GR3026176T3 - Protein complexes having factor viii:c activity and production thereof - Google Patents

Protein complexes having factor viii:c activity and production thereof

Info

Publication number: GR3026176T3
Authority: GR; Greece
Prior art keywords: factor viii; human factor; domain; polypeptide; activity
Prior art date: 1989-11-17

Application number

GR980400352T

Other languages

English (en)

Inventor

Barbara Chapman

Rae Lyn Burke

Mirella Ezban Rasmussen

Jan Moller Mikkelsen

Original Assignee

Novo Nordisk As

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1998-02-18

Publication date

1998-05-29

1998-02-18 Application filed by Novo Nordisk As, Chiron Corp filed Critical Novo Nordisk As

1998-05-29 Publication of GR3026176T3 publication Critical patent/GR3026176T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Diabetes (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

GR980400352T 1989-11-17 1998-02-18 Protein complexes having factor viii:c activity and production thereof GR3026176T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43863989A	1989-11-17	1989-11-17
PCT/DK1990/000291 WO1991007490A1 (en)	1989-11-17	1990-11-15	Protein complexes having factor viii:c activity and production thereof

Publications (1)

Publication Number	Publication Date
GR3026176T3 true GR3026176T3 (en)	1998-05-29

Family

ID=23741420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR980400352T GR3026176T3 (en)	1989-11-17	1998-02-18	Protein complexes having factor viii:c activity and production thereof

Country Status (22)

Country	Link
EP (2)	EP0670332A3 (el)
JP (3)	JP2865861B2 (el)
KR (2)	KR927003812A (el)
AT (1)	ATE163194T1 (el)
AU (1)	AU656311B2 (el)
CA (2)	CA2135744A1 (el)
DE (1)	DE69032043T2 (el)
DK (1)	DK0500734T3 (el)
ES (1)	ES2112255T3 (el)
FI (2)	FI944903A7 (el)
GR (1)	GR3026176T3 (el)
HU (2)	HUT70457A (el)
IE (1)	IE904140A1 (el)
IL (2)	IL96368A0 (el)
NO (2)	NO921946L (el)
NZ (1)	NZ236094A (el)
PL (1)	PL167083B1 (el)
PT (1)	PT95923B (el)
SK (1)	SK130194A3 (el)
WO (1)	WO1991007490A1 (el)
YU (2)	YU218690A (el)
ZA (1)	ZA909167B (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE465222C5 (sv) *	1989-12-15	1998-02-10	Pharmacia & Upjohn Ab	Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5326700A (en) *	1990-11-06	1994-07-05	Eli Lilly And Company	DNA sequences encoding t-PA derivatives with cleavable sites
SE468050C (sv) *	1991-03-15	1998-04-27	Pharmacia & Upjohn Ab	Rekombinant derivat av human faktor VIII
CA2078721A1 (en) *	1991-09-24	1993-03-25	Hiroshi Yonemura	Process for preparing human coagulation factor viii protein complex
DK53792D0 (da) *	1992-04-24	1992-04-24	Novo Nordisk As	Fremgangsmaade til fremstilling af proteiner
EP0768361A1 (en) *	1995-10-16	1997-04-16	Shin-Etsu Chemical Co., Ltd.	Liquid crystal composition and liquid crystal display element comprising the same
ATE319817T1 (de)	1996-04-24	2006-03-15	Univ Michigan	Gegen inaktivierung resistenter faktor viii
US8183344B2 (en)	1996-04-24	2012-05-22	University Of Michigan	Inactivation resistant factor VIII
GB2318732A (en)	1996-11-01	1998-05-06	Johnson & Johnson Medical	Wound healing compositions containing alpha-1-antitrypsin
US6221349B1 (en)	1998-10-20	2001-04-24	Avigen, Inc.	Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en)	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
DE60115613T2 (de) *	2000-03-22	2006-08-24	Octagene Gmbh	Herstellung von rekombinanten muteine des blutgerinnungsfaktors viii in humanen zellinien
EP2292780B1 (en)	2003-09-30	2017-08-23	The Trustees Of The University Of Pennsylvania	Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
EP1707634A1 (en)	2005-03-29	2006-10-04	Octapharma AG	Method for isolation of recombinantly produced proteins
EP2359865B1 (en)	2005-04-07	2013-10-02	The Trustees of The University of Pennsylvania	Method of increasing the function of an AAV vector
EP1739179A1 (en)	2005-06-30	2007-01-03	Octapharma AG	Serum-free stable transfection and production of recombinant human proteins in human cell lines
WO2011095604A1 (en)	2010-02-04	2011-08-11	Octapharma Biopharmaceuticals Gmbh	Half-life prolongation of proteins
SG183929A1 (en)	2010-03-29	2012-10-30	Univ Pennsylvania	Pharmacologically induced transgene ablation system
US9315825B2 (en)	2010-03-29	2016-04-19	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
AU2012219380B2 (en)	2011-02-17	2017-04-13	The Trustees Of The University Of Pennsylvania	Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer
US9719106B2 (en)	2013-04-29	2017-08-01	The Trustees Of The University Of Pennsylvania	Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
CN108093639B (zh)	2015-04-16	2022-07-19	埃默里大学	用于肝脏中蛋白质表达的重组启动子和载体及其用途
KR20230042754A (ko)	2020-08-07	2023-03-29	아미쿠스 세라퓨틱스, 인코포레이티드	소포 표적화 단백질 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652530A (en)	1967-08-28	1972-03-28	American Nat Red Cross	Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en)	1970-05-01	1971-12-28	Baxter Laboratories Inc	Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US4069216A (en)	1975-06-16	1978-01-17	Edward Shanbrom, Inc.	Simplified methods for preparation of very high purity Factor VIII concentrate
AU577259B2 (en) *	1982-08-13	1988-09-22	Zymogenetics Inc.	Glycolytic promters for regulated protein expression protease inhibitor
EP0162067B1 (en) *	1983-10-28	1992-07-15	Genetics Institute, Inc.	Production of factor viii and related products
DE3683980D1 (de) *	1985-04-12	1992-04-02	Genetics Inst	Neue prokoagulierungsproteine.
FI98829C (fi)	1986-01-27	1997-08-25	Chiron Corp	Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
AU588965B2 (en) *	1986-02-06	1989-09-28	Alcatel Australia Limited	Telephone hook-switch

