukleinsäuren
RU92004585A (ru)	1996-09-20	Промотор, днк-последовательность, вектор, клетки, способ экспрессии днк
ATE154392T1 (de)	1997-06-15	Kalzium-geregelter promotor
DE69932644D1 (de)	2006-09-14	Menschliches Protein mit in vitro antiproliferativer Aktivität.