1990
- 1990-11-15 KR KR1019920701170A patent/KR927003812A/ko not_active Abandoned
- 1990-11-15 CA CA002135744A patent/CA2135744A1/en not_active Abandoned
- 1990-11-15 ES ES90917369T patent/ES2112255T3/es not_active Expired - Lifetime
- 1990-11-15 CA CA002068728A patent/CA2068728A1/en not_active Abandoned
- 1990-11-15 HU HU9500546A patent/HUT70457A/hu unknown
- 1990-11-15 EP EP95107535A patent/EP0670332A3/en not_active Ceased
- 1990-11-15 EP EP90917369A patent/EP0500734B1/en not_active Expired - Lifetime
- 1990-11-15 AU AU67525/90A patent/AU656311B2/en not_active Ceased
- 1990-11-15 ZA ZA909167A patent/ZA909167B/xx unknown
- 1990-11-15 NZ NZ236094A patent/NZ236094A/xx unknown
- 1990-11-15 JP JP3500068A patent/JP2865861B2/ja not_active Expired - Lifetime
- 1990-11-15 HU HU9201629A patent/HUT64591A/hu unknown
- 1990-11-15 KR KR1019950704440A patent/KR960701899A/ko not_active Abandoned
- 1990-11-15 DK DK90917369.2T patent/DK0500734T3/da active
- 1990-11-15 DE DE69032043T patent/DE69032043T2/de not_active Expired - Lifetime
- 1990-11-15 WO PCT/DK1990/000291 patent/WO1991007490A1/en not_active Ceased
- 1990-11-15 FI FI944903A patent/FI944903A7/fi unknown
- 1990-11-15 AT AT90917369T patent/ATE163194T1/de not_active IP Right Cessation
- 1990-11-15 FI FI922204A patent/FI922204A7/fi not_active Application Discontinuation
- 1990-11-16 YU YU218690A patent/YU218690A/sh unknown
- 1990-11-16 IE IE414090A patent/IE904140A1/en not_active Application Discontinuation
- 1990-11-16 PL PL90287807A patent/PL167083B1/pl unknown
- 1990-11-16 IL IL96368A patent/IL96368A0/xx unknown
- 1990-11-16 PT PT95923A patent/PT95923B/pt not_active IP Right Cessation
1992
- 1992-05-15 NO NO92921946A patent/NO921946L/no unknown
1994
- 1994-10-14 IL IL11130494A patent/IL111304A0/xx unknown
- 1994-10-18 NO NO943949A patent/NO943949D0/no unknown
- 1994-10-26 SK SK1301-94A patent/SK130194A3/sk unknown
- 1994-12-28 YU YU78194A patent/YU78194A/sh unknown
1995
- 1995-06-13 JP JP7146581A patent/JP2771129B2/ja not_active Expired - Lifetime
1998
- 1998-02-18 GR GR980400352T patent/GR3026176T3/el unknown
- 1998-08-24 JP JP10237850A patent/JPH11130800A/ja active Pending

Also Published As

Publication number	Publication date
CA2068728A1 (en)	1991-05-18
WO1991007490A1 (en)	1991-05-30
DE69032043T2 (de)	1998-06-04
HUT64591A (en)	1994-01-28
CA2135744A1 (en)	1991-05-18
YU78194A (sh)	1997-05-28
FI922204A0 (fi)	1992-05-14
FI922204L (fi)	1992-05-14
PT95923B (pt)	1998-04-30
PL287807A1 (en)	1991-09-23
YU218690A (sh)	1993-05-28
ATE163194T1 (de)	1998-02-15
JPH11130800A (ja)	1999-05-18
EP0670332A2 (en)	1995-09-06
FI922204A7 (fi)	1992-05-14
NZ236094A (en)	1993-04-28
EP0500734B1 (en)	1998-02-11
AU6752590A (en)	1991-06-13
JPH05502025A (ja)	1993-04-15
EP0670332A3 (en)	1995-10-25
JP2865861B2 (ja)	1999-03-08
PT95923A (pt)	1991-09-13
NO943949D0 (no)	1994-10-18
KR960701899A (ko)	1996-03-28
PL167083B1 (pl)	1995-07-31
JPH0856656A (ja)	1996-03-05
ES2112255T3 (es)	1998-04-01
IL111304A0 (en)	1994-12-29
HUT70457A (en)	1995-10-30
HU9500546D0 (en)	1995-04-28
ZA909167B (en)	1993-10-15
NO943949L (no)	1992-07-13
FI944903A0 (fi)	1994-10-19
KR927003812A (ko)	1992-12-18
NO921946D0 (no)	1992-05-15
HU9201629D0 (en)	1992-08-28
FI944903L (fi)	1994-10-19
SK130194A3 (en)	1997-06-04
IE904140A1 (en)	1991-05-22
JP2771129B2 (ja)	1998-07-02
AU656311B2 (en)	1995-02-02
DK0500734T3 (da)	1998-03-30
DE69032043D1 (de)	1998-03-19
FI944903A7 (fi)	1994-10-19
IL96368A0 (en)	1991-08-16
NO921946L (no)	1992-07-13
EP0500734A1 (en)	1992-09-02

Publication	Publication Date	Title
HUT70457A (en)	1995-10-30	Protein complexes having factor viii:c activity and production thereof
IE812224L (en)	1982-03-25	Interferon
AU4067985A (en)	1985-09-24	Hosts and methods for producing recombinant products in high yields
IE883612L (en)	1989-06-04	Vectors and compounds for direct expression of activated human protein c
HUT47638A (en)	1989-03-28	Dna structures comprising kluyveromyces alpha-factor leading sequence regulating the selection of heterologous polypeptides
DE3650538D1 (de)	1996-08-08	Interleukin-4 protein mit bcgf- und tcgf-aktivität gegenüber menschlichen zellen (menschliches interleukin-4)
IL94361A0 (en)	1991-03-10	Polypeptides,recombinant dna molecules and method of producing a human hemoglobin like protein
ATE414775T1 (de)	2008-12-15	Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren
DK244289A (da)	1989-11-21	Fibronectinbindende protein, dets anvendelse og fremstilling samt midler til brug ved fremstillingen
ATE79403T1 (de)	1992-08-15	Herstellung von thrombin-inhibitoren.
ATE358725T1 (de)	2007-04-15	Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
AU7873798A (en)	1998-07-17	N-terminally extended proteins expressed in yeast
CA2032167A1 (en)	1990-11-02	Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
ATE295890T1 (de)	2005-06-15	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
ATE131494T1 (de)	1995-12-15	Herstellung von fusionsproteinen oder - polypeptiden
RU92004585A (ru)	1996-09-20	Промотор, днк-последовательность, вектор, клетки, способ экспрессии днк
KR870005090A (ko)	1987-06-04	변이주 인식사슬
GR3024625T3 (es)	1997-12-31	Calcium-regulated promoter
DE69932644D1 (de)	2006-09-14	Menschliches Protein mit in vitro antiproliferativer Aktivität.
EP0603393A4 (en)	1995-03-29	INTERLEUKIN 6 HUMAN RECOMBINATION WITH HOMOGENEOUS N TERMINATION AND PRODUCTION OF THIS INTERLEUKIN.